GenTIGSA Gene Database on Rare Genetic Disorders
  Beta Version

Variants from 496 rare genetic disorders, with a total of 857 reported, submitted from India

Achondroplasia

An  Autosomal dominant  mode(s) within the Bone disorders  category

Benign 1
Benign/Likely benign 1
Likely pathogenic 3
Pathogenic 5
Pathogenic/Likely pathogenic 1

Variant name Variant type Germline classification Molecular consequence Grch38 Location dbSNP_ID Submitter
NM_000142.5(FGFR3):c.1183C>A (p.Leu395Ile) single nucleotide variant Likely pathogenic missense variant|non-coding transcript variant|intron variant Chr4:1804437 rs2108797528 .Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
NM_000142.5(FGFR3):c.1144G>A (p.Gly382Ser) single nucleotide variant Likely pathogenic missense variant|non-coding transcript variant|intron variant Chr4:1804398 rs1360936268 .Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
NM_000142.5(FGFR3):c.1118A>G (p.Tyr373Cys) single nucleotide variant Pathogenic missense variant|non-coding transcript variant|intron variant Chr4:1804372 rs121913485 .Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
NM_000142.5(FGFR3):c.746C>G (p.Ser249Cys) single nucleotide variant Pathogenic missense variant|non-coding transcript variant Chr4:1801841 rs121913483 .Bioinformatics dept., Datar Cancer Genetics Limited, India
.Neuberg Centre For Genomic Medicine, NCGM
.Suma Genomics
NM_000142.5(FGFR3):c.1620C>G (p.Asn540Lys) single nucleotide variant Pathogenic/Likely pathogenic missense variant|non-coding transcript variant Chr4:1805644 rs28933068 .Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
NM_000142.5(FGFR3):c.1620C>A (p.Asn540Lys) single nucleotide variant Pathogenic missense variant|non-coding transcript variant Chr4:1805644 rs28933068 .Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
.Neuberg Centre For Genomic Medicine, NCGM
NM_000142.5(FGFR3):c.742C>T (p.Arg248Cys) single nucleotide variant Pathogenic missense variant|non-coding transcript variant Chr4:1801837 rs121913482 .Institute of Medical Genetics and Genomics, Sir Ganga Ram Hospital
.Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
.Neuberg Centre For Genomic Medicine, NCGM
NM_000142.5(FGFR3):c.1138G>A (p.Gly380Arg) single nucleotide variant Pathogenic missense variant|non-coding transcript variant|intron variant Chr4:1804392 rs28931614 .Genetics laboratory, Department of Obstetrics & Gynae, Institute of Kidney Diseases & Research Centre Dr. H.L. Trivedi Institute Of Transplantation Sciences
.Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
.Neuberg Centre For Genomic Medicine, NCGM
NM_001308093.3(GATA4):c.*1256A>T single nucleotide variant Benign 3 prime UTR variant Chr8:11759731 rs12458 .Central Research Laboratory, Sri Devaraj Urs Academy of Higher Education and Research
NM_001308093.3(GATA4):c.*852G>A single nucleotide variant Benign/Likely benign 3 prime UTR variant Chr8:11759327 rs804290 .Central Research Laboratory, Sri Devaraj Urs Academy of Higher Education and Research
NM_000138.5(FBN1):c.1130G>A (p.Cys377Tyr) single nucleotide variant Likely pathogenic missense variant Chr15:48520676 rs1597583989 .Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India

Graph displaying all Indian institutes, the rare genetic disorders they studied, and the variants submitted to ClinVar