GenTIGSA Gene Database on Rare Genetic Disorders

Variants in ClinVar from 539 of 916 Rare Genetic Disorders of GenTIGS

Mucopolysaccharidosis type 1

An  Autosomal recessive  mode(s) within the Metabolic disorders/Lysosomal storage disorders  category

Pathogenic 3
Pathogenic/Likely pathogenic 1

Variant name Variant type GRCH38 location Germline classification Molecular consequence dbSNP_ID Submitter
NM_000203.5(IDUA):c.784del (p.His262fs) Deletion Chr4:1001872 Pathogenic Frameshift variant|non-coding transcript variant rs757928590 .Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics
.Neuberg Centre For Genomic Medicine, NCGM
NM_000203.5(IDUA):c.152G>A (p.Gly51Asp) Single nucleotide variant Chr4:987236 Pathogenic Missense variant|non-coding transcript variant|intron variant rs794726877
NM_000203.5(IDUA):c.1469T>C (p.Leu490Pro) Single nucleotide variant Chr4:1003102 Pathogenic/Likely pathogenic Missense variant|non-coding transcript variant rs121965027 .Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics
.Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
.Neuberg Centre For Genomic Medicine, NCGM
NM_000203.5(IDUA):c.1A>G (p.Met1Val) Single nucleotide variant Chr4:987085 Pathogenic Missense variant|initiator_codon_variant|non-coding transcript variant|intron variant rs1553914737

Indian Institutes & Variant Submission Overview
Chromosome-wise Variant Distribution