GenTIGSA Gene Database on Rare Genetic Disorders

Variants in ClinVar from 539 of 916 Rare Genetic Disorders of GenTIGS

Autoimmune lymphoproliferative syndrome

An  Autosomal dominant, Autosomal recessive  mode(s) within the Immune disorders  category

Likely pathogenic 1
Pathogenic/Likely pathogenic 2

Variant name Variant type GRCH38 location Germline classification Molecular consequence dbSNP_ID Submitter
NM_000043.6(FAS):c.776T>C (p.Ile259Thr) Single nucleotide variant Chr10:89014218 Likely pathogenic Missense variant|3 prime UTR variant|non-coding transcript variant rs1848675068 .Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
NM_033360.4(KRAS):c.436G>C (p.Ala146Pro) Single nucleotide variant Chr12:25225628 Pathogenic/Likely pathogenic Missense variant rs121913527 .Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
NM_002524.5(NRAS):c.35G>A (p.Gly12Asp) Single nucleotide variant Chr1:114716126 Pathogenic/Likely pathogenic Missense variant rs121913237 .Lifecell International Pvt. Ltd

Indian Institutes & Variant Submission Overview
Chromosome-wise Variant Distribution