GenTIGSA Gene Database on Rare Genetic Disorders

Variants in ClinVar from 539 of 916 Rare Genetic Disorders of GenTIGS

Arginase deficiency

An  Autosomal recessive  mode(s) within the Metabolic disorders  category

Conflicting classifications of pathogenicity 1
Pathogenic 1
Pathogenic/Likely pathogenic 2

Variant name Variant type GRCH38 location Germline classification Molecular consequence dbSNP_ID Submitter
NM_000045.4(ARG1):c.839del (p.Pro280fs) Deletion Chr6:131583776 Pathogenic Frameshift variant|non-coding transcript variant|intron variant rs2114551140 .Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics
NM_000045.4(ARG1):c.428A>G (p.Gln143Arg) Single nucleotide variant Chr6:131581341 Conflicting classifications of pathogenicity Missense variant|non-coding transcript variant|intron variant rs754259099 .Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
.Lifecell International Pvt. Ltd
.Medical Genetics, Christian Medical College
NM_000045.4(ARG1):c.295G>A (p.Gly99Arg) Single nucleotide variant Chr6:131579275 Pathogenic/Likely pathogenic Missense variant|non-coding transcript variant|intron variant rs753829097 .Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India
NM_000045.4(ARG1):c.32T>C (p.Ile11Thr) Single nucleotide variant Chr6:131573314 Pathogenic/Likely pathogenic Missense variant|non-coding transcript variant rs28941474 .Lifecell International Pvt. Ltd

Indian Institutes & Variant Submission Overview
Chromosome-wise Variant Distribution