GenTIGSA Gene Database on Rare Genetic Disorders
  Beta Version

Tumor protein p53 (TP53) Associated conditions:  1. Interstitial cystitis  2. Adrenocortical carcinoma  3. Choroid plexus papilloma  4. Diamond-Blackfan anemia  5. Glioblastoma  6. Papillary renal cell carcinoma  7. Multiple myeloma  8. Hereditary breast ovarian cancer syndrome  9. Acute megakaryoblastic leukemia  10. Familial cancer of breast  11. Li-Fraumeni syndrome 
mRNA Information: Transcript Variants and Protein Isoforms
SNo. Status mRNA accession Protein accession Genomic DNA accession (Chromosome) mRNA location on genomic DNA Assembly UniProtkb ID
1 REVIEWED NM_001276760.3 NP_001263689.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
2 REVIEWED NR_176326.1 - NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
3 REVIEWED NM_001407271.1 NP_001394200.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
4 REVIEWED NM_001407270.1 NP_001394199.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
5 REVIEWED NM_001407269.1 NP_001394198.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
6 REVIEWED NM_001407268.1 NP_001394197.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
7 REVIEWED NM_001407267.1 NP_001394196.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
8 REVIEWED NM_001407266.1 NP_001394195.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
9 REVIEWED NM_001407265.1 NP_001394194.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
10 REVIEWED NM_001407264.1 NP_001394193.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
11 REVIEWED NM_001407263.1 NP_001394192.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
12 REVIEWED NM_001407262.1 NP_001394191.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
13 REVIEWED NM_001276761.3 NP_001263690.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
14 REVIEWED NM_000546.6 NP_000537.3 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
15 REVIEWED NM_001276699.3 NP_001263628.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
16 REVIEWED NM_001276698.3 NP_001263627.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
17 REVIEWED NM_001276697.3 NP_001263626.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
18 REVIEWED NM_001276696.3 NP_001263625.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
19 REVIEWED NM_001276695.3 NP_001263624.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
20 REVIEWED NM_001126118.2 NP_001119590.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
21 REVIEWED NM_001126117.2 NP_001119589.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
22 REVIEWED NM_001126116.2 NP_001119588.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
23 REVIEWED NM_001126115.2 NP_001119587.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
24 REVIEWED NM_001126114.3 NP_001119586.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
25 REVIEWED NM_001126113.3 NP_001119585.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5
26 REVIEWED NM_001126112.3 NP_001119584.1 NC_000017.11 (7668420..7687489, complement) Reference GRCh38.p14 Primary Assembly Q53GA5

Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.

PubMed Links for Transcript Variants (Isoforms)
Link 1Link 2Link 3Link 4Link 5Link 6Link 7Link 8Link 9Link 10Link 11Link 1211341 reference articles

Variant Information Tumor protein p53 (TP53Mutation Visualization Dashboard: Pathogenic variant distribution chart

 

IndiGenomes variants: Exploring and mapping pathogenic variants in gene Tumor protein p53 (TP53)
ClinVar variants:Revealing mutagenic patterns

GO Term of Tumor protein p53 (TP53)
SNo. Reported in speceis Evidence Qualifier GO term Category Pubmed Link
1Homo sapiensIDAinvolved_innegative regulation of transcription by RNA polymerase IIProcess10329733 
2Homo sapiensISSinvolved_innegative regulation of transcription by RNA polymerase IIProcess19749791 
3Homo sapiensIEAinvolved_inmitophagyProcess
4Homo sapiensIDApart_ofchromatinComponent15710329 17805299 22521434 
23629966 24289924 
5Homo sapiensIMPpart_ofchromatinComponent30089260 
6Homo sapiensISApart_ofchromatinComponent
7Homo sapiensIDAenablestranscription cis-regulatory region bindingFunction15710329 17996705 
8Homo sapiensIBAenablesRNA polymerase II cis-regulatory region sequence-specific DNA bindingFunction21873635 
9Homo sapiensIDAenablesRNA polymerase II cis-regulatory region sequence-specific DNA bindingFunction22578566 24289924 
10Homo sapiensISSenablesRNA polymerase II cis-regulatory region sequence-specific DNA bindingFunction
11Homo sapiensIBAenablesDNA-binding transcription factor activity, RNA polymerase II-specificFunction21873635 
12Homo sapiensIDAenablesDNA-binding transcription factor activity, RNA polymerase II-specificFunction17310983 24289924 24652652 
13Homo sapiensISAenablesDNA-binding transcription factor activity, RNA polymerase II-specificFunction
14Homo sapiensIDAenablescis-regulatory region sequence-specific DNA bindingFunction10329733 
15Homo sapiensIDAenablescore promoter sequence-specific DNA bindingFunction23629966 
16Homo sapiensIPIenablesTFIID-class transcription factor complex bindingFunction24289924 
17Homo sapiensIDAenablesDNA-binding transcription repressor activity, RNA polymerase II-specificFunction10329733 
18Homo sapiensIDAenablesDNA-binding transcription activator activity, RNA polymerase II-specificFunction12609999 17145718 17146433 
22578566 
19Homo sapiensIEAinvolved_inin utero embryonic developmentProcess
20Homo sapiensIEAinvolved_insomitogenesisProcess
21Homo sapiensIEAinvolved_inrelease of cytochrome c from mitochondriaProcess
22Homo sapiensIPIenablesprotease bindingFunction11923872 
23Homo sapiensIPIenablesp53 bindingFunction25417702 
24Homo sapiensIMPinvolved_inhematopoietic progenitor cell differentiationProcess30146126 
25Homo sapiensIEAinvolved_inT cell proliferation involved in immune responseProcess
26Homo sapiensIEAinvolved_inB cell lineage commitmentProcess
27Homo sapiensIEAinvolved_inT cell lineage commitmentProcess
28Homo sapiensIEAinvolved_inresponse to ischemiaProcess
29Homo sapiensIDAenablesDNA bindingFunction15358771 
30Homo sapiensIMPenablesDNA bindingFunction2144364 15629713 
31Homo sapiensIDAenableschromatin bindingFunction16322561 17599062 
32Homo sapiensIDAenablesDNA-binding transcription factor activityFunction7587074 18549481 
33Homo sapiensIMPenablesDNA-binding transcription factor activityFunction16479015 
34Homo sapiensIDAenablesmRNA 3'-UTR bindingFunction16213212 
35Homo sapiensIDAenablescopper ion bindingFunction7824276 
36Homo sapiensIPIenablesprotein bindingFunction1465435 7663514 7799929 
8207801 8344494 8675009 
8875926 8875929 9050995 
9188558 9194564 9194565 
9380510 9472015 9529249 
9733515 9807817 9827557 
10196247 10226625 10415337 
10518217 10597287 10608892 
10666337 10823891 11080164 
11146555 11178989 11359905 
11388671 11427532 11546806 
11672523 11684014 11706030 
11781842 11861836 11877378 
11950834 12006491 12080348 
12620801 12667443 12692135 
12702766 12730672 12750254 
12915590 14557665 14627987 
14744935 14759370 14963330 
14985081 15044383 15068796 
15133049 15144954 15205477 
15310821 15364927 15525938 
15542844 15577914 15580310 
15604276 15660129 15687255 
15710329 15735003 15735006 
15782130 15855171 15916963 
15960975 15989956 16003391 
16151013 16169070 16189514 
16227626 16319068 16322561 
16376338 16376884 16377624 
16402859 16415881 16432196 
16442532 16443602 16474402 
16493710 16601686 16611888 
16616141 16690937 16713569 
16732283 16753148 16793543 
16845383 16847267 16951253 
16959611 17080083 17098746 
17108971 17121812 17139261 
17145718 17159902 17170702 
17184779 17237821 17245430 
17254968 17268548 17274640 
17290220 17298945 17310983 
17317671 17347673 17438265 
17470788 17482142 17568776 
17612295 17662718 17707234 
17719541 17719542 17805299 
17875722 17904127 17906639 
17964266 18087040 18172499 
18230339 18235501 18235502 
18275817 18309296 18316739 
18354501 18382127 18388957 
18391200 18485870 18504427 
18510931 18566590 18624398 
18656471 18690848 18695251 
18812399 18952844 18977328 
19008854 19011621 19043414 
19098711 19151705 19166840 
19196987 19217391 19234109 
19255450 19339993 19345189 
19411066 19433796 19483087 
19508870 19521340 19536131 
19556538 19619542 19626115 
19651603 19656744 19680552 
19684601 19740107 19798103 
19805293 19833129 19857493 
19883646 19933256 20075864 
20096447 20118233 20123734 
20124405 20134482 20153329 
20159018 20167603 20173098 
20206173 20227041 20228809 
20385133 20421506 20452352 
20515689 20534433 20562916 
20591429 20622899 20660729 
20705607 20708156 20713054 
20864041 20959462 21057547 
21078964 21081126 21130767 
21132010 21170034 21170087 
21245319 21317932 21390126 
21397192 21423215 21460856 
21471221 21513714 21597459 
21625211 21653829 21670263 
21726810 21741598 21782458 
21821029 21831840 21857681 
21892170 21900206 21952639 
21988832 22056774 22085928 
22103682 22124327 22265415 
22340593 22451927 22499945 
22510990 22522597 22575647 
22653443 22659184 22723347 
22726440 22810585 22810586 
22819825 22945289 22975381 
23010591 23063560 23092970 
23320542 23431171 23576507 
23623661 23734815 23752197 
23776060 23870121 24207125 
24219989 24380853 24449765 
24492002 24667498 24814347 
25168243 25241761 25314079 
25402006 25422469 25502805 
25579814 25591766 25609649 
25651062 25670079 25837623 
25857266 26302407 26331536 
26789255 27107012 27323408 
27519799 27605672 28842590 
29187402 29340707 29628311 
29997244 31467278 31511497 
31515488 31837246 32606738 
32814053 33591310 34316702 
34404770 34591612 35044719 
35122041 35140242 
37Homo sapiensIDAlocated_innucleusComponent7720704 14744935 14963330 
16322561 16507995 17403783 
18756595 19011621 19234109 
20096447 20810912 21597459 
24101517 24289924 
38Homo sapiensIMPlocated_innucleusComponent16479015 
39Homo sapiensIDAlocated_innucleoplasmComponent11080164 12915590 
40Homo sapiensTASlocated_innucleoplasmComponent
41Homo sapiensIEAlocated_inreplication forkComponent
42Homo sapiensIGIpart_oftranscription regulator complexComponent17145718 
43Homo sapiensIDAlocated_innucleolusComponent12080348 
44Homo sapiensIDAlocated_incytoplasmComponent7720704 14744935 16131611 
19011621 20096447 20810912 
21597459 23629966 
45Homo sapiensIMPlocated_incytoplasmComponent16479015 
46Homo sapiensIDAlocated_inmitochondrionComponent12667443 24101517 25168243 
47Homo sapiensIEAlocated_inmitochondrial matrixComponent
48Homo sapiensIEAlocated_inendoplasmic reticulumComponent
49Homo sapiensIDAlocated_incentrosomeComponent28842590 
50Homo sapiensIDAlocated_incytosolComponent14963330 24101517 
51Homo sapiensTASlocated_incytosolComponent
52Homo sapiensIMPinvolved_innucleotide-excision repairProcess7663514 
53Homo sapiensIEAinvolved_indouble-strand break repairProcess
54Homo sapiensIDAinvolved_inregulation of DNA-templated transcriptionProcess7587074 
55Homo sapiensIMPinvolved_inregulation of DNA-templated transcriptionProcess25417702 
56Homo sapiensIBAinvolved_inregulation of transcription by RNA polymerase IIProcess21873635 
57Homo sapiensIEAinvolved_inprotein import into nucleusProcess
58Homo sapiensIMPinvolved_inautophagyProcess23629966 
59Homo sapiensIDAacts_upstream_of_or_withinDNA damage responseProcess14744935 
60Homo sapiensIDAinvolved_inDNA damage responseProcess15710329 17938203 
61Homo sapiensIMPinvolved_inDNA damage responseProcess24356969 
62Homo sapiensIMPinvolved_inDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestProcess16213212 
63Homo sapiensIDAinvolved_inDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorProcess16213212 
64Homo sapiensIMPinvolved_inDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorProcess7958916 16479015 
65Homo sapiensIDAacts_upstream_of_or_withinER overload responseProcess14744935 
66Homo sapiensIEAinvolved_intransforming growth factor beta receptor signaling pathwayProcess
67Homo sapiensIEPinvolved_inRas protein signal transductionProcess9054499 
68Homo sapiensIEAinvolved_ingastrulationProcess
69Homo sapiensIEAinvolved_inneuroblast proliferationProcess
70Homo sapiensIEAinvolved_innegative regulation of neuroblast proliferationProcess
71Homo sapiensIDAinvolved_inprotein localizationProcess16507995 
72Homo sapiensIEAinvolved_innegative regulation of DNA replicationProcess
73Homo sapiensTASenableszinc ion bindingFunction10065153 
74Homo sapiensIDAinvolved_innegative regulation of cell population proliferationProcess22783376 
75Homo sapiensIMPinvolved_innegative regulation of cell population proliferationProcess12730672 
76Homo sapiensISSacts_upstream_ofnegative regulation of cell population proliferationProcess30514107 
77Homo sapiensISSinvolved_innegative regulation of cell population proliferationProcess
78Homo sapiensISSinvolved_indetermination of adult lifespanProcess
79Homo sapiensIMPinvolved_inmRNA transcriptionProcess16479015 
80Homo sapiensIEAinvolved_inrRNA transcriptionProcess
81Homo sapiensIEAinvolved_inresponse to salt stressProcess
82Homo sapiensIEAinvolved_inresponse to inorganic substanceProcess
83Homo sapiensIEAinvolved_inresponse to X-rayProcess
84Homo sapiensIMPinvolved_inresponse to gamma radiationProcess7958916 
85Homo sapiensIDAinvolved_inpositive regulation of gene expressionProcess15314173 20332243 26100857 
86Homo sapiensIMPacts_upstream_of_or_withinpositive regulation of gene expressionProcess30089260 
87Homo sapiensIMPinvolved_inpositive regulation of gene expressionProcess19160485 
88Homo sapiensISSinvolved_inpositive regulation of gene expressionProcess
89Homo sapiensIEAinvolved_incardiac muscle cell apoptotic processProcess
90Homo sapiensIEAinvolved_inpositive regulation of cardiac muscle cell apoptotic processProcess
91Homo sapiensIEAinvolved_inglial cell proliferationProcess
92Homo sapiensIMPinvolved_inviral processProcess22574148 
93Homo sapiensIDAlocated_innuclear matrixComponent11080164 
94Homo sapiensIDAcolocalizes_withnuclear bodyComponent10360174 
95Homo sapiensIDAlocated_inPML bodyComponent12006491 22869143 
96Homo sapiensIPIpart_oftranscription repressor complexComponent8875929 18677113 
97Homo sapiensIEAinvolved_inglucose catabolic process to lactate via pyruvateProcess
98Homo sapiensIPIenablesenzyme bindingFunction17805299 
99Homo sapiensIEAinvolved_incerebellum developmentProcess
100Homo sapiensIMPinvolved_innegative regulation of cell growthProcess8986812 
101Homo sapiensIDAinvolved_inDNA damage response, signal transduction by p53 class mediatorProcess15149599 
102Homo sapiensIMPinvolved_inDNA damage response, signal transduction by p53 class mediatorProcess20160708 
103Homo sapiensIEAinvolved_innegative regulation of transforming growth factor beta receptor signaling pathwayProcess
104Homo sapiensIPIenablesreceptor tyrosine kinase bindingFunction23027130 
105Homo sapiensIMPinvolved_inmitotic G1 DNA damage checkpoint signalingProcess7958916 
106Homo sapiensEXPenablesubiquitin protein ligase bindingFunction8875929 
107Homo sapiensIPIenablesubiquitin protein ligase bindingFunction8875929 
108Homo sapiensIDApart_ofprotein-containing complexComponent9529249 17310983 
109Homo sapiensIMPpart_ofprotein-containing complexComponent15629713 
110Homo sapiensIEAinvolved_inT cell differentiation in thymusProcess
111Homo sapiensIGIinvolved_intumor necrosis factor-mediated signaling pathwayProcess22499991 
112Homo sapiensIEAinvolved_inregulation of tissue remodelingProcess
113Homo sapiensIDAinvolved_incellular response to UVProcess16213212 23629966 
114Homo sapiensIEAenableshistone deacetylase regulator activityFunction
115Homo sapiensIEAinvolved_inmulticellular organism growthProcess
116Homo sapiensIEAinvolved_inpositive regulation of mitochondrial membrane permeabilityProcess
117Homo sapiensIEAlocated_insite of double-strand breakComponent
118Homo sapiensIDAinvolved_inpositive regulation of transcription from RNA polymerase II promoter in response to stressProcess30089260 
119Homo sapiensIDAenablesATP-dependent DNA/DNA annealing activityFunction8183576 
120Homo sapiensIDAacts_upstream_of_or_withincellular response to glucose starvationProcess14744935 
121Homo sapiensIDAinvolved_incellular response to glucose starvationProcess21471221 
122Homo sapiensIDAacts_upstream_of_or_withinintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorProcess14654789 14744935 
123Homo sapiensIDAinvolved_inintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorProcess17403783 
124Homo sapiensIMPinvolved_inintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorProcess16213212 
125Homo sapiensIPIenablesidentical protein bindingFunction10876243 14759370 14985081 
15629713 16291740 16461914 
17612295 17620598 18087040 
19011621 19339993 19667193 
20004160 20159469 20364130 
21178074 21522129 21988832 
22653443 22972749 25402006 
25609649 31837246 
126Homo sapiensIPIenableshistone deacetylase bindingFunction23629966 
127Homo sapiensIDAacts_upstream_of_or_withinregulation of apoptotic processProcess14744935 
128Homo sapiensIDAinvolved_inpositive regulation of apoptotic processProcess12667443 15565177 20959462 
129Homo sapiensIGIinvolved_innegative regulation of apoptotic processProcess12203124 12433990 
130Homo sapiensIMPinvolved_innegative regulation of apoptotic processProcess20124405 
131Homo sapiensIEAlocated_ingerm cell nucleusComponent
132Homo sapiensISSinvolved_inentrainment of circadian clock by photoperiodProcess
133Homo sapiensIEAinvolved_inmitochondrial DNA repairProcess
134Homo sapiensIEAinvolved_inregulation of DNA damage response, signal transduction by p53 class mediatorProcess
135Homo sapiensIEAinvolved_inpositive regulation of neuron apoptotic processProcess
136Homo sapiensIPIenablesprotein self-associationFunction14985081 
137Homo sapiensIDAinvolved_intranscription initiation-coupled chromatin remodelingProcess16322561 
138Homo sapiensIEAinvolved_innegative regulation of proteolysisProcess
139Homo sapiensIDAinvolved_innegative regulation of DNA-templated transcriptionProcess9271120 24051492 
140Homo sapiensIMPinvolved_innegative regulation of DNA-templated transcriptionProcess23629966 
141Homo sapiensNASinvolved_innegative regulation of DNA-templated transcriptionProcess16492744 
142Homo sapiensIDAinvolved_inpositive regulation of DNA-templated transcriptionProcess16322561 17403783 20378837 
143Homo sapiensIMPinvolved_inpositive regulation of DNA-templated transcriptionProcess20096447 
144Homo sapiensIDAinvolved_inpositive regulation of RNA polymerase II transcription preinitiation complex assemblyProcess24289924 
145Homo sapiensIDAacts_upstream_of_or_withinpositive regulation of transcription by RNA polymerase IIProcess17599062 
146Homo sapiensIDAinvolved_inpositive regulation of transcription by RNA polymerase IIProcess11672523 17145718 17310983 
18549481 20959462 24652652 
147Homo sapiensIGIacts_upstream_of_or_withinpositive regulation of transcription by RNA polymerase IIProcess16061649 
148Homo sapiensIMPinvolved_inpositive regulation of transcription by RNA polymerase IIProcess17146433 24356969 
149Homo sapiensIEPinvolved_inresponse to antibioticProcess20810912 
150Homo sapiensIPIenablesprotein heterodimerization activityFunction10837489 
151Homo sapiensIEAinvolved_infibroblast proliferationProcess
152Homo sapiensIMPinvolved_innegative regulation of fibroblast proliferationProcess10962037 
153Homo sapiensISSinvolved_incircadian behaviorProcess
154Homo sapiensIMPinvolved_inbone marrow developmentProcess30146126 
155Homo sapiensIEAinvolved_inembryonic organ developmentProcess
156Homo sapiensISSinvolved_inpositive regulation of peptidyl-tyrosine phosphorylationProcess19749791 
157Homo sapiensIEAinvolved_inprotein stabilizationProcess
158Homo sapiensIPIenablesprotein-folding chaperone bindingFunction15358771 18086682 
159Homo sapiensTASinvolved_innegative regulation of helicase activityProcess7663514 
160Homo sapiensIEAinvolved_inprotein tetramerizationProcess
161Homo sapiensIEAinvolved_inchromosome organizationProcess
162Homo sapiensIEAinvolved_inneuron apoptotic processProcess
163Homo sapiensIPIenablesprotein phosphatase 2A bindingFunction17245430 
164Homo sapiensIDAinvolved_inregulation of cell cycleProcess15149599 
165Homo sapiensIGIinvolved_inregulation of cell cycleProcess12203124 12433990 
166Homo sapiensIMPinvolved_inregulation of cell cycleProcess7958916 
167Homo sapiensISSacts_upstream_ofregulation of cell cycleProcess30514107 
168Homo sapiensIDAinvolved_innegative regulation of telomerase activityProcess10597287 
169Homo sapiensIMPinvolved_inhematopoietic stem cell differentiationProcess30146126 
170Homo sapiensIEAinvolved_innegative regulation of glial cell proliferationProcess
171Homo sapiensIEAinvolved_intype II interferon-mediated signaling pathwayProcess
172Homo sapiensIEAinvolved_incardiac septum morphogenesisProcess
173Homo sapiensIEAinvolved_inpositive regulation of transcription from RNA polymerase II promoter in response to hypoxiaProcess
174Homo sapiensIPIenablesRNA polymerase II-specific DNA-binding transcription factor bindingFunction15705871 18549481 19505873 
23329847 
175Homo sapiensIEAinvolved_inpositive regulation of programmed necrotic cell deathProcess
176Homo sapiensIDAinvolved_inprotein-containing complex assemblyProcess12915590 
177Homo sapiensIEAinvolved_inintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressProcess
178Homo sapiensIEAinvolved_inthymocyte apoptotic processProcess
179Homo sapiensISSinvolved_inpositive regulation of thymocyte apoptotic processProcess
180Homo sapiensIEAinvolved_innecroptotic processProcess
181Homo sapiensIEPinvolved_incellular response to hypoxiaProcess20810912 
182Homo sapiensIEPinvolved_incellular response to xenobiotic stimulusProcess20810912 
183Homo sapiensIMPinvolved_incellular response to ionizing radiationProcess20160708 
184Homo sapiensIDAinvolved_incellular response to gamma radiationProcess16213212 
185Homo sapiensIEAinvolved_incellular response to UV-CProcess
186Homo sapiensEXPenables14-3-3 protein bindingFunction20206173 
187Homo sapiensIEAinvolved_instem cell proliferationProcess
188Homo sapiensIDAinvolved_insignal transduction by p53 class mediatorProcess15314173 
189Homo sapiensIMPinvolved_inintrinsic apoptotic signaling pathway by p53 class mediatorProcess12172011 16322561 17310983 
190Homo sapiensIEAinvolved_inreactive oxygen species metabolic processProcess
191Homo sapiensIDAinvolved_incellular response to actinomycin DProcess15314173 
192Homo sapiensIDAinvolved_inpositive regulation of release of cytochrome c from mitochondriaProcess14963330 
193Homo sapiensIMPinvolved_incellular senescenceProcess12080348 
194Homo sapiensIMPinvolved_inreplicative senescenceProcess19951988 
195Homo sapiensIMPinvolved_inoxidative stress-induced premature senescenceProcess19951988 
196Homo sapiensTASinvolved_inintrinsic apoptotic signaling pathwayProcess16462759 
197Homo sapiensIDAinvolved_inoligodendrocyte apoptotic processProcess7720704 
198Homo sapiensIEAenablesMDM2/MDM4 family protein bindingFunction
199Homo sapiensIPIenablesdisordered domain specific bindingFunction15629713 
200Homo sapiensIPIenablesgeneral transcription initiation factor bindingFunction15053879 
201Homo sapiensEXPenablesmolecular function activator activityFunction14759370 16793543 
202Homo sapiensIPIenablesmolecular function activator activityFunction7559631 
203Homo sapiensIMPinvolved_inpositive regulation of execution phase of apoptosisProcess14985081 
204Homo sapiensIEAinvolved_innegative regulation of mitophagyProcess
205Homo sapiensIEAinvolved_inregulation of mitochondrial membrane permeability involved in apoptotic processProcess
206Homo sapiensIEAinvolved_inregulation of intrinsic apoptotic signaling pathway by p53 class mediatorProcess
207Homo sapiensIMPacts_upstream_of_negative_effectregulation of cell cycle G2/M phase transitionProcess10962037 
208Homo sapiensIDAinvolved_inpositive regulation of miRNA transcriptionProcess20546595 
209Homo sapiensIGIinvolved_inpositive regulation of miRNA transcriptionProcess22499991 
210Homo sapiensIMPinvolved_inpositive regulation of miRNA transcriptionProcess22578566 
211Homo sapiensIDAinvolved_innegative regulation of G1 to G0 transitionProcess15314173 
212Homo sapiensIMPinvolved_innegative regulation of G1 to G0 transitionProcess21471221 
213Homo sapiensIEAinvolved_innegative regulation of miRNA processingProcess
214Homo sapiensIEAinvolved_innegative regulation of glucose catabolic process to lactate via pyruvateProcess
215Homo sapiensIMPinvolved_innegative regulation of pentose-phosphate shuntProcess21336310 
216Homo sapiensIEAinvolved_inintrinsic apoptotic signaling pathway in response to hypoxiaProcess
217Homo sapiensISSinvolved_inpositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressProcess
218Homo sapiensIDAenablespromoter-specific chromatin bindingFunction20725088 24356969 
219Homo sapiensIEAinvolved_inregulation of fibroblast apoptotic processProcess
220Homo sapiensIEAinvolved_innegative regulation of reactive oxygen species metabolic processProcess
221Homo sapiensIMPinvolved_inpositive regulation of reactive oxygen species metabolic processProcess20160708 
222Homo sapiensIEAinvolved_innegative regulation of stem cell proliferationProcess
223Homo sapiensIDAinvolved_inpositive regulation of cellular senescenceProcess29474172 
224Homo sapiensISSinvolved_inpositive regulation of cellular senescenceProcess
225Homo sapiensIMPinvolved_inpositive regulation of intrinsic apoptotic signaling pathwayProcess14963330 27031958 
226Homo sapiensISSinvolved_inpositive regulation of intrinsic apoptotic signaling pathwayProcess