Tumor protein p53 (TP53) Associated conditions: 1. Interstitial cystitis 2. Adrenocortical carcinoma 3. Choroid plexus papilloma 4. Diamond-Blackfan anemia 5. Glioblastoma 6. Papillary renal cell carcinoma 7. Multiple myeloma 8. Hereditary breast ovarian cancer syndrome 9. Acute megakaryoblastic leukemia 10. Li-Fraumeni syndrome
SNo. | Status | mRNA accession | Protein accession | Genomic DNA accession (Chromosome) | mRNA location on genomic DNA | Assembly | UniProtkb ID |
1 | REVIEWED | NM_001276760.3 | NP_001263689.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
2 | REVIEWED | NR_176326.1 | - | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
3 | REVIEWED | NM_001407271.1 | NP_001394200.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
4 | REVIEWED | NM_001407270.1 | NP_001394199.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
5 | REVIEWED | NM_001407269.1 | NP_001394198.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
6 | REVIEWED | NM_001407268.1 | NP_001394197.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
7 | REVIEWED | NM_001407267.1 | NP_001394196.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
8 | REVIEWED | NM_001407266.1 | NP_001394195.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
9 | REVIEWED | NM_001407265.1 | NP_001394194.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
10 | REVIEWED | NM_001407264.1 | NP_001394193.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
11 | REVIEWED | NM_001407263.1 | NP_001394192.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
12 | REVIEWED | NM_001407262.1 | NP_001394191.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
13 | REVIEWED | NM_001276761.3 | NP_001263690.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
14 | REVIEWED | NM_000546.6 | NP_000537.3 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
15 | REVIEWED | NM_001276699.3 | NP_001263628.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
16 | REVIEWED | NM_001276698.3 | NP_001263627.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
17 | REVIEWED | NM_001276697.3 | NP_001263626.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
18 | REVIEWED | NM_001276696.3 | NP_001263625.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
19 | REVIEWED | NM_001276695.3 | NP_001263624.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
20 | REVIEWED | NM_001126118.2 | NP_001119590.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
21 | REVIEWED | NM_001126117.2 | NP_001119589.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
22 | REVIEWED | NM_001126116.2 | NP_001119588.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
23 | REVIEWED | NM_001126115.2 | NP_001119587.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
24 | REVIEWED | NM_001126114.3 | NP_001119586.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
25 | REVIEWED | NM_001126113.3 | NP_001119585.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
26 | REVIEWED | NM_001126112.3 | NP_001119584.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.
PubMed Links for Transcript Variants
1088347 1303181 1321290 1327751 1349102 1349175 1394225 1437144 1454855 1459726 1465435 1565143 1565144 1591732 1600943 1614537 1631137 1631151 1644930 1647768 1661671 1672732 1673792 1679237 1683921 1694291 1699228 1705009 1737852 1762941 1848668 1849234 1868473 1905840 1915267 1933902 1939648 1978757 1999338 2047879 2141171 2144364 2156209 2259385 2263646 2531845 2839831 2905688 2946935 2994241 3001719 3025664 3456488 3894933 4006916 6396087 7559631 7587074 7663514 7682763 7686617 7689721 7708685 7720704 7724550 7753047 7761466 7773777 7777531 7799929 7809597 7811761 7818536 7824276 7853525 7878469 7887414 7935417 7935455 7954368 7958916 8013454 8016121 8023157 8023159 8028670 8035799 8058315 8083962 8090726 8118819 8125298 8134127 8183576 8207801 8207805 8221626 8266092 8316628 8336944 8344494 8361542 8364550 8380895 8388547 8389468 8395834 8401536 8402617 8405994 8423216 8463313 8513440 8557038 8612585 8617246 8619474 8623534 8623910 8632903 8632915 8633054 8639538 8649785 8663296 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15545268 15548678 15548685 15550400 15554555 15555357 15557124 15557758 15558054 15563462 15564800 15565177 15566643 15569630 15571721 15573180 15574328 15574785 15576338 15577913 15577914 15577944 15578720 15580300 15580302 15580310 15583690 15583825 15592418 15598783 15601585 15604276 15604409 15606307 15607964 15608028 15608668 15609309 15609317 15611070 15611139 15613472 15616590 15621215 15623478 15629713 15632057 15632067 15632413 15633234 15634502 15634909 15638389 15639342 15642401 15642743 15644269 15645452 15647482 15650224 15651660 15654624 15657147 15657348 15657356 15659406 15659650 15660129 15661746 15664194 15670080 15670751 15671037 15671551 15674334 15674341 15674351 15680394 15683227 15687255 15688025 15688418 15696860 15701968 15701975 15702478 15703170 15704837 15705792 15705871 15707991 15709766 15710230 15710329 15710382 15713654 15713674 15713979 15719270 15720412 15721419 15723718 15723837 15731778 15734290 15734740 15734961 15735003 15735006 15735102 15735750 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33591461 33599867 33606978 33619227 33622324 33622989 33627621 33627789 33629306 33631672 33634999 33637876 33644029 33648535 33650658 33653952 33664418 33672023 33673439 33673859 33675808 33676104 33677472 33678118 33691199 33706682 33727444 33735664 33742110 33742136 33745968 33756341 33759598 33760190 33761356 33765973 33767390 33767588 33767783 33769712 33772115 33772787 33780049 33788262 33788740 33791361 33797738 33798680 33799444 33804124 33809907 33811963 33823140 33824292 33824975 33835683 33845483 33849647 33857585 33859071 33859745 33860865 33863900 33864161 33868474 33868791 33872315 33876327 33877544 33879103 33885911 33896384 33896818 33899789 33900379 33904352 33916271 33923162 33926488 33927351 33931764 33932899 33935281 33941851 33942220 33945523 33945616 33945996 33954191 33955355 33955710 33956533 33961781 33963002 33966047 33970925 33972599 33984364 33985476 33988304 33988919 33989438 33992829 34001596 34001963 34012039 34017077 34017087 34027794 34028171 34031188 34032749 34037458 34039707 34040386 34044069 34045312 34051015 34072831 34073316 34074015 34077778 34079125 34085157 34088750 34088837 34090364 34099776 34103685 34110636 34111705 34117297 34133717 34141823 34144191 34145535 34153655 34155600 34163012 34165168 34165573 34168122 34181170 34183772 34184814 34187252 34188037 34188043 34190520 34192538 34193871 34197865 34198491 34198494 34213707 34216644 34218582 34227093 34230611 34232992 34233584 34240179 34240781 34244426 34253820 34257080 34257081 34260915 34266904 34266953 34267025 34267371 34270461 34275793 34279763 34285062 34288813 34291388 34294873 34298892 34302605 34307186 34316702 34319761 34325986 34331475 34333527 34335587 34337857 34343636 34351647 34351910 34353903 34359836 34362424 34366423 34369624 34371129 34373451 34375633 34376372 34380847 34381423 34381934 34389799 34396581 34396583 34397726 34400889 34403252 34403458 34404770 34405395 34408321 34416429 34417460 34421886 34432492 34440884 34445161 34445495 34446759 34446762 34447990 34450259 34452628 34462429 34464900 34465782 34470826 34471223 34475048 34478609 34481841 34492050 34496888 34499221 34502494 34505757 34510715 34512169 34519942 34521849 34528388 34528544 34528662 34529667 34530752 34534740 34536269 34562520 34569598 34576020 34580281 34580516 34583722 34591432 34591612 34593902 34596362 34599296 34599932 34601169 34603310 34608255 34609409 34610483 34618298 34635074 34638542 34638677 34638930 34643467 34645785 34645806 34649141 34650049 34653407 34656159 34657382 34662580 34675114 34675373 34680125 34690091 34697060 34699262 34709727 34710245 34717674 34719669 34725206 34725851 34728216 34728235 34728620 34737428 34742870 34743450 34745095 34747697 34768775 34768862 34769213 34769259 34775479 34779146 34780712 34785767 34788479 34789127 34792696 34793697 34795231 34797282 34799723 34805717 34812534 34826422 34841700 34843402 34849446 34854392 34857760 34861163 34863587 34871733 34873220 34876602 34877770 34878965 34880421 34883204 34900978 34907725 34917906 34918105 34919788 34921507 34928233 34933716 34941177 34941867 34944027 34944103 34944497 34946686 34947995 34948101 34948128 34951009 34953860 34954226 34954873 34962972 34987252 34992144 34993927 34994652 34995174 34999254 35007564 35013873 35022235 35023452 35025136 35026842 35030630 35033608 35037949 35044719 35045253 35048531 35053170 35053274 35058939 35072374 35072516 35073573 35082295 35083527 35083778 35088582 35092378 35101379 35103816 35108639 35114328 35114947 35122027 35122041 35123410 35129760 35131382 35132678 35134126 35136024 35140242 35143532 35159215 35163828 35165289 35166747 35172133 35174643 35179215 35180531 35182466 35190641 35199506 35204825 35216629 35217717 35226388 35227287 35228743 35229971 35232479 35235448 35241646 35247436 35256949 35261216 35263402 35271311 35286522 35290266 35306447 35315319 35322193 35328677 35331964 35333912 35340160 35344507 35351136 35351459 35354846 35367201 35367578 35371302 35383292 35384245 35388737 35390143 35396567 35409289 35414774 35435923 35437704 35438902 35439056 35446349 35446794 35477123 35491653 35501580 35505093 35509820 35538032 35557033 35559673 35563301 35563397 35563538 35563554 35566503 35571038 35575002 35581624 35582925 35584569 35585048 35589715 35593588 35594781 35596192 35597299 35598030 35598233 35598358 35598475 35606354 35609991 35614270 35618207 35625568 35635656 35636055 35654045 35667517 35671810 35672760 35673816 35674210 35679752 35686841 35689249 35694386 35698008 35703957 35705773 35716965 35717675 35725923 35737165 35760678 35764786 35768267 35774082 35778432 35780773 35782979 35786616 35792897 35795731 35802772 35809339 35819196 35820297 35831314 35834073 35835334 35840793 35841248 35847579 35853732 35853868 35854898 35867400 35872366 35883598 35889210 35896951 35904997 35906707 35920317 35921289 35931247 35931280 35968984 35971249 35975690 35982156 35987950 35992795 35995868 35996546 35996826 36017858 36037124 36045334 36048559 36049099 36057605 36069545 36069815 36073532 36077492 36083231 36087186 36114006 36117041 36117108 36123588 36123933 36124964 36125118 36163934 36165173 36166584 36167829 36171565 36181537 36194647 36197521 36198274 36198537 36208777 36217030 36221953 36239052 36243803 36244648 36251540 36251972 36252649 36260193 36264169 36275718 36288643 36290859 36291102 36293489 36298868 36305094 36308175 36323304 36329109 36334078 36335243 36351964 36352176 36352191 36354374 36355424 36356333 36358651 36359803 36359870 36376537 36377597 36379126 36380314 36382415 36394085 36395886 36396725 36397719 36400749 36402224 36403175 36408933 36413407 36429016 36430324 36433728 36438681 36449143 36450137 36461070 36477655 36485102 36485136 36499753 36508676 36518052 36519010 36522371 36522487 36525166 36544023 36549455 36555140 36555484 36563059 36563883 36565718 36574363 36576589 36585906 36591909 36604421 36604691 36608871 36622249 36634201 36638271 36657266 36661736 36672246 36672841 36674782 36675156 36681079 36696149 36707464 36708564 36709106 36739824 36740682 36749137 36749630 36766831 36766853 36778116 36786034 36788081 36788227 36801644 36804453 36813920 36822563 36826085 36827466 36833388 36841672 36843235 36847420 36853312 36867535 36883155 36899866 36910346 36923534 36926116 36931259 36931700 36940027 36942988 36961831 36964217 36974003 36976911 36977456 36979441 37011832 37012416 37029683 37041128 37042869 37048159 37055376 37059101 37060380 37072703 37078708 37083525 37093780 37101199 37113088 37126387 37130837 37139921 37140445 37150312 37151849 37161532 37163621 37163715 37175937 37198983 37201730 37225855 37236026 37244040 37247280 37247912 37257244 37262951 37267865 37296499 37300745 37344660 37356458 37356984 37358838 37369845 37371478 37372326 37441266 37452087 37477799 37480565 37499040 37500626 37511311 37511582 37518096 37525904 37536630 37537199 37566086 37575080 37604640 37605254 37611430 37612638 37622400 37625101 37628868 37680633
IndiGenomes variants: Eexploring and mapping pathogenic variants in gene Tumor protein p53 (TP53)
ClinVar variants:Revealing mutagenic patterns
SNo. | Reported in speceis | Evidence | Qualifier | GO term | Category | Pubmed Link |
1 | Homo sapiens | IDA | involved_in | negative regulation of transcription by RNA polymerase II | Process | 10329733 |
2 | Homo sapiens | ISS | involved_in | negative regulation of transcription by RNA polymerase II | Process | 19749791 |
3 | Homo sapiens | IEA | involved_in | mitophagy | Process | - |
4 | Homo sapiens | IDA | part_of | chromatin | Component | 15710329 17805299 22521434 23629966 24289924 |
5 | Homo sapiens | IMP | part_of | chromatin | Component | 30089260 |
6 | Homo sapiens | ISA | part_of | chromatin | Component | - |
7 | Homo sapiens | IDA | enables | transcription cis-regulatory region binding | Function | 15710329 17996705 |
8 | Homo sapiens | IBA | enables | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Function | 21873635 |
9 | Homo sapiens | IDA | enables | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Function | 22578566 24289924 |
10 | Homo sapiens | ISS | enables | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Function | - |
11 | Homo sapiens | IBA | enables | DNA-binding transcription factor activity, RNA polymerase II-specific | Function | 21873635 |
12 | Homo sapiens | IDA | enables | DNA-binding transcription factor activity, RNA polymerase II-specific | Function | 17310983 24289924 24652652 |
13 | Homo sapiens | ISA | enables | DNA-binding transcription factor activity, RNA polymerase II-specific | Function | - |
14 | Homo sapiens | IDA | enables | cis-regulatory region sequence-specific DNA binding | Function | 10329733 |
15 | Homo sapiens | IDA | enables | core promoter sequence-specific DNA binding | Function | 23629966 |
16 | Homo sapiens | IPI | enables | TFIID-class transcription factor complex binding | Function | 24289924 |
17 | Homo sapiens | IDA | enables | DNA-binding transcription repressor activity, RNA polymerase II-specific | Function | 10329733 |
18 | Homo sapiens | IDA | enables | DNA-binding transcription activator activity, RNA polymerase II-specific | Function | 12609999 17145718 17146433 22578566 |
19 | Homo sapiens | IEA | involved_in | in utero embryonic development | Process | - |
20 | Homo sapiens | IEA | involved_in | somitogenesis | Process | - |
21 | Homo sapiens | IEA | involved_in | release of cytochrome c from mitochondria | Process | - |
22 | Homo sapiens | IPI | enables | protease binding | Function | 11923872 |
23 | Homo sapiens | IPI | enables | p53 binding | Function | 25417702 |
24 | Homo sapiens | IMP | involved_in | hematopoietic progenitor cell differentiation | Process | 30146126 |
25 | Homo sapiens | IEA | involved_in | T cell proliferation involved in immune response | Process | - |
26 | Homo sapiens | IEA | involved_in | B cell lineage commitment | Process | - |
27 | Homo sapiens | IEA | involved_in | T cell lineage commitment | Process | - |
28 | Homo sapiens | IEA | involved_in | response to ischemia | Process | - |
29 | Homo sapiens | IDA | enables | DNA binding | Function | 15358771 |
30 | Homo sapiens | IMP | enables | DNA binding | Function | 2144364 15629713 |
31 | Homo sapiens | IDA | enables | chromatin binding | Function | 16322561 17599062 |
32 | Homo sapiens | IDA | enables | DNA-binding transcription factor activity | Function | 7587074 18549481 |
33 | Homo sapiens | IMP | enables | DNA-binding transcription factor activity | Function | 16479015 |
34 | Homo sapiens | IDA | enables | mRNA 3'-UTR binding | Function | 16213212 |
35 | Homo sapiens | IDA | enables | copper ion binding | Function | 7824276 |
36 | Homo sapiens | IPI | enables | protein binding | Function | 1465435 7663514 7799929 8207801 8344494 8675009 8875926 8875929 9050995 9188558 9194564 9194565 9380510 9472015 9529249 9733515 9807817 9827557 10196247 10226625 10415337 10518217 10597287 10608892 10666337 10823891 11080164 11146555 11178989 11359905 11388671 11427532 11546806 11672523 11684014 11706030 11781842 11861836 11877378 11950834 12006491 12080348 12620801 12667443 12692135 12702766 12730672 12750254 12915590 14557665 14627987 14744935 14759370 14963330 14985081 15044383 15068796 15133049 15144954 15205477 15310821 15364927 15525938 15542844 15577914 15580310 15604276 15660129 15687255 15710329 15735003 15735006 15782130 15855171 15916963 15960975 15989956 16003391 16151013 16169070 16189514 16227626 16319068 16322561 16376338 16376884 16377624 16402859 16415881 16432196 16442532 16443602 16474402 16493710 16601686 16611888 16616141 16690937 16713569 16732283 16753148 16793543 16845383 16847267 16951253 16959611 17080083 17098746 17108971 17121812 17139261 17145718 17159902 17170702 17184779 17237821 17245430 17254968 17268548 17274640 17290220 17298945 17310983 17317671 17347673 17438265 17470788 17482142 17568776 17612295 17662718 17707234 17719541 17719542 17805299 17875722 17904127 17906639 17964266 18087040 18172499 18230339 18235501 18235502 18275817 18309296 18316739 18354501 18382127 18388957 18391200 18485870 18504427 18510931 18566590 18624398 18656471 18690848 18695251 18812399 18952844 18977328 19008854 19011621 19043414 19098711 19151705 19166840 19196987 19217391 19234109 19255450 19339993 19345189 19411066 19433796 19483087 19508870 19521340 19536131 19556538 19619542 19626115 19651603 19656744 19680552 19684601 19740107 19798103 19805293 19833129 19857493 19883646 19933256 20075864 20096447 20118233 20123734 20124405 20134482 20153329 20159018 20167603 20173098 20206173 20227041 20228809 20385133 20421506 20452352 20515689 20534433 20562916 20591429 20622899 20660729 20705607 20708156 20713054 20864041 20959462 21057547 21078964 21081126 21130767 21132010 21170034 21170087 21245319 21317932 21390126 21397192 21423215 21460856 21471221 21513714 21597459 21625211 21653829 21670263 21726810 21741598 21782458 21821029 21831840 21857681 21892170 21900206 21952639 21988832 22056774 22085928 22103682 22124327 22265415 22340593 22451927 22499945 22510990 22522597 22575647 22653443 22659184 22723347 22726440 22810585 22810586 22819825 22945289 22975381 23010591 23063560 23092970 23320542 23431171 23576507 23623661 23734815 23752197 23776060 23870121 24207125 24219989 24380853 24449765 24492002 24667498 24814347 25168243 25241761 25314079 25402006 25422469 25502805 25579814 25591766 25609649 25651062 25670079 25837623 25857266 26302407 26331536 26789255 27107012 27323408 27519799 27605672 28842590 29187402 29340707 29628311 29997244 31467278 31511497 31515488 31837246 32606738 32814053 33591310 34316702 34404770 34591612 35044719 35122041 35140242 |
37 | Homo sapiens | IDA | located_in | nucleus | Component | 7720704 14744935 14963330 16322561 16507995 17403783 18756595 19011621 19234109 20096447 20810912 21597459 24101517 24289924 |
38 | Homo sapiens | IMP | located_in | nucleus | Component | 16479015 |
39 | Homo sapiens | IDA | located_in | nucleoplasm | Component | 11080164 12915590 |
40 | Homo sapiens | TAS | located_in | nucleoplasm | Component | - |
41 | Homo sapiens | IEA | located_in | replication fork | Component | - |
42 | Homo sapiens | IGI | part_of | transcription regulator complex | Component | 17145718 |
43 | Homo sapiens | IDA | located_in | nucleolus | Component | 12080348 |
44 | Homo sapiens | IDA | located_in | cytoplasm | Component | 7720704 14744935 16131611 19011621 20096447 20810912 21597459 23629966 |
45 | Homo sapiens | IMP | located_in | cytoplasm | Component | 16479015 |
46 | Homo sapiens | IDA | located_in | mitochondrion | Component | 12667443 24101517 25168243 |
47 | Homo sapiens | IEA | located_in | mitochondrial matrix | Component | - |
48 | Homo sapiens | IEA | located_in | endoplasmic reticulum | Component | - |
49 | Homo sapiens | IDA | located_in | centrosome | Component | 28842590 |
50 | Homo sapiens | IDA | located_in | cytosol | Component | 14963330 24101517 |
51 | Homo sapiens | TAS | located_in | cytosol | Component | - |
52 | Homo sapiens | IMP | involved_in | nucleotide-excision repair | Process | 7663514 |
53 | Homo sapiens | IEA | involved_in | double-strand break repair | Process | - |
54 | Homo sapiens | IDA | involved_in | regulation of DNA-templated transcription | Process | 7587074 |
55 | Homo sapiens | IMP | involved_in | regulation of DNA-templated transcription | Process | 25417702 |
56 | Homo sapiens | IBA | involved_in | regulation of transcription by RNA polymerase II | Process | 21873635 |
57 | Homo sapiens | IEA | involved_in | protein import into nucleus | Process | - |
58 | Homo sapiens | IMP | involved_in | autophagy | Process | 23629966 |
59 | Homo sapiens | IDA | acts_upstream_of_or_within | DNA damage response | Process | 14744935 |
60 | Homo sapiens | IDA | involved_in | DNA damage response | Process | 15710329 17938203 |
61 | Homo sapiens | IMP | involved_in | DNA damage response | Process | 24356969 |
62 | Homo sapiens | IMP | involved_in | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | Process | 16213212 |
63 | Homo sapiens | IDA | involved_in | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | Process | 16213212 |
64 | Homo sapiens | IMP | involved_in | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | Process | 7958916 16479015 |
65 | Homo sapiens | IDA | acts_upstream_of_or_within | ER overload response | Process | 14744935 |
66 | Homo sapiens | IEA | involved_in | transforming growth factor beta receptor signaling pathway | Process | - |
67 | Homo sapiens | IEP | involved_in | Ras protein signal transduction | Process | 9054499 |
68 | Homo sapiens | IEA | involved_in | gastrulation | Process | - |
69 | Homo sapiens | IEA | involved_in | neuroblast proliferation | Process | - |
70 | Homo sapiens | IEA | involved_in | negative regulation of neuroblast proliferation | Process | - |
71 | Homo sapiens | IDA | involved_in | protein localization | Process | 16507995 |
72 | Homo sapiens | IEA | involved_in | negative regulation of DNA replication | Process | - |
73 | Homo sapiens | TAS | enables | zinc ion binding | Function | 10065153 |
74 | Homo sapiens | IDA | involved_in | negative regulation of cell population proliferation | Process | 22783376 |
75 | Homo sapiens | IMP | involved_in | negative regulation of cell population proliferation | Process | 12730672 |
76 | Homo sapiens | ISS | acts_upstream_of | negative regulation of cell population proliferation | Process | 30514107 |
77 | Homo sapiens | ISS | involved_in | negative regulation of cell population proliferation | Process | - |
78 | Homo sapiens | ISS | involved_in | determination of adult lifespan | Process | - |
79 | Homo sapiens | IMP | involved_in | mRNA transcription | Process | 16479015 |
80 | Homo sapiens | IEA | involved_in | rRNA transcription | Process | - |
81 | Homo sapiens | IEA | involved_in | response to salt stress | Process | - |
82 | Homo sapiens | IEA | involved_in | response to inorganic substance | Process | - |
83 | Homo sapiens | IEA | involved_in | response to X-ray | Process | - |
84 | Homo sapiens | IMP | involved_in | response to gamma radiation | Process | 7958916 |
85 | Homo sapiens | IDA | involved_in | positive regulation of gene expression | Process | 15314173 20332243 26100857 |
86 | Homo sapiens | IMP | acts_upstream_of_or_within | positive regulation of gene expression | Process | 30089260 |
87 | Homo sapiens | IMP | involved_in | positive regulation of gene expression | Process | 19160485 |
88 | Homo sapiens | ISS | involved_in | positive regulation of gene expression | Process | - |
89 | Homo sapiens | IEA | involved_in | cardiac muscle cell apoptotic process | Process | - |
90 | Homo sapiens | IEA | involved_in | positive regulation of cardiac muscle cell apoptotic process | Process | - |
91 | Homo sapiens | IEA | involved_in | glial cell proliferation | Process | - |
92 | Homo sapiens | IMP | involved_in | viral process | Process | 22574148 |
93 | Homo sapiens | IDA | located_in | nuclear matrix | Component | 11080164 |
94 | Homo sapiens | IDA | colocalizes_with | nuclear body | Component | 10360174 |
95 | Homo sapiens | IDA | located_in | PML body | Component | 12006491 22869143 |
96 | Homo sapiens | IPI | part_of | transcription repressor complex | Component | 8875929 18677113 |
97 | Homo sapiens | IEA | involved_in | glucose catabolic process to lactate via pyruvate | Process | - |
98 | Homo sapiens | IPI | enables | enzyme binding | Function | 17805299 |
99 | Homo sapiens | IEA | involved_in | cerebellum development | Process | - |
100 | Homo sapiens | IMP | involved_in | negative regulation of cell growth | Process | 8986812 |
101 | Homo sapiens | IDA | involved_in | DNA damage response, signal transduction by p53 class mediator | Process | 15149599 |
102 | Homo sapiens | IMP | involved_in | DNA damage response, signal transduction by p53 class mediator | Process | 20160708 |
103 | Homo sapiens | IEA | involved_in | negative regulation of transforming growth factor beta receptor signaling pathway | Process | - |
104 | Homo sapiens | IPI | enables | receptor tyrosine kinase binding | Function | 23027130 |
105 | Homo sapiens | IMP | involved_in | mitotic G1 DNA damage checkpoint signaling | Process | 7958916 |
106 | Homo sapiens | EXP | enables | ubiquitin protein ligase binding | Function | 8875929 |
107 | Homo sapiens | IPI | enables | ubiquitin protein ligase binding | Function | 8875929 |
108 | Homo sapiens | IDA | part_of | protein-containing complex | Component | 9529249 17310983 |
109 | Homo sapiens | IMP | part_of | protein-containing complex | Component | 15629713 |
110 | Homo sapiens | IEA | involved_in | T cell differentiation in thymus | Process | - |
111 | Homo sapiens | IGI | involved_in | tumor necrosis factor-mediated signaling pathway | Process | 22499991 |
112 | Homo sapiens | IEA | involved_in | regulation of tissue remodeling | Process | - |
113 | Homo sapiens | IDA | involved_in | cellular response to UV | Process | 16213212 23629966 |
114 | Homo sapiens | IEA | enables | histone deacetylase regulator activity | Function | - |
115 | Homo sapiens | IEA | involved_in | multicellular organism growth | Process | - |
116 | Homo sapiens | IEA | involved_in | positive regulation of mitochondrial membrane permeability | Process | - |
117 | Homo sapiens | IEA | located_in | site of double-strand break | Component | - |
118 | Homo sapiens | IDA | involved_in | positive regulation of transcription from RNA polymerase II promoter in response to stress | Process | 30089260 |
119 | Homo sapiens | IDA | enables | ATP-dependent DNA/DNA annealing activity | Function | 8183576 |
120 | Homo sapiens | IDA | acts_upstream_of_or_within | cellular response to glucose starvation | Process | 14744935 |
121 | Homo sapiens | IDA | involved_in | cellular response to glucose starvation | Process | 21471221 |
122 | Homo sapiens | IDA | acts_upstream_of_or_within | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | Process | 14654789 14744935 |
123 | Homo sapiens | IDA | involved_in | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | Process | 17403783 |
124 | Homo sapiens | IMP | involved_in | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | Process | 16213212 |
125 | Homo sapiens | IPI | enables | identical protein binding | Function | 10876243 14759370 14985081 15629713 16291740 16461914 17612295 17620598 18087040 19011621 19339993 19667193 20004160 20159469 20364130 21178074 21522129 21988832 22653443 22972749 25402006 25609649 31837246 |
126 | Homo sapiens | IPI | enables | histone deacetylase binding | Function | 23629966 |
127 | Homo sapiens | IDA | acts_upstream_of_or_within | regulation of apoptotic process | Process | 14744935 |
128 | Homo sapiens | IDA | involved_in | positive regulation of apoptotic process | Process | 12667443 15565177 20959462 |
129 | Homo sapiens | IGI | involved_in | negative regulation of apoptotic process | Process | 12203124 12433990 |
130 | Homo sapiens | IMP | involved_in | negative regulation of apoptotic process | Process | 20124405 |
131 | Homo sapiens | IEA | located_in | germ cell nucleus | Component | - |
132 | Homo sapiens | ISS | involved_in | entrainment of circadian clock by photoperiod | Process | - |
133 | Homo sapiens | IEA | involved_in | mitochondrial DNA repair | Process | - |
134 | Homo sapiens | IEA | involved_in | regulation of DNA damage response, signal transduction by p53 class mediator | Process | - |
135 | Homo sapiens | IEA | involved_in | positive regulation of neuron apoptotic process | Process | - |
136 | Homo sapiens | IPI | enables | protein self-association | Function | 14985081 |
137 | Homo sapiens | IDA | involved_in | transcription initiation-coupled chromatin remodeling | Process | 16322561 |
138 | Homo sapiens | IEA | involved_in | negative regulation of proteolysis | Process | - |
139 | Homo sapiens | IDA | involved_in | negative regulation of DNA-templated transcription | Process | 9271120 24051492 |
140 | Homo sapiens | IMP | involved_in | negative regulation of DNA-templated transcription | Process | 23629966 |
141 | Homo sapiens | NAS | involved_in | negative regulation of DNA-templated transcription | Process | 16492744 |
142 | Homo sapiens | IDA | involved_in | positive regulation of DNA-templated transcription | Process | 16322561 17403783 20378837 |
143 | Homo sapiens | IMP | involved_in | positive regulation of DNA-templated transcription | Process | 20096447 |
144 | Homo sapiens | IDA | involved_in | positive regulation of RNA polymerase II transcription preinitiation complex assembly | Process | 24289924 |
145 | Homo sapiens | IDA | acts_upstream_of_or_within | positive regulation of transcription by RNA polymerase II | Process | 17599062 |
146 | Homo sapiens | IDA | involved_in | positive regulation of transcription by RNA polymerase II | Process | 11672523 17145718 17310983 18549481 20959462 24652652 |
147 | Homo sapiens | IGI | acts_upstream_of_or_within | positive regulation of transcription by RNA polymerase II | Process | 16061649 |
148 | Homo sapiens | IMP | involved_in | positive regulation of transcription by RNA polymerase II | Process | 17146433 24356969 |
149 | Homo sapiens | IEP | involved_in | response to antibiotic | Process | 20810912 |
150 | Homo sapiens | IPI | enables | protein heterodimerization activity | Function | 10837489 |
151 | Homo sapiens | IEA | involved_in | fibroblast proliferation | Process | - |
152 | Homo sapiens | IMP | involved_in | negative regulation of fibroblast proliferation | Process | 10962037 |
153 | Homo sapiens | ISS | involved_in | circadian behavior | Process | - |
154 | Homo sapiens | IMP | involved_in | bone marrow development | Process | 30146126 |
155 | Homo sapiens | IEA | involved_in | embryonic organ development | Process | - |
156 | Homo sapiens | ISS | involved_in | positive regulation of peptidyl-tyrosine phosphorylation | Process | 19749791 |
157 | Homo sapiens | IEA | involved_in | protein stabilization | Process | - |
158 | Homo sapiens | IPI | enables | protein-folding chaperone binding | Function | 15358771 18086682 |
159 | Homo sapiens | TAS | involved_in | negative regulation of helicase activity | Process | 7663514 |
160 | Homo sapiens | IEA | involved_in | protein tetramerization | Process | - |
161 | Homo sapiens | IEA | involved_in | chromosome organization | Process | - |
162 | Homo sapiens | IEA | involved_in | neuron apoptotic process | Process | - |
163 | Homo sapiens | IPI | enables | protein phosphatase 2A binding | Function | 17245430 |
164 | Homo sapiens | IDA | involved_in | regulation of cell cycle | Process | 15149599 |
165 | Homo sapiens | IGI | involved_in | regulation of cell cycle | Process | 12203124 12433990 |
166 | Homo sapiens | IMP | involved_in | regulation of cell cycle | Process | 7958916 |
167 | Homo sapiens | ISS | acts_upstream_of | regulation of cell cycle | Process | 30514107 |
168 | Homo sapiens | IDA | involved_in | negative regulation of telomerase activity | Process | 10597287 |
169 | Homo sapiens | IMP | involved_in | hematopoietic stem cell differentiation | Process | 30146126 |
170 | Homo sapiens | IEA | involved_in | negative regulation of glial cell proliferation | Process | - |
171 | Homo sapiens | IEA | involved_in | type II interferon-mediated signaling pathway | Process | - |
172 | Homo sapiens | IEA | involved_in | cardiac septum morphogenesis | Process | - |
173 | Homo sapiens | IEA | involved_in | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia | Process | - |
174 | Homo sapiens | IPI | enables | RNA polymerase II-specific DNA-binding transcription factor binding | Function | 15705871 18549481 19505873 23329847 |
175 | Homo sapiens | IEA | involved_in | positive regulation of programmed necrotic cell death | Process | - |
176 | Homo sapiens | IDA | involved_in | protein-containing complex assembly | Process | 12915590 |
177 | Homo sapiens | IEA | involved_in | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | Process | - |
178 | Homo sapiens | IEA | involved_in | thymocyte apoptotic process | Process | - |
179 | Homo sapiens | ISS | involved_in | positive regulation of thymocyte apoptotic process | Process | - |
180 | Homo sapiens | IEA | involved_in | necroptotic process | Process | - |
181 | Homo sapiens | IEP | involved_in | cellular response to hypoxia | Process | 20810912 |
182 | Homo sapiens | IEP | involved_in | cellular response to xenobiotic stimulus | Process | 20810912 |
183 | Homo sapiens | IMP | involved_in | cellular response to ionizing radiation | Process | 20160708 |
184 | Homo sapiens | IDA | involved_in | cellular response to gamma radiation | Process | 16213212 |
185 | Homo sapiens | IEA | involved_in | cellular response to UV-C | Process | - |
186 | Homo sapiens | EXP | enables | 14-3-3 protein binding | Function | 20206173 |
187 | Homo sapiens | IEA | involved_in | stem cell proliferation | Process | - |
188 | Homo sapiens | IDA | involved_in | signal transduction by p53 class mediator | Process | 15314173 |
189 | Homo sapiens | IMP | involved_in | intrinsic apoptotic signaling pathway by p53 class mediator | Process | 12172011 16322561 17310983 |
190 | Homo sapiens | IEA | involved_in | reactive oxygen species metabolic process | Process | - |
191 | Homo sapiens | IDA | involved_in | cellular response to actinomycin D | Process | 15314173 |
192 | Homo sapiens | IDA | involved_in | positive regulation of release of cytochrome c from mitochondria | Process | 14963330 |
193 | Homo sapiens | IMP | involved_in | cellular senescence | Process | 12080348 |
194 | Homo sapiens | IMP | involved_in | replicative senescence | Process | 19951988 |
195 | Homo sapiens | IMP | involved_in | oxidative stress-induced premature senescence | Process | 19951988 |
196 | Homo sapiens | TAS | involved_in | intrinsic apoptotic signaling pathway | Process | 16462759 |
197 | Homo sapiens | IDA | involved_in | oligodendrocyte apoptotic process | Process | 7720704 |
198 | Homo sapiens | IEA | enables | MDM2/MDM4 family protein binding | Function | - |
199 | Homo sapiens | IPI | enables | disordered domain specific binding | Function | 15629713 |
200 | Homo sapiens | IPI | enables | general transcription initiation factor binding | Function | 15053879 |
201 | Homo sapiens | EXP | enables | molecular function activator activity | Function | 14759370 16793543 |
202 | Homo sapiens | IPI | enables | molecular function activator activity | Function | 7559631 |
203 | Homo sapiens | IMP | involved_in | positive regulation of execution phase of apoptosis | Process | 14985081 |
204 | Homo sapiens | IEA | involved_in | negative regulation of mitophagy | Process | - |
205 | Homo sapiens | IEA | involved_in | regulation of mitochondrial membrane permeability involved in apoptotic process | Process | - |
206 | Homo sapiens | IEA | involved_in | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | Process | - |
207 | Homo sapiens | IMP | acts_upstream_of_negative_effect | regulation of cell cycle G2/M phase transition | Process | 10962037 |
208 | Homo sapiens | IDA | involved_in | positive regulation of miRNA transcription | Process | 20546595 |
209 | Homo sapiens | IGI | involved_in | positive regulation of miRNA transcription | Process | 22499991 |
210 | Homo sapiens | IMP | involved_in | positive regulation of miRNA transcription | Process | 22578566 |
211 | Homo sapiens | IDA | involved_in | negative regulation of G1 to G0 transition | Process | 15314173 |
212 | Homo sapiens | IMP | involved_in | negative regulation of G1 to G0 transition | Process | 21471221 |
213 | Homo sapiens | IEA | involved_in | negative regulation of miRNA processing | Process | - |
214 | Homo sapiens | IEA | involved_in | negative regulation of glucose catabolic process to lactate via pyruvate | Process | - |
215 | Homo sapiens | IMP | involved_in | negative regulation of pentose-phosphate shunt | Process | 21336310 |
216 | Homo sapiens | IEA | involved_in | intrinsic apoptotic signaling pathway in response to hypoxia | Process | - |
217 | Homo sapiens | ISS | involved_in | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | Process | - |
218 | Homo sapiens | IDA | enables | promoter-specific chromatin binding | Function | 20725088 24356969 |
219 | Homo sapiens | IEA | involved_in | regulation of fibroblast apoptotic process | Process | - |
220 | Homo sapiens | IEA | involved_in | negative regulation of reactive oxygen species metabolic process | Process | - |
221 | Homo sapiens | IMP | involved_in | positive regulation of reactive oxygen species metabolic process | Process | 20160708 |
222 | Homo sapiens | IEA | involved_in | negative regulation of stem cell proliferation | Process | - |
223 | Homo sapiens | IDA | involved_in | positive regulation of cellular senescence | Process | 29474172 |
224 | Homo sapiens | ISS | involved_in | positive regulation of cellular senescence | Process | - |
225 | Homo sapiens | IMP | involved_in | positive regulation of intrinsic apoptotic signaling pathway | Process | 14963330 27031958 |
226 | Homo sapiens | ISS | involved_in | positive regulation of intrinsic apoptotic signaling pathway | Process | - |