Tumor protein p53 (TP53) Associated conditions: 1. Interstitial cystitis 2. Adrenocortical carcinoma 3. Choroid plexus papilloma 4. Diamond-Blackfan anemia 5. Glioblastoma 6. Papillary renal cell carcinoma 7. Multiple myeloma 8. Hereditary breast ovarian cancer syndrome 9. Acute megakaryoblastic leukemia 10. Familial cancer of breast 11. Li-Fraumeni syndrome
SNo. | Status | mRNA accession | Protein accession | Genomic DNA accession (Chromosome) | mRNA location on genomic DNA | Assembly | UniProtkb ID |
1 | REVIEWED | NM_001276760.3 | NP_001263689.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
2 | REVIEWED | NR_176326.1 | - | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
3 | REVIEWED | NM_001407271.1 | NP_001394200.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
4 | REVIEWED | NM_001407270.1 | NP_001394199.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
5 | REVIEWED | NM_001407269.1 | NP_001394198.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
6 | REVIEWED | NM_001407268.1 | NP_001394197.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
7 | REVIEWED | NM_001407267.1 | NP_001394196.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
8 | REVIEWED | NM_001407266.1 | NP_001394195.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
9 | REVIEWED | NM_001407265.1 | NP_001394194.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
10 | REVIEWED | NM_001407264.1 | NP_001394193.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
11 | REVIEWED | NM_001407263.1 | NP_001394192.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
12 | REVIEWED | NM_001407262.1 | NP_001394191.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
13 | REVIEWED | NM_001276761.3 | NP_001263690.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
14 | REVIEWED | NM_000546.6 | NP_000537.3 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
15 | REVIEWED | NM_001276699.3 | NP_001263628.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
16 | REVIEWED | NM_001276698.3 | NP_001263627.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
17 | REVIEWED | NM_001276697.3 | NP_001263626.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
18 | REVIEWED | NM_001276696.3 | NP_001263625.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
19 | REVIEWED | NM_001276695.3 | NP_001263624.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
20 | REVIEWED | NM_001126118.2 | NP_001119590.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
21 | REVIEWED | NM_001126117.2 | NP_001119589.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
22 | REVIEWED | NM_001126116.2 | NP_001119588.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
23 | REVIEWED | NM_001126115.2 | NP_001119587.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
24 | REVIEWED | NM_001126114.3 | NP_001119586.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
25 | REVIEWED | NM_001126113.3 | NP_001119585.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
26 | REVIEWED | NM_001126112.3 | NP_001119584.1 | NC_000017.11 | (7668420..7687489, complement) | Reference GRCh38.p14 Primary Assembly | Q53GA5 |
Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.
PubMed Links for Transcript Variants (Isoforms)
Link 1Link 2Link 3Link 4Link 5Link 6Link 7Link 8Link 9Link 10Link 11Link 1211341 reference articlesVariant Information Tumor protein p53 (TP53) Mutation Visualization Dashboard: Pathogenic variant distribution chart
IndiGenomes variants: Exploring and mapping pathogenic variants in gene Tumor protein p53 (TP53)
ClinVar variants:Revealing mutagenic patterns
SNo. | Reported in speceis | Evidence | Qualifier | GO term | Category | Pubmed Link |
1 | Homo sapiens | IDA | involved_in | negative regulation of transcription by RNA polymerase II | Process | 10329733 |
2 | Homo sapiens | ISS | involved_in | negative regulation of transcription by RNA polymerase II | Process | 19749791 |
3 | Homo sapiens | IEA | involved_in | mitophagy | Process | - |
4 | Homo sapiens | IDA | part_of | chromatin | Component | 15710329 17805299 22521434 23629966 24289924 |
5 | Homo sapiens | IMP | part_of | chromatin | Component | 30089260 |
6 | Homo sapiens | ISA | part_of | chromatin | Component | - |
7 | Homo sapiens | IDA | enables | transcription cis-regulatory region binding | Function | 15710329 17996705 |
8 | Homo sapiens | IBA | enables | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Function | 21873635 |
9 | Homo sapiens | IDA | enables | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Function | 22578566 24289924 |
10 | Homo sapiens | ISS | enables | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Function | - |
11 | Homo sapiens | IBA | enables | DNA-binding transcription factor activity, RNA polymerase II-specific | Function | 21873635 |
12 | Homo sapiens | IDA | enables | DNA-binding transcription factor activity, RNA polymerase II-specific | Function | 17310983 24289924 24652652 |
13 | Homo sapiens | ISA | enables | DNA-binding transcription factor activity, RNA polymerase II-specific | Function | - |
14 | Homo sapiens | IDA | enables | cis-regulatory region sequence-specific DNA binding | Function | 10329733 |
15 | Homo sapiens | IDA | enables | core promoter sequence-specific DNA binding | Function | 23629966 |
16 | Homo sapiens | IPI | enables | TFIID-class transcription factor complex binding | Function | 24289924 |
17 | Homo sapiens | IDA | enables | DNA-binding transcription repressor activity, RNA polymerase II-specific | Function | 10329733 |
18 | Homo sapiens | IDA | enables | DNA-binding transcription activator activity, RNA polymerase II-specific | Function | 12609999 17145718 17146433 22578566 |
19 | Homo sapiens | IEA | involved_in | in utero embryonic development | Process | - |
20 | Homo sapiens | IEA | involved_in | somitogenesis | Process | - |
21 | Homo sapiens | IEA | involved_in | release of cytochrome c from mitochondria | Process | - |
22 | Homo sapiens | IPI | enables | protease binding | Function | 11923872 |
23 | Homo sapiens | IPI | enables | p53 binding | Function | 25417702 |
24 | Homo sapiens | IMP | involved_in | hematopoietic progenitor cell differentiation | Process | 30146126 |
25 | Homo sapiens | IEA | involved_in | T cell proliferation involved in immune response | Process | - |
26 | Homo sapiens | IEA | involved_in | B cell lineage commitment | Process | - |
27 | Homo sapiens | IEA | involved_in | T cell lineage commitment | Process | - |
28 | Homo sapiens | IEA | involved_in | response to ischemia | Process | - |
29 | Homo sapiens | IDA | enables | DNA binding | Function | 15358771 |
30 | Homo sapiens | IMP | enables | DNA binding | Function | 2144364 15629713 |
31 | Homo sapiens | IDA | enables | chromatin binding | Function | 16322561 17599062 |
32 | Homo sapiens | IDA | enables | DNA-binding transcription factor activity | Function | 7587074 18549481 |
33 | Homo sapiens | IMP | enables | DNA-binding transcription factor activity | Function | 16479015 |
34 | Homo sapiens | IDA | enables | mRNA 3'-UTR binding | Function | 16213212 |
35 | Homo sapiens | IDA | enables | copper ion binding | Function | 7824276 |
36 | Homo sapiens | IPI | enables | protein binding | Function | 1465435 7663514 7799929 8207801 8344494 8675009 8875926 8875929 9050995 9188558 9194564 9194565 9380510 9472015 9529249 9733515 9807817 9827557 10196247 10226625 10415337 10518217 10597287 10608892 10666337 10823891 11080164 11146555 11178989 11359905 11388671 11427532 11546806 11672523 11684014 11706030 11781842 11861836 11877378 11950834 12006491 12080348 12620801 12667443 12692135 12702766 12730672 12750254 12915590 14557665 14627987 14744935 14759370 14963330 14985081 15044383 15068796 15133049 15144954 15205477 15310821 15364927 15525938 15542844 15577914 15580310 15604276 15660129 15687255 15710329 15735003 15735006 15782130 15855171 15916963 15960975 15989956 16003391 16151013 16169070 16189514 16227626 16319068 16322561 16376338 16376884 16377624 16402859 16415881 16432196 16442532 16443602 16474402 16493710 16601686 16611888 16616141 16690937 16713569 16732283 16753148 16793543 16845383 16847267 16951253 16959611 17080083 17098746 17108971 17121812 17139261 17145718 17159902 17170702 17184779 17237821 17245430 17254968 17268548 17274640 17290220 17298945 17310983 17317671 17347673 17438265 17470788 17482142 17568776 17612295 17662718 17707234 17719541 17719542 17805299 17875722 17904127 17906639 17964266 18087040 18172499 18230339 18235501 18235502 18275817 18309296 18316739 18354501 18382127 18388957 18391200 18485870 18504427 18510931 18566590 18624398 18656471 18690848 18695251 18812399 18952844 18977328 19008854 19011621 19043414 19098711 19151705 19166840 19196987 19217391 19234109 19255450 19339993 19345189 19411066 19433796 19483087 19508870 19521340 19536131 19556538 19619542 19626115 19651603 19656744 19680552 19684601 19740107 19798103 19805293 19833129 19857493 19883646 19933256 20075864 20096447 20118233 20123734 20124405 20134482 20153329 20159018 20167603 20173098 20206173 20227041 20228809 20385133 20421506 20452352 20515689 20534433 20562916 20591429 20622899 20660729 20705607 20708156 20713054 20864041 20959462 21057547 21078964 21081126 21130767 21132010 21170034 21170087 21245319 21317932 21390126 21397192 21423215 21460856 21471221 21513714 21597459 21625211 21653829 21670263 21726810 21741598 21782458 21821029 21831840 21857681 21892170 21900206 21952639 21988832 22056774 22085928 22103682 22124327 22265415 22340593 22451927 22499945 22510990 22522597 22575647 22653443 22659184 22723347 22726440 22810585 22810586 22819825 22945289 22975381 23010591 23063560 23092970 23320542 23431171 23576507 23623661 23734815 23752197 23776060 23870121 24207125 24219989 24380853 24449765 24492002 24667498 24814347 25168243 25241761 25314079 25402006 25422469 25502805 25579814 25591766 25609649 25651062 25670079 25837623 25857266 26302407 26331536 26789255 27107012 27323408 27519799 27605672 28842590 29187402 29340707 29628311 29997244 31467278 31511497 31515488 31837246 32606738 32814053 33591310 34316702 34404770 34591612 35044719 35122041 35140242 |
37 | Homo sapiens | IDA | located_in | nucleus | Component | 7720704 14744935 14963330 16322561 16507995 17403783 18756595 19011621 19234109 20096447 20810912 21597459 24101517 24289924 |
38 | Homo sapiens | IMP | located_in | nucleus | Component | 16479015 |
39 | Homo sapiens | IDA | located_in | nucleoplasm | Component | 11080164 12915590 |
40 | Homo sapiens | TAS | located_in | nucleoplasm | Component | - |
41 | Homo sapiens | IEA | located_in | replication fork | Component | - |
42 | Homo sapiens | IGI | part_of | transcription regulator complex | Component | 17145718 |
43 | Homo sapiens | IDA | located_in | nucleolus | Component | 12080348 |
44 | Homo sapiens | IDA | located_in | cytoplasm | Component | 7720704 14744935 16131611 19011621 20096447 20810912 21597459 23629966 |
45 | Homo sapiens | IMP | located_in | cytoplasm | Component | 16479015 |
46 | Homo sapiens | IDA | located_in | mitochondrion | Component | 12667443 24101517 25168243 |
47 | Homo sapiens | IEA | located_in | mitochondrial matrix | Component | - |
48 | Homo sapiens | IEA | located_in | endoplasmic reticulum | Component | - |
49 | Homo sapiens | IDA | located_in | centrosome | Component | 28842590 |
50 | Homo sapiens | IDA | located_in | cytosol | Component | 14963330 24101517 |
51 | Homo sapiens | TAS | located_in | cytosol | Component | - |
52 | Homo sapiens | IMP | involved_in | nucleotide-excision repair | Process | 7663514 |
53 | Homo sapiens | IEA | involved_in | double-strand break repair | Process | - |
54 | Homo sapiens | IDA | involved_in | regulation of DNA-templated transcription | Process | 7587074 |
55 | Homo sapiens | IMP | involved_in | regulation of DNA-templated transcription | Process | 25417702 |
56 | Homo sapiens | IBA | involved_in | regulation of transcription by RNA polymerase II | Process | 21873635 |
57 | Homo sapiens | IEA | involved_in | protein import into nucleus | Process | - |
58 | Homo sapiens | IMP | involved_in | autophagy | Process | 23629966 |
59 | Homo sapiens | IDA | acts_upstream_of_or_within | DNA damage response | Process | 14744935 |
60 | Homo sapiens | IDA | involved_in | DNA damage response | Process | 15710329 17938203 |
61 | Homo sapiens | IMP | involved_in | DNA damage response | Process | 24356969 |
62 | Homo sapiens | IMP | involved_in | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | Process | 16213212 |
63 | Homo sapiens | IDA | involved_in | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | Process | 16213212 |
64 | Homo sapiens | IMP | involved_in | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | Process | 7958916 16479015 |
65 | Homo sapiens | IDA | acts_upstream_of_or_within | ER overload response | Process | 14744935 |
66 | Homo sapiens | IEA | involved_in | transforming growth factor beta receptor signaling pathway | Process | - |
67 | Homo sapiens | IEP | involved_in | Ras protein signal transduction | Process | 9054499 |
68 | Homo sapiens | IEA | involved_in | gastrulation | Process | - |
69 | Homo sapiens | IEA | involved_in | neuroblast proliferation | Process | - |
70 | Homo sapiens | IEA | involved_in | negative regulation of neuroblast proliferation | Process | - |
71 | Homo sapiens | IDA | involved_in | protein localization | Process | 16507995 |
72 | Homo sapiens | IEA | involved_in | negative regulation of DNA replication | Process | - |
73 | Homo sapiens | TAS | enables | zinc ion binding | Function | 10065153 |
74 | Homo sapiens | IDA | involved_in | negative regulation of cell population proliferation | Process | 22783376 |
75 | Homo sapiens | IMP | involved_in | negative regulation of cell population proliferation | Process | 12730672 |
76 | Homo sapiens | ISS | acts_upstream_of | negative regulation of cell population proliferation | Process | 30514107 |
77 | Homo sapiens | ISS | involved_in | negative regulation of cell population proliferation | Process | - |
78 | Homo sapiens | ISS | involved_in | determination of adult lifespan | Process | - |
79 | Homo sapiens | IMP | involved_in | mRNA transcription | Process | 16479015 |
80 | Homo sapiens | IEA | involved_in | rRNA transcription | Process | - |
81 | Homo sapiens | IEA | involved_in | response to salt stress | Process | - |
82 | Homo sapiens | IEA | involved_in | response to inorganic substance | Process | - |
83 | Homo sapiens | IEA | involved_in | response to X-ray | Process | - |
84 | Homo sapiens | IMP | involved_in | response to gamma radiation | Process | 7958916 |
85 | Homo sapiens | IDA | involved_in | positive regulation of gene expression | Process | 15314173 20332243 26100857 |
86 | Homo sapiens | IMP | acts_upstream_of_or_within | positive regulation of gene expression | Process | 30089260 |
87 | Homo sapiens | IMP | involved_in | positive regulation of gene expression | Process | 19160485 |
88 | Homo sapiens | ISS | involved_in | positive regulation of gene expression | Process | - |
89 | Homo sapiens | IEA | involved_in | cardiac muscle cell apoptotic process | Process | - |
90 | Homo sapiens | IEA | involved_in | positive regulation of cardiac muscle cell apoptotic process | Process | - |
91 | Homo sapiens | IEA | involved_in | glial cell proliferation | Process | - |
92 | Homo sapiens | IMP | involved_in | viral process | Process | 22574148 |
93 | Homo sapiens | IDA | located_in | nuclear matrix | Component | 11080164 |
94 | Homo sapiens | IDA | colocalizes_with | nuclear body | Component | 10360174 |
95 | Homo sapiens | IDA | located_in | PML body | Component | 12006491 22869143 |
96 | Homo sapiens | IPI | part_of | transcription repressor complex | Component | 8875929 18677113 |
97 | Homo sapiens | IEA | involved_in | glucose catabolic process to lactate via pyruvate | Process | - |
98 | Homo sapiens | IPI | enables | enzyme binding | Function | 17805299 |
99 | Homo sapiens | IEA | involved_in | cerebellum development | Process | - |
100 | Homo sapiens | IMP | involved_in | negative regulation of cell growth | Process | 8986812 |
101 | Homo sapiens | IDA | involved_in | DNA damage response, signal transduction by p53 class mediator | Process | 15149599 |
102 | Homo sapiens | IMP | involved_in | DNA damage response, signal transduction by p53 class mediator | Process | 20160708 |
103 | Homo sapiens | IEA | involved_in | negative regulation of transforming growth factor beta receptor signaling pathway | Process | - |
104 | Homo sapiens | IPI | enables | receptor tyrosine kinase binding | Function | 23027130 |
105 | Homo sapiens | IMP | involved_in | mitotic G1 DNA damage checkpoint signaling | Process | 7958916 |
106 | Homo sapiens | EXP | enables | ubiquitin protein ligase binding | Function | 8875929 |
107 | Homo sapiens | IPI | enables | ubiquitin protein ligase binding | Function | 8875929 |
108 | Homo sapiens | IDA | part_of | protein-containing complex | Component | 9529249 17310983 |
109 | Homo sapiens | IMP | part_of | protein-containing complex | Component | 15629713 |
110 | Homo sapiens | IEA | involved_in | T cell differentiation in thymus | Process | - |
111 | Homo sapiens | IGI | involved_in | tumor necrosis factor-mediated signaling pathway | Process | 22499991 |
112 | Homo sapiens | IEA | involved_in | regulation of tissue remodeling | Process | - |
113 | Homo sapiens | IDA | involved_in | cellular response to UV | Process | 16213212 23629966 |
114 | Homo sapiens | IEA | enables | histone deacetylase regulator activity | Function | - |
115 | Homo sapiens | IEA | involved_in | multicellular organism growth | Process | - |
116 | Homo sapiens | IEA | involved_in | positive regulation of mitochondrial membrane permeability | Process | - |
117 | Homo sapiens | IEA | located_in | site of double-strand break | Component | - |
118 | Homo sapiens | IDA | involved_in | positive regulation of transcription from RNA polymerase II promoter in response to stress | Process | 30089260 |
119 | Homo sapiens | IDA | enables | ATP-dependent DNA/DNA annealing activity | Function | 8183576 |
120 | Homo sapiens | IDA | acts_upstream_of_or_within | cellular response to glucose starvation | Process | 14744935 |
121 | Homo sapiens | IDA | involved_in | cellular response to glucose starvation | Process | 21471221 |
122 | Homo sapiens | IDA | acts_upstream_of_or_within | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | Process | 14654789 14744935 |
123 | Homo sapiens | IDA | involved_in | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | Process | 17403783 |
124 | Homo sapiens | IMP | involved_in | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | Process | 16213212 |
125 | Homo sapiens | IPI | enables | identical protein binding | Function | 10876243 14759370 14985081 15629713 16291740 16461914 17612295 17620598 18087040 19011621 19339993 19667193 20004160 20159469 20364130 21178074 21522129 21988832 22653443 22972749 25402006 25609649 31837246 |
126 | Homo sapiens | IPI | enables | histone deacetylase binding | Function | 23629966 |
127 | Homo sapiens | IDA | acts_upstream_of_or_within | regulation of apoptotic process | Process | 14744935 |
128 | Homo sapiens | IDA | involved_in | positive regulation of apoptotic process | Process | 12667443 15565177 20959462 |
129 | Homo sapiens | IGI | involved_in | negative regulation of apoptotic process | Process | 12203124 12433990 |
130 | Homo sapiens | IMP | involved_in | negative regulation of apoptotic process | Process | 20124405 |
131 | Homo sapiens | IEA | located_in | germ cell nucleus | Component | - |
132 | Homo sapiens | ISS | involved_in | entrainment of circadian clock by photoperiod | Process | - |
133 | Homo sapiens | IEA | involved_in | mitochondrial DNA repair | Process | - |
134 | Homo sapiens | IEA | involved_in | regulation of DNA damage response, signal transduction by p53 class mediator | Process | - |
135 | Homo sapiens | IEA | involved_in | positive regulation of neuron apoptotic process | Process | - |
136 | Homo sapiens | IPI | enables | protein self-association | Function | 14985081 |
137 | Homo sapiens | IDA | involved_in | transcription initiation-coupled chromatin remodeling | Process | 16322561 |
138 | Homo sapiens | IEA | involved_in | negative regulation of proteolysis | Process | - |
139 | Homo sapiens | IDA | involved_in | negative regulation of DNA-templated transcription | Process | 9271120 24051492 |
140 | Homo sapiens | IMP | involved_in | negative regulation of DNA-templated transcription | Process | 23629966 |
141 | Homo sapiens | NAS | involved_in | negative regulation of DNA-templated transcription | Process | 16492744 |
142 | Homo sapiens | IDA | involved_in | positive regulation of DNA-templated transcription | Process | 16322561 17403783 20378837 |
143 | Homo sapiens | IMP | involved_in | positive regulation of DNA-templated transcription | Process | 20096447 |
144 | Homo sapiens | IDA | involved_in | positive regulation of RNA polymerase II transcription preinitiation complex assembly | Process | 24289924 |
145 | Homo sapiens | IDA | acts_upstream_of_or_within | positive regulation of transcription by RNA polymerase II | Process | 17599062 |
146 | Homo sapiens | IDA | involved_in | positive regulation of transcription by RNA polymerase II | Process | 11672523 17145718 17310983 18549481 20959462 24652652 |
147 | Homo sapiens | IGI | acts_upstream_of_or_within | positive regulation of transcription by RNA polymerase II | Process | 16061649 |
148 | Homo sapiens | IMP | involved_in | positive regulation of transcription by RNA polymerase II | Process | 17146433 24356969 |
149 | Homo sapiens | IEP | involved_in | response to antibiotic | Process | 20810912 |
150 | Homo sapiens | IPI | enables | protein heterodimerization activity | Function | 10837489 |
151 | Homo sapiens | IEA | involved_in | fibroblast proliferation | Process | - |
152 | Homo sapiens | IMP | involved_in | negative regulation of fibroblast proliferation | Process | 10962037 |
153 | Homo sapiens | ISS | involved_in | circadian behavior | Process | - |
154 | Homo sapiens | IMP | involved_in | bone marrow development | Process | 30146126 |
155 | Homo sapiens | IEA | involved_in | embryonic organ development | Process | - |
156 | Homo sapiens | ISS | involved_in | positive regulation of peptidyl-tyrosine phosphorylation | Process | 19749791 |
157 | Homo sapiens | IEA | involved_in | protein stabilization | Process | - |
158 | Homo sapiens | IPI | enables | protein-folding chaperone binding | Function | 15358771 18086682 |
159 | Homo sapiens | TAS | involved_in | negative regulation of helicase activity | Process | 7663514 |
160 | Homo sapiens | IEA | involved_in | protein tetramerization | Process | - |
161 | Homo sapiens | IEA | involved_in | chromosome organization | Process | - |
162 | Homo sapiens | IEA | involved_in | neuron apoptotic process | Process | - |
163 | Homo sapiens | IPI | enables | protein phosphatase 2A binding | Function | 17245430 |
164 | Homo sapiens | IDA | involved_in | regulation of cell cycle | Process | 15149599 |
165 | Homo sapiens | IGI | involved_in | regulation of cell cycle | Process | 12203124 12433990 |
166 | Homo sapiens | IMP | involved_in | regulation of cell cycle | Process | 7958916 |
167 | Homo sapiens | ISS | acts_upstream_of | regulation of cell cycle | Process | 30514107 |
168 | Homo sapiens | IDA | involved_in | negative regulation of telomerase activity | Process | 10597287 |
169 | Homo sapiens | IMP | involved_in | hematopoietic stem cell differentiation | Process | 30146126 |
170 | Homo sapiens | IEA | involved_in | negative regulation of glial cell proliferation | Process | - |
171 | Homo sapiens | IEA | involved_in | type II interferon-mediated signaling pathway | Process | - |
172 | Homo sapiens | IEA | involved_in | cardiac septum morphogenesis | Process | - |
173 | Homo sapiens | IEA | involved_in | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia | Process | - |
174 | Homo sapiens | IPI | enables | RNA polymerase II-specific DNA-binding transcription factor binding | Function | 15705871 18549481 19505873 23329847 |
175 | Homo sapiens | IEA | involved_in | positive regulation of programmed necrotic cell death | Process | - |
176 | Homo sapiens | IDA | involved_in | protein-containing complex assembly | Process | 12915590 |
177 | Homo sapiens | IEA | involved_in | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | Process | - |
178 | Homo sapiens | IEA | involved_in | thymocyte apoptotic process | Process | - |
179 | Homo sapiens | ISS | involved_in | positive regulation of thymocyte apoptotic process | Process | - |
180 | Homo sapiens | IEA | involved_in | necroptotic process | Process | - |
181 | Homo sapiens | IEP | involved_in | cellular response to hypoxia | Process | 20810912 |
182 | Homo sapiens | IEP | involved_in | cellular response to xenobiotic stimulus | Process | 20810912 |
183 | Homo sapiens | IMP | involved_in | cellular response to ionizing radiation | Process | 20160708 |
184 | Homo sapiens | IDA | involved_in | cellular response to gamma radiation | Process | 16213212 |
185 | Homo sapiens | IEA | involved_in | cellular response to UV-C | Process | - |
186 | Homo sapiens | EXP | enables | 14-3-3 protein binding | Function | 20206173 |
187 | Homo sapiens | IEA | involved_in | stem cell proliferation | Process | - |
188 | Homo sapiens | IDA | involved_in | signal transduction by p53 class mediator | Process | 15314173 |
189 | Homo sapiens | IMP | involved_in | intrinsic apoptotic signaling pathway by p53 class mediator | Process | 12172011 16322561 17310983 |
190 | Homo sapiens | IEA | involved_in | reactive oxygen species metabolic process | Process | - |
191 | Homo sapiens | IDA | involved_in | cellular response to actinomycin D | Process | 15314173 |
192 | Homo sapiens | IDA | involved_in | positive regulation of release of cytochrome c from mitochondria | Process | 14963330 |
193 | Homo sapiens | IMP | involved_in | cellular senescence | Process | 12080348 |
194 | Homo sapiens | IMP | involved_in | replicative senescence | Process | 19951988 |
195 | Homo sapiens | IMP | involved_in | oxidative stress-induced premature senescence | Process | 19951988 |
196 | Homo sapiens | TAS | involved_in | intrinsic apoptotic signaling pathway | Process | 16462759 |
197 | Homo sapiens | IDA | involved_in | oligodendrocyte apoptotic process | Process | 7720704 |
198 | Homo sapiens | IEA | enables | MDM2/MDM4 family protein binding | Function | - |
199 | Homo sapiens | IPI | enables | disordered domain specific binding | Function | 15629713 |
200 | Homo sapiens | IPI | enables | general transcription initiation factor binding | Function | 15053879 |
201 | Homo sapiens | EXP | enables | molecular function activator activity | Function | 14759370 16793543 |
202 | Homo sapiens | IPI | enables | molecular function activator activity | Function | 7559631 |
203 | Homo sapiens | IMP | involved_in | positive regulation of execution phase of apoptosis | Process | 14985081 |
204 | Homo sapiens | IEA | involved_in | negative regulation of mitophagy | Process | - |
205 | Homo sapiens | IEA | involved_in | regulation of mitochondrial membrane permeability involved in apoptotic process | Process | - |
206 | Homo sapiens | IEA | involved_in | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | Process | - |
207 | Homo sapiens | IMP | acts_upstream_of_negative_effect | regulation of cell cycle G2/M phase transition | Process | 10962037 |
208 | Homo sapiens | IDA | involved_in | positive regulation of miRNA transcription | Process | 20546595 |
209 | Homo sapiens | IGI | involved_in | positive regulation of miRNA transcription | Process | 22499991 |
210 | Homo sapiens | IMP | involved_in | positive regulation of miRNA transcription | Process | 22578566 |
211 | Homo sapiens | IDA | involved_in | negative regulation of G1 to G0 transition | Process | 15314173 |
212 | Homo sapiens | IMP | involved_in | negative regulation of G1 to G0 transition | Process | 21471221 |
213 | Homo sapiens | IEA | involved_in | negative regulation of miRNA processing | Process | - |
214 | Homo sapiens | IEA | involved_in | negative regulation of glucose catabolic process to lactate via pyruvate | Process | - |
215 | Homo sapiens | IMP | involved_in | negative regulation of pentose-phosphate shunt | Process | 21336310 |
216 | Homo sapiens | IEA | involved_in | intrinsic apoptotic signaling pathway in response to hypoxia | Process | - |
217 | Homo sapiens | ISS | involved_in | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | Process | - |
218 | Homo sapiens | IDA | enables | promoter-specific chromatin binding | Function | 20725088 24356969 |
219 | Homo sapiens | IEA | involved_in | regulation of fibroblast apoptotic process | Process | - |
220 | Homo sapiens | IEA | involved_in | negative regulation of reactive oxygen species metabolic process | Process | - |
221 | Homo sapiens | IMP | involved_in | positive regulation of reactive oxygen species metabolic process | Process | 20160708 |
222 | Homo sapiens | IEA | involved_in | negative regulation of stem cell proliferation | Process | - |
223 | Homo sapiens | IDA | involved_in | positive regulation of cellular senescence | Process | 29474172 |
224 | Homo sapiens | ISS | involved_in | positive regulation of cellular senescence | Process | - |
225 | Homo sapiens | IMP | involved_in | positive regulation of intrinsic apoptotic signaling pathway | Process | 14963330 27031958 |
226 | Homo sapiens | ISS | involved_in | positive regulation of intrinsic apoptotic signaling pathway | Process | - |