GenTIGS

Tumor protein p53 (TP53) Associated conditions: 1. Interstitial cystitis 2. Adrenocortical carcinoma 3. Choroid plexus papilloma 4. Diamond-Blackfan anemia 5. Glioblastoma 6. Papillary renal cell carcinoma 7. Multiple myeloma 8. Hereditary breast ovarian cancer syndrome 9. Acute megakaryoblastic leukemia 10. Familial cancer of breast 11. Li-Fraumeni syndrome

mRNA Information: Transcript Variants and Protein Isoforms

SNo.	Status	mRNA accession	Protein accession	Genomic DNA accession (Chromosome)	mRNA location on genomic DNA	Assembly	UniProtkb ID
1	REVIEWED	NM_001276760.3	NP_001263689.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
2	REVIEWED	NR_176326.1	-	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
3	REVIEWED	NM_001407271.1	NP_001394200.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
4	REVIEWED	NM_001407270.1	NP_001394199.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
5	REVIEWED	NM_001407269.1	NP_001394198.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
6	REVIEWED	NM_001407268.1	NP_001394197.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
7	REVIEWED	NM_001407267.1	NP_001394196.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
8	REVIEWED	NM_001407266.1	NP_001394195.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
9	REVIEWED	NM_001407265.1	NP_001394194.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
10	REVIEWED	NM_001407264.1	NP_001394193.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
11	REVIEWED	NM_001407263.1	NP_001394192.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
12	REVIEWED	NM_001407262.1	NP_001394191.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
13	REVIEWED	NM_001276761.3	NP_001263690.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
14	REVIEWED	NM_000546.6	NP_000537.3	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
15	REVIEWED	NM_001276699.3	NP_001263628.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
16	REVIEWED	NM_001276698.3	NP_001263627.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
17	REVIEWED	NM_001276697.3	NP_001263626.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
18	REVIEWED	NM_001276696.3	NP_001263625.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
19	REVIEWED	NM_001276695.3	NP_001263624.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
20	REVIEWED	NM_001126118.2	NP_001119590.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
21	REVIEWED	NM_001126117.2	NP_001119589.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
22	REVIEWED	NM_001126116.2	NP_001119588.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
23	REVIEWED	NM_001126115.2	NP_001119587.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
24	REVIEWED	NM_001126114.3	NP_001119586.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
25	REVIEWED	NM_001126113.3	NP_001119585.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-
26	REVIEWED	NM_001126112.3	NP_001119584.1	NC_000017.11	(7668420..7687489, complement)	Reference GRCh38.p14 Primary Assembly	-

Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.

PubMed Links for Transcript Variants (Isoforms)

Link 1 Link 2 Link 3 Link 4 Link 5 Link 6 Link 7 Link 8 Link 9 Link 10 Link 11 Link 1211615 reference articles

Variant Information Tumor protein p53 (TP53) Mutation Visualization Dashboard: Pathogenic variant distribution chart

IndiGenomes variants: Exploring and mapping pathogenic variants in gene Tumor protein p53 (TP53)

ClinVar variants:Revealing mutagenic patterns

GO Term of Tumor protein p53 (TP53)

SNo.	Reported in speceis	Evidence	Qualifier	GO term	Category	Pubmed Link
1	Homo sapiens	IDA	involved_in	negative regulation of transcription by RNA polymerase II	Process	10329733 15340061
2	Homo sapiens	IEA	involved_in	negative regulation of transcription by RNA polymerase II	Process	-
3	Homo sapiens	ISS	involved_in	negative regulation of transcription by RNA polymerase II	Process	19749791
4	Homo sapiens	IBA	is_active_in	chromatin	Component	-
5	Homo sapiens	IDA	located_in	chromatin	Component	15710329 17805299 22521434 23629966 24289924
6	Homo sapiens	IMP	located_in	chromatin	Component	30089260
7	Homo sapiens	ISA	located_in	chromatin	Component	-
8	Homo sapiens	IDA	enables	transcription cis-regulatory region binding	Function	15710329 16131611 17996705
9	Homo sapiens	IEA	enables	transcription cis-regulatory region binding	Function	-
10	Homo sapiens	IBA	enables	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Function	-
11	Homo sapiens	IDA	enables	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Function	22578566 24289924
12	Homo sapiens	IEA	enables	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Function	-
13	Homo sapiens	ISS	enables	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Function	-
14	Homo sapiens	IBA	enables	DNA-binding transcription factor activity, RNA polymerase II-specific	Function	-
15	Homo sapiens	IDA	enables	DNA-binding transcription factor activity, RNA polymerase II-specific	Function	17310983 24289924 24652652 34381247 35618207 36634798 38653238
16	Homo sapiens	ISA	enables	DNA-binding transcription factor activity, RNA polymerase II-specific	Function	-
17	Homo sapiens	IDA	enables	cis-regulatory region sequence-specific DNA binding	Function	10329733
18	Homo sapiens	IDA	enables	core promoter sequence-specific DNA binding	Function	23629966
19	Homo sapiens	IPI	enables	TFIID-class transcription factor complex binding	Function	24289924
20	Homo sapiens	IPI	enables	transcription coactivator binding	Function	11950834
21	Homo sapiens	IDA	enables	DNA-binding transcription repressor activity, RNA polymerase II-specific	Function	10329733
22	Homo sapiens	IDA	enables	DNA-binding transcription activator activity, RNA polymerase II-specific	Function	12609999 17145718 17146433 22578566
23	Homo sapiens	IPI	enables	protease binding	Function	11923872
24	Homo sapiens	IPI	enables	p53 binding	Function	25417702
25	Homo sapiens	IMP	involved_in	hematopoietic progenitor cell differentiation	Process	30146126
26	Homo sapiens	IDA	enables	DNA binding	Function	15358771
27	Homo sapiens	IEA	enables	DNA binding	Function	-
28	Homo sapiens	IMP	enables	DNA binding	Function	2144364 15629713
29	Homo sapiens	IDA	enables	chromatin binding	Function	16322561 17599062 26334721
30	Homo sapiens	IDA	enables	DNA-binding transcription factor activity	Function	7587074 18549481 26334721
31	Homo sapiens	IEA	enables	DNA-binding transcription factor activity	Function	-
32	Homo sapiens	IMP	enables	DNA-binding transcription factor activity	Function	16479015
33	Homo sapiens	IDA	enables	mRNA 3'-UTR binding	Function	16213212
34	Homo sapiens	IDA	enables	copper ion binding	Function	7824276
35	Homo sapiens	IPI	enables	protein binding	Function	1321290 1465435 7663514 7799929 8207801 8344494 8388547 8675009 8875926 8875929 9050995 9188558 9194564 9194565 9380510 9472015 9529249 9733515 9807817 9827557 9926942 10196247 10226625 10415337 10518217 10597287 10608892 10618715 10666337 10724175 10823891 11080164 11146555 11178989 11359905 11388671 11427532 11546806 11571640 11672523 11684014 11706030 11781842 11861836 11877378 11907332 11923872 12006491 12080348 12397362 12534345 12620801 12667443 12692135 12702766 12730672 12750254 12898523 12915590 14557665 14627987 14704432 14744935 14759370 14963330 14966293 14985081 15044383 15068796 15103385 15133049 15144954 15175323 15205477 15254196 15310821 15327968 15364927 15525938 15542844 15577914 15580310 15604276 15660129 15687255 15710329 15710382 15735003 15735006 15782130 15848166 15855171 15862297 15896780 15907477 15916963 15960975 15989956 16003391 16151013 16169070 16189514 16212962 16227626 16319068 16322561 16376338 16376884 16377624 16402859 16415881 16432196 16442532 16443602 16474402 16493710 16511572 16601686 16611888 16690937 16713569 16732283 16753148 16793543 16845383 16847267 16951253 16959611 17080083 17098746 17108971 17121812 17139261 17145718 17159902 17170702 17184779 17237821 17245430 17254968 17268548 17274640 17290220 17298945 17310983 17317671 17347673 17438265 17470788 17482142 17568776 17612295 17662718 17707234 17719541 17719542 17805299 17875722 17904127 17906639 17964266 18087040 18172499 18230339 18235501 18235502 18275817 18309296 18316739 18354501 18382127 18388957 18391200 18485870 18504427 18510931 18566590 18624398 18656471 18690848 18695251 18812399 18833288 18952844 18977328 19008854 19011621 19043414 19098711 19151705 19166840 19196987 19217391 19234109 19255450 19339993 19345189 19411066 19433796 19483087 19508870 19521340 19536131 19556538 19619542 19626115 19651603 19656744 19680552 19684601 19740107 19798103 19805293 19833129 19857493 19933256 20075864 20096447 20118233 20123734 20124405 20134482 20153329 20159018 20167603 20173098 20206173 20227041 20228809 20385133 20421506 20452352 20515689 20534433 20562916 20591429 20622899 20660729 20705607 20708156 20713054 20818423 20864041 20959462 21057547 21078964 21081126 21130767 21132010 21170034 21170087 21245319 21317932 21390126 21397192 21423215 21460856 21471221 21513714 21597459 21625211 21653829 21670263 21726810 21741598 21782458 21821029 21831840 21857681 21892170 21900206 21952639 21988832 22056774 22085928 22103682 22124327 22265415 22340593 22451927 22499945 22510990 22522597 22575647 22653443 22659184 22723347 22726440 22761572 22810585 22810586 22819825 22945289 22975381 23010591 23063560 23092970 23320542 23431171 23576507 23623661 23734815 23752197 23776060 23870121 24207125 24219989 24380853 24449765 24492002 24625977 24667498 24722188 24814347 25168243 25241761 25314079 25402006 25422469 25502805 25579814 25591766 25609649 25651062 25670079 25837623 25857266 26302407 26331536 26334721 26789255 27107012 27323408 27519799 27605672 28842590 29187402 29340707 29628311 29997244 31467278 31511497 31515488 31837246 32606738 32814053 33591310 33961781 34316702 34404770 34591612 34591642 35044719 35122041 35140242 35271311 35512704 36931259 39009827 40205054
36	Homo sapiens	IBA	is_active_in	nucleus	Component	-
37	Homo sapiens	IDA	is_active_in	nucleus	Component	36108750
38	Homo sapiens	IDA	located_in	nucleus	Component	7720704 14744935 14963330 15340061 16131611 16322561 16507995 17403783 18756595 19011621 19234109 20096447 20810912 21597459 22914926 24101517 24289924 24625977 26634371
39	Homo sapiens	IEA	located_in	nucleus	Component	-
40	Homo sapiens	IMP	located_in	nucleus	Component	16479015
41	Homo sapiens	IDA	located_in	nucleoplasm	Component	11080164 12915590
42	Homo sapiens	TAS	located_in	nucleoplasm	Component	-
43	Homo sapiens	IGI	part_of	transcription regulator complex	Component	17145718
44	Homo sapiens	IDA	located_in	nucleolus	Component	12080348
45	Homo sapiens	IDA	located_in	cytoplasm	Component	7720704 14744935 15340061 16131611 19011621 20096447 20810912 21597459 23629966 24625977 26634371
46	Homo sapiens	IEA	located_in	cytoplasm	Component	-
47	Homo sapiens	IMP	located_in	cytoplasm	Component	16479015
48	Homo sapiens	IDA	located_in	mitochondrion	Component	12667443 24101517 25168243
49	Homo sapiens	IEA	located_in	mitochondrion	Component	-
50	Homo sapiens	IEA	located_in	mitochondrial matrix	Component	-
51	Homo sapiens	IEA	located_in	endoplasmic reticulum	Component	-
52	Homo sapiens	IDA	located_in	centrosome	Component	28842590
53	Homo sapiens	IEA	located_in	centrosome	Component	-
54	Homo sapiens	IDA	located_in	cytosol	Component	14963330 24101517
55	Homo sapiens	TAS	located_in	cytosol	Component	-
56	Homo sapiens	IMP	involved_in	nucleotide-excision repair	Process	7663514
57	Homo sapiens	IDA	involved_in	regulation of DNA-templated transcription	Process	7587074
58	Homo sapiens	IEA	involved_in	regulation of DNA-templated transcription	Process	-
59	Homo sapiens	IMP	involved_in	regulation of DNA-templated transcription	Process	25417702
60	Homo sapiens	IDA	involved_in	regulation of transcription by RNA polymerase II	Process	30089260
61	Homo sapiens	IMP	involved_in	autophagy	Process	23629966
62	Homo sapiens	IEA	involved_in	apoptotic process	Process	-
63	Homo sapiens	IDA	acts_upstream_of_or_within	DNA damage response	Process	14744935
64	Homo sapiens	IDA	involved_in	DNA damage response	Process	15710329 17938203 30089260
65	Homo sapiens	IMP	involved_in	DNA damage response	Process	24356969
66	Homo sapiens	IEA	involved_in	response to oxidative stress	Process	-
67	Homo sapiens	IDA	acts_upstream_of_or_within	ER overload response	Process	14744935
68	Homo sapiens	IEP	involved_in	Ras protein signal transduction	Process	9054499
69	Homo sapiens	IEA	involved_in	circadian rhythm	Process	-
70	Homo sapiens	IDA	involved_in	intracellular protein localization	Process	15340061 16507995
71	Homo sapiens	TAS	enables	zinc ion binding	Function	10065153
72	Homo sapiens	IDA	involved_in	negative regulation of cell population proliferation	Process	22783376
73	Homo sapiens	IEA	involved_in	negative regulation of cell population proliferation	Process	-
74	Homo sapiens	IMP	involved_in	negative regulation of cell population proliferation	Process	12730672
75	Homo sapiens	ISS	acts_upstream_of	negative regulation of cell population proliferation	Process	30514107
76	Homo sapiens	ISS	involved_in	negative regulation of cell population proliferation	Process	-
77	Homo sapiens	IEA	involved_in	determination of adult lifespan	Process	-
78	Homo sapiens	ISS	involved_in	determination of adult lifespan	Process	-
79	Homo sapiens	IMP	involved_in	mRNA transcription	Process	16479015
80	Homo sapiens	IEA	involved_in	response to xenobiotic stimulus	Process	-
81	Homo sapiens	IEA	involved_in	response to UV	Process	-
82	Homo sapiens	IEA	involved_in	response to ionizing radiation	Process	-
83	Homo sapiens	IMP	involved_in	response to gamma radiation	Process	7958916
84	Homo sapiens	IDA	involved_in	positive regulation of gene expression	Process	15314173 20332243 26100857
85	Homo sapiens	IMP	involved_in	positive regulation of gene expression	Process	19160485
86	Homo sapiens	ISS	involved_in	positive regulation of gene expression	Process	-
87	Homo sapiens	IEA	involved_in	programmed cell death	Process	-
88	Homo sapiens	IMP	involved_in	viral process	Process	22574148
89	Homo sapiens	IDA	located_in	nuclear matrix	Component	11080164
90	Homo sapiens	IDA	colocalizes_with	nuclear body	Component	10360174
91	Homo sapiens	IDA	located_in	PML body	Component	12006491 22869143
92	Homo sapiens	IEA	located_in	PML body	Component	-
93	Homo sapiens	IPI	enables	enzyme binding	Function	17805299
94	Homo sapiens	IMP	involved_in	negative regulation of cell growth	Process	8986812
95	Homo sapiens	IDA	involved_in	DNA damage response, signal transduction by p53 class mediator	Process	15149599 16213212 29681526
96	Homo sapiens	IMP	involved_in	DNA damage response, signal transduction by p53 class mediator	Process	7958916 16213212 16479015 20160708
97	Homo sapiens	IPI	enables	receptor tyrosine kinase binding	Function	23027130
98	Homo sapiens	IMP	involved_in	mitotic G1 DNA damage checkpoint signaling	Process	7958916
99	Homo sapiens	EXP	enables	ubiquitin protein ligase binding	Function	8875929
100	Homo sapiens	IEA	enables	ubiquitin protein ligase binding	Function	-
101	Homo sapiens	IPI	enables	ubiquitin protein ligase binding	Function	8875929
102	Homo sapiens	IDA	involved_in	negative regulation of telomere maintenance via telomerase	Process	10597287
103	Homo sapiens	IDA	part_of	protein-containing complex	Component	9529249 17310983
104	Homo sapiens	IMP	part_of	protein-containing complex	Component	15629713
105	Homo sapiens	IGI	involved_in	tumor necrosis factor-mediated signaling pathway	Process	22499991
106	Homo sapiens	IDA	involved_in	cellular response to UV	Process	16213212
107	Homo sapiens	IDA	enables	ATP-dependent DNA/DNA annealing activity	Function	8183576
108	Homo sapiens	IDA	acts_upstream_of_or_within	cellular response to glucose starvation	Process	14744935
109	Homo sapiens	IDA	involved_in	cellular response to glucose starvation	Process	21471221
110	Homo sapiens	IBA	involved_in	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Process	-
111	Homo sapiens	IDA	acts_upstream_of_or_within	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Process	14654789 14744935
112	Homo sapiens	IDA	involved_in	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Process	17403783
113	Homo sapiens	IEA	involved_in	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Process	-
114	Homo sapiens	IMP	involved_in	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Process	16213212
115	Homo sapiens	IPI	enables	identical protein binding	Function	10876243 14759370 14985081 15629713 16291740 16461914 17612295 17620598 18087040 19011621 19339993 19667193 20004160 20159469 20364130 21178074 21522129 21988832 22653443 22972749 25402006 25609649 31837246 35512704
116	Homo sapiens	IPI	enables	histone deacetylase binding	Function	23629966
117	Homo sapiens	IBA	involved_in	regulation of apoptotic process	Process	-
118	Homo sapiens	IDA	acts_upstream_of_or_within	regulation of apoptotic process	Process	14744935
119	Homo sapiens	IDA	involved_in	positive regulation of apoptotic process	Process	12667443 15565177 20959462
120	Homo sapiens	IDA	involved_in	negative regulation of apoptotic process	Process	16131611
121	Homo sapiens	IGI	involved_in	negative regulation of apoptotic process	Process	12203124 12433990
122	Homo sapiens	IMP	involved_in	negative regulation of apoptotic process	Process	20124405
123	Homo sapiens	IEA	involved_in	entrainment of circadian clock by photoperiod	Process	-
124	Homo sapiens	ISS	involved_in	entrainment of circadian clock by photoperiod	Process	-
125	Homo sapiens	IDA	involved_in	transcription initiation-coupled chromatin remodeling	Process	16322561
126	Homo sapiens	IDA	involved_in	negative regulation of DNA-templated transcription	Process	9271120 24051492
127	Homo sapiens	IEA	involved_in	negative regulation of DNA-templated transcription	Process	-
128	Homo sapiens	IMP	involved_in	negative regulation of DNA-templated transcription	Process	23629966
129	Homo sapiens	NAS	involved_in	negative regulation of DNA-templated transcription	Process	16492744
130	Homo sapiens	IDA	involved_in	positive regulation of DNA-templated transcription	Process	16322561 17403783 20378837
131	Homo sapiens	IEA	involved_in	positive regulation of DNA-templated transcription	Process	-
132	Homo sapiens	IMP	involved_in	positive regulation of DNA-templated transcription	Process	20096447
133	Homo sapiens	IDA	involved_in	positive regulation of RNA polymerase II transcription preinitiation complex assembly	Process	24289924
134	Homo sapiens	IBA	involved_in	positive regulation of transcription by RNA polymerase II	Process	-
135	Homo sapiens	IDA	acts_upstream_of_or_within	positive regulation of transcription by RNA polymerase II	Process	17599062
136	Homo sapiens	IDA	involved_in	positive regulation of transcription by RNA polymerase II	Process	11672523 16131611 17145718 17310983 18549481 20959462 24652652 30089260
137	Homo sapiens	IEA	involved_in	positive regulation of transcription by RNA polymerase II	Process	-
138	Homo sapiens	IGI	acts_upstream_of_or_within	positive regulation of transcription by RNA polymerase II	Process	16061649
139	Homo sapiens	IMP	involved_in	positive regulation of transcription by RNA polymerase II	Process	7958916 17146433 24356969
140	Homo sapiens	ISS	involved_in	positive regulation of transcription by RNA polymerase II	Process	-
141	Homo sapiens	IEP	involved_in	response to antibiotic	Process	20810912
142	Homo sapiens	IEA	enables	metal ion binding	Function	-
143	Homo sapiens	IPI	enables	protein heterodimerization activity	Function	10837489
144	Homo sapiens	IMP	involved_in	negative regulation of fibroblast proliferation	Process	10962037
145	Homo sapiens	IEA	involved_in	rhythmic process	Process	-
146	Homo sapiens	IEA	involved_in	circadian behavior	Process	-
147	Homo sapiens	ISS	involved_in	circadian behavior	Process	-
148	Homo sapiens	IMP	involved_in	bone marrow development	Process	30146126
149	Homo sapiens	IEA	involved_in	negative regulation of DNA metabolic process	Process	-
150	Homo sapiens	IPI	enables	protein-folding chaperone binding	Function	15358771 18086682
151	Homo sapiens	TAS	involved_in	negative regulation of helicase activity	Process	7663514
152	Homo sapiens	IEA	involved_in	protein tetramerization	Process	-
153	Homo sapiens	IPI	enables	protein phosphatase 2A binding	Function	17245430
154	Homo sapiens	IDA	involved_in	regulation of cell cycle	Process	15149599
155	Homo sapiens	IGI	involved_in	regulation of cell cycle	Process	12203124 12433990
156	Homo sapiens	IMP	involved_in	regulation of cell cycle	Process	7958916
157	Homo sapiens	ISS	acts_upstream_of	regulation of cell cycle	Process	30514107
158	Homo sapiens	IMP	involved_in	hematopoietic stem cell differentiation	Process	30146126
159	Homo sapiens	IEA	involved_in	type II interferon-mediated signaling pathway	Process	-
160	Homo sapiens	IPI	enables	RNA polymerase II-specific DNA-binding transcription factor binding	Function	15705871 18549481 19505873 23329847
161	Homo sapiens	IEA	involved_in	positive regulation of programmed necrotic cell death	Process	-
162	Homo sapiens	IDA	involved_in	protein-containing complex assembly	Process	12915590
163	Homo sapiens	IEA	involved_in	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Process	-
164	Homo sapiens	IEA	involved_in	positive regulation of thymocyte apoptotic process	Process	-
165	Homo sapiens	ISS	involved_in	positive regulation of thymocyte apoptotic process	Process	-
166	Homo sapiens	IEA	involved_in	cellular response to hypoxia	Process	-
167	Homo sapiens	IEP	involved_in	cellular response to hypoxia	Process	20810912
168	Homo sapiens	IEP	involved_in	cellular response to xenobiotic stimulus	Process	20810912
169	Homo sapiens	IEA	involved_in	cellular response to ionizing radiation	Process	-
170	Homo sapiens	IMP	involved_in	cellular response to ionizing radiation	Process	20160708
171	Homo sapiens	IDA	involved_in	cellular response to gamma radiation	Process	16213212
172	Homo sapiens	EXP	enables	14-3-3 protein binding	Function	20206173
173	Homo sapiens	IDA	involved_in	signal transduction by p53 class mediator	Process	15314173 18549481 25384516 29681526
174	Homo sapiens	IMP	involved_in	intrinsic apoptotic signaling pathway by p53 class mediator	Process	12172011 16322561 17310983
175	Homo sapiens	IDA	involved_in	cellular response to actinomycin D	Process	15314173
176	Homo sapiens	IDA	involved_in	positive regulation of release of cytochrome c from mitochondria	Process	14963330
177	Homo sapiens	IMP	involved_in	cellular senescence	Process	12080348
178	Homo sapiens	IMP	involved_in	replicative senescence	Process	19951988
179	Homo sapiens	IMP	involved_in	oxidative stress-induced premature senescence	Process	19951988
180	Homo sapiens	IEA	involved_in	apoptotic signaling pathway	Process	-
181	Homo sapiens	TAS	involved_in	intrinsic apoptotic signaling pathway	Process	16462759
182	Homo sapiens	IDA	involved_in	oligodendrocyte apoptotic process	Process	7720704
183	Homo sapiens	IEA	enables	MDM2/MDM4 family protein binding	Function	-
184	Homo sapiens	IPI	enables	disordered domain specific binding	Function	15629713
185	Homo sapiens	IPI	enables	general transcription initiation factor binding	Function	15053879
186	Homo sapiens	EXP	enables	molecular function activator activity	Function	14759370 16793543
187	Homo sapiens	IPI	enables	molecular function activator activity	Function	7559631
188	Homo sapiens	IDA	enables	molecular condensate scaffold activity	Function	31953488 35618207 36108750 36634798 38653238
189	Homo sapiens	IMP	involved_in	positive regulation of execution phase of apoptosis	Process	14985081
190	Homo sapiens	IMP	acts_upstream_of_negative_effect	regulation of cell cycle G2/M phase transition	Process	10962037
191	Homo sapiens	IDA	involved_in	positive regulation of miRNA transcription	Process	20546595
192	Homo sapiens	IGI	involved_in	positive regulation of miRNA transcription	Process	22499991
193	Homo sapiens	IMP	acts_upstream_of_or_within	positive regulation of miRNA transcription	Process	30089260
194	Homo sapiens	IMP	involved_in	positive regulation of miRNA transcription	Process	22578566
195	Homo sapiens	IDA	involved_in	negative regulation of G1 to G0 transition	Process	15314173
196	Homo sapiens	IMP	involved_in	negative regulation of G1 to G0 transition	Process	21471221
197	Homo sapiens	IMP	involved_in	negative regulation of pentose-phosphate shunt	Process	21336310
198	Homo sapiens	IBA	enables	promoter-specific chromatin binding	Function	-
199	Homo sapiens	IDA	enables	promoter-specific chromatin binding	Function	20725088 24356969 24652652
200	Homo sapiens	IMP	involved_in	positive regulation of reactive oxygen species metabolic process	Process	20160708
201	Homo sapiens	IDA	involved_in	positive regulation of cellular senescence	Process	29474172
202	Homo sapiens	IEA	involved_in	positive regulation of cellular senescence	Process	-
203	Homo sapiens	ISS	involved_in	positive regulation of cellular senescence	Process	-
204	Homo sapiens	IEA	involved_in	regulation of intrinsic apoptotic signaling pathway	Process	-
205	Homo sapiens	IMP	involved_in	positive regulation of intrinsic apoptotic signaling pathway	Process	14963330 27031958
206	Homo sapiens	ISS	involved_in	positive regulation of intrinsic apoptotic signaling pathway	Process	-