Variant Name	Variant Type	Variant Genomic Location	Clinical Significance	Phenotype Condition	Review Status	ClinGen Allele	dbSNP ID	Variation/condition record
NM_000245.4(MET):c.3281A>G (p.His1094Arg)	SNV Germline	Chr7:116777410	Pathogenic/Likely pathogenic	Papillary renal cell carcinoma type 1 Condition: not provided Renal cell carcinoma Hereditary cancer-predisposing syndrome MET-related disorder Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Papillary renal cell carcinoma type 1	Criteria Provided Multiple Submitters No Conflicts	CA221506	rs_121913243	8 SubmittersRCV000014901 RCV000079490 RCV001376564 RCV002321481 RCV003407332 RCV005394153
NM_000245.4(MET):c.2908C>T (p.Arg970Cys)	SNV Germline	Chr7:116771869	Conflicting classifications of pathogenicity	Condition: not provided not specified Papillary renal cell carcinoma type 1 Hereditary cancer-predisposing syndrome Renal cell carcinoma MET-related disorder Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Papillary renal cell carcinoma type 1	Criteria Provided Conflicting Classifications	CA160413	rs_34589476	26 SubmittersRCV000034528 RCV000121339 RCV000123119 RCV000131706 RCV001507128 RCV003914903 RCV005394192
NM_000245.4(MET):c.2975C>T (p.Thr992Ile)	SNV Germline/somatic	Chr7:116771936	Conflicting classifications of pathogenicity	Condition: not provided not specified Papillary renal cell carcinoma type 1 Hereditary cancer-predisposing syndrome Congenital diaphragmatic hernia Renal cell carcinoma Classic Hodgkin lymphoma MET-related disorder Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Papillary renal cell carcinoma type 1	Criteria Provided Conflicting Classifications	CA160417	rs_56391007	28 SubmittersRCV000034529 RCV000121340 RCV000123120 RCV000163261 RCV000203290 RCV001507182 RCV002227927 RCV003891465 RCV005394193
NM_000245.4(MET):c.504G>T (p.Glu168Asp)	SNV Germline	Chr7:116699588	Conflicting classifications of pathogenicity	Condition: not provided not specified Papillary renal cell carcinoma type 1 Hereditary cancer-predisposing syndrome Renal cell carcinoma Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Papillary renal cell carcinoma type 1	Criteria Provided Conflicting Classifications	CA147098	rs_55985569	23 SubmittersRCV000034532 RCV000079496 RCV000119201 RCV000129671 RCV001507196 RCV005394194
NM_000245.4(MET):c.967A>G (p.Ser323Gly)	SNV Germline	Chr7:116700051	Conflicting classifications of pathogenicity	Condition: not provided Papillary renal cell carcinoma type 1 Hereditary cancer-predisposing syndrome Renal cell carcinoma not specified Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Papillary renal cell carcinoma type 1 Hepatocellular carcinoma Arthrogryposis, distal, IIa 11 MET-related disorder	Criteria Provided Conflicting Classifications	CA215665	rs_201467281	13 SubmittersRCV000034535 RCV000123136 RCV000563453 RCV001507142 RCV000599960 RCV005394196 RCV003944878
NM_000245.4(MET):c.103A>T (p.Met35Leu)	SNV Germline	Chr7:116699187	Conflicting classifications of pathogenicity	not specified Hereditary cancer-predisposing syndrome Renal cell carcinoma Osteofibrous dysplasia Hereditary cancer Condition: not provided	Criteria Provided Conflicting Classifications	CA160424	rs_375353223	7 SubmittersRCV000121342 RCV000567367 RCV001391320 RCV001292685 RCV003492526 RCV001548349
NM_000245.4(MET):c.3218C>T (p.Pro1073Leu)	SNV Germline	Chr7:116775070	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Renal cell carcinoma Papillary renal cell carcinoma type 1 not specified Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Papillary renal cell carcinoma type 1 Hereditary cancer	Criteria Provided Conflicting Classifications	CA189948	rs_370529693	11 SubmittersRCV000164064 RCV001534185 RCV001312227 RCV005246658 RCV002228447 RCV005031633 RCV003492548
NM_000245.4(MET):c.406G>A (p.Val136Ile)	SNV Germline	Chr7:116699490	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Papillary renal cell carcinoma type 1 Condition: not provided Osteofibrous dysplasia Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97 Hepatocellular carcinoma Breast carcinoma Renal cell carcinoma MET-related disorder not specified Osteofibrous dysplasia Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97 Arthrogryposis, distal, IIa 11 Hepatocellular carcinoma Hereditary cancer	Criteria Provided Conflicting Classifications	CA167281	rs_199701987	15 SubmittersRCV000130870 RCV000199439 RCV000484898 RCV000515234 RCV001262296 RCV001328509 RCV003415953 RCV003320572 RCV005394482 RCV005235038
NM_000245.4(MET):c.1081G>T (p.Ala361Ser)	SNV Germline	Chr7:116700165	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Renal cell carcinoma Autosomal recessive nonsyndromic hearing loss 97 Condition: not provided Osteofibrous dysplasia Hepatocellular carcinoma Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97	Criteria Provided Conflicting Classifications	CA192400	rs_786202310	5 SubmittersRCV000165054 RCV001218524 RCV003468731 RCV004777608 RCV002498817
NM_000245.4(MET):c.1669A>G (p.Thr557Ala)	SNV Germline	Chr7:116740993	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Papillary renal cell carcinoma type 1 Hepatocellular carcinoma Papillary renal cell carcinoma type 1 Osteofibrous dysplasia Autosomal recessive nonsyndromic hearing loss 97 Renal cell carcinoma Hepatocellular carcinoma Papillary renal cell carcinoma type 1 Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Autosomal recessive nonsyndromic hearing loss 97 MET-related disorder Autosomal recessive nonsyndromic hearing loss 97 Condition: not provided	Criteria Provided Conflicting Classifications	CA188720	rs_374733251	11 SubmittersRCV000163595 RCV000167933 RCV000765920 RCV001293448 RCV005031678 RCV003398834 RCV003467280 RCV001812140
NM_000245.4(MET):c.2825C>T (p.Ser942Leu)	SNV Germline	Chr7:116771592	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Autosomal recessive nonsyndromic hearing loss 97 Renal cell carcinoma Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Hepatocellular carcinoma Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97 Condition: not provided not specified Hereditary cancer	Criteria Provided Conflicting Classifications	CA195544	rs_375576430	7 SubmittersRCV000166311 RCV003462209 RCV001293426 RCV005042337 RCV001589036 RCV004596092 RCV005235073
NM_000245.4(MET):c.1132G>A (p.Val378Ile)	SNV Germline	Chr7:116700216	Conflicting classifications of pathogenicity	Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97 Renal cell carcinoma Condition: not provided Hereditary cancer-predisposing syndrome Hereditary papillary renal cell carcinoma Arthrogryposis, distal, IIa 11 Papillary renal cell carcinoma type 1 Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia	Criteria Provided Conflicting Classifications	CA334728	rs_749738523	9 SubmittersRCV000168398 RCV003468833 RCV001293437 RCV001562203 RCV001009954 RCV005600798 RCV005396501
NM_000245.4(MET):c.632T>G (p.Leu211Trp)	SNV Germline	Chr7:116699716	Conflicting classifications of pathogenicity	Papillary renal cell carcinoma type 1 Hereditary cancer-predisposing syndrome Renal cell carcinoma Condition: not provided not specified Osteofibrous dysplasia Papillary renal cell carcinoma type 1 Arthrogryposis, distal, IIa 11 Autosomal recessive nonsyndromic hearing loss 97 Hepatocellular carcinoma	Criteria Provided Conflicting Classifications	CA337368	rs_45483396	7 SubmittersRCV000197671 RCV001025145 RCV001450055 RCV001706186 RCV003320598 RCV005396614
NM_000245.4(MET):c.2555T>A (p.Met852Lys)	SNV Germline	Chr7:116763240	Conflicting classifications of pathogenicity	Renal cell carcinoma Condition: not provided Hereditary cancer-predisposing syndrome not specified Osteofibrous dysplasia Hepatocellular carcinoma Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97	Criteria Provided Conflicting Classifications	CA349639	rs_369758288	6 SubmittersRCV000205486 RCV001775668 RCV002433900 RCV003493494 RCV002503800
NM_000245.4(MET):c.4145G>A (p.Arg1382Gln)	SNV Germline	Chr7:116796096	Conflicting classifications of pathogenicity	Renal cell carcinoma Condition: not provided not specified Hereditary cancer-predisposing syndrome Osteofibrous dysplasia Hepatocellular carcinoma Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97 Arthrogryposis, distal, IIa 11	Criteria Provided Conflicting Classifications	CA349710	rs_752694306	6 SubmittersRCV000205567 RCV001775670 RCV002267939 RCV002256115 RCV005396639
NM_000245.4(MET):c.1853C>T (p.Thr618Met)	SNV Germline	Chr7:116755506	Conflicting classifications of pathogenicity	Renal cell carcinoma Hereditary cancer-predisposing syndrome Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Papillary renal cell carcinoma type 1 Condition: not provided	Criteria Provided Conflicting Classifications	CA4448284	rs_753407699	5 SubmittersRCV000235673 RCV000573538 RCV005044500 RCV003225052
NM_000245.4(MET):c.1336A>G (p.Ile446Val)	SNV Germline	Chr7:116731803	Conflicting classifications of pathogenicity	Renal cell carcinoma Hereditary cancer-predisposing syndrome Condition: not provided Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Papillary renal cell carcinoma type 1	Criteria Provided Conflicting Classifications	CA4448135	rs_779022887	4 SubmittersRCV000239364 RCV000574879 RCV003114412 RCV002487111
NM_000245.4(MET):c.1174C>A (p.Pro392Thr)	SNV Germline	Chr7:116700258	Conflicting classifications of pathogenicity	Papillary renal cell carcinoma type 1 Hereditary cancer-predisposing syndrome Osteofibrous dysplasia Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97 Hepatocellular carcinoma Renal cell carcinoma Autosomal recessive nonsyndromic hearing loss 97 not specified	Criteria Provided Conflicting Classifications	CA10628009	rs_886061943	6 SubmittersRCV000335138 RCV000570504 RCV000765918 RCV001312205 RCV003470320 RCV003320637
NM_000245.4(MET):c.2971C>T (p.Pro991Ser)	SNV Germline	Chr7:116771932	Conflicting classifications of pathogenicity	Papillary renal cell carcinoma type 1 Condition: not provided Osteofibrous dysplasia Hereditary cancer-predisposing syndrome Renal cell carcinoma	Criteria Provided Conflicting Classifications	CA4448619	rs_768678989	5 SubmittersRCV000476062 RCV001755706 RCV001788226 RCV001018130 RCV001312218
NM_000245.4(MET):c.2318C>T (p.Pro773Leu)	SNV Germline	Chr7:116759444	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Osteofibrous dysplasia Renal cell carcinoma Condition: not provided Hereditary cancer Autosomal recessive nonsyndromic hearing loss 97 MET-related disorder	Criteria Provided Conflicting Classifications	CA4448450	rs_771333219	11 SubmittersRCV000572470 RCV001292908 RCV001293447 RCV001566122 RCV003492062 RCV003470498 RCV004745408
NM_000245.4(MET):c.143C>G (p.Ala48Gly)	SNV Germline	Chr7:116699227	Conflicting classifications of pathogenicity	Renal cell carcinoma Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Papillary renal cell carcinoma type 1 Hereditary cancer-predisposing syndrome Autosomal recessive nonsyndromic hearing loss 97	Criteria Provided Conflicting Classifications	CA4447947	rs_80256822	4 SubmittersRCV000458343 RCV000765914 RCV002393162 RCV003463962
NM_000245.4(MET):c.4150G>A (p.Ala1384Thr)	SNV Germline	Chr7:116796101	Conflicting classifications of pathogenicity	Renal cell carcinoma Hereditary cancer-predisposing syndrome Condition: not provided Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Papillary renal cell carcinoma type 1 Arthrogryposis, distal, IIa 11 Autosomal recessive nonsyndromic hearing loss 97	Criteria Provided Conflicting Classifications	CA4448838	rs_758486336	6 SubmittersRCV000472109 RCV001022049 RCV003223643 RCV005034001 RCV003463961
NM_000245.4(MET):c.142G>A (p.Ala48Thr)	SNV Germline	Chr7:116699226	Conflicting classifications of pathogenicity	Renal cell carcinoma Hereditary cancer-predisposing syndrome Osteofibrous dysplasia Hepatocellular carcinoma Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97 Condition: not provided Autosomal recessive nonsyndromic hearing loss 97 MET-related disorder Papillary renal cell carcinoma type 1	Criteria Provided Conflicting Classifications	CA4447946	rs_374050750	8 SubmittersRCV000532694 RCV000569043 RCV000764682 RCV001547448 RCV003470697 RCV004745439 RCV005248095
NM_000245.4(MET):c.2684C>T (p.Thr895Met)	SNV Germline	Chr7:116769745	Conflicting classifications of pathogenicity	Renal cell carcinoma Hereditary cancer-predisposing syndrome Condition: not provided Osteofibrous dysplasia Hepatocellular carcinoma Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97 MET-related disorder Papillary renal cell carcinoma type 1	Criteria Provided Conflicting Classifications	CA4448549	rs_199502137	7 SubmittersRCV000541456 RCV001016448 RCV001591188 RCV002476079 RCV003392361 RCV003444568
NM_000245.4(MET):c.1643C>T (p.Ser548Leu)	SNV Germline	Chr7:116740967	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Renal cell carcinoma Osteofibrous dysplasia Condition: not provided	Criteria Provided Conflicting Classifications	CA4448215	rs_767715328	5 SubmittersRCV000567437 RCV000821666 RCV001293997 RCV004773023
NM_000245.4(MET):c.4090C>T (p.Pro1364Ser)	SNV Germline	Chr7:116796041	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Renal cell carcinoma Condition: not provided Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97 Hepatocellular carcinoma Osteofibrous dysplasia	Criteria Provided Conflicting Classifications	CA4448826	rs_765332671	4 SubmittersRCV000572542 RCV000704365 RCV001775899 RCV002491137
NM_000245.4(MET):c.803C>T (p.Thr268Ile)	SNV Germline	Chr7:116699887	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Papillary renal cell carcinoma type 1 Renal cell carcinoma Osteofibrous dysplasia Hepatocellular carcinoma Arthrogryposis, distal, IIa 11 Autosomal recessive nonsyndromic hearing loss 97 Papillary renal cell carcinoma type 1	Criteria Provided Conflicting Classifications	CA4448031	rs_757427533	4 SubmittersRCV000572749 RCV000628723 RCV001293446 RCV005034131
NM_000245.4(MET):c.818C>A (p.Thr273Asn)	SNV Germline	Chr7:116699902	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Renal cell carcinoma Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97 Hepatocellular carcinoma Osteofibrous dysplasia Condition: not provided Autosomal recessive nonsyndromic hearing loss 97	Criteria Provided Conflicting Classifications	CA4448034	rs_368144654	5 SubmittersRCV000564380 RCV000628765 RCV002483539 RCV003237941 RCV003465263
NM_000245.4(MET):c.306C>G (p.Ser102Arg)	SNV Germline	Chr7:116699390	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Renal cell carcinoma Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Autosomal recessive nonsyndromic hearing loss 97 Papillary renal cell carcinoma type 1 Hepatocellular carcinoma	Criteria Provided Conflicting Classifications	CA4447973	rs_749383450	3 SubmittersRCV001018441 RCV002233914 RCV005034203
NM_000245.4(MET):c.850A>G (p.Ile284Val)	SNV Germline	Chr7:116699934	Conflicting classifications of pathogenicity	Papillary renal cell carcinoma type 1 Renal cell carcinoma Condition: not provided Hereditary cancer-predisposing syndrome Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Autosomal recessive nonsyndromic hearing loss 97 Papillary renal cell carcinoma type 1 Hepatocellular carcinoma	Criteria Provided Conflicting Classifications	CA4448040	rs_776014448	5 SubmittersRCV000628763 RCV001312226 RCV005000399 RCV002448925 RCV005034202
NM_000245.4(MET):c.1862C>T (p.Thr621Ile)	SNV Germline	Chr7:116755515	Conflicting classifications of pathogenicity	Condition: not provided Renal cell carcinoma Hereditary cancer-predisposing syndrome Osteofibrous dysplasia Autosomal recessive nonsyndromic hearing loss 97 Papillary renal cell carcinoma type 1 Hepatocellular carcinoma not specified	Criteria Provided Conflicting Classifications	CA4448286	rs_375951814	7 SubmittersRCV001756034 RCV000628759 RCV001013433 RCV002483765 RCV004596305
NM_000245.4(MET):c.2375A>G (p.His792Arg)	SNV Germline	Chr7:116763060	Conflicting classifications of pathogenicity	Renal cell carcinoma Hereditary cancer-predisposing syndrome Osteofibrous dysplasia Autosomal recessive nonsyndromic hearing loss 97 Papillary renal cell carcinoma type 1 Hepatocellular carcinoma	Criteria Provided Conflicting Classifications	CA164897661	rs_980467681	3 SubmittersRCV000628747 RCV001015499 RCV002477372
NM_000245.4(MET):c.4034T>C (p.Ile1345Thr)	SNV Germline	Chr7:116795985	Conflicting classifications of pathogenicity	Renal cell carcinoma Condition: not provided Osteofibrous dysplasia Autosomal recessive nonsyndromic hearing loss 97 Papillary renal cell carcinoma type 1 Hepatocellular carcinoma Hereditary cancer-predisposing syndrome not specified Autosomal recessive nonsyndromic hearing loss 97 MET-related disorder	Criteria Provided Conflicting Classifications	CA4448820	rs_768188910	7 SubmittersRCV000628769 RCV001766335 RCV000765921 RCV001021839 RCV002268220 RCV003459489 RCV004745512
NM_000245.4(MET):c.762A>C (p.Glu254Asp)	SNV Germline	Chr7:116699846	Conflicting classifications of pathogenicity	Renal cell carcinoma Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Papillary renal cell carcinoma type 1 Hereditary cancer-predisposing syndrome Condition: not provided Autosomal recessive nonsyndromic hearing loss 97 Papillary renal cell carcinoma type 1 MET-related disorder not specified	Criteria Provided Conflicting Classifications	CA4448024	rs_760278126	10 SubmittersRCV000688808 RCV000765915 RCV001026638 RCV001797126 RCV003465566 RCV002291688 RCV003953235 RCV005231270
NM_000245.4(MET):c.569A>G (p.Asp190Gly)	SNV Germline	Chr7:116699653	Conflicting classifications of pathogenicity	Papillary renal cell carcinoma type 1 Renal cell carcinoma Papillary renal cell carcinoma type 1 Hepatocellular carcinoma Arthrogryposis, distal, IIa 11 Osteofibrous dysplasia Autosomal recessive nonsyndromic hearing loss 97 Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA164888564	rs_1028165414	4 SubmittersRCV000709028 RCV001339744 RCV005034330 RCV002343581
NM_000245.4(MET):c.1640G>A (p.Arg547Gln)	SNV Germline	Chr7:116740964	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Renal cell carcinoma Hereditary cancer Condition: not provided Papillary renal cell carcinoma type 1 Hepatocellular carcinoma Arthrogryposis, distal, IIa 11 Osteofibrous dysplasia Autosomal recessive nonsyndromic hearing loss 97	Criteria Provided Conflicting Classifications	CA4448214	rs_761951444	8 SubmittersRCV001012533 RCV001328501 RCV003492139 RCV003238200 RCV005034331
NM_000245.4(MET):c.800A>G (p.Glu267Gly)	SNV Germline	Chr7:116699884	Conflicting classifications of pathogenicity	Renal cell carcinoma Hereditary cancer-predisposing syndrome Papillary renal cell carcinoma type 1 Hepatocellular carcinoma Arthrogryposis, distal, IIa 11 Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia	Criteria Provided Conflicting Classifications	CA4448030	rs_751564290	3 SubmittersRCV002234741 RCV002422742 RCV005036166
NM_000245.4(MET):c.1414C>T (p.Pro472Ser)	SNV Germline	Chr7:116739971	Conflicting classifications of pathogenicity	Renal cell carcinoma Hereditary cancer-predisposing syndrome Condition: not provided Papillary renal cell carcinoma type 1 Arthrogryposis, distal, IIa 11 Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia	Criteria Provided Conflicting Classifications	CA4448162	rs_376589619	4 SubmittersRCV000823670 RCV002390710 RCV004792541 RCV005036229
NM_000245.4(MET):c.4118A>G (p.Asp1373Gly)	SNV Germline	Chr7:116796069	Conflicting classifications of pathogenicity	Renal cell carcinoma Papillary renal cell carcinoma type 1 Hereditary cancer-predisposing syndrome Condition: not provided Papillary renal cell carcinoma type 1 Arthrogryposis, distal, IIa 11 Hepatocellular carcinoma Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia	Criteria Provided Conflicting Classifications	CA4448832	rs_773898036	5 SubmittersRCV000823281 RCV002254714 RCV002332721 RCV002464330 RCV005036228
NM_000245.4(MET):c.1450C>T (p.His484Tyr)	SNV Germline	Chr7:116740007	Conflicting classifications of pathogenicity	Papillary renal cell carcinoma type 1 Renal cell carcinoma Hereditary cancer-predisposing syndrome Autosomal recessive nonsyndromic hearing loss 97 Osteofibrous dysplasia Arthrogryposis, distal, IIa 11 Autosomal recessive nonsyndromic hearing loss 97 Papillary renal cell carcinoma type 1 Hepatocellular carcinoma	Criteria Provided Conflicting Classifications	CA4448163	rs_771272439	4 SubmittersRCV001052826 RCV001358788 RCV002393269 RCV003462554 RCV005036345
NM_000245.4(MET):c.4122C>A (p.Asn1374Lys)	SNV Germline	Chr7:116796073	Conflicting classifications of pathogenicity	Renal cell carcinoma Hereditary cancer-predisposing syndrome Autosomal recessive nonsyndromic hearing loss 97 Papillary renal cell carcinoma type 1 Hepatocellular carcinoma Osteofibrous dysplasia Condition: not provided	Criteria Provided Conflicting Classifications	CA369118437	rs_370767911	5 SubmittersRCV001247842 RCV002259098 RCV002480850 RCV004720817
NM_000245.4(MET):c.3842C>G (p.Ala1281Gly)	SNV Germline	Chr7:116795698	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Osteofibrous dysplasia Renal cell carcinoma Condition: not provided	Criteria Provided Conflicting Classifications	CA4448789	rs_750337451	4 SubmittersRCV002366112 RCV001292882 RCV001871741 RCV005432655
NM_000245.4(MET):c.3403A>T (p.Ser1135Cys)	SNV Germline	Chr7:116778838	Conflicting classifications of pathogenicity	Renal cell carcinoma Hereditary cancer-predisposing syndrome Arthrogryposis, distal, IIa 11 Hepatocellular carcinoma Osteofibrous dysplasia Papillary renal cell carcinoma type 1 Autosomal recessive nonsyndromic hearing loss 97	Criteria Provided Conflicting Classifications	CA368990081	rs_1394199299	3 SubmittersRCV001321691 RCV002341660 RCV005040180
NM_000245.4(MET):c.617T>C (p.Phe206Ser)	SNV Germline	Chr7:116699701	Conflicting classifications of pathogenicity	Condition: not provided Renal cell carcinoma Hereditary cancer-predisposing syndrome Ovarian cancer Osteofibrous dysplasia Autosomal recessive nonsyndromic hearing loss 97 Arthrogryposis, distal, IIa 11 Papillary renal cell carcinoma type 1 Hepatocellular carcinoma	Criteria Provided Conflicting Classifications	CA4448009	rs_746295363	6 SubmittersRCV001776321 RCV001885127 RCV002359250 RCV003154195 RCV005397014

NM_000245.4(MET):c.3281A>G (p.His1094Arg)

SNV
Germline

Chr7:116777410

Pathogenic/Likely pathogenic

Papillary renal cell carcinoma type 1
Condition: not provided
Renal cell carcinoma
Hereditary cancer-predisposing syndrome
MET-related disorder
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Papillary renal cell carcinoma type 1

Criteria Provided
Multiple Submitters
No Conflicts

CA221506

rs_121913243

8 SubmittersRCV000014901 RCV000079490 RCV001376564 RCV002321481 RCV003407332 RCV005394153

NM_000245.4(MET):c.2908C>T (p.Arg970Cys)

SNV
Germline

Chr7:116771869

Conflicting classifications of pathogenicity

Condition: not provided
not specified
Papillary renal cell carcinoma type 1
Hereditary cancer-predisposing syndrome
Renal cell carcinoma
MET-related disorder
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Papillary renal cell carcinoma type 1

Criteria Provided
Conflicting Classifications

CA160413

rs_34589476

26 SubmittersRCV000034528 RCV000121339 RCV000123119 RCV000131706 RCV001507128 RCV003914903 RCV005394192

NM_000245.4(MET):c.2975C>T (p.Thr992Ile)

SNV
Germline/somatic

Chr7:116771936

Conflicting classifications of pathogenicity

Condition: not provided
not specified
Papillary renal cell carcinoma type 1
Hereditary cancer-predisposing syndrome
Congenital diaphragmatic hernia
Renal cell carcinoma
Classic Hodgkin lymphoma
MET-related disorder
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Papillary renal cell carcinoma type 1

Criteria Provided
Conflicting Classifications

CA160417

rs_56391007

28 SubmittersRCV000034529 RCV000121340 RCV000123120 RCV000163261 RCV000203290 RCV001507182 RCV002227927 RCV003891465 RCV005394193

NM_000245.4(MET):c.504G>T (p.Glu168Asp)

SNV
Germline

Chr7:116699588

Conflicting classifications of pathogenicity

Condition: not provided
not specified
Papillary renal cell carcinoma type 1
Hereditary cancer-predisposing syndrome
Renal cell carcinoma
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Papillary renal cell carcinoma type 1

Criteria Provided
Conflicting Classifications

CA147098

rs_55985569

23 SubmittersRCV000034532 RCV000079496 RCV000119201 RCV000129671 RCV001507196 RCV005394194

NM_000245.4(MET):c.967A>G (p.Ser323Gly)

SNV
Germline

Chr7:116700051

Conflicting classifications of pathogenicity

Condition: not provided
Papillary renal cell carcinoma type 1
Hereditary cancer-predisposing syndrome
Renal cell carcinoma
not specified
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma
Arthrogryposis, distal, IIa 11
MET-related disorder

Criteria Provided
Conflicting Classifications

CA215665

rs_201467281

13 SubmittersRCV000034535 RCV000123136 RCV000563453 RCV001507142 RCV000599960 RCV005394196 RCV003944878

NM_000245.4(MET):c.103A>T (p.Met35Leu)

SNV
Germline

Chr7:116699187

Conflicting classifications of pathogenicity

not specified
Hereditary cancer-predisposing syndrome
Renal cell carcinoma
Osteofibrous dysplasia
Hereditary cancer
Condition: not provided

Criteria Provided
Conflicting Classifications

CA160424

rs_375353223

7 SubmittersRCV000121342 RCV000567367 RCV001391320 RCV001292685 RCV003492526 RCV001548349

NM_000245.4(MET):c.3218C>T (p.Pro1073Leu)

SNV
Germline

Chr7:116775070

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Renal cell carcinoma
Papillary renal cell carcinoma type 1
not specified
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Papillary renal cell carcinoma type 1
Hereditary cancer

Criteria Provided
Conflicting Classifications

CA189948

rs_370529693

11 SubmittersRCV000164064 RCV001534185 RCV001312227 RCV005246658 RCV002228447 RCV005031633 RCV003492548

NM_000245.4(MET):c.406G>A (p.Val136Ile)

SNV
Germline

Chr7:116699490

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Papillary renal cell carcinoma type 1
Condition: not provided
Osteofibrous dysplasia
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97
Hepatocellular carcinoma
Breast carcinoma
Renal cell carcinoma
MET-related disorder
not specified
Osteofibrous dysplasia
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97
Arthrogryposis, distal, IIa 11
Hepatocellular carcinoma
Hereditary cancer

Criteria Provided
Conflicting Classifications

CA167281

rs_199701987

15 SubmittersRCV000130870 RCV000199439 RCV000484898 RCV000515234 RCV001262296 RCV001328509 RCV003415953 RCV003320572 RCV005394482 RCV005235038

NM_000245.4(MET):c.1081G>T (p.Ala361Ser)

SNV
Germline

Chr7:116700165

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Renal cell carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Condition: not provided
Osteofibrous dysplasia
Hepatocellular carcinoma
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97

Criteria Provided
Conflicting Classifications

CA192400

rs_786202310

5 SubmittersRCV000165054 RCV001218524 RCV003468731 RCV004777608 RCV002498817

NM_000245.4(MET):c.1669A>G (p.Thr557Ala)

SNV
Germline

Chr7:116740993

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma
Papillary renal cell carcinoma type 1
Osteofibrous dysplasia
Autosomal recessive nonsyndromic hearing loss 97
Renal cell carcinoma
Hepatocellular carcinoma
Papillary renal cell carcinoma type 1
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Autosomal recessive nonsyndromic hearing loss 97
MET-related disorder
Autosomal recessive nonsyndromic hearing loss 97
Condition: not provided

Criteria Provided
Conflicting Classifications

CA188720

rs_374733251

11 SubmittersRCV000163595 RCV000167933 RCV000765920 RCV001293448 RCV005031678 RCV003398834 RCV003467280 RCV001812140

NM_000245.4(MET):c.2825C>T (p.Ser942Leu)

SNV
Germline

Chr7:116771592

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Autosomal recessive nonsyndromic hearing loss 97
Renal cell carcinoma
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Hepatocellular carcinoma
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97
Condition: not provided
not specified
Hereditary cancer

Criteria Provided
Conflicting Classifications

CA195544

rs_375576430

7 SubmittersRCV000166311 RCV003462209 RCV001293426 RCV005042337 RCV001589036 RCV004596092 RCV005235073

NM_000245.4(MET):c.1132G>A (p.Val378Ile)

SNV
Germline

Chr7:116700216

Conflicting classifications of pathogenicity

Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97
Renal cell carcinoma
Condition: not provided
Hereditary cancer-predisposing syndrome
Hereditary papillary renal cell carcinoma
Arthrogryposis, distal, IIa 11
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia

Criteria Provided
Conflicting Classifications

CA334728

rs_749738523

9 SubmittersRCV000168398 RCV003468833 RCV001293437 RCV001562203 RCV001009954 RCV005600798 RCV005396501

NM_000245.4(MET):c.632T>G (p.Leu211Trp)

SNV
Germline

Chr7:116699716

Conflicting classifications of pathogenicity

Papillary renal cell carcinoma type 1
Hereditary cancer-predisposing syndrome
Renal cell carcinoma
Condition: not provided
not specified
Osteofibrous dysplasia
Papillary renal cell carcinoma type 1
Arthrogryposis, distal, IIa 11
Autosomal recessive nonsyndromic hearing loss 97
Hepatocellular carcinoma

Criteria Provided
Conflicting Classifications

CA337368

rs_45483396

7 SubmittersRCV000197671 RCV001025145 RCV001450055 RCV001706186 RCV003320598 RCV005396614

NM_000245.4(MET):c.2555T>A (p.Met852Lys)

SNV
Germline

Chr7:116763240

Conflicting classifications of pathogenicity

Renal cell carcinoma
Condition: not provided
Hereditary cancer-predisposing syndrome
not specified
Osteofibrous dysplasia
Hepatocellular carcinoma
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97

Criteria Provided
Conflicting Classifications

CA349639

rs_369758288

6 SubmittersRCV000205486 RCV001775668 RCV002433900 RCV003493494 RCV002503800

NM_000245.4(MET):c.4145G>A (p.Arg1382Gln)

SNV
Germline

Chr7:116796096

Conflicting classifications of pathogenicity

Renal cell carcinoma
Condition: not provided
not specified
Hereditary cancer-predisposing syndrome
Osteofibrous dysplasia
Hepatocellular carcinoma
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97
Arthrogryposis, distal, IIa 11

Criteria Provided
Conflicting Classifications

CA349710

rs_752694306

6 SubmittersRCV000205567 RCV001775670 RCV002267939 RCV002256115 RCV005396639

NM_000245.4(MET):c.1853C>T (p.Thr618Met)

SNV
Germline

Chr7:116755506

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Papillary renal cell carcinoma type 1
Condition: not provided

Criteria Provided
Conflicting Classifications

CA4448284

rs_753407699

5 SubmittersRCV000235673 RCV000573538 RCV005044500 RCV003225052

NM_000245.4(MET):c.1336A>G (p.Ile446Val)

SNV
Germline

Chr7:116731803

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Condition: not provided
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Papillary renal cell carcinoma type 1

Criteria Provided
Conflicting Classifications

CA4448135

rs_779022887

4 SubmittersRCV000239364 RCV000574879 RCV003114412 RCV002487111

NM_000245.4(MET):c.1174C>A (p.Pro392Thr)

SNV
Germline

Chr7:116700258

Conflicting classifications of pathogenicity

Papillary renal cell carcinoma type 1
Hereditary cancer-predisposing syndrome
Osteofibrous dysplasia
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97
Hepatocellular carcinoma
Renal cell carcinoma
Autosomal recessive nonsyndromic hearing loss 97
not specified

Criteria Provided
Conflicting Classifications

CA10628009

rs_886061943

6 SubmittersRCV000335138 RCV000570504 RCV000765918 RCV001312205 RCV003470320 RCV003320637

NM_000245.4(MET):c.2971C>T (p.Pro991Ser)

SNV
Germline

Chr7:116771932

Conflicting classifications of pathogenicity

Papillary renal cell carcinoma type 1
Condition: not provided
Osteofibrous dysplasia
Hereditary cancer-predisposing syndrome
Renal cell carcinoma

Criteria Provided
Conflicting Classifications

CA4448619

rs_768678989

5 SubmittersRCV000476062 RCV001755706 RCV001788226 RCV001018130 RCV001312218

NM_000245.4(MET):c.2318C>T (p.Pro773Leu)

SNV
Germline

Chr7:116759444

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Osteofibrous dysplasia
Renal cell carcinoma
Condition: not provided
Hereditary cancer
Autosomal recessive nonsyndromic hearing loss 97
MET-related disorder

Criteria Provided
Conflicting Classifications

CA4448450

rs_771333219

11 SubmittersRCV000572470 RCV001292908 RCV001293447 RCV001566122 RCV003492062 RCV003470498 RCV004745408

NM_000245.4(MET):c.143C>G (p.Ala48Gly)

SNV
Germline

Chr7:116699227

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Papillary renal cell carcinoma type 1
Hereditary cancer-predisposing syndrome
Autosomal recessive nonsyndromic hearing loss 97

Criteria Provided
Conflicting Classifications

CA4447947

rs_80256822

4 SubmittersRCV000458343 RCV000765914 RCV002393162 RCV003463962

NM_000245.4(MET):c.4150G>A (p.Ala1384Thr)

SNV
Germline

Chr7:116796101

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Condition: not provided
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Papillary renal cell carcinoma type 1
Arthrogryposis, distal, IIa 11
Autosomal recessive nonsyndromic hearing loss 97

Criteria Provided
Conflicting Classifications

CA4448838

rs_758486336

6 SubmittersRCV000472109 RCV001022049 RCV003223643 RCV005034001 RCV003463961

NM_000245.4(MET):c.142G>A (p.Ala48Thr)

SNV
Germline

Chr7:116699226

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Osteofibrous dysplasia
Hepatocellular carcinoma
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97
Condition: not provided
Autosomal recessive nonsyndromic hearing loss 97
MET-related disorder
Papillary renal cell carcinoma type 1

Criteria Provided
Conflicting Classifications

CA4447946

rs_374050750

8 SubmittersRCV000532694 RCV000569043 RCV000764682 RCV001547448 RCV003470697 RCV004745439 RCV005248095

NM_000245.4(MET):c.2684C>T (p.Thr895Met)

SNV
Germline

Chr7:116769745

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Condition: not provided
Osteofibrous dysplasia
Hepatocellular carcinoma
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97
MET-related disorder
Papillary renal cell carcinoma type 1

Criteria Provided
Conflicting Classifications

CA4448549

rs_199502137

7 SubmittersRCV000541456 RCV001016448 RCV001591188 RCV002476079 RCV003392361 RCV003444568

NM_000245.4(MET):c.1643C>T (p.Ser548Leu)

SNV
Germline

Chr7:116740967

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Renal cell carcinoma
Osteofibrous dysplasia
Condition: not provided

Criteria Provided
Conflicting Classifications

CA4448215

rs_767715328

5 SubmittersRCV000567437 RCV000821666 RCV001293997 RCV004773023

NM_000245.4(MET):c.4090C>T (p.Pro1364Ser)

SNV
Germline

Chr7:116796041

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Renal cell carcinoma
Condition: not provided
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97
Hepatocellular carcinoma
Osteofibrous dysplasia

Criteria Provided
Conflicting Classifications

CA4448826

rs_765332671

4 SubmittersRCV000572542 RCV000704365 RCV001775899 RCV002491137

NM_000245.4(MET):c.803C>T (p.Thr268Ile)

SNV
Germline

Chr7:116699887

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Papillary renal cell carcinoma type 1
Renal cell carcinoma
Osteofibrous dysplasia
Hepatocellular carcinoma
Arthrogryposis, distal, IIa 11
Autosomal recessive nonsyndromic hearing loss 97
Papillary renal cell carcinoma type 1

Criteria Provided
Conflicting Classifications

CA4448031

rs_757427533

4 SubmittersRCV000572749 RCV000628723 RCV001293446 RCV005034131

NM_000245.4(MET):c.818C>A (p.Thr273Asn)

SNV
Germline

Chr7:116699902

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Renal cell carcinoma
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97
Hepatocellular carcinoma
Osteofibrous dysplasia
Condition: not provided
Autosomal recessive nonsyndromic hearing loss 97

Criteria Provided
Conflicting Classifications

CA4448034

rs_368144654

5 SubmittersRCV000564380 RCV000628765 RCV002483539 RCV003237941 RCV003465263

NM_000245.4(MET):c.306C>G (p.Ser102Arg)

SNV
Germline

Chr7:116699390

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Renal cell carcinoma
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Autosomal recessive nonsyndromic hearing loss 97
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma

Criteria Provided
Conflicting Classifications

CA4447973

rs_749383450

3 SubmittersRCV001018441 RCV002233914 RCV005034203

NM_000245.4(MET):c.850A>G (p.Ile284Val)

SNV
Germline

Chr7:116699934

Conflicting classifications of pathogenicity

Papillary renal cell carcinoma type 1
Renal cell carcinoma
Condition: not provided
Hereditary cancer-predisposing syndrome
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Autosomal recessive nonsyndromic hearing loss 97
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma

Criteria Provided
Conflicting Classifications

CA4448040

rs_776014448

5 SubmittersRCV000628763 RCV001312226 RCV005000399 RCV002448925 RCV005034202

NM_000245.4(MET):c.1862C>T (p.Thr621Ile)

SNV
Germline

Chr7:116755515

Conflicting classifications of pathogenicity

Condition: not provided
Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Osteofibrous dysplasia
Autosomal recessive nonsyndromic hearing loss 97
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma
not specified

Criteria Provided
Conflicting Classifications

CA4448286

rs_375951814

7 SubmittersRCV001756034 RCV000628759 RCV001013433 RCV002483765 RCV004596305

NM_000245.4(MET):c.2375A>G (p.His792Arg)

SNV
Germline

Chr7:116763060

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Osteofibrous dysplasia
Autosomal recessive nonsyndromic hearing loss 97
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma

Criteria Provided
Conflicting Classifications

CA164897661

rs_980467681

3 SubmittersRCV000628747 RCV001015499 RCV002477372

NM_000245.4(MET):c.4034T>C (p.Ile1345Thr)

SNV
Germline

Chr7:116795985

Conflicting classifications of pathogenicity

Renal cell carcinoma
Condition: not provided
Osteofibrous dysplasia
Autosomal recessive nonsyndromic hearing loss 97
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma
Hereditary cancer-predisposing syndrome
not specified
Autosomal recessive nonsyndromic hearing loss 97
MET-related disorder

Criteria Provided
Conflicting Classifications

CA4448820

rs_768188910

7 SubmittersRCV000628769 RCV001766335 RCV000765921 RCV001021839 RCV002268220 RCV003459489 RCV004745512

NM_000245.4(MET):c.762A>C (p.Glu254Asp)

SNV
Germline

Chr7:116699846

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Papillary renal cell carcinoma type 1
Hereditary cancer-predisposing syndrome
Condition: not provided
Autosomal recessive nonsyndromic hearing loss 97
Papillary renal cell carcinoma type 1
MET-related disorder
not specified

Criteria Provided
Conflicting Classifications

CA4448024

rs_760278126

10 SubmittersRCV000688808 RCV000765915 RCV001026638 RCV001797126 RCV003465566 RCV002291688 RCV003953235 RCV005231270

NM_000245.4(MET):c.569A>G (p.Asp190Gly)

SNV
Germline

Chr7:116699653

Conflicting classifications of pathogenicity

Papillary renal cell carcinoma type 1
Renal cell carcinoma
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma
Arthrogryposis, distal, IIa 11
Osteofibrous dysplasia
Autosomal recessive nonsyndromic hearing loss 97
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA164888564

rs_1028165414

4 SubmittersRCV000709028 RCV001339744 RCV005034330 RCV002343581

NM_000245.4(MET):c.1640G>A (p.Arg547Gln)

SNV
Germline

Chr7:116740964

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Renal cell carcinoma
Hereditary cancer
Condition: not provided
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma
Arthrogryposis, distal, IIa 11
Osteofibrous dysplasia
Autosomal recessive nonsyndromic hearing loss 97

Criteria Provided
Conflicting Classifications

CA4448214

rs_761951444

8 SubmittersRCV001012533 RCV001328501 RCV003492139 RCV003238200 RCV005034331

NM_000245.4(MET):c.800A>G (p.Glu267Gly)

SNV
Germline

Chr7:116699884

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma
Arthrogryposis, distal, IIa 11
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia

Criteria Provided
Conflicting Classifications

CA4448030

rs_751564290

3 SubmittersRCV002234741 RCV002422742 RCV005036166

NM_000245.4(MET):c.1414C>T (p.Pro472Ser)

SNV
Germline

Chr7:116739971

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Condition: not provided
Papillary renal cell carcinoma type 1
Arthrogryposis, distal, IIa 11
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia

Criteria Provided
Conflicting Classifications

CA4448162

rs_376589619

4 SubmittersRCV000823670 RCV002390710 RCV004792541 RCV005036229

NM_000245.4(MET):c.4118A>G (p.Asp1373Gly)

SNV
Germline

Chr7:116796069

Conflicting classifications of pathogenicity

Renal cell carcinoma
Papillary renal cell carcinoma type 1
Hereditary cancer-predisposing syndrome
Condition: not provided
Papillary renal cell carcinoma type 1
Arthrogryposis, distal, IIa 11
Hepatocellular carcinoma
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia

Criteria Provided
Conflicting Classifications

CA4448832

rs_773898036

5 SubmittersRCV000823281 RCV002254714 RCV002332721 RCV002464330 RCV005036228

NM_000245.4(MET):c.1450C>T (p.His484Tyr)

SNV
Germline

Chr7:116740007

Conflicting classifications of pathogenicity

Papillary renal cell carcinoma type 1
Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Autosomal recessive nonsyndromic hearing loss 97
Osteofibrous dysplasia
Arthrogryposis, distal, IIa 11
Autosomal recessive nonsyndromic hearing loss 97
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma

Criteria Provided
Conflicting Classifications

CA4448163

rs_771272439

4 SubmittersRCV001052826 RCV001358788 RCV002393269 RCV003462554 RCV005036345

NM_000245.4(MET):c.4122C>A (p.Asn1374Lys)

SNV
Germline

Chr7:116796073

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Autosomal recessive nonsyndromic hearing loss 97
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma
Osteofibrous dysplasia
Condition: not provided

Criteria Provided
Conflicting Classifications

CA369118437

rs_370767911

5 SubmittersRCV001247842 RCV002259098 RCV002480850 RCV004720817

NM_000245.4(MET):c.3842C>G (p.Ala1281Gly)

SNV
Germline

Chr7:116795698

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Osteofibrous dysplasia
Renal cell carcinoma
Condition: not provided

Criteria Provided
Conflicting Classifications

CA4448789

rs_750337451

4 SubmittersRCV002366112 RCV001292882 RCV001871741 RCV005432655

NM_000245.4(MET):c.3403A>T (p.Ser1135Cys)

SNV
Germline

Chr7:116778838

Conflicting classifications of pathogenicity

Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Arthrogryposis, distal, IIa 11
Hepatocellular carcinoma
Osteofibrous dysplasia
Papillary renal cell carcinoma type 1
Autosomal recessive nonsyndromic hearing loss 97

Criteria Provided
Conflicting Classifications

CA368990081

rs_1394199299

3 SubmittersRCV001321691 RCV002341660 RCV005040180

NM_000245.4(MET):c.617T>C (p.Phe206Ser)

SNV
Germline

Chr7:116699701

Conflicting classifications of pathogenicity

Condition: not provided
Renal cell carcinoma
Hereditary cancer-predisposing syndrome
Ovarian cancer
Osteofibrous dysplasia
Autosomal recessive nonsyndromic hearing loss 97
Arthrogryposis, distal, IIa 11
Papillary renal cell carcinoma type 1
Hepatocellular carcinoma

Criteria Provided
Conflicting Classifications

CA4448009

rs_746295363

6 SubmittersRCV001776321 RCV001885127 RCV002359250 RCV003154195 RCV005397014