Total 5 pathogenic variants reported for Glioblastoma

Variant Name	Variant Type	Variant Genomic Location	Clinical Significance	Phenotype Condition	Review Status	ClinGen Allele	dbSNP ID	Variation/condition record
NM_005896.4(IDH1):c.395G>A (p.Arg132His)	SNV Germline/somatic	Chr2:208248388	Pathogenic/Likely pathogenic	Glioblastoma multiforme, somatic Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria Condition: not provided Glioma susceptibility 1 Enchondromatosis Metaphyseal chondromatosis Neoplasm	Criteria Provided Multiple Submitters No Conflicts	CA170874	rs_121913500	10 SubmittersRCV000144504 RCV000853347 RCV001269510 RCV001542733 RCV002227447 RCV003387509 RCV004668802
NM_000051.4(ATM):c.8535G>A (p.Trp2845Ter)	SNV Germline	Chr11:108345859	Pathogenic/Likely pathogenic	Ataxia-telangiectasia syndrome Glioblastoma Condition: not provided Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts		rs_1555138291	6 SubmittersRCV000671076 RCV000722036 RCV000991563 RCV003465507
NM_022552.5(DNMT3A):c.2710C>T (p.Pro904Ser)	SNV Somatic	Chr2:25234308	Likely pathogenic	Glioblastoma	No Assertion Criteria Provided		rs_1558650888	1 SubmittersRCV000785978