Variant Name	Variant Type	Variant Genomic Location	Clinical Significance	Phenotype Condition	Review Status	ClinGen Allele	dbSNP ID	Variation/condition record
NM_024675.4(PALB2):c.1653T>A (p.Tyr551Ter)	SNV Germline	Chr16:23634893	Pathogenic/Likely pathogenic	Fanconi anemia complementation group N Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Multiple Submitters No Conflicts	CA251717	rs_118203997	13 SubmittersRCV000001302 RCV000217204 RCV000235772 RCV000476387 RCV005053882
NM_024675.4(PALB2):c.3549C>G (p.Tyr1183Ter)	SNV Germline	Chr16:23603471	Pathogenic/Likely pathogenic	Fanconi anemia complementation group N Familial cancer of breast not specified Hereditary cancer-predisposing syndrome Condition: not provided Pancreatic cancer, susceptibility to, 3 PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5 Inherited breast cancer and ovarian cancer Hereditary breast ovarian cancer syndrome	Criteria Provided Multiple Submitters No Conflicts	CA151250	rs_118203998	25 SubmittersRCV000001304 RCV000114634 RCV000121742 RCV000129158 RCV000212830 RCV001355428 RCV004528063 RCV005053883 RCV005430457 RCV005623061
NM_024675.4(PALB2):c.2962C>T (p.Gln988Ter)	SNV Germline	Chr16:23623003	Pathogenic	Fanconi anemia complementation group N Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Multiple Submitters No Conflicts	CA164468	rs_118203999	9 SubmittersRCV000001306 RCV000129469 RCV000662710 RCV000657596 RCV005053884
NM_024675.4(PALB2):c.2057G>A (p.Arg686Lys)	SNV Germline	Chr16:23630097	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified PALB2-related disorder	Criteria Provided Conflicting Classifications	CA279492933	rs_267604470	8 SubmittersRCV000774635 RCV000704434 RCV001572169 RCV003226185 RCV004537269
NC_000016.10:g.23641315C>G	SNV Germline	Chr16:23641315	Conflicting classifications of pathogenicity	Fanconi anemia complementation group N Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA269467	rs_138200248	4 SubmittersRCV000282144 RCV000374410 RCV001030094 RCV000829438
NM_024675.4(PALB2):c.1000T>G (p.Tyr334Asp)	SNV Germline	Chr16:23635546	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Condition: not provided Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA193504	rs_202241382	8 SubmittersRCV000165476 RCV000402501 RCV000483117 RCV001087026 RCV004595925
NM_024675.4(PALB2):c.1001A>G (p.Tyr334Cys)	SNV Germline	Chr16:23635545	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Hereditary cancer not specified Breast and/or ovarian cancer Hereditary breast ovarian cancer syndrome PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA288383	rs_200620434	22 SubmittersRCV000114449 RCV000116060 RCV000212784 RCV000415191 RCV000781695 RCV001798290 RCV003483471 RCV004529916 RCV005359039
NM_024675.4(PALB2):c.1010T>C (p.Leu337Ser)	SNV Germline	Chr16:23635536	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Condition: not provided Malignant tumor of breast Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA151212	rs_45494092	28 SubmittersRCV000114450 RCV000121752 RCV000127306 RCV001116860 RCV000755592 RCV001354445 RCV001798291
NM_024675.4(PALB2):c.1027C>T (p.Gln343Ter)	SNV Germline	Chr16:23635519	Pathogenic	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Breast-ovarian cancer, familial, susceptibility to, 5 Hereditary breast ovarian cancer syndrome	Criteria Provided Multiple Submitters No Conflicts	CA151215	rs_180177097	10 SubmittersRCV000215551 RCV001030193 RCV001040014 RCV005053906 RCV003155912
NM_024675.4(PALB2):c.110G>A (p.Arg37His)	SNV Germline	Chr16:23637951	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 PALB2-related disorder	Criteria Provided Conflicting Classifications	CA288386	rs_202194596	14 SubmittersRCV000114460 RCV000116061 RCV000212768 RCV000780571 RCV002483177 RCV004739369
NM_024675.4(PALB2):c.1145G>T (p.Ser382Ile)	SNV Germline	Chr16:23635401	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA269483	rs_515726063	11 SubmittersRCV000114461 RCV000483203 RCV000567033 RCV002483178
NM_024675.4(PALB2):c.1194G>A (p.Val398=)	SNV Germline	Chr16:23635352	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Fanconi anemia complementation group N Condition: not provided Breast and/or ovarian cancer Malignant tumor of breast Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA151219	rs_61755173	29 SubmittersRCV000114462 RCV000127307 RCV000212786 RCV000327932 RCV000588666 RCV001170350 RCV001357080 RCV005234992
NM_024675.4(PALB2):c.11C>T (p.Pro4Leu)	SNV Germline	Chr16:23641147	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Esophageal atresia/tracheoesophageal fistula Fanconi anemia complementation group N Condition: not provided Breast and/or ovarian cancer PALB2-related disorder Malignant tumor of breast not specified	Criteria Provided Conflicting Classifications	CA288392	rs_45619737	15 SubmittersRCV000116063 RCV000114464 RCV000515208 RCV000590674 RCV001798292 RCV004739370 RCV001358373 RCV001797625
NM_024675.4(PALB2):c.1250C>A (p.Ser417Tyr)	SNV Germline	Chr16:23635296	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified Hereditary breast ovarian cancer syndrome PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA288398	rs_45510998	21 SubmittersRCV000114466 RCV000116065 RCV000590540 RCV001255214 RCV003483472 RCV004739371 RCV005394371
NM_024675.4(PALB2):c.13C>T (p.Pro5Ser)	SNV Germline	Chr16:23641145	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA269492	rs_377085677	17 SubmittersRCV000114472 RCV000116068 RCV000589509 RCV001818256 RCV004739372 RCV005359040
NM_024675.4(PALB2):c.1544A>G (p.Lys515Arg)	SNV Germline	Chr16:23635002	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Hereditary cancer-predisposing syndrome Condition: not provided Familial ovarian cancer Breast and/or ovarian cancer PALB2-related disorder Hereditary cancer	Criteria Provided Conflicting Classifications	CA163908	rs_515726072	19 SubmittersRCV000114479 RCV000235723 RCV000129175 RCV000586359 RCV001355376 RCV003149776 RCV004528789 RCV004700413
NM_024675.4(PALB2):c.1633G>T (p.Glu545Ter)	SNV Germline	Chr16:23634913	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Malignant tumor of breast Gastric cancer PALB2-related disorder	Criteria Provided Multiple Submitters No Conflicts	CA167823	rs_180177103	14 SubmittersRCV000114484 RCV000131237 RCV000255843 RCV001357967 RCV003162529 RCV004529917
NM_024675.4(PALB2):c.1699C>T (p.His567Tyr)	SNV Germline	Chr16:23630455	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Condition: not provided not specified Breast-ovarian cancer, familial, susceptibility to, 5 PALB2-related disorder	Criteria Provided Conflicting Classifications	CA288416	rs_370422990	18 SubmittersRCV000114495 RCV000116072 RCV001292820 RCV000588850 RCV001171429 RCV005359042 RCV004529918
NM_024675.4(PALB2):c.196C>T (p.Gln66Ter)	SNV Germline	Chr16:23637865	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Hereditary breast ovarian cancer syndrome Breast and/or ovarian cancer Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Multiple Submitters No Conflicts	CA187393	rs_180177083	18 SubmittersRCV000114503 RCV000163078 RCV000235795 RCV000588616 RCV001798296 RCV005016383
NM_024675.4(PALB2):c.2200A>T (p.Thr734Ser)	SNV Germline	Chr16:23629954	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified Malignant tumor of breast Endometrial carcinoma	Criteria Provided Conflicting Classifications	CA288435	rs_45543843	13 SubmittersRCV000114515 RCV000116081 RCV000586054 RCV000855600 RCV001356351 RCV001358251
NM_024675.4(PALB2):c.2323C>T (p.Gln775Ter)	SNV Germline	Chr16:23629831	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Malignant tumor of breast Hereditary breast ovarian cancer syndrome Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Multiple Submitters No Conflicts	CA192039	rs_180177111	13 SubmittersRCV000114521 RCV000164897 RCV000413982 RCV001355683 RCV003155914 RCV005053908
NM_024675.4(PALB2):c.232G>A (p.Val78Ile)	SNV Germline	Chr16:23636314	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided Malignant tumor of breast Breast and/or ovarian cancer PALB2-related disorder	Criteria Provided Conflicting Classifications	CA288441	rs_515726085	17 SubmittersRCV000114522 RCV000116083 RCV000212771 RCV000587015 RCV001356931 RCV003149780 RCV004529921
NM_024675.4(PALB2):c.2386G>T (p.Gly796Ter)	SNV Germline	Chr16:23629768	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Fanconi anemia complementation group N Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N	Criteria Provided Multiple Submitters No Conflicts	CA163823	rs_180177112	14 SubmittersRCV000114524 RCV000129116 RCV000236024 RCV001781442 RCV003330435
NM_024675.4(PALB2):c.23C>T (p.Pro8Leu)	SNV Germline	Chr16:23641135	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Hereditary breast ovarian cancer syndrome PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA299799	rs_150390726	13 SubmittersRCV000114527 RCV000160872 RCV000589826 RCV002225301 RCV004529922 RCV005359045
NM_024675.4(PALB2):c.2514+3A>G	SNV Germline	Chr16:23629637	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast and/or ovarian cancer Familial pancreatic carcinoma	Criteria Provided Conflicting Classifications	CA269537	rs_515726088	9 SubmittersRCV000114530 RCV000160843 RCV000573333 RCV005016384 RCV003149781 RCV005359046
PALB2:c.2515-1G>T	SNV Germline	Chr16:23629276	Pathogenic/Likely pathogenic	Pancreatic cancer, susceptibility to, 3 Condition: not provided Familial cancer of breast Familial cancer of breast Hereditary cancer-predisposing syndrome Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA114879	rs_587776417	7 SubmittersRCV000001312 RCV000133479 RCV001030317 RCV001171466 RCV002426654
NM_024675.4(PALB2):c.2559C>T (p.Gly853=)	SNV Germline	Chr16:23629231	Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Reviewed By Expert Panel	CA269540	rs_180177115	12 SubmittersRCV000114536 RCV000116088 RCV000212813 RCV001171467
NM_024675.4(PALB2):c.2586+10A>G	SNV Germline	Chr16:23629194	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Condition: not provided Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Endometrial carcinoma Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA292645	rs_373321719	15 SubmittersRCV000114537 RCV000127295 RCV000588544 RCV000580770 RCV001118200 RCV001358400 RCV003149782
NM_024675.4(PALB2):c.2674G>A (p.Glu892Lys)	SNV Germline	Chr16:23626310	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Fanconi anemia complementation group N not specified Familial ovarian cancer Familial cancer of breast Fanconi anemia complementation group N PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA167879	rs_45476495	22 SubmittersRCV000114549 RCV000131257 RCV000587708 RCV001118198 RCV000483553 RCV003483473 RCV004739374 RCV005016385
NM_024675.4(PALB2):c.2718G>A (p.Trp906Ter)	SNV Germline	Chr16:23626266	Pathogenic	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Hereditary breast ovarian cancer syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Multiple Submitters No Conflicts	CA269561	rs_180177122	14 SubmittersRCV000114552 RCV000255170 RCV000562748 RCV002498481 RCV004782240 RCV005394374
NM_024675.4(PALB2):c.2749-18C>T	SNV Germline	Chr16:23624112	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided Breast and/or ovarian cancer Hereditary breast ovarian cancer syndrome	Criteria Provided Conflicting Classifications	CA269568	rs_182194007	13 SubmittersRCV000114555 RCV000127298 RCV000212817 RCV000679766 RCV003149784 RCV004764763
NM_024675.4(PALB2):c.2752C>T (p.Pro918Ser)	SNV Germline	Chr16:23624091	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified	Criteria Provided Conflicting Classifications	CA192533	rs_515726094	11 SubmittersRCV000114556 RCV000165106 RCV000478088 RCV001171432
NM_024675.4(PALB2):c.2761C>T (p.Gln921Ter)	SNV Germline	Chr16:23624082	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA269569	rs_180177124	4 SubmittersRCV001030342 RCV003162530
NM_024675.4(PALB2):c.2773G>C (p.Val925Leu)	SNV Germline	Chr16:23624070	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Condition: not provided Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA164110	rs_180177125	13 SubmittersRCV000114558 RCV000129279 RCV000764047 RCV000235847 RCV001798299
NM_024675.4(PALB2):c.2816T>G (p.Leu939Trp)	SNV Germline	Chr16:23624027	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N not specified Malignant tumor of breast Condition: not provided PALB2-related disorder Breast and/or ovarian cancer Hereditary breast ovarian cancer syndrome	Criteria Provided Conflicting Classifications	CA151239	rs_45478192	34 SubmittersRCV000114561 RCV000116092 RCV000306515 RCV000417395 RCV001356702 RCV000586156 RCV004528790 RCV001170349 RCV004760375
NM_024675.4(PALB2):c.2835-1G>C	SNV Germline	Chr16:23623131	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Multiple Submitters No Conflicts	CA331795	rs_515726099	9 SubmittersRCV000114567 RCV000220116 RCV001171468 RCV004589552 RCV005016386
NM_024675.4(PALB2):c.2851T>C (p.Ser951Pro)	SNV Germline	Chr16:23623114	Conflicting classifications of pathogenicity	not specified Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA161355	rs_149522412	21 SubmittersRCV000121763 RCV000129725 RCV001030355 RCV000397940 RCV000589520 RCV005359047
NM_024675.4(PALB2):c.2869A>C (p.Lys957Gln)	SNV Germline	Chr16:23623096	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N not specified	Criteria Provided Conflicting Classifications	CA299741	rs_515726103	13 SubmittersRCV000114573 RCV000160848 RCV000212818 RCV000764046 RCV003226198
NM_024675.4(PALB2):c.2903C>G (p.Ala968Gly)	SNV Germline	Chr16:23623062	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N PALB2-related disorder	Criteria Provided Conflicting Classifications	CA167762	rs_369132015	14 SubmittersRCV000114574 RCV000131197 RCV000215879 RCV001704012 RCV005394375 RCV004545746
NM_024675.4(PALB2):c.298C>T (p.Leu100Phe)	SNV Germline	Chr16:23636248	Conflicting classifications of pathogenicity	Familial cancer of breast Fanconi anemia complementation group N Hereditary cancer-predisposing syndrome Condition: not provided not specified PALB2-related disorder Pancreatic cancer, susceptibility to, 3 Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA288454	rs_61756147	18 SubmittersRCV000114577 RCV001119843 RCV000116095 RCV000212772 RCV001192907 RCV004528791 RCV001355228 RCV001249253 RCV003492442
NM_024675.4(PALB2):c.3056T>C (p.Val1019Ala)	SNV Germline	Chr16:23621419	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA168345	rs_376619846	11 SubmittersRCV000114589 RCV000131550 RCV000235226 RCV001192771 RCV005359048
NM_024675.4(PALB2):c.3113G>A (p.Trp1038Ter)	SNV Germline	Chr16:23621362	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Hereditary breast ovarian cancer syndrome Familial cancer of breast Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Malignant tumor of breast Breast-ovarian cancer, familial, susceptibility to, 5 Breast and/or ovarian cancer PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 NICE approved PARP inhibitor treatment Inherited breast cancer and ovarian cancer Inherited ovarian cancer (without breast cancer)	Reviewed By Expert Panel	CA251004	rs_180177132	34 SubmittersRCV000114591 RCV000116096 RCV000212822 RCV000588093 RCV001171469 RCV001535480 RCV003389455 RCV003492443 RCV004528792 RCV005016387 RCV004577322 RCV004584191 RCV004584192
NM_024675.4(PALB2):c.3128G>C (p.Gly1043Ala)	SNV Germline	Chr16:23614077	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA168501	rs_377713277	14 SubmittersRCV000114598 RCV000131630 RCV000485289 RCV000780560 RCV002483180
NM_024675.4(PALB2):c.315G>C (p.Glu105Asp)	SNV Germline	Chr16:23636231	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified Hereditary breast ovarian cancer syndrome Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N PALB2-related disorder	Criteria Provided Conflicting Classifications	CA288463	rs_515726108	17 SubmittersRCV000114600 RCV000116099 RCV000212773 RCV001174951 RCV005359049 RCV002490766 RCV004529924
NM_024675.4(PALB2):c.3202-1G>C	SNV Germline	Chr16:23608013	Pathogenic/Likely pathogenic	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA269608	rs_515726111	9 SubmittersRCV000114605 RCV000160851 RCV002321588
NM_024675.4(PALB2):c.3251C>T (p.Ser1084Leu)	SNV Germline	Chr16:23607963	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Condition: not provided Malignant tumor of breast Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 not specified PALB2-related disorder	Criteria Provided Conflicting Classifications	CA239946	rs_62625271	17 SubmittersRCV000114610 RCV000160852 RCV001116749 RCV000656940 RCV001358132 RCV000764043 RCV003493439 RCV004739377
NM_024675.4(PALB2):c.3256C>T (p.Arg1086Ter)	SNV Germline	Chr16:23607958	Pathogenic/Likely pathogenic	Pancreatic cancer, susceptibility to, 3 Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Hereditary breast ovarian cancer syndrome Malignant tumor of breast Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Gastric cancer Breast and/or ovarian cancer Breast-ovarian cancer, familial, susceptibility to, 5 PALB2-related disorder	Criteria Provided Multiple Submitters No Conflicts	CA211207	rs_587776527	24 SubmittersRCV000114612 RCV000212825 RCV000160853 RCV000168017 RCV001030644 RCV002307393 RCV005003472 RCV003162531 RCV003149788 RCV003315406 RCV004528793
NM_024675.4(PALB2):c.3307G>A (p.Val1103Met)	SNV Germline	Chr16:23607907	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Hereditary breast ovarian cancer syndrome Condition: not provided not specified Breast-ovarian cancer, familial, susceptibility to, 5 PALB2-related disorder	Criteria Provided Conflicting Classifications	CA288475	rs_201657283	16 SubmittersRCV000116103 RCV000114616 RCV001030643 RCV000656941 RCV000212827 RCV005359050 RCV004739378
NM_024675.4(PALB2):c.3321G>A (p.Leu1107=)	SNV Germline	Chr16:23607893	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA269613	rs_515726113	4 SubmittersRCV001030409 RCV001019988
NM_024675.4(PALB2):c.3350+11A>G	SNV Germline	Chr16:23607853	Conflicting classifications of pathogenicity	not specified Familial cancer of breast Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA269616	rs_515726114	5 SubmittersRCV000424366 RCV001030411 RCV002466432
NM_024675.4(PALB2):c.3350+4A>G	SNV Germline	Chr16:23607860	Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5 PALB2-related disorder PALB2-related cancer predisposition Malignant tumor of breast	Reviewed By Expert Panel	CA269618	rs_180177136	17 SubmittersRCV000114621 RCV000213830 RCV000433683 RCV003315407 RCV004528794 RCV005359051 RCV004798779
NM_024675.4(PALB2):c.3356T>C (p.Leu1119Pro)	SNV Germline	Chr16:23603664	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA331796	rs_515726116	8 SubmittersRCV000114623 RCV000481742 RCV000574823 RCV005016389
NM_024675.4(PALB2):c.3428T>A (p.Leu1143His)	SNV Germline	Chr16:23603592	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided bilateral breast cancer Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N not specified	Criteria Provided Conflicting Classifications	CA288478	rs_62625284	22 SubmittersRCV000114625 RCV000116104 RCV000585950 RCV001004833 RCV000764041 RCV004528795 RCV005394376 RCV001804169
NM_024675.4(PALB2):c.344G>T (p.Gly115Val)	SNV Germline	Chr16:23636202	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided PALB2-related disorder Malignant tumor of breast Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA193686	rs_145598272	14 SubmittersRCV000114628 RCV000165559 RCV000589320 RCV004528796 RCV001357627 RCV003149789
NM_024675.4(PALB2):c.400G>A (p.Asp134Asn)	SNV Germline	Chr16:23636146	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided Breast and/or ovarian cancer Hereditary breast ovarian cancer syndrome	Criteria Provided Conflicting Classifications	CA163622	rs_139555085	17 SubmittersRCV000114637 RCV000128994 RCV000200990 RCV000590187 RCV001798302 RCV002225308
NM_024675.4(PALB2):c.48+1G>C	SNV Germline	Chr16:23641109	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast	Criteria Provided Conflicting Classifications	CA269629	rs_515726118	4 SubmittersRCV000213648 RCV000236723 RCV001030106
NM_024675.4(PALB2):c.503C>A (p.Ser168Ter)	SNV Germline	Chr16:23636043	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA269633	rs_515726122	7 SubmittersRCV000114642 RCV000562468 RCV003332116
NM_024675.4(PALB2):c.505C>A (p.Leu169Ile)	SNV Germline	Chr16:23636041	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA269636	rs_180177086	3 SubmittersRCV001030154 RCV002336247
NM_024675.4(PALB2):c.53A>G (p.Lys18Arg)	SNV Germline	Chr16:23638125	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Condition: not provided Hereditary breast ovarian cancer syndrome	Criteria Provided Conflicting Classifications	CA161315	rs_138789658	25 SubmittersRCV000114647 RCV000121743 RCV000129207 RCV000376271 RCV000440737 RCV002225309
NM_024675.4(PALB2):c.620C>G (p.Pro207Arg)	SNV Germline	Chr16:23635926	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA331799	rs_515726125	7 SubmittersRCV000114649 RCV000776330 RCV001572249
NM_024675.4(PALB2):c.629C>T (p.Pro210Leu)	SNV Germline	Chr16:23635917	Conflicting classifications of pathogenicity	not specified Breast and/or ovarian cancer Fanconi anemia complementation group N Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Hereditary breast ovarian cancer syndrome Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA161333	rs_57605939	23 SubmittersRCV000121750 RCV001798303 RCV000306267 RCV000114650 RCV000131969 RCV001705820 RCV002225310 RCV001358034
NM_024675.4(PALB2):c.656A>G (p.Asp219Gly)	SNV Germline	Chr16:23635890	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified Hereditary cancer PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA294094	rs_45594034	19 SubmittersRCV000114652 RCV000129603 RCV000589693 RCV000855601 RCV003492444 RCV004542814 RCV005359053
NM_024675.4(PALB2):c.751C>T (p.Gln251Ter)	SNV Germline	Chr16:23635795	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast and/or ovarian cancer	Criteria Provided Multiple Submitters No Conflicts	CA269645	rs_180177091	16 SubmittersRCV000114657 RCV000210097 RCV000413603 RCV004813057 RCV004796018 RCV003492446
NM_024675.4(PALB2):c.814G>A (p.Glu272Lys)	SNV Germline	Chr16:23635732	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Condition: not provided	Criteria Provided Conflicting Classifications	CA193995	rs_515726127	11 SubmittersRCV000114664 RCV000165689 RCV004595926 RCV002483181 RCV003477491
NM_024675.4(PALB2):c.897T>C (p.Ser299=)	SNV Germline	Chr16:23635649	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Hereditary cancer-predisposing syndrome Condition: not provided Fanconi anemia complementation group N Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA269660	rs_180177095	11 SubmittersRCV000114668 RCV000419649 RCV000566337 RCV000858848 RCV001118310 RCV001798304
NM_024675.4(PALB2):c.899C>T (p.Thr300Ile)	SNV Germline	Chr16:23635647	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Hereditary cancer-predisposing syndrome Malignant tumor of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA161336	rs_528541334	14 SubmittersRCV000114669 RCV000121751 RCV000219489 RCV001354467 RCV001284670
NM_024675.4(PALB2):c.94C>G (p.Leu32Val)	SNV Germline	Chr16:23638084	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided Fanconi anemia complementation group N Malignant tumor of breast PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA161318	rs_151316635	20 SubmittersRCV000114673 RCV000116117 RCV000121744 RCV000656932 RCV001119845 RCV001357251 RCV004529927 RCV005016391
NM_024675.4(PALB2):c.1240C>T (p.Arg414Ter)	SNV Germline	Chr16:23635306	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Malignant tumor of breast Hereditary breast ovarian cancer syndrome Gastric cancer PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 1 Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Multiple Submitters No Conflicts	CA288395	rs_180177100	29 SubmittersRCV000116064 RCV000123331 RCV000254674 RCV001354096 RCV000588541 RCV003162546 RCV004529946 RCV004555854 RCV004668783 RCV005003478
NM_024675.4(PALB2):c.1347A>G (p.Lys449=)	SNV Germline	Chr16:23635199	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Pancreatic cancer, susceptibility to, 3 not specified	Criteria Provided Conflicting Classifications	CA288401	rs_587780205	8 SubmittersRCV000116066 RCV000590184 RCV001087089 RCV001356241 RCV001818286
NM_024675.4(PALB2):c.1564C>T (p.Pro522Ser)	SNV Germline	Chr16:23634982	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA288407	rs_373876101	10 SubmittersRCV000116069 RCV000205286 RCV000563884 RCV001192765 RCV001357507
NM_024675.4(PALB2):c.1697G>A (p.Arg566His)	SNV Germline	Chr16:23630457	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast not specified Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Breast-ovarian cancer, familial, susceptibility to, 5 Breast-ovarian cancer, familial, susceptibility to, 2 PALB2-related disorder	Criteria Provided Conflicting Classifications	CA288413	rs_144617793	16 SubmittersRCV000116071 RCV000229982 RCV001030254 RCV000564017 RCV005016399 RCV005359104 RCV005623303 RCV004542828
NM_024675.4(PALB2):c.1733G>T (p.Ser578Ile)	SNV Germline	Chr16:23630421	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA288419	rs_587780207	6 SubmittersRCV000116074 RCV000474485 RCV000567502 RCV002483190
NM_024675.4(PALB2):c.194C>T (p.Pro65Leu)	SNV Germline	Chr16:23637867	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome not specified Familial cancer of breast Condition: not provided Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA161321	rs_62625272	21 SubmittersRCV000116075 RCV000121745 RCV000168167 RCV000585283 RCV001030125
NM_024675.4(PALB2):c.1987C>T (p.Arg663Cys)	SNV Germline	Chr16:23630167	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast not specified Familial pancreatic carcinoma	Criteria Provided Conflicting Classifications	CA288422	rs_62625277	12 SubmittersRCV000116076 RCV000212804 RCV000410272 RCV002509225 RCV005365003
NM_024675.4(PALB2):c.2078A>G (p.His693Arg)	SNV Germline	Chr16:23630076	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA288425	rs_587780208	4 SubmittersRCV000116077 RCV000576106 RCV000467228
NM_024675.4(PALB2):c.2230G>A (p.Glu744Lys)	SNV Germline	Chr16:23629924	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA288438	rs_62625278	8 SubmittersRCV000116082 RCV000234885 RCV000635763 RCV002265611
NM_024675.4(PALB2):c.2379C>T (p.Gly793=)	SNV Germline	Chr16:23629775	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Familial cancer of breast Condition: not provided not specified Malignant tumor of breast PALB2-related disorder	Criteria Provided Conflicting Classifications	CA288444	rs_377626805	16 SubmittersRCV000116084 RCV000292657 RCV000200135 RCV000212811 RCV000780574 RCV001354155 RCV004542829
NM_024675.4(PALB2):c.2509G>A (p.Glu837Lys)	SNV Germline	Chr16:23629645	Conflicting classifications of pathogenicity	not specified Hereditary cancer-predisposing syndrome Condition: not provided Fanconi anemia complementation group N Familial cancer of breast Breast and/or ovarian cancer Hereditary breast ovarian cancer syndrome PALB2-related disorder Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA161349	rs_587778587	19 SubmittersRCV000121758 RCV000116087 RCV000656936 RCV000318539 RCV000989556 RCV001798359 RCV001030647 RCV004529947 RCV001356207
NM_024675.4(PALB2):c.2846G>A (p.Cys949Tyr)	SNV Germline	Chr16:23623119	Conflicting classifications of pathogenicity	not specified Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA161352	rs_587778588	8 SubmittersRCV000121761 RCV000635686 RCV000656938 RCV001804846 RCV005016400
NM_024675.4(PALB2):c.2897T>C (p.Ile966Thr)	SNV Germline	Chr16:23623068	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Triple-negative breast cancer Condition: not provided Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N not specified Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA210470	rs_587780214	18 SubmittersRCV000116094 RCV000204848 RCV000202384 RCV000212819 RCV000764045 RCV002267857 RCV004760383
NM_024675.4(PALB2):c.3132A>C (p.Gln1044His)	SNV Germline	Chr16:23614073	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA288460	rs_587780216	3 SubmittersRCV000116098 RCV000454267 RCV000635880
NM_024675.4(PALB2):c.353T>C (p.Ile118Thr)	SNV Germline	Chr16:23636193	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA288485	rs_370404126	10 SubmittersRCV000116107 RCV000212774 RCV000211074 RCV002222397
NM_024675.4(PALB2):c.3549C>A (p.Tyr1183Ter)	SNV Germline	Chr16:23603471	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Hereditary breast ovarian cancer syndrome Condition: not provided Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 1 PALB2-related disorder Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N	Reviewed By Expert Panel	CA288488	rs_118203998	22 SubmittersRCV000116108 RCV000200012 RCV000587765 RCV000212831 RCV000763376 RCV003493446 RCV004528809 RCV005394394
NM_024675.4(PALB2):c.551G>C (p.Ser184Thr)	SNV Germline	Chr16:23635995	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA288489	rs_587780220	5 SubmittersRCV000116109 RCV000559113 RCV001024216 RCV002498499
NM_024675.4(PALB2):c.571C>G (p.Pro191Ala)	SNV Germline	Chr16:23635975	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA288492	rs_587780221	5 SubmittersRCV000116110 RCV000211086 RCV000774642
NM_024675.4(PALB2):c.856C>T (p.Pro286Ser)	SNV Germline	Chr16:23635690	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Condition: not provided Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA288495	rs_45585833	9 SubmittersRCV000567956 RCV000410687 RCV001174832 RCV000766543 RCV005394395
NM_024675.4(PALB2):c.928A>G (p.Ser310Gly)	SNV Germline	Chr16:23635618	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Malignant tumor of breast not specified Breast and/or ovarian cancer PALB2-related disorder	Criteria Provided Conflicting Classifications	CA288501	rs_45561331	12 SubmittersRCV000116115 RCV000200242 RCV000212782 RCV001354315 RCV001290583 RCV003149811 RCV004528810
NM_024675.4(PALB2):c.949A>C (p.Thr317Pro)	SNV Germline	Chr16:23635597	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA288504	rs_587780223	8 SubmittersRCV000116116 RCV000212783 RCV000472765 RCV002483191
NM_024675.4(PALB2):c.1054G>C (p.Glu352Gln)	SNV Germline	Chr16:23635492	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA167241	rs_201035780	10 SubmittersRCV000119209 RCV000130853 RCV000858055 RCV001356550
NM_024675.4(PALB2):c.2456A>G (p.Lys819Arg)	SNV Germline	Chr16:23629698	Conflicting classifications of pathogenicity	not specified Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA161343	rs_587778585	10 SubmittersRCV000121755 RCV000129773 RCV000410682 RCV000657026
NM_024675.4(PALB2):c.2258G>A (p.Arg753Gln)	SNV Germline	Chr16:23629896	Conflicting classifications of pathogenicity	not specified Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA161346	rs_587778586	14 SubmittersRCV000121757 RCV000195647 RCV000588075 RCV000561765
NM_024675.4(PALB2):c.12T>C (p.Pro4=)	SNV Germline	Chr16:23641146	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA299688	rs_567706422	14 SubmittersRCV000123332 RCV000160826 RCV000212765 RCV000858740 RCV001121824
NM_024675.4(PALB2):c.1637T>C (p.Val546Ala)	SNV Germline	Chr16:23634909	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided PALB2-related disorder Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA332967	rs_148647206	9 SubmittersRCV000123333 RCV000215046 RCV000589758 RCV004739425 RCV002492444
NM_024675.4(PALB2):c.2087C>T (p.Thr696Met)	SNV Germline	Chr16:23630067	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA170045	rs_587780820	11 SubmittersRCV000123336 RCV000132543 RCV001030277 RCV004530058 RCV005016426 RCV003492552
NM_024675.4(PALB2):c.2289G>C (p.Leu763Phe)	SNV Germline	Chr16:23629865	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided Malignant tumor of breast Breast and/or ovarian cancer PALB2-related disorder	Criteria Provided Conflicting Classifications	CA294144	rs_373478248	22 SubmittersRCV000123338 RCV000130052 RCV000212808 RCV000587948 RCV001357632 RCV001798407 RCV004528842
NM_024675.4(PALB2):c.2571G>A (p.Leu857=)	SNV Germline	Chr16:23629219	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA332973	rs_587780821	6 SubmittersRCV000123339 RCV000486288 RCV000560973 RCV001535717
NM_024675.4(PALB2):c.2753C>A (p.Pro918Gln)	SNV Germline	Chr16:23624090	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided PALB2-related disorder	Criteria Provided Conflicting Classifications	CA332974	rs_587780822	10 SubmittersRCV000123341 RCV000220315 RCV000507163 RCV001546031 RCV004739426
NM_024675.4(PALB2):c.722A>G (p.Asn241Ser)	SNV Germline	Chr16:23635824	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA168406	rs_587780823	5 SubmittersRCV000123343 RCV000131587
NM_024675.4(PALB2):c.769G>A (p.Gly257Ser)	SNV Germline	Chr16:23635777	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Breast-ovarian cancer, familial, susceptibility to, 5 Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N PALB2-related disorder Condition: not provided	Criteria Provided Conflicting Classifications	CA194606	rs_587780824	9 SubmittersRCV000123344 RCV000165945 RCV003226206 RCV003492553 RCV005394457 RCV004530060 RCV004589611
NM_024675.4(PALB2):c.1697G>C (p.Arg566Pro)	SNV Germline	Chr16:23630457	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA163866	rs_144617793	7 SubmittersRCV000129134 RCV001775617 RCV000476315 RCV005394468
NM_024675.4(PALB2):c.2712G>A (p.Trp904Ter)	SNV Germline	Chr16:23626272	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA164329	rs_587781457	6 SubmittersRCV000129390 RCV000485246 RCV000799015
NM_024675.4(PALB2):c.2417C>T (p.Pro806Leu)	SNV Germline	Chr16:23629737	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Pancreatic cancer, susceptibility to, 3 Breast and/or ovarian cancer Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA164360	rs_45464991	12 SubmittersRCV000129403 RCV000204760 RCV000235688 RCV001192769 RCV001030305 RCV003149891 RCV001355012
NM_024675.4(PALB2):c.438A>C (p.Arg146Ser)	SNV Germline	Chr16:23636108	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast	Criteria Provided Conflicting Classifications	CA294070	rs_587781498	8 SubmittersRCV000129467 RCV000212775 RCV000410126
NM_024675.4(PALB2):c.2743G>A (p.Ala915Thr)	SNV Germline	Chr16:23626241	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Diffuse midline glioma, H3 K27-altered PALB2-related disorder Malignant tumor of breast Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA164485	rs_374736398	11 SubmittersRCV000129474 RCV000471567 RCV000481045 RCV003315231 RCV004545873 RCV001355149 RCV005600709
NM_024675.4(PALB2):c.3508C>T (p.His1170Tyr)	SNV Germline	Chr16:23603512	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Hereditary breast ovarian cancer syndrome Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA294118	rs_200283306	20 SubmittersRCV000129794 RCV000226949 RCV000212829 RCV001818304 RCV004760389 RCV005359213
NM_024675.4(PALB2):c.3201+1G>T	SNV Germline	Chr16:23614003	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA165631	rs_587776423	4 SubmittersRCV000130058 RCV001206798
NM_024675.4(PALB2):c.1955G>A (p.Ser652Asn)	SNV Germline	Chr16:23630199	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Hereditary breast ovarian cancer syndrome Endometrial carcinoma Condition: not provided not specified	Criteria Provided Conflicting Classifications	CA165693	rs_587781818	11 SubmittersRCV000130094 RCV000226926 RCV000302799 RCV001030649 RCV001358211 RCV000842453 RCV001030271
NM_024675.4(PALB2):c.1364A>G (p.Asn455Ser)	SNV Germline	Chr16:23635182	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA294158	rs_587781824	7 SubmittersRCV000130104 RCV000409652 RCV000212792 RCV001116859
NM_024675.4(PALB2):c.3044C>T (p.Thr1015Ile)	SNV Germline	Chr16:23621431	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided not specified Familial cancer of breast	Criteria Provided Conflicting Classifications	CA165765	rs_367840862	7 SubmittersRCV000130130 RCV000236113 RCV000781686 RCV000689784
NM_024675.4(PALB2):c.1042C>A (p.Gln348Lys)	SNV Germline	Chr16:23635504	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Chordoma PALB2-related disorder	Criteria Provided Conflicting Classifications	CA165871	rs_375699023	12 SubmittersRCV000130172 RCV000232741 RCV000589687 RCV001251061 RCV002266924 RCV004739441
NM_024675.4(PALB2):c.1756G>A (p.Asp586Asn)	SNV Germline	Chr16:23630398	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA166193	rs_587781954	10 SubmittersRCV000130326 RCV000411835 RCV000481375 RCV000764051 RCV001798444
NM_024675.4(PALB2):c.563C>G (p.Ala188Gly)	SNV Germline	Chr16:23635983	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Condition: not provided	Criteria Provided Conflicting Classifications	CA166273	rs_587781975	7 SubmittersRCV000130368 RCV000168329 RCV001818311 RCV004791275
NM_024675.4(PALB2):c.424A>T (p.Lys142Ter)	SNV Germline	Chr16:23636122	Pathogenic	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast PALB2-related disorder Malignant tumor of breast Breast cancer, susceptibility to	Criteria Provided Multiple Submitters No Conflicts	CA166400	rs_587782005	14 SubmittersRCV000130421 RCV000412725 RCV000476449 RCV003387508 RCV001357166 RCV002251434
NM_024675.4(PALB2):c.3146T>C (p.Met1049Thr)	SNV Germline	Chr16:23614059	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Malignant tumor of breast not specified Fanconi anemia complementation group N Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N PALB2-related disorder	Criteria Provided Conflicting Classifications	CA166426	rs_138273800	18 SubmittersRCV000130431 RCV000204730 RCV000482622 RCV001355887 RCV001194140 RCV002505109 RCV003389456 RCV003444205 RCV004544294
NM_024675.4(PALB2):c.3476G>A (p.Trp1159Ter)	SNV Germline	Chr16:23603544	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA166575	rs_587782050	3 SubmittersRCV000130518 RCV003453075
NM_024675.4(PALB2):c.2521A>G (p.Thr841Ala)	SNV Germline	Chr16:23629269	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA166713	rs_368990417	2 SubmittersRCV000130589 RCV000470365
NM_024675.4(PALB2):c.3307G>C (p.Val1103Leu)	SNV Germline	Chr16:23607907	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast and/or ovarian cancer not specified Ovarian cancer	Criteria Provided Conflicting Classifications	CA166991	rs_201657283	12 SubmittersRCV000130728 RCV000226292 RCV000483048 RCV000764042 RCV003149901 RCV001194142 RCV003153422
NM_024675.4(PALB2):c.557A>T (p.Asn186Ile)	SNV Germline	Chr16:23635989	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Familial cancer of breast Pancreatic cancer, susceptibility to, 3 not specified	Criteria Provided Conflicting Classifications	CA167050	rs_587782164	12 SubmittersRCV000130756 RCV000197454 RCV000588642 RCV003315411 RCV002478396 RCV004595933
NM_024675.4(PALB2):c.3257G>A (p.Arg1086Gln)	SNV Germline	Chr16:23607957	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Hereditary breast ovarian cancer syndrome PALB2-related disorder Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA294240	rs_146377793	17 SubmittersRCV000130835 RCV000203792 RCV000590502 RCV000855603 RCV002225436 RCV004739448 RCV005016447
NM_024675.4(PALB2):c.1189A>T (p.Thr397Ser)	SNV Germline	Chr16:23635357	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Breast and/or ovarian cancer Familial ovarian cancer Inherited breast cancer and ovarian cancer not specified Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA294249	rs_367578415	15 SubmittersRCV000130855 RCV000205533 RCV000586638 RCV003149904 RCV003447500 RCV004584197 RCV002267878 RCV005359248
NM_024675.4(PALB2):c.1127G>C (p.Ser376Thr)	SNV Germline	Chr16:23635419	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA167264	rs_587782200	5 SubmittersRCV000130860 RCV000465244 RCV003159104
NM_024675.4(PALB2):c.2947A>T (p.Thr983Ser)	SNV Germline	Chr16:23623018	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA167318	rs_587782211	5 SubmittersRCV000130889 RCV000206313 RCV000522868
NM_024675.4(PALB2):c.734C>T (p.Ala245Val)	SNV Germline	Chr16:23635812	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast not specified Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA167345	rs_571063157	12 SubmittersRCV000130900 RCV000483902 RCV000200032 RCV001030168 RCV003315412 RCV005394483
NM_024675.4(PALB2):c.3492G>T (p.Trp1164Cys)	SNV Germline	Chr16:23603528	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA167348	rs_587782217	7 SubmittersRCV000130901 RCV000412141 RCV000487310 RCV004551258
NM_024675.4(PALB2):c.2619T>G (p.Ser873Arg)	SNV Germline	Chr16:23626365	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided Familial ovarian cancer	Criteria Provided Conflicting Classifications	CA168079	rs_587782387	13 SubmittersRCV000199659 RCV000131395 RCV000507756 RCV001281710 RCV001357530
NM_024675.4(PALB2):c.2257C>T (p.Arg753Ter)	SNV Germline	Chr16:23629897	Pathogenic	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Hereditary breast ovarian cancer syndrome Malignant tumor of breast Fanconi anemia complementation group N Gastric cancer Breast and/or ovarian cancer Breast-ovarian cancer, familial, susceptibility to, 5 PALB2-related disorder	Criteria Provided Multiple Submitters No Conflicts	CA168247	rs_180177110	26 SubmittersRCV000131502 RCV000236519 RCV000466579 RCV000824730 RCV001264577 RCV001781472 RCV003162588 RCV003492624 RCV004597749 RCV004739453
NM_024675.4(PALB2):c.1258C>T (p.Gln420Ter)	SNV Germline	Chr16:23635288	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA168278	rs_587782446	5 SubmittersRCV000131515 RCV000529684 RCV000657737
NM_024675.4(PALB2):c.18G>T (p.Gly6=)	SNV Germline	Chr16:23641140	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Hereditary breast ovarian cancer syndrome	Criteria Provided Multiple Submitters No Conflicts	CA168342	rs_587782462	15 SubmittersRCV000131549 RCV000432017 RCV000557471 RCV002265620
NM_024675.4(PALB2):c.3320T>C (p.Leu1107Pro)	SNV Germline	Chr16:23607894	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Breast-ovarian cancer, familial, susceptibility to, 5 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA168427	rs_149194681	12 SubmittersRCV000131597 RCV000204289 RCV000235261 RCV001818326 RCV003315413 RCV005394489
NM_024675.4(PALB2):c.10C>T (p.Pro4Ser)	SNV Germline	Chr16:23641148	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA294407	rs_587782483	8 SubmittersRCV000131600 RCV000205368 RCV004696852
NM_024675.4(PALB2):c.3296C>G (p.Thr1099Arg)	SNV Germline	Chr16:23607918	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome not specified Familial cancer of breast Condition: not provided Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5 Hereditary breast ovarian cancer syndrome	Criteria Provided Conflicting Classifications	CA168538	rs_142132127	23 SubmittersRCV000131652 RCV000235868 RCV000410212 RCV000657014 RCV001294230 RCV002478400 RCV005359278 RCV005411346
NM_024675.4(PALB2):c.3350+5G>A	SNV Germline	Chr16:23607859	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Hereditary breast ovarian cancer syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Condition: not provided PALB2-related disorder Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N	Criteria Provided Multiple Submitters No Conflicts	CA168760	rs_587782566	14 SubmittersRCV000131789 RCV000526519 RCV001824643 RCV005359282 RCV004998280 RCV004739459 RCV004796031
NM_024675.4(PALB2):c.2557G>A (p.Gly853Ser)	SNV Germline	Chr16:23629233	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA168790	rs_587782579	10 SubmittersRCV000131807 RCV000230627 RCV000483722 RCV001800443 RCV002478401
NM_024675.4(PALB2):c.740C>G (p.Thr247Arg)	SNV Germline	Chr16:23635806	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA169202	rs_587782658	9 SubmittersRCV000132073 RCV000211087 RCV000588870
NM_024675.4(PALB2):c.2608G>A (p.Val870Ile)	SNV Germline	Chr16:23626376	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome not specified Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA294480	rs_376641234	12 SubmittersRCV000132122 RCV000212815 RCV000227189 RCV000656937
NM_024675.4(PALB2):c.2401G>A (p.Asp801Asn)	SNV Germline	Chr16:23629753	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided See cases	Criteria Provided Conflicting Classifications	CA169572	rs_587782765	8 SubmittersRCV000167989 RCV000132292 RCV001570317 RCV002251997
NM_024675.4(PALB2):c.292A>G (p.Ile98Val)	SNV Germline	Chr16:23636254	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Hereditary breast ovarian cancer syndrome	Criteria Provided Conflicting Classifications	CA169811	rs_587782831	8 SubmittersRCV000132416 RCV000471839 RCV001753518 RCV002225448
NM_024675.4(PALB2):c.2852C>T (p.Ser951Phe)	SNV Germline	Chr16:23623113	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Malignant tumor of breast Familial cancer of breast	Criteria Provided Conflicting Classifications	CA170010	rs_587782889	5 SubmittersRCV000132527 RCV000590893 RCV000535908
NM_024675.4(PALB2):c.995T>A (p.Leu332His)	SNV Germline	Chr16:23635551	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA170038	rs_377149139	13 SubmittersRCV000132538 RCV000199494 RCV000589127 RCV001354291
NM_024675.4(PALB2):c.1108C>T (p.Gln370Ter)	SNV Germline	Chr16:23635438	Pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA294547	rs_587776411	8 SubmittersRCV000133472 RCV001030200 RCV001525190
NM_024675.4(PALB2):c.1571C>G (p.Ser524Ter)	SNV Germline	Chr16:23634975	Pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA294552	rs_587776413	8 SubmittersRCV000133475 RCV000701075 RCV000454158
NM_024675.4(PALB2):c.2074C>T (p.Gln692Ter)	SNV Germline	Chr16:23630080	Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Hereditary breast ovarian cancer syndrome	Reviewed By Expert Panel	CA294556	rs_587776415	9 SubmittersRCV000133477 RCV000562385 RCV001030275 RCV003155925
NM_024675.4(PALB2):c.2834+1G>T	SNV Germline	Chr16:23624008	Pathogenic/Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Multiple Submitters No Conflicts	CA294560	rs_587776419	9 SubmittersRCV000133481 RCV000567638 RCV000411304 RCV000763377
NM_024675.4(PALB2):c.3201+1G>C	SNV Germline	Chr16:23614003	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA191641	rs_587776423	10 SubmittersRCV000164723 RCV000230297 RCV000133485
NM_024675.4(PALB2):c.451C>T (p.Gln151Ter)	SNV Germline	Chr16:23636095	Pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Hereditary breast ovarian cancer syndrome	Criteria Provided Multiple Submitters No Conflicts	CA294565	rs_587776407	9 SubmittersRCV000133491 RCV000456418 RCV000576041 RCV004586565
NM_024675.4(PALB2):c.48G>A (p.Lys16=)	SNV Germline	Chr16:23641110	Pathogenic/Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Multiple Submitters No Conflicts	CA294568	rs_587776405	8 SubmittersRCV000133492 RCV000566830 RCV001030105 RCV004796039
NM_024675.4(PALB2):c.3404G>A (p.Gly1135Glu)	SNV Germline	Chr16:23603616	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Carcinoma of colon not specified Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA299753	rs_730881894	12 SubmittersRCV000232726 RCV000589198 RCV000570480 RCV001030415 RCV000855602 RCV002492638
NM_024675.4(PALB2):c.3278T>C (p.Ile1093Thr)	SNV Germline	Chr16:23607936	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Malignant tumor of breast Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA299750	rs_45616636	9 SubmittersRCV000160854 RCV000197231 RCV000223658 RCV001357444 RCV003483530
NM_024675.4(PALB2):c.3235G>T (p.Ala1079Ser)	SNV Germline	Chr16:23607979	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA299697	rs_730881878	12 SubmittersRCV000160829 RCV000543305 RCV000564254 RCV001797644 RCV005359383
NM_024675.4(PALB2):c.3202-8G>T	SNV Germline	Chr16:23608020	Conflicting classifications of pathogenicity	not specified Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Hereditary breast ovarian cancer syndrome Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA299680	rs_367979106	7 SubmittersRCV000160822 RCV000476584 RCV000580700 RCV001284321 RCV005359382 RCV001798556
NM_024675.4(PALB2):c.3202-8G>A	SNV Germline	Chr16:23608020	Conflicting classifications of pathogenicity	not specified Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA299679	rs_367979106	7 SubmittersRCV000160821 RCV000488296 RCV001081288 RCV000579984
NM_024675.4(PALB2):c.2922G>T (p.Lys974Asn)	SNV Germline	Chr16:23623043	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA299744	rs_730881892	11 SubmittersRCV000160849 RCV000566246 RCV000205333 RCV002267894 RCV001355089
NM_024675.4(PALB2):c.2834+1G>A	SNV Germline	Chr16:23624008	Pathogenic/Likely pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Malignant tumor of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA299740	rs_587776419	9 SubmittersRCV000160847 RCV000635960 RCV001016726 RCV001268941 RCV002478488
NM_024675.4(PALB2):c.2699C>T (p.Ala900Val)	SNV Germline	Chr16:23626285	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA299734	rs_730881890	7 SubmittersRCV000160844 RCV000216145 RCV000555792 RCV002485001 RCV005394561
NM_024675.4(PALB2):c.2353C>T (p.Pro785Ser)	SNV Germline	Chr16:23629801	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Hereditary cancer	Criteria Provided Conflicting Classifications	CA299731	rs_730881889	7 SubmittersRCV000160842 RCV000460019 RCV001015124 RCV004700497
NM_024675.4(PALB2):c.2329G>A (p.Asp777Asn)	SNV Germline	Chr16:23629825	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA299728	rs_148026749	8 SubmittersRCV000160841 RCV000204167 RCV000212809
NM_024675.4(PALB2):c.2229T>A (p.Tyr743Ter)	SNV Germline	Chr16:23629925	Pathogenic/Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA299725	rs_730881888	6 SubmittersRCV000160839 RCV002426793 RCV004992040 RCV002466252
NM_024675.4(PALB2):c.2128A>G (p.Thr710Ala)	SNV Germline	Chr16:23630026	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N PALB2-related disorder	Criteria Provided Conflicting Classifications	CA299722	rs_730881887	12 SubmittersRCV000160838 RCV000232377 RCV000569204 RCV000780572 RCV002485000 RCV004535048
NM_024675.4(PALB2):c.2106A>G (p.Ile702Met)	SNV Germline	Chr16:23630048	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA299719	rs_730881886	10 SubmittersRCV000160837 RCV000211076 RCV000212805
NM_024675.4(PALB2):c.2020G>A (p.Asp674Asn)	SNV Germline	Chr16:23630134	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast	Criteria Provided Conflicting Classifications	CA299716	rs_730881885	6 SubmittersRCV000160836 RCV000217309 RCV000548729 RCV002505195
NM_024675.4(PALB2):c.1724G>A (p.Trp575Ter)	SNV Germline	Chr16:23630430	Pathogenic/Likely pathogenic	Condition: not provided Familial cancer of breast Hereditary breast ovarian cancer syndrome PALB2-related disorder Fanconi anemia complementation group N Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA299691	rs_730881876	11 SubmittersRCV000160827 RCV001238865 RCV003155926 RCV004724950 RCV001781504 RCV000771400
NM_024675.4(PALB2):c.1610C>T (p.Ser537Leu)	SNV Germline	Chr16:23634936	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Carcinoma of colon Fanconi anemia complementation group N PALB2-related disorder	Criteria Provided Conflicting Classifications	CA299796	rs_142103232	14 SubmittersRCV000160871 RCV000168207 RCV000220923 RCV001030240 RCV001121722 RCV004535051
NM_024675.4(PALB2):c.1492G>T (p.Asp498Tyr)	SNV Germline	Chr16:23635054	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Fanconi anemia complementation group N Hereditary breast ovarian cancer syndrome Condition: not provided Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA185966	rs_75023630	14 SubmittersRCV000160870 RCV000197379 RCV000200991 RCV000368837 RCV001030650 RCV000858743 RCV001356483
NM_024675.4(PALB2):c.1471G>C (p.Ala491Pro)	SNV Germline	Chr16:23635075	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast PALB2-related disorder	Criteria Provided Conflicting Classifications	CA299793	rs_577969558	7 SubmittersRCV000160869 RCV000216241 RCV000635626 RCV002485002 RCV004535050
NM_024675.4(PALB2):c.1407C>G (p.Cys469Trp)	SNV Germline	Chr16:23635139	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA299710	rs_730881883	5 SubmittersRCV000160834 RCV000810010 RCV000571438
NM_024675.4(PALB2):c.1400G>A (p.Gly467Asp)	SNV Germline	Chr16:23635146	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast	Criteria Provided Conflicting Classifications	CA299790	rs_730881906	5 SubmittersRCV000160868 RCV000212793 RCV000549785
NM_024675.4(PALB2):c.1156A>G (p.Thr386Ala)	SNV Germline	Chr16:23635390	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Familial cancer of breast	Criteria Provided Conflicting Classifications	CA299787	rs_148102335	6 SubmittersRCV000160867 RCV000773131 RCV002492639 RCV000528086
NM_024675.4(PALB2):c.688G>T (p.Glu230Ter)	SNV Germline	Chr16:23635858	Pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA299784	rs_730881905	8 SubmittersRCV000160866 RCV000471920 RCV000561729
NM_024675.4(PALB2):c.587G>A (p.Arg196Lys)	SNV Germline	Chr16:23635959	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast PALB2-related disorder	Criteria Provided Conflicting Classifications	CA299781	rs_730881904	7 SubmittersRCV000160865 RCV000216462 RCV000228567 RCV004535049
NM_024675.4(PALB2):c.397A>G (p.Ser133Gly)	SNV Germline	Chr16:23636149	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA299704	rs_730881881	6 SubmittersRCV000227552 RCV000587887 RCV000454193
NM_024675.4(PALB2):c.212-2A>G	SNV Germline	Chr16:23636336	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N Fanconi anemia complementation group N PALB2-related disorder Hereditary breast ovarian cancer syndrome	Criteria Provided Conflicting Classifications	CA299700	rs_730881879	13 SubmittersRCV000160830 RCV000206312 RCV000213220 RCV002498799 RCV001781505 RCV004739509 RCV004800300
NM_024675.4(PALB2):c.161A>G (p.Glu54Gly)	SNV Germline	Chr16:23637900	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA299763	rs_730881898	5 SubmittersRCV000160859 RCV000212769 RCV000463943 RCV000780564
NM_024675.4(PALB2):c.109-2A>G	SNV Germline	Chr16:23637954	Pathogenic/Likely pathogenic	Condition: not provided Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA299762	rs_730881897	9 SubmittersRCV000160858 RCV005016482 RCV000572657 RCV000803061
NM_024675.4(PALB2):c.43G>T (p.Glu15Ter)	SNV Germline	Chr16:23641115	Pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA299713	rs_730881884	6 SubmittersRCV000160835 RCV000567534 RCV001036521
NM_024675.4(PALB2):c.-5G>T	SNV Germline	Chr16:23641162	Conflicting classifications of pathogenicity	not specified Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA299687	rs_730881875	3 SubmittersRCV000160825 RCV000561746
NM_024675.4(PALB2):c.3545T>C (p.Val1182Ala)	SNV Germline	Chr16:23603475	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA196999	rs_747149179	4 SubmittersRCV000166908 RCV000548591
NM_024675.4(PALB2):c.3244A>G (p.Ser1082Gly)	SNV Germline	Chr16:23607970	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Condition: not provided	Criteria Provided Conflicting Classifications	CA196312	rs_786203345	8 SubmittersRCV000166614 RCV000232382 RCV002505212 RCV004998351
NM_024675.4(PALB2):c.3114-5C>T	SNV Germline	Chr16:23614096	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA198420	rs_753307725	6 SubmittersRCV000167480 RCV000934763 RCV001775654
NM_024675.4(PALB2):c.2986G>T (p.Glu996Ter)	SNV Germline	Chr16:23622979	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Malignant tumor of breast	Criteria Provided Multiple Submitters No Conflicts	CA197777	rs_786203775	6 SubmittersRCV000167226 RCV000227242 RCV000485825 RCV002271440
NM_024675.4(PALB2):c.2792T>G (p.Leu931Arg)	SNV Germline	Chr16:23624051	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Breast-ovarian cancer, familial, susceptibility to, 5 Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA196017	rs_773831304	16 SubmittersRCV000166492 RCV000408812 RCV000483646 RCV002298494 RCV003389046 RCV001354782
NM_024675.4(PALB2):c.2782G>A (p.Val928Met)	SNV Germline	Chr16:23624061	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA192592	rs_771288520	3 SubmittersRCV000165137 RCV002516474
NM_024675.4(PALB2):c.2748+1G>T	SNV Germline	Chr16:23626235	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Hereditary breast ovarian cancer syndrome	Criteria Provided Multiple Submitters No Conflicts	CA193676	rs_753153576	12 SubmittersRCV000165555 RCV000635768 RCV000487378 RCV003155927
NM_024675.4(PALB2):c.2662A>T (p.Ile888Leu)	SNV Germline	Chr16:23626322	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA192991	rs_786202468	4 SubmittersRCV000165291 RCV000456550 RCV002284368
NM_024675.4(PALB2):c.2474G>C (p.Arg825Thr)	SNV Germline	Chr16:23629680	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided not specified Familial cancer of breast Breast-ovarian cancer, familial, susceptibility to, 5 Endometrial carcinoma	Criteria Provided Conflicting Classifications	CA192462	rs_146218439	13 SubmittersRCV000165079 RCV000236812 RCV000780569 RCV001086620 RCV005359498 RCV001256975
NM_024675.4(PALB2):c.2453T>C (p.Phe818Ser)	SNV Germline	Chr16:23629701	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Hereditary cancer	Criteria Provided Conflicting Classifications	CA186194	rs_370908330	7 SubmittersRCV000162394 RCV000476189 RCV004589674 RCV005235052
NM_024675.4(PALB2):c.2356C>T (p.His786Tyr)	SNV Germline	Chr16:23629798	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Familial cancer of breast Pancreatic cancer, susceptibility to, 3 not specified Condition: not provided Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA197222	rs_786203608	10 SubmittersRCV000166996 RCV000226421 RCV002505215 RCV003321534 RCV001566992 RCV003129793
NM_024675.4(PALB2):c.2344C>T (p.Pro782Ser)	SNV Germline	Chr16:23629810	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Malignant tumor of breast not specified Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Familial cancer of breast	Criteria Provided Conflicting Classifications	CA196135	rs_786203296	11 SubmittersRCV000166543 RCV000470017 RCV000478256 RCV001355915 RCV003479039 RCV002492670
NM_024675.4(PALB2):c.2336C>G (p.Ser779Ter)	SNV Germline	Chr16:23629818	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Hereditary breast ovarian cancer syndrome PALB2-related disorder Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA194883	rs_764509489	11 SubmittersRCV000457524 RCV000166057 RCV003226227 RCV004528915 RCV000480723
NM_024675.4(PALB2):c.2277A>G (p.Gln759=)	SNV Germline	Chr16:23629877	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Fanconi anemia complementation group N Breast and/or ovarian cancer PALB2-related disorder	Criteria Provided Conflicting Classifications	CA193209	rs_786202524	11 SubmittersRCV000165372 RCV000472744 RCV000614133 RCV001119745 RCV003150021 RCV004535111
NM_024675.4(PALB2):c.2228A>T (p.Tyr743Phe)	SNV Germline	Chr16:23629926	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA191248	rs_141749524	2 SubmittersRCV000164551 RCV000698708
NM_024675.4(PALB2):c.2228A>G (p.Tyr743Cys)	SNV Germline	Chr16:23629926	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome not specified Hereditary breast ovarian cancer syndrome Breast and/or ovarian cancer Familial pancreatic carcinoma Familial cancer of breast Condition: not provided Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA189784	rs_141749524	13 SubmittersRCV000164010 RCV000781684 RCV001030648 RCV003150010 RCV005359455 RCV000197626 RCV000255110 RCV000296163
NM_024675.4(PALB2):c.2134G>C (p.Ala712Pro)	SNV Germline	Chr16:23630020	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Familial cancer of breast	Criteria Provided Conflicting Classifications	CA194955	rs_765942523	5 SubmittersRCV000166087 RCV000459199 RCV002485027
NM_024675.4(PALB2):c.2100A>T (p.Ser700=)	SNV Germline	Chr16:23630054	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Familial cancer of breast not specified Condition: not provided PALB2-related disorder	Criteria Provided Conflicting Classifications	CA190176	rs_757145884	10 SubmittersRCV000164155 RCV000347505 RCV000200038 RCV000611803 RCV001358505 RCV004539543
NM_024675.4(PALB2):c.2067G>A (p.Ser689=)	SNV Germline	Chr16:23630087	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Fanconi anemia complementation group N Condition: not provided Carcinoma of colon PALB2-related disorder	Criteria Provided Conflicting Classifications	CA193263	rs_371149159	16 SubmittersRCV000165391 RCV000197495 RCV000420216 RCV001119747 RCV001284030 RCV001356268 RCV004535112
NM_024675.4(PALB2):c.1958G>A (p.Cys653Tyr)	SNV Germline	Chr16:23630196	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA198426	rs_771246748	3 SubmittersRCV000167483 RCV000456974
NM_024675.4(PALB2):c.1930G>T (p.Gly644Ter)	SNV Germline	Chr16:23630224	Pathogenic	Hereditary cancer-predisposing syndrome	Criteria Provided Single Submitter	CA192870	rs_786202439	1 SubmittersRCV000165251
NM_024675.4(PALB2):c.1766C>T (p.Thr589Met)	SNV Germline	Chr16:23630388	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Carcinoma of colon Malignant tumor of breast PALB2-related disorder	Criteria Provided Conflicting Classifications	CA198251	rs_773340677	11 SubmittersRCV000167418 RCV000474329 RCV000479496 RCV001175052 RCV001030258 RCV001357624 RCV004739545
NM_024675.4(PALB2):c.1748T>C (p.Leu583Ser)	SNV Germline	Chr16:23630406	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA195224	rs_587782151	7 SubmittersRCV000166198 RCV000464125 RCV000996241 RCV005230014 RCV005016500
NM_024675.4(PALB2):c.1691A>G (p.Lys564Arg)	SNV Germline	Chr16:23630463	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA194670	rs_62625276	7 SubmittersRCV000165968 RCV000197146 RCV001030253
NM_024675.4(PALB2):c.1662A>G (p.Glu554=)	SNV Germline	Chr16:23634884	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA193865	rs_786202692	9 SubmittersRCV000165629 RCV000462332 RCV001567936 RCV003491900
NM_024675.4(PALB2):c.1659C>G (p.His553Gln)	SNV Germline	Chr16:23634887	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA196924	rs_370318597	4 SubmittersRCV000166875 RCV000547924 RCV001201201
NM_024675.4(PALB2):c.1599T>C (p.Thr533=)	SNV Germline	Chr16:23634947	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N not specified PALB2-related disorder Condition: not provided Familial pancreatic carcinoma	Criteria Provided Conflicting Classifications	CA186523	rs_786201088	10 SubmittersRCV000162589 RCV000232866 RCV001121723 RCV001818362 RCV004544477 RCV001704155 RCV005359395
NM_024675.4(PALB2):c.1526G>A (p.Gly509Asp)	SNV Germline	Chr16:23635020	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA195692	rs_786203176	5 SubmittersRCV000166375 RCV000458684 RCV000765273 RCV002228767
NM_024675.4(PALB2):c.1510G>A (p.Val504Ile)	SNV Germline	Chr16:23635036	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA196712	rs_771846754	3 SubmittersRCV000166778 RCV000816945
NM_024675.4(PALB2):c.1454C>T (p.Thr485Ile)	SNV Germline	Chr16:23635092	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Carcinoma of colon	Criteria Provided Conflicting Classifications	CA193882	rs_786202699	5 SubmittersRCV000165637 RCV000205126 RCV000507136 RCV001030228
NM_024675.4(PALB2):c.1451T>A (p.Leu484Ter)	SNV Germline	Chr16:23635095	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Generalized hypopigmentation Basal cell carcinoma Hereditary breast ovarian cancer syndrome Familial cancer of breast Malignant tumor of breast Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA197580	rs_786203714	12 SubmittersRCV000167136 RCV000414940 RCV000587378 RCV001310142 RCV001356904 RCV001543564
NM_024675.4(PALB2):c.1421G>A (p.Ser474Asn)	SNV Germline	Chr16:23635125	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast	Criteria Provided Conflicting Classifications	CA190537	rs_786201806	6 SubmittersRCV000164284 RCV000235242 RCV000693357
NM_024675.4(PALB2):c.1408A>G (p.Thr470Ala)	SNV Germline	Chr16:23635138	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Inherited breast cancer and ovarian cancer Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA191289	rs_150636811	10 SubmittersRCV000164567 RCV000525404 RCV000480806 RCV002265643 RCV005237616 RCV005359480
NM_024675.4(PALB2):c.1379A>G (p.Gln460Arg)	SNV Germline	Chr16:23635167	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Condition: not provided Hereditary breast ovarian cancer syndrome Familial cancer of breast Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 PALB2-related disorder not specified	Criteria Provided Conflicting Classifications	CA196834	rs_749494645	16 SubmittersRCV000166836 RCV000289282 RCV000483813 RCV001030716 RCV000989572 RCV005396492 RCV004739541 RCV000780567
NM_024675.4(PALB2):c.1273G>A (p.Val425Met)	SNV Germline	Chr16:23635273	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Malignant tumor of breast Condition: not provided Breast and/or ovarian cancer Hereditary breast ovarian cancer syndrome PALB2-related disorder not specified	Criteria Provided Conflicting Classifications	CA197697	rs_576081828	13 SubmittersRCV000167189 RCV000205365 RCV001358598 RCV000236471 RCV003491915 RCV004689644 RCV004539565 RCV001030212
NM_024675.4(PALB2):c.1252A>G (p.Asn418Asp)	SNV Germline	Chr16:23635294	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA194782	rs_786202943	7 SubmittersRCV000166018 RCV000228629 RCV001775647 RCV005016498
NM_024675.4(PALB2):c.1123C>A (p.Leu375Ile)	SNV Germline	Chr16:23635423	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified PALB2-related disorder	Criteria Provided Conflicting Classifications	CA196837	rs_373298267	13 SubmittersRCV000166837 RCV000198293 RCV000236203 RCV001420780 RCV004545875
NM_024675.4(PALB2):c.1097A>G (p.Asn366Ser)	SNV Germline	Chr16:23635449	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided PALB2-related disorder	Criteria Provided Conflicting Classifications	CA191737	rs_554849907	6 SubmittersRCV000164773 RCV000204324 RCV005054172 RCV004535105
NM_024675.4(PALB2):c.1093A>G (p.Arg365Gly)	SNV Germline	Chr16:23635453	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast	Criteria Provided Conflicting Classifications	CA191954	rs_773001248	8 SubmittersRCV000164864 RCV000486708 RCV000205169 RCV002485020
NM_024675.4(PALB2):c.1030A>G (p.Asn344Asp)	SNV Germline	Chr16:23635516	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA194420	rs_786202850	4 SubmittersRCV000165880 RCV000230594 RCV004692776
NM_024675.4(PALB2):c.980G>A (p.Cys327Tyr)	SNV Germline	Chr16:23635566	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA193324	rs_786202550	5 SubmittersRCV000165411 RCV000460541 RCV001836740
NM_024675.4(PALB2):c.950C>T (p.Thr317Ile)	SNV Germline	Chr16:23635596	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Malignant tumor of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA191811	rs_45548638	8 SubmittersRCV000164806 RCV000200449 RCV001357471 RCV000766544
NM_024675.4(PALB2):c.940C>T (p.Gln314Ter)	SNV Germline	Chr16:23635606	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Hereditary breast ovarian cancer syndrome	Criteria Provided Multiple Submitters No Conflicts	CA197949	rs_786203821	9 SubmittersRCV000167296 RCV000463323 RCV000523563 RCV000586368
NM_024675.4(PALB2):c.829G>A (p.Asp277Asn)	SNV Germline	Chr16:23635717	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Carcinoma of colon Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA195935	rs_778309339	9 SubmittersRCV000166462 RCV000235601 RCV000477600 RCV001030179 RCV001336120
NM_024675.4(PALB2):c.813T>A (p.Ser271Arg)	SNV Germline	Chr16:23635733	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified	Criteria Provided Conflicting Classifications	CA195966	rs_786203246	9 SubmittersRCV000166472 RCV000556676 RCV001555224 RCV001193465
NM_024675.4(PALB2):c.788A>G (p.Glu263Gly)	SNV Germline	Chr16:23635758	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA192260	rs_745553724	8 SubmittersRCV000164996 RCV000485489 RCV000233981 RCV005016493
NM_024675.4(PALB2):c.739A>G (p.Thr247Ala)	SNV Germline	Chr16:23635807	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Familial cancer of breast	Criteria Provided Conflicting Classifications	CA195172	rs_786203040	6 SubmittersRCV000166174 RCV000459460 RCV002485029
NM_024675.4(PALB2):c.637G>C (p.Val213Leu)	SNV Germline	Chr16:23635909	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA198128	rs_786203875	5 SubmittersRCV000167372 RCV000635925 RCV001193467 RCV002485041
NM_024675.4(PALB2):c.495C>T (p.Gly165=)	SNV Germline	Chr16:23636051	Conflicting classifications of pathogenicity	not specified Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Bile duct cancer	Criteria Provided Conflicting Classifications	CA193911	rs_200937538	15 SubmittersRCV000444952 RCV000532734 RCV000679773 RCV000165654 RCV001119841 RCV001357741
NM_024675.4(PALB2):c.266A>G (p.Asp89Gly)	SNV Germline	Chr16:23636280	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA190463	rs_786201790	2 SubmittersRCV000164258 RCV002517613
NM_024675.4(PALB2):c.101G>T (p.Arg34Leu)	SNV Germline	Chr16:23638077	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Fanconi anemia complementation group N Familial cancer of breast Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA196241	rs_144944814	9 SubmittersRCV000166587 RCV000456690 RCV000520497 RCV002498826
NM_024675.4(PALB2):c.100C>T (p.Arg34Cys)	SNV Germline	Chr16:23638078	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Inherited breast cancer and ovarian cancer	Criteria Provided Conflicting Classifications	CA191499	rs_373483056	14 SubmittersRCV000164663 RCV000199940 RCV000236984 RCV002222417 RCV004808602
NM_024675.4(PALB2):c.36G>A (p.Glu12=)	SNV Germline	Chr16:23641122	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA192309	rs_760609798	6 SubmittersRCV000165018 RCV000476001 RCV004998329
NM_024675.4(PALB2):c.3106G>C (p.Val1036Leu)	SNV Germline	Chr16:23621369	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome not specified Carcinoma of colon Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast	Criteria Provided Conflicting Classifications	CA334122	rs_756906403	12 SubmittersRCV000168000 RCV000479177 RCV000216674 RCV001731498 RCV001030381 RCV002485044
NM_024675.4(PALB2):c.2835-1G>A	SNV Germline	Chr16:23623131	Pathogenic/Likely pathogenic	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome PALB2-related disorder	Criteria Provided Multiple Submitters No Conflicts	CA334206	rs_515726099	5 SubmittersRCV000168057 RCV000255033 RCV000454148 RCV004528920
NM_024675.4(PALB2):c.1659C>A (p.His553Gln)	SNV Germline	Chr16:23634887	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA334554	rs_370318597	6 SubmittersRCV000519942 RCV000582233 RCV000168288
NM_024675.4(PALB2):c.1316G>T (p.Gly439Val)	SNV Germline	Chr16:23635230	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA334035	rs_537258442	13 SubmittersRCV000167944 RCV000588409 RCV000565232 RCV000765276 RCV001818401
NM_024675.4(PALB2):c.1115G>C (p.Ser372Thr)	SNV Germline	Chr16:23635431	Conflicting classifications of pathogenicity	Familial cancer of breast Fanconi anemia complementation group N Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA334752	rs_786204243	4 SubmittersRCV000168425 RCV000765277 RCV000774638
NM_024675.4(PALB2):c.1096A>G (p.Asn366Asp)	SNV Germline	Chr16:23635450	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Inherited breast cancer and ovarian cancer	Criteria Provided Conflicting Classifications	CA334083	rs_786204080	6 SubmittersRCV000167975 RCV000774639 RCV004808606
NM_024675.4(PALB2):c.85A>G (p.Ser29Gly)	SNV Germline	Chr16:23638093	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA333979	rs_776110440	5 SubmittersRCV000167900 RCV000217631 RCV002262763
NM_024675.4(PALB2):c.2505C>T (p.Ser835=)	SNV Germline	Chr16:23629649	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Malignant tumor of breast not specified	Criteria Provided Conflicting Classifications	CA246241	rs_756502783	12 SubmittersRCV000575425 RCV001085109 RCV000724499 RCV001354928 RCV003321538
NM_024675.4(PALB2):c.3538A>G (p.Ile1180Val)	SNV Germline	Chr16:23603482	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA335883	rs_863224788	10 SubmittersRCV000195715 RCV000216876 RCV000478251 RCV001251265 RCV002492923 RCV005396619
NM_024675.4(PALB2):c.3473A>G (p.His1158Arg)	SNV Germline	Chr16:23603547	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Breast and/or ovarian cancer PALB2-related disorder Condition: not provided	Criteria Provided Conflicting Classifications	CA338566	rs_45505500	9 SubmittersRCV000199321 RCV000217762 RCV001798672 RCV004739589 RCV004998415
NM_024675.4(PALB2):c.3448C>T (p.Leu1150Phe)	SNV Germline	Chr16:23603572	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA337664	rs_863224787	6 SubmittersRCV000198123 RCV000776376 RCV001284322
NM_024675.4(PALB2):c.3260G>A (p.Ser1087Asn)	SNV Germline	Chr16:23607954	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA336127	rs_863224786	2 SubmittersRCV000196033 RCV001019497
NM_024675.4(PALB2):c.3202-9C>T	SNV Germline	Chr16:23608021	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Pancreatic cancer, susceptibility to, 3 Condition: not provided not specified	Criteria Provided Conflicting Classifications	CA336806	rs_757444247	7 SubmittersRCV000196913 RCV000579396 RCV001354308 RCV001711353 RCV001818478
NM_024675.4(PALB2):c.3103A>G (p.Ile1035Val)	SNV Germline	Chr16:23621372	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Chordoma	Criteria Provided Conflicting Classifications	CA336715	rs_863224783	10 SubmittersRCV000196785 RCV000220160 RCV001797063 RCV002266931
NM_024675.4(PALB2):c.2515-1G>C	SNV Germline	Chr16:23629276	Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA337588	rs_587776417	5 SubmittersRCV000198016 RCV000580827 RCV000985889
NM_024675.4(PALB2):c.2506G>T (p.Val836Phe)	SNV Germline	Chr16:23629648	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA335985	rs_536644825	5 SubmittersRCV000195841 RCV000584448 RCV001030312
NM_024675.4(PALB2):c.2360C>T (p.Thr787Ile)	SNV Germline	Chr16:23629794	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Carcinoma of colon not specified	Criteria Provided Conflicting Classifications	CA337312	rs_201042302	14 SubmittersRCV000197564 RCV000216753 RCV000236931 RCV001030299 RCV004586620
NM_024675.4(PALB2):c.2176C>T (p.Pro726Ser)	SNV Germline	Chr16:23629978	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA337127	rs_566813395	6 SubmittersRCV000197340 RCV000569353 RCV001775663 RCV005361158
NM_024675.4(PALB2):c.2140G>A (p.Asp714Asn)	SNV Germline	Chr16:23630014	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Familial pancreatic carcinoma	Criteria Provided Conflicting Classifications	CA335668	rs_45537237	7 SubmittersRCV000195423 RCV000562225 RCV003223619 RCV005361157
NM_024675.4(PALB2):c.1337A>T (p.Asp446Val)	SNV Germline	Chr16:23635209	Conflicting classifications of pathogenicity	Familial cancer of breast Retinoblastoma Condition: not provided Hereditary cancer-predisposing syndrome not specified Fanconi anemia complementation group N Familial cancer of breast Pancreatic cancer, susceptibility to, 3 PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA339587	rs_146434474	12 SubmittersRCV000200861 RCV000761148 RCV000255070 RCV000562823 RCV001194137 RCV002492922 RCV004530198 RCV005600809
NM_024675.4(PALB2):c.985C>G (p.Leu329Val)	SNV Germline	Chr16:23635561	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA336763	rs_863224792	3 SubmittersRCV000196873 RCV001030192 RCV005452958
NM_024675.4(PALB2):c.929G>A (p.Ser310Asn)	SNV Germline	Chr16:23635617	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome not specified PALB2-related disorder	Criteria Provided Conflicting Classifications	CA336641	rs_370887726	9 SubmittersRCV000196709 RCV000480147 RCV000570793 RCV004689672 RCV004739590
NM_024675.4(PALB2):c.380A>G (p.His127Arg)	SNV Germline	Chr16:23636166	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA338916	rs_863224789	6 SubmittersRCV000199860 RCV001804936 RCV001030147
NM_024675.4(PALB2):c.3073G>A (p.Ala1025Thr)	SNV Germline	Chr16:23621402	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Fanconi anemia complementation group N not specified Breast and/or ovarian cancer Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA277851	rs_746872839	12 SubmittersRCV000202108 RCV000213208 RCV000479987 RCV001116750 RCV001174762 RCV003491950 RCV005396622
NM_024675.4(PALB2):c.3350+1G>A	SNV Germline	Chr16:23607863	Pathogenic/Likely pathogenic	Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA348374	rs_864622192	3 SubmittersRCV000204129
NM_024675.4(PALB2):c.3331C>G (p.Pro1111Ala)	SNV Germline	Chr16:23607883	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Condition: not provided Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Hereditary breast ovarian cancer syndrome	Criteria Provided Conflicting Classifications	CA350039	rs_864622193	10 SubmittersRCV000222857 RCV000205952 RCV001800527 RCV000587389 RCV002478727 RCV004764779
NM_024675.4(PALB2):c.3271C>T (p.Gln1091Ter)	SNV Germline	Chr16:23607943	Pathogenic/Likely pathogenic	Familial cancer of breast Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Multiple Submitters No Conflicts	CA350661	rs_864622138	5 SubmittersRCV000206656 RCV000708617 RCV004692825
NM_024675.4(PALB2):c.2834+2T>G	SNV Germline	Chr16:23624007	Pathogenic	Familial cancer of breast	Criteria Provided Single Submitter	CA349966	rs_864622481	1 SubmittersRCV000205865
NM_024675.4(PALB2):c.2561A>G (p.Asn854Ser)	SNV Germline	Chr16:23629229	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA348183	rs_146455175	8 SubmittersRCV000203889 RCV000573572 RCV000679765
NM_024675.4(PALB2):c.1647C>A (p.His549Gln)	SNV Germline	Chr16:23634899	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided Breast and/or ovarian cancer Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA348236	rs_747842085	11 SubmittersRCV000203956 RCV000219639 RCV000479905 RCV000766620 RCV001798683 RCV005396646
NM_024675.4(PALB2):c.1457A>T (p.Lys486Ile)	SNV Germline	Chr16:23635089	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA349277	rs_864622291	4 SubmittersRCV000205091 RCV000780561 RCV001030229 RCV002390544
NM_024675.4(PALB2):c.761C>A (p.Ser254Ter)	SNV Germline	Chr16:23635785	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA350807	rs_864622695	2 SubmittersRCV000206812 RCV002390551
NM_024675.4(PALB2):c.508A>G (p.Arg170Gly)	SNV Germline	Chr16:23636038	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified	Criteria Provided Conflicting Classifications	CA349481	rs_864622622	8 SubmittersRCV000205323 RCV000215139 RCV000484020 RCV003114369
NM_024675.4(PALB2):c.398G>T (p.Ser133Ile)	SNV Germline	Chr16:23636148	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA348953	rs_864622411	5 SubmittersRCV000204748 RCV000575642 RCV005016566 RCV005361185
NM_024675.4(PALB2):c.226A>G (p.Ile76Val)	SNV Germline	Chr16:23636320	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Carcinoma of colon Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 not specified	Criteria Provided Conflicting Classifications	CA348162	rs_541028076	8 SubmittersRCV000203860 RCV000223229 RCV000590079 RCV001030134 RCV005016565 RCV001526861
NM_024675.4(PALB2):c.149A>C (p.Lys50Thr)	SNV Germline	Chr16:23637912	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Hereditary cancer-predisposing syndrome Condition: not provided Breast and/or ovarian cancer Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA349816	rs_763598472	13 SubmittersRCV000205692 RCV000236334 RCV000221595 RCV000656934 RCV003491955 RCV001357513
NM_024675.4(PALB2):c.109C>T (p.Arg37Cys)	SNV Germline	Chr16:23637952	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided PALB2-related disorder not specified	Criteria Provided Conflicting Classifications	CA348301	rs_200048921	10 SubmittersRCV000204029 RCV000561601 RCV000485666 RCV004530229 RCV002247634
NM_024675.4(PALB2):c.1042C>T (p.Gln348Ter)	SNV Germline	Chr16:23635504	Pathogenic	Condition: not provided Familial cancer of breast Hereditary breast ovarian cancer syndrome Hereditary cancer-predisposing syndrome Malignant tumor of breast	Criteria Provided Multiple Submitters No Conflicts	CA10575850	rs_375699023	10 SubmittersRCV000255651 RCV000409735 RCV000416712 RCV000568484 RCV001358472
NM_024675.4(PALB2):c.2755G>A (p.Val919Ile)	SNV Germline	Chr16:23624088	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Breast and/or ovarian cancer Chordoma not specified	Criteria Provided Conflicting Classifications	CA7963488	rs_775193384	10 SubmittersRCV000211057 RCV000454132 RCV000478723 RCV005016571 RCV003150103 RCV002266935 RCV002465567
NM_024675.4(PALB2):c.1478C>T (p.Pro493Leu)	SNV Germline	Chr16:23635068	Conflicting classifications of pathogenicity	Familial cancer of breast Pilocytic astrocytoma Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA7963704	rs_770965402	7 SubmittersRCV000211081 RCV000761143 RCV000217376 RCV001582721
NM_024675.4(PALB2):c.1194G>T (p.Val398=)	SNV Germline	Chr16:23635352	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA10576114	rs_61755173	5 SubmittersRCV000211072 RCV002336588 RCV004998437
NM_024675.4(PALB2):c.3544G>C (p.Val1182Leu)	SNV Germline	Chr16:23603476	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10579910	rs_876660474	2 SubmittersRCV000215738 RCV000802184
NM_024675.4(PALB2):c.3494C>T (p.Ser1165Leu)	SNV Germline	Chr16:23603526	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Chordoma	Criteria Provided Conflicting Classifications	CA7963328	rs_773829275	12 SubmittersRCV000220953 RCV002478804 RCV000485944 RCV000535759 RCV001121621 RCV002266936
NM_024675.4(PALB2):c.3412G>A (p.Ala1138Thr)	SNV Germline	Chr16:23603608	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA7963343	rs_577651839	8 SubmittersRCV000215508 RCV000686283 RCV000759188 RCV005016592
NM_024675.4(PALB2):c.3392T>C (p.Ile1131Thr)	SNV Germline	Chr16:23603628	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA10579918	rs_876658196	10 SubmittersRCV000215576 RCV000229527 RCV000590765 RCV005396705
NM_024675.4(PALB2):c.3358G>T (p.Glu1120Ter)	SNV Germline	Chr16:23603662	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10579919	rs_876658773	4 SubmittersRCV000215626 RCV003454620
NM_024675.4(PALB2):c.3350G>A (p.Arg1117Lys)	SNV Germline	Chr16:23607864	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Breast-ovarian cancer, familial, susceptibility to, 5 Hereditary breast ovarian cancer syndrome Condition: not provided	Reviewed By Expert Panel	CA10579920	rs_876659859	9 SubmittersRCV000217139 RCV000533846 RCV002271470 RCV003315422 RCV002277578 RCV004998471
NM_024675.4(PALB2):c.3232T>A (p.Cys1078Ser)	SNV Germline	Chr16:23607982	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Carcinoma of colon Condition: not provided not specified	Criteria Provided Conflicting Classifications	CA10579924	rs_876659587	8 SubmittersRCV000214649 RCV000530258 RCV001030400 RCV001788088 RCV003230458
NM_024675.4(PALB2):c.3225T>A (p.Ser1075Arg)	SNV Germline	Chr16:23607989	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA7963396	rs_202222149	7 SubmittersRCV000218610 RCV000466966 RCV002500726 RCV005396711
NM_024675.4(PALB2):c.3201+3A>C	SNV Germline	Chr16:23614001	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10579928	rs_876660215	2 SubmittersRCV000216437 RCV001853618
NM_024675.4(PALB2):c.3165C>A (p.Tyr1055Ter)	SNV Germline	Chr16:23614040	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA10579929	rs_876658157	4 SubmittersRCV000222632 RCV001857756 RCV004998440
NM_024675.4(PALB2):c.3114G>A (p.Trp1038Ter)	SNV Germline	Chr16:23614091	Pathogenic	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10579930	rs_778345761	4 SubmittersRCV000222262 RCV001030388 RCV001070907
NM_024675.4(PALB2):c.3113+5G>C	SNV Germline	Chr16:23621357	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Multiple Submitters No Conflicts	CA10579931	rs_876659463	13 SubmittersRCV000214215 RCV000231026 RCV000255512 RCV005016593 RCV005416112
NM_024675.4(PALB2):c.3096G>C (p.Met1032Ile)	SNV Germline	Chr16:23621379	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA7963436	rs_778705498	3 SubmittersRCV000217483 RCV001216363
NM_024675.4(PALB2):c.3061G>A (p.Gly1021Arg)	SNV Germline	Chr16:23621414	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Breast and/or ovarian cancer Condition: not provided	Criteria Provided Conflicting Classifications	CA7963440	rs_143808171	8 SubmittersRCV000214675 RCV000558947 RCV002265691 RCV001798715 RCV003328567
NM_024675.4(PALB2):c.2978C>T (p.Thr993Met)	SNV Germline	Chr16:23622987	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast not specified Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5 Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA7963457	rs_61756146	12 SubmittersRCV000213330 RCV000236936 RCV000544190 RCV002267960 RCV002478799 RCV005396720
NM_024675.4(PALB2):c.2968G>T (p.Glu990Ter)	SNV Germline	Chr16:23622997	Pathogenic	Hereditary cancer-predisposing syndrome Breast neoplasm Condition: not provided Familial cancer of breast Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Multiple Submitters No Conflicts	CA10579941	rs_876659036	10 SubmittersRCV000219424 RCV000504617 RCV000657700 RCV000635907 RCV004796114 RCV005361290
NM_024675.4(PALB2):c.2835G>A (p.Arg945=)	SNV Germline	Chr16:23623130	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10579948	rs_876659983	3 SubmittersRCV000217381 RCV000483812 RCV001320081
NM_024675.4(PALB2):c.2693G>A (p.Trp898Ter)	SNV Germline	Chr16:23626291	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Breast and/or ovarian cancer	Criteria Provided Multiple Submitters No Conflicts	CA10579954	rs_876658983	6 SubmittersRCV000216899 RCV000478895 RCV002518293 RCV003491974
NM_024675.4(PALB2):c.2674G>T (p.Glu892Ter)	SNV Germline	Chr16:23626310	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Inherited breast cancer and ovarian cancer	Criteria Provided Multiple Submitters No Conflicts	CA10579956	rs_45476495	6 SubmittersRCV000217992 RCV001045962 RCV005237756
NM_024675.4(PALB2):c.2667T>A (p.Thr889=)	SNV Germline	Chr16:23626317	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10579957	rs_876659224	4 SubmittersRCV000216116 RCV001118199 RCV005090094
NM_024675.4(PALB2):c.2630G>A (p.Trp877Ter)	SNV Germline	Chr16:23626354	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10579959	rs_876660678	3 SubmittersRCV000213186 RCV001064019
NM_024675.4(PALB2):c.2512C>G (p.Gln838Glu)	SNV Germline	Chr16:23629642	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA10579963	rs_750650768	6 SubmittersRCV000213341 RCV000635607 RCV002478788 RCV003223625
NM_024675.4(PALB2):c.2506G>C (p.Val836Leu)	SNV Germline	Chr16:23629648	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast B lymphoblastic leukemia lymphoma with t(12 21)(p13 q22) TEL-AML1 (ETV6-RUNX1) Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA7963565	rs_536644825	6 SubmittersRCV000215537 RCV000687946 RCV000761094 RCV002494591
NM_024675.4(PALB2):c.2506G>A (p.Val836Ile)	SNV Germline	Chr16:23629648	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast not specified Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA7963564	rs_536644825	12 SubmittersRCV000214970 RCV000586837 RCV000457210 RCV001420721 RCV005016588 RCV005361295
NM_024675.4(PALB2):c.2448C>G (p.Phe816Leu)	SNV Germline	Chr16:23629706	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA10579970	rs_876659879	4 SubmittersRCV000215749 RCV000635843 RCV002247661
NM_024675.4(PALB2):c.2437A>G (p.Ile813Val)	SNV Germline	Chr16:23629717	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA10579971	rs_766396469	2 SubmittersRCV000216460
NM_024675.4(PALB2):c.2167A>T (p.Met723Leu)	SNV Germline	Chr16:23629987	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA10579981	rs_876660336	5 SubmittersRCV000217611 RCV000467128 RCV003153509 RCV005016605
NM_024675.4(PALB2):c.2167A>G (p.Met723Val)	SNV Germline	Chr16:23629987	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10579982	rs_876660336	2 SubmittersRCV000214669 RCV001350792
NM_024675.4(PALB2):c.2147A>G (p.Asn716Ser)	SNV Germline	Chr16:23630007	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Papillary thyroid carcinoma Condition: not provided not specified PALB2-related disorder	Criteria Provided Conflicting Classifications	CA7963618	rs_148335539	8 SubmittersRCV000214302 RCV000458608 RCV000761167 RCV001567281 RCV002271471 RCV004532798
NM_024675.4(PALB2):c.2108T>G (p.Leu703Ter)	SNV Germline	Chr16:23630046	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA7963621	rs_752592662	3 SubmittersRCV000223583 RCV001221815
NM_024675.4(PALB2):c.1919C>A (p.Ser640Ter)	SNV Germline	Chr16:23630235	Pathogenic	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Multiple Submitters No Conflicts	CA7963646	rs_760094988	10 SubmittersRCV000214899 RCV000479396 RCV000545701 RCV005016586
NM_024675.4(PALB2):c.1918T>G (p.Ser640Ala)	SNV Germline	Chr16:23630236	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Familial cancer of breast Pancreatic cancer, susceptibility to, 3 not specified	Criteria Provided Conflicting Classifications	CA10579991	rs_876659058	7 SubmittersRCV000221223 RCV000635882 RCV002478798 RCV002509316
NM_024675.4(PALB2):c.1918T>A (p.Ser640Thr)	SNV Germline	Chr16:23630236	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA10579992	rs_876659058	2 SubmittersRCV000221530 RCV003133189
NM_024675.4(PALB2):c.1804C>G (p.Gln602Glu)	SNV Germline	Chr16:23630350	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10579997	rs_876660475	3 SubmittersRCV000218759 RCV000538187
NM_024675.4(PALB2):c.1767G>A (p.Thr589=)	SNV Germline	Chr16:23630387	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Familial cancer of breast not specified Breast-ovarian cancer, familial, susceptibility to, 5 PALB2-related disorder Condition: not provided	Criteria Provided Conflicting Classifications	CA7963663	rs_769849072	13 SubmittersRCV000217926 RCV001121719 RCV000457514 RCV000436798 RCV005365148 RCV004532777 RCV002478785
NM_024675.4(PALB2):c.1744T>C (p.Ser582Pro)	SNV Germline	Chr16:23630410	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10579999	rs_876659597	2 SubmittersRCV000214800 RCV001316625
NM_024675.4(PALB2):c.1732A>G (p.Ser578Gly)	SNV Germline	Chr16:23630422	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA7963665	rs_764023822	7 SubmittersRCV000217898 RCV000464403 RCV000985887 RCV001030256 RCV005361246
NM_024675.4(PALB2):c.1702C>A (p.Gln568Lys)	SNV Germline	Chr16:23630452	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 PALB2-related disorder not specified	Criteria Provided Conflicting Classifications	CA10580001	rs_876659354	7 SubmittersRCV000214422 RCV000818865 RCV002494593 RCV004541351 RCV004701288
NM_024675.4(PALB2):c.1694G>A (p.Ser565Asn)	SNV Germline	Chr16:23630460	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified	Criteria Provided Conflicting Classifications	CA10580002	rs_876659914	5 SubmittersRCV000214165 RCV000536671 RCV001753674 RCV004526647
NM_024675.4(PALB2):c.1588C>T (p.Leu530Phe)	SNV Germline	Chr16:23634958	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10580006	rs_876659671	3 SubmittersRCV000218879 RCV000635734
NM_024675.4(PALB2):c.1573G>T (p.Asp525Tyr)	SNV Germline	Chr16:23634973	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10580007	rs_876659074	2 SubmittersRCV000219759 RCV001857775
NM_024675.4(PALB2):c.1540G>A (p.Gly514Arg)	SNV Germline	Chr16:23635006	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA7963698	rs_756778249	12 SubmittersRCV000214985 RCV000589880 RCV000989570 RCV001027798 RCV003224228
NM_024675.4(PALB2):c.1456A>G (p.Lys486Glu)	SNV Germline	Chr16:23635090	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA10580008	rs_876658949	3 SubmittersRCV000215703 RCV000811638 RCV001570464
NM_024675.4(PALB2):c.1378C>T (p.Gln460Ter)	SNV Germline	Chr16:23635168	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10580012	rs_876658166	4 SubmittersRCV000222117 RCV001853499
NM_024675.4(PALB2):c.1079A>G (p.Asp360Gly)	SNV Germline	Chr16:23635467	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA10580022	rs_876659751	8 SubmittersRCV000220824 RCV000679759 RCV000459883 RCV002500734
NM_024675.4(PALB2):c.1072C>T (p.Pro358Ser)	SNV Germline	Chr16:23635474	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA10580023	rs_876660876	6 SubmittersRCV000220349 RCV000235363 RCV000466160 RCV002494599
NM_024675.4(PALB2):c.1052C>A (p.Thr351Lys)	SNV Germline	Chr16:23635494	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA10580024	rs_876658656	5 SubmittersRCV000218423 RCV000531194 RCV005016578
NM_024675.4(PALB2):c.908T>C (p.Leu303Pro)	SNV Germline	Chr16:23635638	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA7963747	rs_774057025	5 SubmittersRCV000216402 RCV000822728 RCV001284671
NM_024675.4(PALB2):c.902A>G (p.Asp301Gly)	SNV Germline	Chr16:23635644	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Pancreatic cancer, susceptibility to, 3 not specified	Criteria Provided Conflicting Classifications	CA7963748	rs_759014440	8 SubmittersRCV000215213 RCV000461086 RCV000478906 RCV001354911 RCV004800343
NM_024675.4(PALB2):c.844A>G (p.Arg282Gly)	SNV Germline	Chr16:23635702	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Breast and/or ovarian cancer	Criteria Provided Conflicting Classifications	CA7963752	rs_45447991	9 SubmittersRCV000220267 RCV000462094 RCV000759905 RCV003491976
NM_024675.4(PALB2):c.826C>T (p.His276Tyr)	SNV Germline	Chr16:23635720	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10580030	rs_876658815	2 SubmittersRCV000215431 RCV000544750
NM_024675.4(PALB2):c.773G>A (p.Ser258Asn)	SNV Germline	Chr16:23635773	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA7963758	rs_371289600	4 SubmittersRCV000215658 RCV000635854 RCV002485415
NM_024675.4(PALB2):c.619C>T (p.Pro207Ser)	SNV Germline	Chr16:23635927	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10580036	rs_374090568	2 SubmittersRCV000214926 RCV001370562
NM_024675.4(PALB2):c.595C>T (p.Leu199Phe)	SNV Germline	Chr16:23635951	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10580037	rs_876660851	3 SubmittersRCV000216403 RCV003765443
NM_024675.4(PALB2):c.583A>G (p.Ile195Val)	SNV Germline	Chr16:23635963	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA7963779	rs_760784181	8 SubmittersRCV000215618 RCV001030160 RCV001234307 RCV005016591 RCV005365161
NM_024675.4(PALB2):c.541G>T (p.Glu181Ter)	SNV Germline	Chr16:23636005	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Hereditary breast ovarian cancer syndrome	Criteria Provided Multiple Submitters No Conflicts	CA10580039	rs_864622280	4 SubmittersRCV000219378 RCV001060848 RCV005237732
NM_024675.4(PALB2):c.347T>A (p.Leu116Ter)	SNV Germline	Chr16:23636199	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA10580044	rs_876660465	5 SubmittersRCV000223009 RCV000709748 RCV003227721
NM_024675.4(PALB2):c.338C>G (p.Pro113Arg)	SNV Germline	Chr16:23636208	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA7963798	rs_374425261	3 SubmittersRCV000219266 RCV000552379
NM_024675.4(PALB2):c.308G>A (p.Gly103Glu)	SNV Germline	Chr16:23636238	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA10580046	rs_876660794	2 SubmittersRCV000222248 RCV001854715
NM_024675.4(PALB2):c.229T>C (p.Cys77Arg)	SNV Germline	Chr16:23636317	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided not specified Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA7963811	rs_760045493	10 SubmittersRCV000222033 RCV000472473 RCV000485885 RCV001818541 RCV005361343
NM_024675.4(PALB2):c.154G>A (p.Val52Ile)	SNV Germline	Chr16:23637907	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA10580051	rs_876659444	2 SubmittersRCV000215013 RCV000482119
NM_024675.4(PALB2):c.115C>T (p.Gln39Ter)	SNV Germline	Chr16:23637946	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10580053	rs_876659319	4 SubmittersRCV000223492 RCV000551161
NM_024675.4(PALB2):c.48+2T>G	SNV Germline	Chr16:23641108	Likely pathogenic	Hereditary cancer-predisposing syndrome	Criteria Provided Single Submitter	CA10580057	rs_876659679	1 SubmittersRCV000221819
NM_024675.4(PALB2):c.3420G>A (p.Trp1140Ter)	SNV Germline	Chr16:23603600	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA10583349	rs_878855118	2 SubmittersRCV000226507 RCV004020882
NM_024675.4(PALB2):c.2964A>G (p.Gln988=)	SNV Germline	Chr16:23623001	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified PALB2-related disorder	Criteria Provided Conflicting Classifications	CA7963460	rs_777244673	6 SubmittersRCV000229549 RCV000563128 RCV000759903 RCV001192741 RCV004725117
NM_024675.4(PALB2):c.2840T>C (p.Leu947Ser)	SNV Germline	Chr16:23623125	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Inherited breast cancer and ovarian cancer not specified Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA7963465	rs_45464500	10 SubmittersRCV000229185 RCV000564890 RCV000587839 RCV005055099 RCV005238770 RCV005003582
NM_024675.4(PALB2):c.2624T>C (p.Met875Thr)	SNV Germline	Chr16:23626360	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA10583359	rs_878855110	3 SubmittersRCV000231157 RCV000780566 RCV004649110
NM_024675.4(PALB2):c.2594C>G (p.Ser865Ter)	SNV Germline	Chr16:23626390	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA10583360	rs_746604683	3 SubmittersRCV000234617 RCV003352808
NM_024675.4(PALB2):c.2509G>T (p.Glu837Ter)	SNV Germline	Chr16:23629645	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Pancreatic cancer, susceptibility to, 3 Hereditary breast ovarian cancer syndrome	Criteria Provided Multiple Submitters No Conflicts	CA10583361	rs_587778587	7 SubmittersRCV000227927 RCV000454198 RCV000235331 RCV001030314 RCV001193462
NM_024675.4(PALB2):c.2201C>A (p.Thr734Asn)	SNV Germline	Chr16:23629953	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Condition: not provided not specified Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA10583365	rs_878855107	17 SubmittersRCV000233965 RCV000569446 RCV001119746 RCV001566044 RCV001820767 RCV002487088 RCV004739637 RCV005361461
NM_024675.4(PALB2):c.2066C>T (p.Ser689Leu)	SNV Germline	Chr16:23630088	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome PALB2-related disorder	Criteria Provided Conflicting Classifications	CA7963627	rs_749602688	6 SubmittersRCV000228021 RCV001030274 RCV000774634 RCV004541455
NM_024675.4(PALB2):c.1753G>A (p.Asp585Asn)	SNV Germline	Chr16:23630401	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA10583370	rs_878855102	5 SubmittersRCV000227668 RCV000773064 RCV002277593
NM_024675.4(PALB2):c.1463G>T (p.Ser488Ile)	SNV Germline	Chr16:23635083	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA7963705	rs_767926590	8 SubmittersRCV000226177 RCV000564692 RCV000589383 RCV002487087
NM_024675.4(PALB2):c.1369G>T (p.Glu457Ter)	SNV Germline	Chr16:23635177	Pathogenic	Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10583374	rs_878855099	2 SubmittersRCV000231944
NM_024675.4(PALB2):c.1226A>G (p.Tyr409Cys)	SNV Germline	Chr16:23635320	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Hereditary cancer	Criteria Provided Conflicting Classifications	CA10583375	rs_878855097	7 SubmittersRCV000230943 RCV000709387 RCV000985884 RCV003492015
NM_024675.4(PALB2):c.365A>G (p.Asp122Gly)	SNV Germline	Chr16:23636181	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA10583383	rs_866367185	4 SubmittersRCV000232654 RCV001189069 RCV004721317
NM_024675.4(PALB2):c.212-3C>T	SNV Germline	Chr16:23636337	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA10583385	rs_878855106	3 SubmittersRCV000228404 RCV000569563
NM_024675.4(PALB2):c.79G>T (p.Glu27Ter)	SNV Germline/somatic	Chr16:23638099	Pathogenic/Likely pathogenic	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Malignant tumor of breast Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N Fanconi anemia complementation group N Lung cancer PALB2-related disorder	Criteria Provided Multiple Submitters No Conflicts	CA10583387	rs_878855122	16 SubmittersRCV000228882 RCV000255635 RCV000454231 RCV001175093 RCV002500815 RCV003485568 RCV002282082 RCV004532964
NM_024675.4(PALB2):c.48+7G>C	SNV Germline	Chr16:23641103	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided PALB2-related disorder	Criteria Provided Conflicting Classifications	CA7963885	rs_190626072	10 SubmittersRCV000230746 RCV000580140 RCV000433452 RCV000586925 RCV004541457
NM_024675.4(PALB2):c.7G>T (p.Glu3Ter)	SNV Germline	Chr16:23641151	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Reviewed By Expert Panel	CA10583388	rs_878855123	8 SubmittersRCV000231797 RCV000582525 RCV000657770
NM_024675.4(PALB2):c.2T>C (p.Met1Thr)	SNV Germline	Chr16:23641156	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA7963891	rs_756519825	4 SubmittersRCV000230496 RCV002436040
NM_024675.4(PALB2):c.3492G>A (p.Trp1164Ter)	SNV Germline	Chr16:23603528	Pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA10584499	rs_587782217	8 SubmittersRCV000235984 RCV000662671 RCV001020433
NM_024675.4(PALB2):c.3491G>A (p.Trp1164Ter)	SNV Germline	Chr16:23603529	Pathogenic/Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10584500	rs_879254113	6 SubmittersRCV000235914 RCV000454361 RCV000477362
NM_024675.4(PALB2):c.3436C>G (p.Gln1146Glu)	SNV Germline	Chr16:23603584	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA10584501	rs_879254033	4 SubmittersRCV000236192 RCV001854872 RCV001183519
NM_024675.4(PALB2):c.2996+5G>T	SNV Germline	Chr16:23622964	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided PALB2-related disorder not specified	Criteria Provided Conflicting Classifications	CA10584507	rs_879254193	11 SubmittersRCV000468560 RCV000562437 RCV000587970 RCV004541468 RCV005238783
NM_024675.4(PALB2):c.2860G>T (p.Glu954Ter)	SNV Germline	Chr16:23623105	Pathogenic	Condition: not provided Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10584509	rs_879254015	2 SubmittersRCV000235480 RCV001854860
NM_024675.4(PALB2):c.2435C>T (p.Pro812Leu)	SNV Germline	Chr16:23629719	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Malignant tumor of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA7963575	rs_774502617	9 SubmittersRCV000235316 RCV000635929 RCV000575251 RCV001357974 RCV002494681 RCV003330604
NM_024675.4(PALB2):c.2197A>G (p.Thr733Ala)	SNV Germline	Chr16:23629957	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA10584511	rs_879254051	7 SubmittersRCV000236085 RCV000470751 RCV000571493 RCV002487097 RCV005230178
NM_024675.4(PALB2):c.2148T>A (p.Asn716Lys)	SNV Germline	Chr16:23630006	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA7963617	rs_770145849	7 SubmittersRCV000236038 RCV000464776 RCV000574979 RCV002479940
NM_024675.4(PALB2):c.2066C>A (p.Ser689Ter)	SNV Germline	Chr16:23630088	Pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA10584512	rs_749602688	3 SubmittersRCV000236381 RCV003454716 RCV002418041
NM_024675.4(PALB2):c.2053A>C (p.Lys685Gln)	SNV Germline	Chr16:23630101	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA10584513	rs_876660397	5 SubmittersRCV000235440 RCV001854851 RCV000566295
NM_024675.4(PALB2):c.1861C>A (p.Pro621Thr)	SNV Germline	Chr16:23630293	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast not specified	Criteria Provided Conflicting Classifications	CA7963654	rs_756116550	10 SubmittersRCV000235273 RCV000454184 RCV000989565 RCV001192764
NM_024675.4(PALB2):c.668T>C (p.Ile223Thr)	SNV Germline	Chr16:23635878	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome not specified	Criteria Provided Conflicting Classifications	CA7963771	rs_150517167	8 SubmittersRCV000236902 RCV000635688 RCV000572381 RCV001193466
NM_024675.4(PALB2):c.472C>T (p.Gln158Ter)	SNV Germline	Chr16:23636074	Pathogenic/Likely pathogenic	Condition: not provided Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10584523	rs_879254197	3 SubmittersRCV000237059 RCV001382726
NM_024675.4(PALB2):c.398G>A (p.Ser133Asn)	SNV Germline	Chr16:23636148	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast not specified Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA10584524	rs_864622411	5 SubmittersRCV000235826 RCV000691656 RCV000780568 RCV000570939
NM_024675.4(PALB2):c.205C>T (p.His69Tyr)	SNV Germline	Chr16:23637856	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast not specified Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA10584525	rs_879253891	8 SubmittersRCV000236918 RCV000575557 RCV000823428 RCV000781688 RCV002494677
NM_024675.4(PALB2):c.155T>C (p.Val52Ala)	SNV Germline	Chr16:23637906	Conflicting classifications of pathogenicity	Breast neoplasm Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA7963833	rs_373970237	8 SubmittersRCV000417330 RCV000235666 RCV000462987 RCV000568339
NM_024675.4(PALB2):c.1A>G (p.Met1Val)	SNV Germline	Chr16:23641157	Pathogenic/Likely pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA10584527	rs_879254144	5 SubmittersRCV000237093 RCV000696235 RCV002418043
NM_024675.4(PALB2):c.3234T>A (p.Cys1078Ter)	SNV Germline	Chr16:23607980	Pathogenic/Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10588601	rs_886039634	6 SubmittersRCV000254975 RCV001525205 RCV001855013
NM_024675.4(PALB2):c.3114-1G>A	SNV Germline	Chr16:23614092	Pathogenic/Likely pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Pancreatic cancer, susceptibility to, 3	Criteria Provided Multiple Submitters No Conflicts	CA10588602	rs_886039619	6 SubmittersRCV000255848 RCV000551424 RCV000569707 RCV005361500
NM_024675.4(PALB2):c.2996+1G>T	SNV Germline	Chr16:23622968	Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10588605	rs_886039626	3 SubmittersRCV000255151 RCV001017834 RCV001379452
NM_024675.4(PALB2):c.2835-2A>C	SNV Germline	Chr16:23623132	Likely pathogenic	Condition: not provided Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10588606	rs_886039613	2 SubmittersRCV000256178 RCV003454780
NM_024675.4(PALB2):c.2514+1G>C	SNV Germline	Chr16:23629639	Likely pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA10588607	rs_886039729	5 SubmittersRCV000255296 RCV001229856 RCV002429197
NM_024675.4(PALB2):c.2368C>T (p.Gln790Ter)	SNV Germline	Chr16:23629786	Pathogenic/Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Fanconi anemia Hereditary cancer Familial cancer of breast Hereditary breast ovarian cancer syndrome	Criteria Provided Multiple Submitters No Conflicts	CA10588608	rs_886039480	11 SubmittersRCV000255054 RCV000454204 RCV000509375 RCV000552634 RCV003155937
NM_024675.4(PALB2):c.1496T>A (p.Leu499Ter)	SNV Germline	Chr16:23635050	Pathogenic/Likely pathogenic	Condition: not provided Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10588610	rs_886039620	2 SubmittersRCV000254924 RCV001390098
NM_024675.4(PALB2):c.1424C>G (p.Ser475Ter)	SNV Germline	Chr16:23635122	Pathogenic/Likely pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA10588611	rs_886039479	4 SubmittersRCV000255228 RCV001066196 RCV002392782
NM_024675.4(PALB2):c.421C>T (p.Gln141Ter)	SNV Germline	Chr16:23636125	Pathogenic/Likely pathogenic	Condition: not provided Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10588614	rs_886039686	3 SubmittersRCV000256010 RCV003454783
NM_024675.4(PALB2):c.178C>T (p.Gln60Ter)	SNV Germline	Chr16:23637883	Pathogenic/Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA10588615	rs_886039747	4 SubmittersRCV000255924 RCV001013160 RCV002518769
NM_024675.4(PALB2):c.3202-1G>A	SNV Germline	Chr16:23608013	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Multiple Submitters No Conflicts	CA16042147	rs_515726111	10 SubmittersRCV000409659 RCV001019201 RCV003493565 RCV002481267
NM_024675.4(PALB2):c.2748+1G>C	SNV Germline	Chr16:23626235	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA16042148	rs_753153576	5 SubmittersRCV000409294 RCV001176291 RCV003315425 RCV003477909
NM_024675.4(PALB2):c.2576C>A (p.Ser859Ter)	SNV Germline	Chr16:23629214	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA16042149	rs_1057517539	4 SubmittersRCV000410429 RCV000454290
NM_024675.4(PALB2):c.3G>A (p.Met1Ile)	SNV Germline	Chr16:23641155	Pathogenic/Likely pathogenic	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Multiple Submitters No Conflicts	CA16042152	rs_1057517585	8 SubmittersRCV000410696 RCV000505935 RCV000567207 RCV004698787
NM_024675.4(PALB2):c.1448C>G (p.Ser483Ter)	SNV Germline	Chr16:23635098	Pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA16607001	rs_1057520736	2 SubmittersRCV000421638 RCV001525971
NM_024675.4(PALB2):c.1746C>T (p.Ser582=)	SNV Germline	Chr16:23630408	Conflicting classifications of pathogenicity	not specified Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA16607213	rs_1057520985	6 SubmittersRCV000430741 RCV000775902 RCV001490679 RCV003477918
NM_024675.4(PALB2):c.1685-14T>A	SNV Germline	Chr16:23630483	Conflicting classifications of pathogenicity	not specified Familial cancer of breast PALB2-related cancer predisposition Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA7963670	rs_780772404	6 SubmittersRCV000443095 RCV000663142 RCV005355771 RCV003584602
NM_024675.4(PALB2):c.1438A>T (p.Lys480Ter)	SNV Germline	Chr16:23635108	Pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA16607220	rs_1057520653	6 SubmittersRCV000424678 RCV001390153 RCV005384711
NM_024675.4(PALB2):c.66A>G (p.Ala22=)	SNV Germline	Chr16:23638112	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Familial cancer of breast	Criteria Provided Conflicting Classifications	CA16607223	rs_1057520982	6 SubmittersRCV000923663 RCV000569467 RCV001119846 RCV001456862
NM_024675.4(PALB2):c.2992G>A (p.Gly998Arg)	SNV Germline	Chr16:23622973	Conflicting classifications of pathogenicity	not specified Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA16607334	rs_1039184417	4 SubmittersRCV000442850 RCV000775926 RCV001046244
NM_024675.4(PALB2):c.1685-1G>C	SNV Germline	Chr16:23630470	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16607339	rs_1057520645	6 SubmittersRCV000431972 RCV001055212 RCV002411312
NM_024675.4(PALB2):c.2993G>C (p.Gly998Ala)	SNV Germline	Chr16:23622972	Conflicting classifications of pathogenicity	not specified Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA16608106	rs_45551636	4 SubmittersRCV000425596 RCV000775893 RCV001038066
NM_024675.4(PALB2):c.1611G>A (p.Ser537=)	SNV Germline	Chr16:23634935	Conflicting classifications of pathogenicity	Familial cancer of breast Fanconi anemia complementation group N Hereditary cancer-predisposing syndrome Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5 not specified	Criteria Provided Conflicting Classifications	CA7963693	rs_730881874	10 SubmittersRCV000989569 RCV001121721 RCV000572139 RCV001703482 RCV005355718 RCV005407090
NM_024675.4(PALB2):c.1424C>A (p.Ser475Ter)	SNV Germline	Chr16:23635122	Pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA16608121	rs_886039479	3 SubmittersRCV000436797 RCV003449055 RCV005384712
NM_024675.4(PALB2):c.3464C>G (p.Ser1155Cys)	SNV Germline	Chr16:23603556	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided	Criteria Provided Conflicting Classifications	CA7963332	rs_755609496	5 SubmittersRCV000454280 RCV000529716 RCV000480681
NM_024675.4(PALB2):c.3202-2A>C	SNV Germline	Chr16:23608014	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA16609588	rs_1060499827	4 SubmittersRCV000454196 RCV000576715
NM_024675.4(PALB2):c.2748+2T>C	SNV Germline	Chr16:23626234	Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA16609594	rs_1060499821	2 SubmittersRCV000454214 RCV003449105
NM_024675.4(PALB2):c.2473A>G (p.Arg825Gly)	SNV Germline	Chr16:23629681	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Familial cancer of breast	Criteria Provided Conflicting Classifications	CA7963569	rs_745747228	4 SubmittersRCV000454362 RCV000764048 RCV001861653
NM_024675.4(PALB2):c.1039G>T (p.Glu347Ter)	SNV Germline	Chr16:23635507	Pathogenic	Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA16609602	rs_1060499812	5 SubmittersRCV000454356 RCV003315427 RCV003239290
NM_024675.4(PALB2):c.931A>T (p.Lys311Ter)	SNV Germline	Chr16:23635615	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA16609604	rs_1060499831	3 SubmittersRCV000454180 RCV003476020
NM_024675.4(PALB2):c.108+1G>A	SNV Germline	Chr16:23638069	Pathogenic/Likely pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Pancreatic cancer, susceptibility to, 3 Breast cancer, susceptibility to	Criteria Provided Multiple Submitters No Conflicts	CA16609606	rs_1060499814	12 SubmittersRCV000454354 RCV000466548 RCV000484652 RCV001258109
NM_024675.4(PALB2):c.106C>T (p.Gln36Ter)	SNV Germline	Chr16:23638072	Pathogenic	Hereditary cancer-predisposing syndrome Familial cancer of breast Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Multiple Submitters No Conflicts	CA16609607	rs_757369748	7 SubmittersRCV000454301 RCV001380280 RCV000657579 RCV000763378
NM_024675.4(PALB2):c.3508C>A (p.His1170Asn)	SNV Germline	Chr16:23603512	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16614807	rs_200283306	3 SubmittersRCV000459786 RCV001192088
NM_024675.4(PALB2):c.3035C>T (p.Thr1012Ile)	SNV Germline	Chr16:23621440	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA7963444	rs_761032954	12 SubmittersRCV000575045 RCV000479556 RCV000475841 RCV005018786
NM_024675.4(PALB2):c.2940C>T (p.Ser980=)	SNV Germline	Chr16:23623025	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA7963464	rs_766049739	7 SubmittersRCV000461224 RCV000580627 RCV001712437 RCV005355903
NM_024675.4(PALB2):c.2834+3A>G	SNV Germline	Chr16:23624006	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16614824	rs_1060502766	2 SubmittersRCV000474406 RCV001016728
NM_024675.4(PALB2):c.1553C>G (p.Ser518Ter)	SNV Germline	Chr16:23634993	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome PALB2-related disorder	Criteria Provided Multiple Submitters No Conflicts	CA16614852	rs_1060502805	5 SubmittersRCV000469612 RCV001012094 RCV004529598
NM_024675.4(PALB2):c.2749-1G>C	SNV Germline	Chr16:23624095	Likely pathogenic	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA16614853	rs_1060502804	3 SubmittersRCV000461242 RCV002509392 RCV005452993
NM_024675.4(PALB2):c.1537A>G (p.Thr513Ala)	SNV Germline	Chr16:23635009	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Carcinoma of colon	Criteria Provided Conflicting Classifications	CA16614855	rs_1060502741	7 SubmittersRCV000474363 RCV000575626 RCV000587874 RCV002480416 RCV001030235
NM_024675.4(PALB2):c.2730T>A (p.Tyr910Ter)	SNV Germline	Chr16:23626254	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA16614856	rs_995629797	9 SubmittersRCV000459119 RCV000568217 RCV002489062 RCV000657580
NM_024675.4(PALB2):c.2677G>T (p.Asp893Tyr)	SNV Germline	Chr16:23626307	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Condition: not provided	Criteria Provided Conflicting Classifications	CA7963508	rs_765077104	8 SubmittersRCV000457988 RCV001016287 RCV003991027 RCV005243235
NM_024675.4(PALB2):c.1383T>A (p.Ser461Arg)	SNV Germline	Chr16:23635163	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA7963711	rs_768482110	8 SubmittersRCV000470251 RCV000781681 RCV000568070 RCV000679760 RCV002481444
NM_024675.4(PALB2):c.1084C>G (p.Leu362Val)	SNV Germline	Chr16:23635462	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16614861	rs_1060502758	2 SubmittersRCV000475695 RCV000572723
NM_024675.4(PALB2):c.880A>G (p.Lys294Glu)	SNV Germline	Chr16:23635666	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA7963750	rs_753676934	5 SubmittersRCV000468876 RCV000574047 RCV002223850
NM_024675.4(PALB2):c.2514+8C>T	SNV Germline	Chr16:23629632	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome PALB2-related disorder	Criteria Provided Conflicting Classifications	CA16614865	rs_1060504706	4 SubmittersRCV000470502 RCV004017633 RCV004740248
NM_024675.4(PALB2):c.2389C>A (p.Gln797Lys)	SNV Germline	Chr16:23629765	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA16614866	rs_1060502768	4 SubmittersRCV000476517 RCV000567346 RCV003318580
NM_024675.4(PALB2):c.2188A>G (p.Ile730Val)	SNV Germline	Chr16:23629966	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome not specified Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA16614873	rs_1060502735	8 SubmittersRCV000468216 RCV000479293 RCV000563382 RCV001199879 RCV001354437
NM_024675.4(PALB2):c.304G>A (p.Val102Ile)	SNV Germline	Chr16:23636242	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA7963803	rs_778573607	6 SubmittersRCV000465446 RCV000562562 RCV003332178
NM_024675.4(PALB2):c.45A>G (p.Glu15=)	SNV Germline	Chr16:23641113	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Familial pancreatic carcinoma Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16614880	rs_1060504718	6 SubmittersRCV000828254 RCV001085519 RCV005355905 RCV003168912
NM_024675.4(PALB2):c.1435C>T (p.Gln479Ter)	SNV Germline	Chr16:23635111	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA16614893	rs_1060502761	2 SubmittersRCV000463150 RCV001011563
NM_024675.4(PALB2):c.1217C>T (p.Ala406Val)	SNV Germline	Chr16:23635329	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA16614898	rs_1060502757	8 SubmittersRCV000463216 RCV000569051 RCV001561387 RCV002481447
NM_024675.4(PALB2):c.1144A>C (p.Ser382Arg)	SNV Germline	Chr16:23635402	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16614900	rs_1060502737	3 SubmittersRCV000476970 RCV000775933
NM_024675.4(PALB2):c.3391A>G (p.Ile1131Val)	SNV Germline	Chr16:23603629	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 not specified	Criteria Provided Conflicting Classifications	CA7963344	rs_774517454	7 SubmittersRCV000456527 RCV000589068 RCV000771464 RCV005355850 RCV004596198
NM_024675.4(PALB2):c.3351-2A>G	SNV Germline	Chr16:23603671	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA16615066	rs_1060502764	5 SubmittersRCV000466376 RCV001020064 RCV004721374
NM_024675.4(PALB2):c.3256C>G (p.Arg1086Gly)	SNV Germline	Chr16:23607958	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided not specified Hereditary breast ovarian cancer syndrome Familial pancreatic carcinoma	Criteria Provided Conflicting Classifications	CA16615072	rs_587776527	6 SubmittersRCV000461441 RCV000773077 RCV003319358 RCV003321613 RCV005355852
NM_024675.4(PALB2):c.2835-3T>C	SNV Germline	Chr16:23623133	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified	Criteria Provided Conflicting Classifications	CA16615078	rs_1060502795	4 SubmittersRCV000468775 RCV001016565 RCV004596199
NM_024675.4(PALB2):c.2711G>A (p.Trp904Ter)	SNV Germline	Chr16:23626273	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Multiple Submitters No Conflicts	CA16615083	rs_1060502726	7 SubmittersRCV000465081 RCV000566729 RCV000522916 RCV005355847
NM_024675.4(PALB2):c.2328C>A (p.Phe776Leu)	SNV Germline	Chr16:23629826	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3 Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA16615088	rs_45508997	4 SubmittersRCV000469475 RCV004943901 RCV005398628
NM_024675.4(PALB2):c.2303G>C (p.Cys768Ser)	SNV Germline	Chr16:23629851	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16615091	rs_1060502770	3 SubmittersRCV000471672 RCV001015017
NM_024675.4(PALB2):c.1696C>T (p.Arg566Cys)	SNV Germline	Chr16:23630458	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA7963668	rs_746582620	10 SubmittersRCV000461240 RCV000586825 RCV000563652 RCV002481446
NM_024675.4(PALB2):c.1366G>T (p.Glu456Ter)	SNV Germline	Chr16:23635180	Pathogenic	Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA16615101	rs_1060502785	3 SubmittersRCV000472293
NM_024675.4(PALB2):c.1103A>G (p.Asn368Ser)	SNV Germline	Chr16:23635443	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA16615103	rs_1060502799	4 SubmittersRCV000469658 RCV000563832 RCV003153633
NM_024675.4(PALB2):c.727A>C (p.Thr243Pro)	SNV Germline	Chr16:23635819	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA16615106	rs_1060502747	4 SubmittersRCV000464943 RCV000567643 RCV001848813
NM_024675.4(PALB2):c.602G>A (p.Ser201Asn)	SNV Germline	Chr16:23635944	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16615115	rs_1060502790	2 SubmittersRCV000476599 RCV004943900
NM_024675.4(PALB2):c.206A>T (p.His69Leu)	SNV Germline	Chr16:23637855	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA16615126	rs_749443090	8 SubmittersRCV000476673 RCV000485056 RCV000569594 RCV005018787
NM_024675.4(PALB2):c.127A>G (p.Lys43Glu)	SNV Germline	Chr16:23637934	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Familial cancer of breast Fanconi anemia complementation group N Pancreatic cancer, susceptibility to, 3	Criteria Provided Conflicting Classifications	CA7963836	rs_765125459	11 SubmittersRCV000474623 RCV000580520 RCV000485071 RCV002481445
NM_024675.4(PALB2):c.2725C>G (p.Leu909Val)	SNV Germline	Chr16:23626259	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16615221	rs_1060502739	3 SubmittersRCV000463483 RCV000572861
NM_024675.4(PALB2):c.2587-2A>C	SNV Germline	Chr16:23626399	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16615225	rs_1060502787	3 SubmittersRCV000460478 RCV002429521
NM_024675.4(PALB2):c.2438T>C (p.Ile813Thr)	SNV Germline	Chr16:23629716	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome PALB2-related disorder	Criteria Provided Conflicting Classifications	CA7963573	rs_763191051	9 SubmittersRCV000476976 RCV000588415 RCV000564912 RCV004533194
NM_024675.4(PALB2):c.2375C>G (p.Ser792Ter)	SNV Germline	Chr16:23629779	Pathogenic/Likely pathogenic	Familial cancer of breast Fanconi anemia complementation group N Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA16615240	rs_1060502748	5 SubmittersRCV000457054 RCV001813781 RCV004649161
NM_024675.4(PALB2):c.1492G>A (p.Asp498Asn)	SNV Germline	Chr16:23635054	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA16615265	rs_75023630	4 SubmittersRCV000466463 RCV000572623 RCV002496776
NM_024675.4(PALB2):c.1343G>A (p.Ser448Asn)	SNV Germline	Chr16:23635203	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA16615266	rs_956172059	5 SubmittersRCV000464002 RCV000564122 RCV000486431
NM_024675.4(PALB2):c.1213C>G (p.Pro405Ala)	SNV Germline	Chr16:23635333	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Breast and/or ovarian cancer PALB2-related disorder Ovarian cancer Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA7963723	rs_545119348	9 SubmittersRCV000456874 RCV000561159 RCV003492059 RCV004529596 RCV003153632 RCV005355849
NM_024675.4(PALB2):c.1048C>T (p.Gln350Ter)	SNV Germline	Chr16:23635498	Pathogenic	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA16615273	rs_1060502788	5 SubmittersRCV000476491 RCV000520926 RCV002402280
NM_024675.4(PALB2):c.661G>A (p.Val221Ile)	SNV Germline	Chr16:23635885	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary breast ovarian cancer syndrome Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16615301	rs_1060502773	7 SubmittersRCV000462286 RCV003324751 RCV005355851 RCV000569599
NM_024675.4(PALB2):c.510A>C (p.Arg170Ser)	SNV Germline	Chr16:23636036	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Fanconi anemia complementation group N Condition: not provided	Criteria Provided Conflicting Classifications	CA16615302	rs_1060502796	5 SubmittersRCV000474642 RCV000571001 RCV001294231 RCV003477982
NM_024675.4(PALB2):c.3421G>A (p.Asp1141Asn)	SNV Germline	Chr16:23603599	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA16620112	rs_1064795975	3 SubmittersRCV000480747 RCV004943925 RCV002525917
NM_024675.4(PALB2):c.3122A>C (p.Lys1041Thr)	SNV Germline	Chr16:23614083	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA7963418	rs_781663559	6 SubmittersRCV000478421 RCV000635632 RCV000708730
NM_024675.4(PALB2):c.3114-6T>C	SNV Germline	Chr16:23614097	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast	Criteria Provided Conflicting Classifications	CA16620116	rs_1064794886	3 SubmittersRCV000482960 RCV001078733
NM_024675.4(PALB2):c.3054G>T (p.Glu1018Asp)	SNV Germline	Chr16:23621421	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Pancreatic cancer, susceptibility to, 3 not specified	Criteria Provided Conflicting Classifications	CA16620118	rs_183489969	7 SubmittersRCV000481068 RCV000561822 RCV000694700 RCV001030372 RCV002268123
NM_024675.4(PALB2):c.2875G>T (p.Val959Leu)	SNV Germline	Chr16:23623090	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA16620123	rs_1064793658	4 SubmittersRCV000484497 RCV000562675 RCV001865437
NM_024675.4(PALB2):c.2836G>A (p.Ala946Thr)	SNV Germline	Chr16:23623129	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16620124	rs_878855113	3 SubmittersRCV000484044 RCV001305631 RCV004943923
NM_024675.4(PALB2):c.2614G>A (p.Val872Met)	SNV Germline	Chr16:23626370	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16620129	rs_1064793628	4 SubmittersRCV000484695 RCV000696384 RCV004659056
NM_024675.4(PALB2):c.2422G>A (p.Gly808Arg)	SNV Germline	Chr16:23629732	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA16620133	rs_1064795507	5 SubmittersRCV000698122 RCV000775954 RCV000486954
NM_024675.4(PALB2):c.2411C>T (p.Ser804Phe)	SNV Germline	Chr16:23629743	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast Pancreatic cancer, susceptibility to, 3 Familial cancer of breast Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA7963582	rs_149836639	7 SubmittersRCV000481392 RCV000581656 RCV000635655 RCV002475930
NM_024675.4(PALB2):c.2340C>T (p.Gly780=)	SNV Germline	Chr16:23629814	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA16620134	rs_1064794853	4 SubmittersRCV000485867 RCV000814645 RCV004943920
NM_024675.4(PALB2):c.2326T>C (p.Phe776Leu)	SNV Germline	Chr16:23629828	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA7963593	rs_764925691	7 SubmittersRCV000486202 RCV000662841 RCV001015195
NM_024675.4(PALB2):c.1600T>G (p.Ser534Ala)	SNV Germline	Chr16:23634946	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Chordoma	Criteria Provided Conflicting Classifications	CA16620143	rs_1064793824	5 SubmittersRCV000484915 RCV000689372 RCV001012375 RCV002266967
NM_024675.4(PALB2):c.1491T>G (p.Asn497Lys)	SNV Germline	Chr16:23635055	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA7963703	rs_374707677	3 SubmittersRCV000635954 RCV000486048 RCV001011852
NM_024675.4(PALB2):c.1463G>C (p.Ser488Thr)	SNV Germline	Chr16:23635083	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA16620145	rs_767926590	5 SubmittersRCV000486572 RCV000538747 RCV002395159 RCV003315431
NM_024675.4(PALB2):c.1337A>G (p.Asp446Gly)	SNV Germline	Chr16:23635209	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA7963717	rs_146434474	3 SubmittersRCV000478568 RCV001010834 RCV000798423
NM_024675.4(PALB2):c.1179A>G (p.Lys393=)	SNV Germline	Chr16:23635367	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA16620151	rs_976340416	5 SubmittersRCV000480231 RCV000567685 RCV001396731
NM_024675.4(PALB2):c.769G>C (p.Gly257Arg)	SNV Germline	Chr16:23635777	Conflicting classifications of pathogenicity	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast	Criteria Provided Conflicting Classifications	CA16620155	rs_587780824	3 SubmittersRCV000485497 RCV002402401 RCV003607293
NM_024675.4(PALB2):c.742G>C (p.Val248Leu)	SNV Germline	Chr16:23635804	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA16620157	rs_572102702	4 SubmittersRCV000478004 RCV000635771 RCV002383910 RCV005355924
NM_024675.4(PALB2):c.163C>T (p.Gln55Ter)	SNV Germline	Chr16:23637898	Pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA16620162	rs_1064793772	2 SubmittersRCV000482275 RCV003168945
NM_024675.4(PALB2):c.108+9A>G	SNV Germline	Chr16:23638061	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast	Criteria Provided Conflicting Classifications	CA16620164	rs_1064795783	2 SubmittersRCV000482406 RCV001495481
NM_024675.4(PALB2):c.20A>G (p.Lys7Arg)	SNV Germline	Chr16:23641138	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome not specified PALB2-related disorder	Criteria Provided Conflicting Classifications	CA16620166	rs_947155109	10 SubmittersRCV000702590 RCV000483460 RCV000571040 RCV003226305 RCV004527591
NM_024675.4(PALB2):c.643G>T (p.Glu215Ter)	SNV Germline	Chr16:23635903	Pathogenic	Breast neoplasm Familial cancer of breast	Criteria Provided Multiple Submitters No Conflicts	CA395136539	rs_1555461693	2 SubmittersRCV000504603 RCV001385716
NM_024675.4(PALB2):c.62T>G (p.Leu21Ter)	SNV Germline	Chr16:23638116	Pathogenic	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA7963863	rs_769240800	9 SubmittersRCV000507280 RCV000535566 RCV000575810
NM_024675.4(PALB2):c.3324C>A (p.Tyr1108Ter)	SNV Germline	Chr16:23607890	Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA395139372	rs_1218512317	2 SubmittersRCV000523756 RCV003362812
NM_024675.4(PALB2):c.1685-2A>G	SNV Germline	Chr16:23630471	Likely pathogenic	Condition: not provided Hereditary cancer-predisposing syndrome Familial cancer of breast PALB2-related disorder Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Multiple Submitters No Conflicts	CA7963669	rs_754660432	6 SubmittersRCV000519126 RCV000568799 RCV001037839 RCV004527630 RCV005411471
NM_024675.4(PALB2):c.119G>A (p.Arg40Lys)	SNV Germline	Chr16:23637942	Conflicting classifications of pathogenicity	Condition: not provided Familial cancer of breast Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA279501900	rs_573118236	5 SubmittersRCV000523351 RCV001063588 RCV000774647 RCV003446134
NM_024675.4(PALB2):c.2596G>T (p.Gly866Cys)	SNV Germline	Chr16:23626388	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome not specified	Criteria Provided Conflicting Classifications	CA7963516	rs_780415750	5 SubmittersRCV000536489 RCV000759899 RCV001187392 RCV004596242
NM_024675.4(PALB2):c.2017G>A (p.Glu673Lys)	SNV Germline	Chr16:23630137	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA395127047	rs_1236182341	3 SubmittersRCV000540647 RCV000569513
NM_024675.4(PALB2):c.1643C>T (p.Ser548Leu)	SNV Germline	Chr16:23634903	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA395130164	rs_1241049372	3 SubmittersRCV000547156 RCV000571222 RCV002259347
NM_024675.4(PALB2):c.1133C>T (p.Pro378Leu)	SNV Germline	Chr16:23635413	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA395133627	rs_1442895662	4 SubmittersRCV000526864 RCV002448657 RCV002293450
NM_024675.4(PALB2):c.1004A>G (p.Asn335Ser)	SNV Germline	Chr16:23635542	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA395134568	rs_1368473544	4 SubmittersRCV000554257 RCV000777235 RCV004719858
NM_024675.4(PALB2):c.223A>T (p.Lys75Ter)	SNV Germline	Chr16:23636323	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Multiple Submitters No Conflicts	CA395138968	rs_1555461875	9 SubmittersRCV000557714 RCV001014881 RCV001008028 RCV005357565
NM_024675.4(PALB2):c.3436C>T (p.Gln1146Ter)	SNV Germline	Chr16:23603584	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA395138158	rs_879254033	3 SubmittersRCV000533343 RCV002456088
NM_024675.4(PALB2):c.3324C>G (p.Tyr1108Ter)	SNV Germline	Chr16:23607890	Pathogenic/Likely pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Multiple Submitters No Conflicts	CA395139370	rs_1218512317	7 SubmittersRCV000550532 RCV001019991 RCV004592566
NM_024675.4(PALB2):c.3476G>T (p.Trp1159Leu)	SNV Germline	Chr16:23603544	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Condition: not provided	Criteria Provided Conflicting Classifications	CA279524947	rs_587782050	6 SubmittersRCV000547300 RCV000564987 RCV003317262 RCV003329296
NM_024675.4(PALB2):c.2821A>G (p.Ile941Val)	SNV Germline	Chr16:23624022	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome Breast-ovarian cancer, familial, susceptibility to, 5 Pancreatic cancer, susceptibility to, 3 Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA7963481	rs_778602038	9 SubmittersRCV000534984 RCV000759902 RCV000572648 RCV005004225
NM_024675.4(PALB2):c.2515-3C>T	SNV Germline	Chr16:23629278	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA279491568	rs_957106428	4 SubmittersRCV000543762 RCV001015746 RCV001775854
NM_024675.4(PALB2):c.2290A>G (p.Lys764Glu)	SNV Germline	Chr16:23629864	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA7963599	rs_573744591	3 SubmittersRCV000551829 RCV000771302
NM_024675.4(PALB2):c.1765A>G (p.Thr589Ala)	SNV Germline	Chr16:23630389	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA395128203	rs_1437053825	4 SubmittersRCV000550043 RCV001013028 RCV003478137
NM_024675.4(PALB2):c.1471G>A (p.Ala491Thr)	SNV Germline	Chr16:23635075	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA279498326	rs_577969558	5 SubmittersRCV000555891 RCV000563308 RCV001545090
NM_024675.4(PALB2):c.1082C>G (p.Thr361Ser)	SNV Germline	Chr16:23635464	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA395133936	rs_1345668733	2 SubmittersRCV000557004 RCV005384760
NM_024675.4(PALB2):c.1061C>G (p.Ser354Cys)	SNV Germline	Chr16:23635485	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA395134068	rs_1555461474	2 SubmittersRCV000532399 RCV005384759
NM_024675.4(PALB2):c.1066A>G (p.Lys356Glu)	SNV Germline	Chr16:23635480	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified Familial pancreatic carcinoma Condition: not provided	Criteria Provided Conflicting Classifications	CA395134035	rs_1202130508	9 SubmittersRCV000544610 RCV000575442 RCV001174761 RCV005357564 RCV001538610
NM_024675.4(PALB2):c.931A>G (p.Lys311Glu)	SNV Germline	Chr16:23635615	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA395135258	rs_1060499831	5 SubmittersRCV000528073 RCV000564202 RCV001584261
NM_024675.4(PALB2):c.935G>A (p.Ser312Asn)	SNV Germline	Chr16:23635611	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA395135226	rs_1407319475	4 SubmittersRCV000553560 RCV000567058 RCV001800745
NM_024675.4(PALB2):c.892G>A (p.Val298Ile)	SNV Germline	Chr16:23635654	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Breast-ovarian cancer, familial, susceptibility to, 5	Criteria Provided Conflicting Classifications	CA395135620	rs_1060502765	5 SubmittersRCV000551680 RCV000563746 RCV001800744 RCV005357568
NM_024675.4(PALB2):c.828C>T (p.His276=)	SNV Germline	Chr16:23635718	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Familial ovarian cancer Fanconi anemia complementation group N Malignant tumor of breast	Criteria Provided Conflicting Classifications	CA279499381	rs_911713488	9 SubmittersRCV000557022 RCV000567452 RCV001171908 RCV001357885 RCV001118311 RCV001354533
NM_024675.4(PALB2):c.718C>A (p.Pro240Thr)	SNV Germline	Chr16:23635828	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided Fanconi anemia complementation group N	Criteria Provided Conflicting Classifications	CA7963768	rs_757567654	5 SubmittersRCV000530439 RCV000568617 RCV001030167 RCV001118312
NM_024675.4(PALB2):c.566G>T (p.Arg189Ile)	SNV Germline	Chr16:23635980	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA7963780	rs_764180110	3 SubmittersRCV000535087 RCV001189068
NM_024675.4(PALB2):c.406A>T (p.Ser136Cys)	SNV Germline	Chr16:23636140	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome not specified	Criteria Provided Conflicting Classifications	CA7963796	rs_144496685	5 SubmittersRCV000542390 RCV001021800 RCV004525963
NM_024675.4(PALB2):c.3394T>C (p.Leu1132=)	SNV Germline	Chr16:23603626	Conflicting classifications of pathogenicity	Familial cancer of breast not specified Fanconi anemia complementation group N Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA494173743	rs_1282821765	7 SubmittersRCV000528385 RCV000602592 RCV001121623 RCV001020184 RCV001796099
NM_024675.4(PALB2):c.2452T>C (p.Phe818Leu)	SNV Germline	Chr16:23629702	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA395124159	rs_1555460328	3 SubmittersRCV000546200 RCV001180795
NM_024675.4(PALB2):c.1702C>T (p.Gln568Ter)	SNV Germline	Chr16:23630452	Pathogenic	Familial cancer of breast Hereditary cancer-predisposing syndrome	Criteria Provided Multiple Submitters No Conflicts	CA395128442	rs_876659354	3 SubmittersRCV000549307 RCV002413486
NM_024675.4(PALB2):c.1507G>C (p.Ala503Pro)	SNV Germline	Chr16:23635039	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA395131030	rs_1555461243	5 SubmittersRCV000540105 RCV000579884 RCV001755821
NM_024675.4(PALB2):c.1458A>G (p.Lys486=)	SNV Germline	Chr16:23635088	Conflicting classifications of pathogenicity	Familial cancer of breast Condition: not provided Hereditary cancer-predisposing syndrome	Criteria Provided Conflicting Classifications	CA494461445	rs_1555461270	4 SubmittersRCV000526724 RCV000985885 RCV004943959
NM_024675.4(PALB2):c.1192G>A (p.Val398Met)	SNV Germline	Chr16:23635354	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA7963726	rs_769097541	5 SubmittersRCV000553689 RCV000771520 RCV001030202
NM_024675.4(PALB2):c.1165C>G (p.Leu389Val)	SNV Germline	Chr16:23635381	Conflicting classifications of pathogenicity	Familial cancer of breast Hereditary cancer-predisposing syndrome Condition: not provided	Criteria Provided Conflicting Classifications	CA395133462	rs_1555461427	4 SubmittersRCV000552765 RCV000777229 RCV003236811

NM_024675.4(PALB2):c.1653T>A (p.Tyr551Ter)

SNV
Germline

Chr16:23634893

Pathogenic/Likely pathogenic

Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA251717

rs_118203997

13 SubmittersRCV000001302 RCV000217204 RCV000235772 RCV000476387 RCV005053882

NM_024675.4(PALB2):c.3549C>G (p.Tyr1183Ter)

SNV
Germline

Chr16:23603471

Pathogenic/Likely pathogenic

Fanconi anemia complementation group N
Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome
Condition: not provided
Pancreatic cancer, susceptibility to, 3
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5
Inherited breast cancer and ovarian cancer
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA151250

rs_118203998

25 SubmittersRCV000001304 RCV000114634 RCV000121742 RCV000129158 RCV000212830 RCV001355428 RCV004528063 RCV005053883 RCV005430457 RCV005623061

NM_024675.4(PALB2):c.2962C>T (p.Gln988Ter)

SNV
Germline

Chr16:23623003

Pathogenic

Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA164468

rs_118203999

9 SubmittersRCV000001306 RCV000129469 RCV000662710 RCV000657596 RCV005053884

NM_024675.4(PALB2):c.2057G>A (p.Arg686Lys)

SNV
Germline

Chr16:23630097

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA279492933

rs_267604470

8 SubmittersRCV000774635 RCV000704434 RCV001572169 RCV003226185 RCV004537269

NC_000016.10:g.23641315C>G

SNV
Germline

Chr16:23641315

Conflicting classifications of pathogenicity

Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA269467

rs_138200248

4 SubmittersRCV000282144 RCV000374410 RCV001030094 RCV000829438

NM_024675.4(PALB2):c.1000T>G (p.Tyr334Asp)

SNV
Germline

Chr16:23635546

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Condition: not provided
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA193504

rs_202241382

8 SubmittersRCV000165476 RCV000402501 RCV000483117 RCV001087026 RCV004595925

NM_024675.4(PALB2):c.1001A>G (p.Tyr334Cys)

SNV
Germline

Chr16:23635545

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Hereditary cancer
not specified
Breast and/or ovarian cancer
Hereditary breast ovarian cancer syndrome
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA288383

rs_200620434

22 SubmittersRCV000114449 RCV000116060 RCV000212784 RCV000415191 RCV000781695 RCV001798290 RCV003483471 RCV004529916 RCV005359039

NM_024675.4(PALB2):c.1010T>C (p.Leu337Ser)

SNV
Germline

Chr16:23635536

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Condition: not provided
Malignant tumor of breast
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA151212

rs_45494092

28 SubmittersRCV000114450 RCV000121752 RCV000127306 RCV001116860 RCV000755592 RCV001354445 RCV001798291

NM_024675.4(PALB2):c.1027C>T (p.Gln343Ter)

SNV
Germline

Chr16:23635519

Pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA151215

rs_180177097

10 SubmittersRCV000215551 RCV001030193 RCV001040014 RCV005053906 RCV003155912

NM_024675.4(PALB2):c.110G>A (p.Arg37His)

SNV
Germline

Chr16:23637951

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA288386

rs_202194596

14 SubmittersRCV000114460 RCV000116061 RCV000212768 RCV000780571 RCV002483177 RCV004739369

NM_024675.4(PALB2):c.1145G>T (p.Ser382Ile)

SNV
Germline

Chr16:23635401

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA269483

rs_515726063

11 SubmittersRCV000114461 RCV000483203 RCV000567033 RCV002483178

NM_024675.4(PALB2):c.1194G>A (p.Val398=)

SNV
Germline

Chr16:23635352

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Fanconi anemia complementation group N
Condition: not provided
Breast and/or ovarian cancer
Malignant tumor of breast
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA151219

rs_61755173

29 SubmittersRCV000114462 RCV000127307 RCV000212786 RCV000327932 RCV000588666 RCV001170350 RCV001357080 RCV005234992

NM_024675.4(PALB2):c.11C>T (p.Pro4Leu)

SNV
Germline

Chr16:23641147

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Esophageal atresia/tracheoesophageal fistula
Fanconi anemia complementation group N
Condition: not provided
Breast and/or ovarian cancer
PALB2-related disorder
Malignant tumor of breast
not specified

Criteria Provided
Conflicting Classifications

CA288392

rs_45619737

15 SubmittersRCV000116063 RCV000114464 RCV000515208 RCV000590674 RCV001798292 RCV004739370 RCV001358373 RCV001797625

NM_024675.4(PALB2):c.1250C>A (p.Ser417Tyr)

SNV
Germline

Chr16:23635296

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Hereditary breast ovarian cancer syndrome
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA288398

rs_45510998

21 SubmittersRCV000114466 RCV000116065 RCV000590540 RCV001255214 RCV003483472 RCV004739371 RCV005394371

NM_024675.4(PALB2):c.13C>T (p.Pro5Ser)

SNV
Germline

Chr16:23641145

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA269492

rs_377085677

17 SubmittersRCV000114472 RCV000116068 RCV000589509 RCV001818256 RCV004739372 RCV005359040

NM_024675.4(PALB2):c.1544A>G (p.Lys515Arg)

SNV
Germline

Chr16:23635002

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial ovarian cancer
Breast and/or ovarian cancer
PALB2-related disorder
Hereditary cancer

Criteria Provided
Conflicting Classifications

CA163908

rs_515726072

19 SubmittersRCV000114479 RCV000235723 RCV000129175 RCV000586359 RCV001355376 RCV003149776 RCV004528789 RCV004700413

NM_024675.4(PALB2):c.1633G>T (p.Glu545Ter)

SNV
Germline

Chr16:23634913

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Malignant tumor of breast
Gastric cancer
PALB2-related disorder

Criteria Provided
Multiple Submitters
No Conflicts

CA167823

rs_180177103

14 SubmittersRCV000114484 RCV000131237 RCV000255843 RCV001357967 RCV003162529 RCV004529917

NM_024675.4(PALB2):c.1699C>T (p.His567Tyr)

SNV
Germline

Chr16:23630455

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Condition: not provided
not specified
Breast-ovarian cancer, familial, susceptibility to, 5
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA288416

rs_370422990

18 SubmittersRCV000114495 RCV000116072 RCV001292820 RCV000588850 RCV001171429 RCV005359042 RCV004529918

NM_024675.4(PALB2):c.196C>T (p.Gln66Ter)

SNV
Germline

Chr16:23637865

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Hereditary breast ovarian cancer syndrome
Breast and/or ovarian cancer
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Multiple Submitters
No Conflicts

CA187393

rs_180177083

18 SubmittersRCV000114503 RCV000163078 RCV000235795 RCV000588616 RCV001798296 RCV005016383

NM_024675.4(PALB2):c.2200A>T (p.Thr734Ser)

SNV
Germline

Chr16:23629954

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Malignant tumor of breast
Endometrial carcinoma

Criteria Provided
Conflicting Classifications

CA288435

rs_45543843

13 SubmittersRCV000114515 RCV000116081 RCV000586054 RCV000855600 RCV001356351 RCV001358251

NM_024675.4(PALB2):c.2323C>T (p.Gln775Ter)

SNV
Germline

Chr16:23629831

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Malignant tumor of breast
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA192039

rs_180177111

13 SubmittersRCV000114521 RCV000164897 RCV000413982 RCV001355683 RCV003155914 RCV005053908

NM_024675.4(PALB2):c.232G>A (p.Val78Ile)

SNV
Germline

Chr16:23636314

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
Malignant tumor of breast
Breast and/or ovarian cancer
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA288441

rs_515726085

17 SubmittersRCV000114522 RCV000116083 RCV000212771 RCV000587015 RCV001356931 RCV003149780 RCV004529921

NM_024675.4(PALB2):c.2386G>T (p.Gly796Ter)

SNV
Germline

Chr16:23629768

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N

Criteria Provided
Multiple Submitters
No Conflicts

CA163823

rs_180177112

14 SubmittersRCV000114524 RCV000129116 RCV000236024 RCV001781442 RCV003330435

NM_024675.4(PALB2):c.23C>T (p.Pro8Leu)

SNV
Germline

Chr16:23641135

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Hereditary breast ovarian cancer syndrome
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA299799

rs_150390726

13 SubmittersRCV000114527 RCV000160872 RCV000589826 RCV002225301 RCV004529922 RCV005359045

NM_024675.4(PALB2):c.2514+3A>G

SNV
Germline

Chr16:23629637

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast and/or ovarian cancer
Familial pancreatic carcinoma

Criteria Provided
Conflicting Classifications

CA269537

rs_515726088

9 SubmittersRCV000114530 RCV000160843 RCV000573333 RCV005016384 RCV003149781 RCV005359046

PALB2:c.2515-1G>T

SNV
Germline

Chr16:23629276

Pathogenic/Likely pathogenic

Pancreatic cancer, susceptibility to, 3
Condition: not provided
Familial cancer of breast
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA114879

rs_587776417

7 SubmittersRCV000001312 RCV000133479 RCV001030317 RCV001171466 RCV002426654

NM_024675.4(PALB2):c.2559C>T (p.Gly853=)

SNV
Germline

Chr16:23629231

Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Reviewed By Expert Panel

CA269540

rs_180177115

12 SubmittersRCV000114536 RCV000116088 RCV000212813 RCV001171467

NM_024675.4(PALB2):c.2586+10A>G

SNV
Germline

Chr16:23629194

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Condition: not provided
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Endometrial carcinoma
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA292645

rs_373321719

15 SubmittersRCV000114537 RCV000127295 RCV000588544 RCV000580770 RCV001118200 RCV001358400 RCV003149782

NM_024675.4(PALB2):c.2674G>A (p.Glu892Lys)

SNV
Germline

Chr16:23626310

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Fanconi anemia complementation group N
not specified
Familial ovarian cancer
Familial cancer of breast
Fanconi anemia complementation group N
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA167879

rs_45476495

22 SubmittersRCV000114549 RCV000131257 RCV000587708 RCV001118198 RCV000483553 RCV003483473 RCV004739374 RCV005016385

NM_024675.4(PALB2):c.2718G>A (p.Trp906Ter)

SNV
Germline

Chr16:23626266

Pathogenic

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Multiple Submitters
No Conflicts

CA269561

rs_180177122

14 SubmittersRCV000114552 RCV000255170 RCV000562748 RCV002498481 RCV004782240 RCV005394374

NM_024675.4(PALB2):c.2749-18C>T

SNV
Germline

Chr16:23624112

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
Breast and/or ovarian cancer
Hereditary breast ovarian cancer syndrome

Criteria Provided
Conflicting Classifications

CA269568

rs_182194007

13 SubmittersRCV000114555 RCV000127298 RCV000212817 RCV000679766 RCV003149784 RCV004764763

NM_024675.4(PALB2):c.2752C>T (p.Pro918Ser)

SNV
Germline

Chr16:23624091

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA192533

rs_515726094

11 SubmittersRCV000114556 RCV000165106 RCV000478088 RCV001171432

NM_024675.4(PALB2):c.2761C>T (p.Gln921Ter)

SNV
Germline

Chr16:23624082

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA269569

rs_180177124

4 SubmittersRCV001030342 RCV003162530

NM_024675.4(PALB2):c.2773G>C (p.Val925Leu)

SNV
Germline

Chr16:23624070

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Condition: not provided
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA164110

rs_180177125

13 SubmittersRCV000114558 RCV000129279 RCV000764047 RCV000235847 RCV001798299

NM_024675.4(PALB2):c.2816T>G (p.Leu939Trp)

SNV
Germline

Chr16:23624027

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
not specified
Malignant tumor of breast
Condition: not provided
PALB2-related disorder
Breast and/or ovarian cancer
Hereditary breast ovarian cancer syndrome

Criteria Provided
Conflicting Classifications

CA151239

rs_45478192

34 SubmittersRCV000114561 RCV000116092 RCV000306515 RCV000417395 RCV001356702 RCV000586156 RCV004528790 RCV001170349 RCV004760375

NM_024675.4(PALB2):c.2835-1G>C

SNV
Germline

Chr16:23623131

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Multiple Submitters
No Conflicts

CA331795

rs_515726099

9 SubmittersRCV000114567 RCV000220116 RCV001171468 RCV004589552 RCV005016386

NM_024675.4(PALB2):c.2851T>C (p.Ser951Pro)

SNV
Germline

Chr16:23623114

Conflicting classifications of pathogenicity

not specified
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA161355

rs_149522412

21 SubmittersRCV000121763 RCV000129725 RCV001030355 RCV000397940 RCV000589520 RCV005359047

NM_024675.4(PALB2):c.2869A>C (p.Lys957Gln)

SNV
Germline

Chr16:23623096

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
not specified

Criteria Provided
Conflicting Classifications

CA299741

rs_515726103

13 SubmittersRCV000114573 RCV000160848 RCV000212818 RCV000764046 RCV003226198

NM_024675.4(PALB2):c.2903C>G (p.Ala968Gly)

SNV
Germline

Chr16:23623062

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA167762

rs_369132015

14 SubmittersRCV000114574 RCV000131197 RCV000215879 RCV001704012 RCV005394375 RCV004545746

NM_024675.4(PALB2):c.298C>T (p.Leu100Phe)

SNV
Germline

Chr16:23636248

Conflicting classifications of pathogenicity

Familial cancer of breast
Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
PALB2-related disorder
Pancreatic cancer, susceptibility to, 3
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA288454

rs_61756147

18 SubmittersRCV000114577 RCV001119843 RCV000116095 RCV000212772 RCV001192907 RCV004528791 RCV001355228 RCV001249253 RCV003492442

NM_024675.4(PALB2):c.3056T>C (p.Val1019Ala)

SNV
Germline

Chr16:23621419

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA168345

rs_376619846

11 SubmittersRCV000114589 RCV000131550 RCV000235226 RCV001192771 RCV005359048

NM_024675.4(PALB2):c.3113G>A (p.Trp1038Ter)

SNV
Germline

Chr16:23621362

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Hereditary breast ovarian cancer syndrome
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Malignant tumor of breast
Breast-ovarian cancer, familial, susceptibility to, 5
Breast and/or ovarian cancer
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
NICE approved PARP inhibitor treatment
Inherited breast cancer and ovarian cancer
Inherited ovarian cancer (without breast cancer)

Reviewed By Expert Panel

CA251004

rs_180177132

34 SubmittersRCV000114591 RCV000116096 RCV000212822 RCV000588093 RCV001171469 RCV001535480 RCV003389455 RCV003492443 RCV004528792 RCV005016387 RCV004577322 RCV004584191 RCV004584192

NM_024675.4(PALB2):c.3128G>C (p.Gly1043Ala)

SNV
Germline

Chr16:23614077

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA168501

rs_377713277

14 SubmittersRCV000114598 RCV000131630 RCV000485289 RCV000780560 RCV002483180

NM_024675.4(PALB2):c.315G>C (p.Glu105Asp)

SNV
Germline

Chr16:23636231

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Hereditary breast ovarian cancer syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA288463

rs_515726108

17 SubmittersRCV000114600 RCV000116099 RCV000212773 RCV001174951 RCV005359049 RCV002490766 RCV004529924

NM_024675.4(PALB2):c.3202-1G>C

SNV
Germline

Chr16:23608013

Pathogenic/Likely pathogenic

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA269608

rs_515726111

9 SubmittersRCV000114605 RCV000160851 RCV002321588

NM_024675.4(PALB2):c.3251C>T (p.Ser1084Leu)

SNV
Germline

Chr16:23607963

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Condition: not provided
Malignant tumor of breast
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
not specified
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA239946

rs_62625271

17 SubmittersRCV000114610 RCV000160852 RCV001116749 RCV000656940 RCV001358132 RCV000764043 RCV003493439 RCV004739377

NM_024675.4(PALB2):c.3256C>T (p.Arg1086Ter)

SNV
Germline

Chr16:23607958

Pathogenic/Likely pathogenic

Pancreatic cancer, susceptibility to, 3
Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome
Malignant tumor of breast
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Gastric cancer
Breast and/or ovarian cancer
Breast-ovarian cancer, familial, susceptibility to, 5
PALB2-related disorder

Criteria Provided
Multiple Submitters
No Conflicts

CA211207

rs_587776527

24 SubmittersRCV000114612 RCV000212825 RCV000160853 RCV000168017 RCV001030644 RCV002307393 RCV005003472 RCV003162531 RCV003149788 RCV003315406 RCV004528793

NM_024675.4(PALB2):c.3307G>A (p.Val1103Met)

SNV
Germline

Chr16:23607907

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome
Condition: not provided
not specified
Breast-ovarian cancer, familial, susceptibility to, 5
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA288475

rs_201657283

16 SubmittersRCV000116103 RCV000114616 RCV001030643 RCV000656941 RCV000212827 RCV005359050 RCV004739378

NM_024675.4(PALB2):c.3321G>A (p.Leu1107=)

SNV
Germline

Chr16:23607893

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA269613

rs_515726113

4 SubmittersRCV001030409 RCV001019988

NM_024675.4(PALB2):c.3350+11A>G

SNV
Germline

Chr16:23607853

Conflicting classifications of pathogenicity

not specified
Familial cancer of breast
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA269616

rs_515726114

5 SubmittersRCV000424366 RCV001030411 RCV002466432

NM_024675.4(PALB2):c.3350+4A>G

SNV
Germline

Chr16:23607860

Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
PALB2-related disorder
PALB2-related cancer predisposition
Malignant tumor of breast

Reviewed By Expert Panel

CA269618

rs_180177136

17 SubmittersRCV000114621 RCV000213830 RCV000433683 RCV003315407 RCV004528794 RCV005359051 RCV004798779

NM_024675.4(PALB2):c.3356T>C (p.Leu1119Pro)

SNV
Germline

Chr16:23603664

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA331796

rs_515726116

8 SubmittersRCV000114623 RCV000481742 RCV000574823 RCV005016389

NM_024675.4(PALB2):c.3428T>A (p.Leu1143His)

SNV
Germline

Chr16:23603592

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
bilateral breast cancer
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
not specified

Criteria Provided
Conflicting Classifications

CA288478

rs_62625284

22 SubmittersRCV000114625 RCV000116104 RCV000585950 RCV001004833 RCV000764041 RCV004528795 RCV005394376 RCV001804169

NM_024675.4(PALB2):c.344G>T (p.Gly115Val)

SNV
Germline

Chr16:23636202

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
PALB2-related disorder
Malignant tumor of breast
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA193686

rs_145598272

14 SubmittersRCV000114628 RCV000165559 RCV000589320 RCV004528796 RCV001357627 RCV003149789

NM_024675.4(PALB2):c.400G>A (p.Asp134Asn)

SNV
Germline

Chr16:23636146

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
Breast and/or ovarian cancer
Hereditary breast ovarian cancer syndrome

Criteria Provided
Conflicting Classifications

CA163622

rs_139555085

17 SubmittersRCV000114637 RCV000128994 RCV000200990 RCV000590187 RCV001798302 RCV002225308

NM_024675.4(PALB2):c.48+1G>C

SNV
Germline

Chr16:23641109

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA269629

rs_515726118

4 SubmittersRCV000213648 RCV000236723 RCV001030106

NM_024675.4(PALB2):c.503C>A (p.Ser168Ter)

SNV
Germline

Chr16:23636043

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA269633

rs_515726122

7 SubmittersRCV000114642 RCV000562468 RCV003332116

NM_024675.4(PALB2):c.505C>A (p.Leu169Ile)

SNV
Germline

Chr16:23636041

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA269636

rs_180177086

3 SubmittersRCV001030154 RCV002336247

NM_024675.4(PALB2):c.53A>G (p.Lys18Arg)

SNV
Germline

Chr16:23638125

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Condition: not provided
Hereditary breast ovarian cancer syndrome

Criteria Provided
Conflicting Classifications

CA161315

rs_138789658

25 SubmittersRCV000114647 RCV000121743 RCV000129207 RCV000376271 RCV000440737 RCV002225309

NM_024675.4(PALB2):c.620C>G (p.Pro207Arg)

SNV
Germline

Chr16:23635926

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA331799

rs_515726125

7 SubmittersRCV000114649 RCV000776330 RCV001572249

NM_024675.4(PALB2):c.629C>T (p.Pro210Leu)

SNV
Germline

Chr16:23635917

Conflicting classifications of pathogenicity

not specified
Breast and/or ovarian cancer
Fanconi anemia complementation group N
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Hereditary breast ovarian cancer syndrome
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA161333

rs_57605939

23 SubmittersRCV000121750 RCV001798303 RCV000306267 RCV000114650 RCV000131969 RCV001705820 RCV002225310 RCV001358034

NM_024675.4(PALB2):c.656A>G (p.Asp219Gly)

SNV
Germline

Chr16:23635890

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Hereditary cancer
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA294094

rs_45594034

19 SubmittersRCV000114652 RCV000129603 RCV000589693 RCV000855601 RCV003492444 RCV004542814 RCV005359053

NM_024675.4(PALB2):c.751C>T (p.Gln251Ter)

SNV
Germline

Chr16:23635795

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast and/or ovarian cancer

Criteria Provided
Multiple Submitters
No Conflicts

CA269645

rs_180177091

16 SubmittersRCV000114657 RCV000210097 RCV000413603 RCV004813057 RCV004796018 RCV003492446

NM_024675.4(PALB2):c.814G>A (p.Glu272Lys)

SNV
Germline

Chr16:23635732

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Condition: not provided

Criteria Provided
Conflicting Classifications

CA193995

rs_515726127

11 SubmittersRCV000114664 RCV000165689 RCV004595926 RCV002483181 RCV003477491

NM_024675.4(PALB2):c.897T>C (p.Ser299=)

SNV
Germline

Chr16:23635649

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome
Condition: not provided
Fanconi anemia complementation group N
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA269660

rs_180177095

11 SubmittersRCV000114668 RCV000419649 RCV000566337 RCV000858848 RCV001118310 RCV001798304

NM_024675.4(PALB2):c.899C>T (p.Thr300Ile)

SNV
Germline

Chr16:23635647

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome
Malignant tumor of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA161336

rs_528541334

14 SubmittersRCV000114669 RCV000121751 RCV000219489 RCV001354467 RCV001284670

NM_024675.4(PALB2):c.94C>G (p.Leu32Val)

SNV
Germline

Chr16:23638084

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
Fanconi anemia complementation group N
Malignant tumor of breast
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA161318

rs_151316635

20 SubmittersRCV000114673 RCV000116117 RCV000121744 RCV000656932 RCV001119845 RCV001357251 RCV004529927 RCV005016391

NM_024675.4(PALB2):c.1240C>T (p.Arg414Ter)

SNV
Germline

Chr16:23635306

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Malignant tumor of breast
Hereditary breast ovarian cancer syndrome
Gastric cancer
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 1
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Multiple Submitters
No Conflicts

CA288395

rs_180177100

29 SubmittersRCV000116064 RCV000123331 RCV000254674 RCV001354096 RCV000588541 RCV003162546 RCV004529946 RCV004555854 RCV004668783 RCV005003478

NM_024675.4(PALB2):c.1347A>G (p.Lys449=)

SNV
Germline

Chr16:23635199

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
not specified

Criteria Provided
Conflicting Classifications

CA288401

rs_587780205

8 SubmittersRCV000116066 RCV000590184 RCV001087089 RCV001356241 RCV001818286

NM_024675.4(PALB2):c.1564C>T (p.Pro522Ser)

SNV
Germline

Chr16:23634982

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA288407

rs_373876101

10 SubmittersRCV000116069 RCV000205286 RCV000563884 RCV001192765 RCV001357507

NM_024675.4(PALB2):c.1697G>A (p.Arg566His)

SNV
Germline

Chr16:23630457

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Breast-ovarian cancer, familial, susceptibility to, 5
Breast-ovarian cancer, familial, susceptibility to, 2
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA288413

rs_144617793

16 SubmittersRCV000116071 RCV000229982 RCV001030254 RCV000564017 RCV005016399 RCV005359104 RCV005623303 RCV004542828

NM_024675.4(PALB2):c.1733G>T (p.Ser578Ile)

SNV
Germline

Chr16:23630421

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA288419

rs_587780207

6 SubmittersRCV000116074 RCV000474485 RCV000567502 RCV002483190

NM_024675.4(PALB2):c.194C>T (p.Pro65Leu)

SNV
Germline

Chr16:23637867

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
not specified
Familial cancer of breast
Condition: not provided
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA161321

rs_62625272

21 SubmittersRCV000116075 RCV000121745 RCV000168167 RCV000585283 RCV001030125

NM_024675.4(PALB2):c.1987C>T (p.Arg663Cys)

SNV
Germline

Chr16:23630167

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
not specified
Familial pancreatic carcinoma

Criteria Provided
Conflicting Classifications

CA288422

rs_62625277

12 SubmittersRCV000116076 RCV000212804 RCV000410272 RCV002509225 RCV005365003

NM_024675.4(PALB2):c.2078A>G (p.His693Arg)

SNV
Germline

Chr16:23630076

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA288425

rs_587780208

4 SubmittersRCV000116077 RCV000576106 RCV000467228

NM_024675.4(PALB2):c.2230G>A (p.Glu744Lys)

SNV
Germline

Chr16:23629924

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA288438

rs_62625278

8 SubmittersRCV000116082 RCV000234885 RCV000635763 RCV002265611

NM_024675.4(PALB2):c.2379C>T (p.Gly793=)

SNV
Germline

Chr16:23629775

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Familial cancer of breast
Condition: not provided
not specified
Malignant tumor of breast
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA288444

rs_377626805

16 SubmittersRCV000116084 RCV000292657 RCV000200135 RCV000212811 RCV000780574 RCV001354155 RCV004542829

NM_024675.4(PALB2):c.2509G>A (p.Glu837Lys)

SNV
Germline

Chr16:23629645

Conflicting classifications of pathogenicity

not specified
Hereditary cancer-predisposing syndrome
Condition: not provided
Fanconi anemia complementation group N
Familial cancer of breast
Breast and/or ovarian cancer
Hereditary breast ovarian cancer syndrome
PALB2-related disorder
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA161349

rs_587778587

19 SubmittersRCV000121758 RCV000116087 RCV000656936 RCV000318539 RCV000989556 RCV001798359 RCV001030647 RCV004529947 RCV001356207

NM_024675.4(PALB2):c.2846G>A (p.Cys949Tyr)

SNV
Germline

Chr16:23623119

Conflicting classifications of pathogenicity

not specified
Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA161352

rs_587778588

8 SubmittersRCV000121761 RCV000635686 RCV000656938 RCV001804846 RCV005016400

NM_024675.4(PALB2):c.2897T>C (p.Ile966Thr)

SNV
Germline

Chr16:23623068

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Triple-negative breast cancer
Condition: not provided
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N
not specified
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA210470

rs_587780214

18 SubmittersRCV000116094 RCV000204848 RCV000202384 RCV000212819 RCV000764045 RCV002267857 RCV004760383

NM_024675.4(PALB2):c.3132A>C (p.Gln1044His)

SNV
Germline

Chr16:23614073

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA288460

rs_587780216

3 SubmittersRCV000116098 RCV000454267 RCV000635880

NM_024675.4(PALB2):c.353T>C (p.Ile118Thr)

SNV
Germline

Chr16:23636193

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA288485

rs_370404126

10 SubmittersRCV000116107 RCV000212774 RCV000211074 RCV002222397

NM_024675.4(PALB2):c.3549C>A (p.Tyr1183Ter)

SNV
Germline

Chr16:23603471

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome
Condition: not provided
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 1
PALB2-related disorder
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N

Reviewed By Expert Panel

CA288488

rs_118203998

22 SubmittersRCV000116108 RCV000200012 RCV000587765 RCV000212831 RCV000763376 RCV003493446 RCV004528809 RCV005394394

NM_024675.4(PALB2):c.551G>C (p.Ser184Thr)

SNV
Germline

Chr16:23635995

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA288489

rs_587780220

5 SubmittersRCV000116109 RCV000559113 RCV001024216 RCV002498499

NM_024675.4(PALB2):c.571C>G (p.Pro191Ala)

SNV
Germline

Chr16:23635975

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA288492

rs_587780221

5 SubmittersRCV000116110 RCV000211086 RCV000774642

NM_024675.4(PALB2):c.856C>T (p.Pro286Ser)

SNV
Germline

Chr16:23635690

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Condition: not provided
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA288495

rs_45585833

9 SubmittersRCV000567956 RCV000410687 RCV001174832 RCV000766543 RCV005394395

NM_024675.4(PALB2):c.928A>G (p.Ser310Gly)

SNV
Germline

Chr16:23635618

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Malignant tumor of breast
not specified
Breast and/or ovarian cancer
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA288501

rs_45561331

12 SubmittersRCV000116115 RCV000200242 RCV000212782 RCV001354315 RCV001290583 RCV003149811 RCV004528810

NM_024675.4(PALB2):c.949A>C (p.Thr317Pro)

SNV
Germline

Chr16:23635597

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA288504

rs_587780223

8 SubmittersRCV000116116 RCV000212783 RCV000472765 RCV002483191

NM_024675.4(PALB2):c.1054G>C (p.Glu352Gln)

SNV
Germline

Chr16:23635492

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA167241

rs_201035780

10 SubmittersRCV000119209 RCV000130853 RCV000858055 RCV001356550

NM_024675.4(PALB2):c.2456A>G (p.Lys819Arg)

SNV
Germline

Chr16:23629698

Conflicting classifications of pathogenicity

not specified
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA161343

rs_587778585

10 SubmittersRCV000121755 RCV000129773 RCV000410682 RCV000657026

NM_024675.4(PALB2):c.2258G>A (p.Arg753Gln)

SNV
Germline

Chr16:23629896

Conflicting classifications of pathogenicity

not specified
Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA161346

rs_587778586

14 SubmittersRCV000121757 RCV000195647 RCV000588075 RCV000561765

NM_024675.4(PALB2):c.12T>C (p.Pro4=)

SNV
Germline

Chr16:23641146

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA299688

rs_567706422

14 SubmittersRCV000123332 RCV000160826 RCV000212765 RCV000858740 RCV001121824

NM_024675.4(PALB2):c.1637T>C (p.Val546Ala)

SNV
Germline

Chr16:23634909

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
PALB2-related disorder
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA332967

rs_148647206

9 SubmittersRCV000123333 RCV000215046 RCV000589758 RCV004739425 RCV002492444

NM_024675.4(PALB2):c.2087C>T (p.Thr696Met)

SNV
Germline

Chr16:23630067

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA170045

rs_587780820

11 SubmittersRCV000123336 RCV000132543 RCV001030277 RCV004530058 RCV005016426 RCV003492552

NM_024675.4(PALB2):c.2289G>C (p.Leu763Phe)

SNV
Germline

Chr16:23629865

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
Malignant tumor of breast
Breast and/or ovarian cancer
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA294144

rs_373478248

22 SubmittersRCV000123338 RCV000130052 RCV000212808 RCV000587948 RCV001357632 RCV001798407 RCV004528842

NM_024675.4(PALB2):c.2571G>A (p.Leu857=)

SNV
Germline

Chr16:23629219

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA332973

rs_587780821

6 SubmittersRCV000123339 RCV000486288 RCV000560973 RCV001535717

NM_024675.4(PALB2):c.2753C>A (p.Pro918Gln)

SNV
Germline

Chr16:23624090

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA332974

rs_587780822

10 SubmittersRCV000123341 RCV000220315 RCV000507163 RCV001546031 RCV004739426

NM_024675.4(PALB2):c.722A>G (p.Asn241Ser)

SNV
Germline

Chr16:23635824

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA168406

rs_587780823

5 SubmittersRCV000123343 RCV000131587

NM_024675.4(PALB2):c.769G>A (p.Gly257Ser)

SNV
Germline

Chr16:23635777

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Breast-ovarian cancer, familial, susceptibility to, 5
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
PALB2-related disorder
Condition: not provided

Criteria Provided
Conflicting Classifications

CA194606

rs_587780824

9 SubmittersRCV000123344 RCV000165945 RCV003226206 RCV003492553 RCV005394457 RCV004530060 RCV004589611

NM_024675.4(PALB2):c.1697G>C (p.Arg566Pro)

SNV
Germline

Chr16:23630457

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA163866

rs_144617793

7 SubmittersRCV000129134 RCV001775617 RCV000476315 RCV005394468

NM_024675.4(PALB2):c.2712G>A (p.Trp904Ter)

SNV
Germline

Chr16:23626272

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA164329

rs_587781457

6 SubmittersRCV000129390 RCV000485246 RCV000799015

NM_024675.4(PALB2):c.2417C>T (p.Pro806Leu)

SNV
Germline

Chr16:23629737

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Pancreatic cancer, susceptibility to, 3
Breast and/or ovarian cancer
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA164360

rs_45464991

12 SubmittersRCV000129403 RCV000204760 RCV000235688 RCV001192769 RCV001030305 RCV003149891 RCV001355012

NM_024675.4(PALB2):c.438A>C (p.Arg146Ser)

SNV
Germline

Chr16:23636108

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA294070

rs_587781498

8 SubmittersRCV000129467 RCV000212775 RCV000410126

NM_024675.4(PALB2):c.2743G>A (p.Ala915Thr)

SNV
Germline

Chr16:23626241

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Diffuse midline glioma, H3 K27-altered
PALB2-related disorder
Malignant tumor of breast
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA164485

rs_374736398

11 SubmittersRCV000129474 RCV000471567 RCV000481045 RCV003315231 RCV004545873 RCV001355149 RCV005600709

NM_024675.4(PALB2):c.3508C>T (p.His1170Tyr)

SNV
Germline

Chr16:23603512

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA294118

rs_200283306

20 SubmittersRCV000129794 RCV000226949 RCV000212829 RCV001818304 RCV004760389 RCV005359213

NM_024675.4(PALB2):c.3201+1G>T

SNV
Germline

Chr16:23614003

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA165631

rs_587776423

4 SubmittersRCV000130058 RCV001206798

NM_024675.4(PALB2):c.1955G>A (p.Ser652Asn)

SNV
Germline

Chr16:23630199

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Hereditary breast ovarian cancer syndrome
Endometrial carcinoma
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA165693

rs_587781818

11 SubmittersRCV000130094 RCV000226926 RCV000302799 RCV001030649 RCV001358211 RCV000842453 RCV001030271

NM_024675.4(PALB2):c.1364A>G (p.Asn455Ser)

SNV
Germline

Chr16:23635182

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA294158

rs_587781824

7 SubmittersRCV000130104 RCV000409652 RCV000212792 RCV001116859

NM_024675.4(PALB2):c.3044C>T (p.Thr1015Ile)

SNV
Germline

Chr16:23621431

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA165765

rs_367840862

7 SubmittersRCV000130130 RCV000236113 RCV000781686 RCV000689784

NM_024675.4(PALB2):c.1042C>A (p.Gln348Lys)

SNV
Germline

Chr16:23635504

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Chordoma
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA165871

rs_375699023

12 SubmittersRCV000130172 RCV000232741 RCV000589687 RCV001251061 RCV002266924 RCV004739441

NM_024675.4(PALB2):c.1756G>A (p.Asp586Asn)

SNV
Germline

Chr16:23630398

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA166193

rs_587781954

10 SubmittersRCV000130326 RCV000411835 RCV000481375 RCV000764051 RCV001798444

NM_024675.4(PALB2):c.563C>G (p.Ala188Gly)

SNV
Germline

Chr16:23635983

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Condition: not provided

Criteria Provided
Conflicting Classifications

CA166273

rs_587781975

7 SubmittersRCV000130368 RCV000168329 RCV001818311 RCV004791275

NM_024675.4(PALB2):c.424A>T (p.Lys142Ter)

SNV
Germline

Chr16:23636122

Pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
PALB2-related disorder
Malignant tumor of breast
Breast cancer, susceptibility to

Criteria Provided
Multiple Submitters
No Conflicts

CA166400

rs_587782005

14 SubmittersRCV000130421 RCV000412725 RCV000476449 RCV003387508 RCV001357166 RCV002251434

NM_024675.4(PALB2):c.3146T>C (p.Met1049Thr)

SNV
Germline

Chr16:23614059

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Malignant tumor of breast
not specified
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA166426

rs_138273800

18 SubmittersRCV000130431 RCV000204730 RCV000482622 RCV001355887 RCV001194140 RCV002505109 RCV003389456 RCV003444205 RCV004544294

NM_024675.4(PALB2):c.3476G>A (p.Trp1159Ter)

SNV
Germline

Chr16:23603544

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA166575

rs_587782050

3 SubmittersRCV000130518 RCV003453075

NM_024675.4(PALB2):c.2521A>G (p.Thr841Ala)

SNV
Germline

Chr16:23629269

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA166713

rs_368990417

2 SubmittersRCV000130589 RCV000470365

NM_024675.4(PALB2):c.3307G>C (p.Val1103Leu)

SNV
Germline

Chr16:23607907

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast and/or ovarian cancer
not specified
Ovarian cancer

Criteria Provided
Conflicting Classifications

CA166991

rs_201657283

12 SubmittersRCV000130728 RCV000226292 RCV000483048 RCV000764042 RCV003149901 RCV001194142 RCV003153422

NM_024675.4(PALB2):c.557A>T (p.Asn186Ile)

SNV
Germline

Chr16:23635989

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
not specified

Criteria Provided
Conflicting Classifications

CA167050

rs_587782164

12 SubmittersRCV000130756 RCV000197454 RCV000588642 RCV003315411 RCV002478396 RCV004595933

NM_024675.4(PALB2):c.3257G>A (p.Arg1086Gln)

SNV
Germline

Chr16:23607957

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Hereditary breast ovarian cancer syndrome
PALB2-related disorder
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA294240

rs_146377793

17 SubmittersRCV000130835 RCV000203792 RCV000590502 RCV000855603 RCV002225436 RCV004739448 RCV005016447

NM_024675.4(PALB2):c.1189A>T (p.Thr397Ser)

SNV
Germline

Chr16:23635357

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast and/or ovarian cancer
Familial ovarian cancer
Inherited breast cancer and ovarian cancer
not specified
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA294249

rs_367578415

15 SubmittersRCV000130855 RCV000205533 RCV000586638 RCV003149904 RCV003447500 RCV004584197 RCV002267878 RCV005359248

NM_024675.4(PALB2):c.1127G>C (p.Ser376Thr)

SNV
Germline

Chr16:23635419

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA167264

rs_587782200

5 SubmittersRCV000130860 RCV000465244 RCV003159104

NM_024675.4(PALB2):c.2947A>T (p.Thr983Ser)

SNV
Germline

Chr16:23623018

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA167318

rs_587782211

5 SubmittersRCV000130889 RCV000206313 RCV000522868

NM_024675.4(PALB2):c.734C>T (p.Ala245Val)

SNV
Germline

Chr16:23635812

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
not specified
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA167345

rs_571063157

12 SubmittersRCV000130900 RCV000483902 RCV000200032 RCV001030168 RCV003315412 RCV005394483

NM_024675.4(PALB2):c.3492G>T (p.Trp1164Cys)

SNV
Germline

Chr16:23603528

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA167348

rs_587782217

7 SubmittersRCV000130901 RCV000412141 RCV000487310 RCV004551258

NM_024675.4(PALB2):c.2619T>G (p.Ser873Arg)

SNV
Germline

Chr16:23626365

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
Familial ovarian cancer

Criteria Provided
Conflicting Classifications

CA168079

rs_587782387

13 SubmittersRCV000199659 RCV000131395 RCV000507756 RCV001281710 RCV001357530

NM_024675.4(PALB2):c.2257C>T (p.Arg753Ter)

SNV
Germline

Chr16:23629897

Pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Hereditary breast ovarian cancer syndrome
Malignant tumor of breast
Fanconi anemia complementation group N
Gastric cancer
Breast and/or ovarian cancer
Breast-ovarian cancer, familial, susceptibility to, 5
PALB2-related disorder

Criteria Provided
Multiple Submitters
No Conflicts

CA168247

rs_180177110

26 SubmittersRCV000131502 RCV000236519 RCV000466579 RCV000824730 RCV001264577 RCV001781472 RCV003162588 RCV003492624 RCV004597749 RCV004739453

NM_024675.4(PALB2):c.1258C>T (p.Gln420Ter)

SNV
Germline

Chr16:23635288

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA168278

rs_587782446

5 SubmittersRCV000131515 RCV000529684 RCV000657737

NM_024675.4(PALB2):c.18G>T (p.Gly6=)

SNV
Germline

Chr16:23641140

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA168342

rs_587782462

15 SubmittersRCV000131549 RCV000432017 RCV000557471 RCV002265620

NM_024675.4(PALB2):c.3320T>C (p.Leu1107Pro)

SNV
Germline

Chr16:23607894

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Breast-ovarian cancer, familial, susceptibility to, 5
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA168427

rs_149194681

12 SubmittersRCV000131597 RCV000204289 RCV000235261 RCV001818326 RCV003315413 RCV005394489

NM_024675.4(PALB2):c.10C>T (p.Pro4Ser)

SNV
Germline

Chr16:23641148

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA294407

rs_587782483

8 SubmittersRCV000131600 RCV000205368 RCV004696852

NM_024675.4(PALB2):c.3296C>G (p.Thr1099Arg)

SNV
Germline

Chr16:23607918

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
not specified
Familial cancer of breast
Condition: not provided
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Hereditary breast ovarian cancer syndrome

Criteria Provided
Conflicting Classifications

CA168538

rs_142132127

23 SubmittersRCV000131652 RCV000235868 RCV000410212 RCV000657014 RCV001294230 RCV002478400 RCV005359278 RCV005411346

NM_024675.4(PALB2):c.3350+5G>A

SNV
Germline

Chr16:23607859

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Condition: not provided
PALB2-related disorder
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N

Criteria Provided
Multiple Submitters
No Conflicts

CA168760

rs_587782566

14 SubmittersRCV000131789 RCV000526519 RCV001824643 RCV005359282 RCV004998280 RCV004739459 RCV004796031

NM_024675.4(PALB2):c.2557G>A (p.Gly853Ser)

SNV
Germline

Chr16:23629233

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA168790

rs_587782579

10 SubmittersRCV000131807 RCV000230627 RCV000483722 RCV001800443 RCV002478401

NM_024675.4(PALB2):c.740C>G (p.Thr247Arg)

SNV
Germline

Chr16:23635806

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA169202

rs_587782658

9 SubmittersRCV000132073 RCV000211087 RCV000588870

NM_024675.4(PALB2):c.2608G>A (p.Val870Ile)

SNV
Germline

Chr16:23626376

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
not specified
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA294480

rs_376641234

12 SubmittersRCV000132122 RCV000212815 RCV000227189 RCV000656937

NM_024675.4(PALB2):c.2401G>A (p.Asp801Asn)

SNV
Germline

Chr16:23629753

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
See cases

Criteria Provided
Conflicting Classifications

CA169572

rs_587782765

8 SubmittersRCV000167989 RCV000132292 RCV001570317 RCV002251997

NM_024675.4(PALB2):c.292A>G (p.Ile98Val)

SNV
Germline

Chr16:23636254

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Hereditary breast ovarian cancer syndrome

Criteria Provided
Conflicting Classifications

CA169811

rs_587782831

8 SubmittersRCV000132416 RCV000471839 RCV001753518 RCV002225448

NM_024675.4(PALB2):c.2852C>T (p.Ser951Phe)

SNV
Germline

Chr16:23623113

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Malignant tumor of breast
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA170010

rs_587782889

5 SubmittersRCV000132527 RCV000590893 RCV000535908

NM_024675.4(PALB2):c.995T>A (p.Leu332His)

SNV
Germline

Chr16:23635551

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA170038

rs_377149139

13 SubmittersRCV000132538 RCV000199494 RCV000589127 RCV001354291

NM_024675.4(PALB2):c.1108C>T (p.Gln370Ter)

SNV
Germline

Chr16:23635438

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA294547

rs_587776411

8 SubmittersRCV000133472 RCV001030200 RCV001525190

NM_024675.4(PALB2):c.1571C>G (p.Ser524Ter)

SNV
Germline

Chr16:23634975

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA294552

rs_587776413

8 SubmittersRCV000133475 RCV000701075 RCV000454158

NM_024675.4(PALB2):c.2074C>T (p.Gln692Ter)

SNV
Germline

Chr16:23630080

Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Reviewed By Expert Panel

CA294556

rs_587776415

9 SubmittersRCV000133477 RCV000562385 RCV001030275 RCV003155925

NM_024675.4(PALB2):c.2834+1G>T

SNV
Germline

Chr16:23624008

Pathogenic/Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Multiple Submitters
No Conflicts

CA294560

rs_587776419

9 SubmittersRCV000133481 RCV000567638 RCV000411304 RCV000763377

NM_024675.4(PALB2):c.3201+1G>C

SNV
Germline

Chr16:23614003

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA191641

rs_587776423

10 SubmittersRCV000164723 RCV000230297 RCV000133485

NM_024675.4(PALB2):c.451C>T (p.Gln151Ter)

SNV
Germline

Chr16:23636095

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA294565

rs_587776407

9 SubmittersRCV000133491 RCV000456418 RCV000576041 RCV004586565

NM_024675.4(PALB2):c.48G>A (p.Lys16=)

SNV
Germline

Chr16:23641110

Pathogenic/Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Multiple Submitters
No Conflicts

CA294568

rs_587776405

8 SubmittersRCV000133492 RCV000566830 RCV001030105 RCV004796039

NM_024675.4(PALB2):c.3404G>A (p.Gly1135Glu)

SNV
Germline

Chr16:23603616

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Carcinoma of colon
not specified
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA299753

rs_730881894

12 SubmittersRCV000232726 RCV000589198 RCV000570480 RCV001030415 RCV000855602 RCV002492638

NM_024675.4(PALB2):c.3278T>C (p.Ile1093Thr)

SNV
Germline

Chr16:23607936

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Malignant tumor of breast
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA299750

rs_45616636

9 SubmittersRCV000160854 RCV000197231 RCV000223658 RCV001357444 RCV003483530

NM_024675.4(PALB2):c.3235G>T (p.Ala1079Ser)

SNV
Germline

Chr16:23607979

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA299697

rs_730881878

12 SubmittersRCV000160829 RCV000543305 RCV000564254 RCV001797644 RCV005359383

NM_024675.4(PALB2):c.3202-8G>T

SNV
Germline

Chr16:23608020

Conflicting classifications of pathogenicity

not specified
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Hereditary breast ovarian cancer syndrome
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA299680

rs_367979106

7 SubmittersRCV000160822 RCV000476584 RCV000580700 RCV001284321 RCV005359382 RCV001798556

NM_024675.4(PALB2):c.3202-8G>A

SNV
Germline

Chr16:23608020

Conflicting classifications of pathogenicity

not specified
Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA299679

rs_367979106

7 SubmittersRCV000160821 RCV000488296 RCV001081288 RCV000579984

NM_024675.4(PALB2):c.2922G>T (p.Lys974Asn)

SNV
Germline

Chr16:23623043

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA299744

rs_730881892

11 SubmittersRCV000160849 RCV000566246 RCV000205333 RCV002267894 RCV001355089

NM_024675.4(PALB2):c.2834+1G>A

SNV
Germline

Chr16:23624008

Pathogenic/Likely pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Malignant tumor of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA299740

rs_587776419

9 SubmittersRCV000160847 RCV000635960 RCV001016726 RCV001268941 RCV002478488

NM_024675.4(PALB2):c.2699C>T (p.Ala900Val)

SNV
Germline

Chr16:23626285

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA299734

rs_730881890

7 SubmittersRCV000160844 RCV000216145 RCV000555792 RCV002485001 RCV005394561

NM_024675.4(PALB2):c.2353C>T (p.Pro785Ser)

SNV
Germline

Chr16:23629801

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Hereditary cancer

Criteria Provided
Conflicting Classifications

CA299731

rs_730881889

7 SubmittersRCV000160842 RCV000460019 RCV001015124 RCV004700497

NM_024675.4(PALB2):c.2329G>A (p.Asp777Asn)

SNV
Germline

Chr16:23629825

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA299728

rs_148026749

8 SubmittersRCV000160841 RCV000204167 RCV000212809

NM_024675.4(PALB2):c.2229T>A (p.Tyr743Ter)

SNV
Germline

Chr16:23629925

Pathogenic/Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA299725

rs_730881888

6 SubmittersRCV000160839 RCV002426793 RCV004992040 RCV002466252

NM_024675.4(PALB2):c.2128A>G (p.Thr710Ala)

SNV
Germline

Chr16:23630026

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA299722

rs_730881887

12 SubmittersRCV000160838 RCV000232377 RCV000569204 RCV000780572 RCV002485000 RCV004535048

NM_024675.4(PALB2):c.2106A>G (p.Ile702Met)

SNV
Germline

Chr16:23630048

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA299719

rs_730881886

10 SubmittersRCV000160837 RCV000211076 RCV000212805

NM_024675.4(PALB2):c.2020G>A (p.Asp674Asn)

SNV
Germline

Chr16:23630134

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA299716

rs_730881885

6 SubmittersRCV000160836 RCV000217309 RCV000548729 RCV002505195

NM_024675.4(PALB2):c.1724G>A (p.Trp575Ter)

SNV
Germline

Chr16:23630430

Pathogenic/Likely pathogenic

Condition: not provided
Familial cancer of breast
Hereditary breast ovarian cancer syndrome
PALB2-related disorder
Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA299691

rs_730881876

11 SubmittersRCV000160827 RCV001238865 RCV003155926 RCV004724950 RCV001781504 RCV000771400

NM_024675.4(PALB2):c.1610C>T (p.Ser537Leu)

SNV
Germline

Chr16:23634936

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Carcinoma of colon
Fanconi anemia complementation group N
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA299796

rs_142103232

14 SubmittersRCV000160871 RCV000168207 RCV000220923 RCV001030240 RCV001121722 RCV004535051

NM_024675.4(PALB2):c.1492G>T (p.Asp498Tyr)

SNV
Germline

Chr16:23635054

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Fanconi anemia complementation group N
Hereditary breast ovarian cancer syndrome
Condition: not provided
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA185966

rs_75023630

14 SubmittersRCV000160870 RCV000197379 RCV000200991 RCV000368837 RCV001030650 RCV000858743 RCV001356483

NM_024675.4(PALB2):c.1471G>C (p.Ala491Pro)

SNV
Germline

Chr16:23635075

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA299793

rs_577969558

7 SubmittersRCV000160869 RCV000216241 RCV000635626 RCV002485002 RCV004535050

NM_024675.4(PALB2):c.1407C>G (p.Cys469Trp)

SNV
Germline

Chr16:23635139

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA299710

rs_730881883

5 SubmittersRCV000160834 RCV000810010 RCV000571438

NM_024675.4(PALB2):c.1400G>A (p.Gly467Asp)

SNV
Germline

Chr16:23635146

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA299790

rs_730881906

5 SubmittersRCV000160868 RCV000212793 RCV000549785

NM_024675.4(PALB2):c.1156A>G (p.Thr386Ala)

SNV
Germline

Chr16:23635390

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA299787

rs_148102335

6 SubmittersRCV000160867 RCV000773131 RCV002492639 RCV000528086

NM_024675.4(PALB2):c.688G>T (p.Glu230Ter)

SNV
Germline

Chr16:23635858

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA299784

rs_730881905

8 SubmittersRCV000160866 RCV000471920 RCV000561729

NM_024675.4(PALB2):c.587G>A (p.Arg196Lys)

SNV
Germline

Chr16:23635959

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA299781

rs_730881904

7 SubmittersRCV000160865 RCV000216462 RCV000228567 RCV004535049

NM_024675.4(PALB2):c.397A>G (p.Ser133Gly)

SNV
Germline

Chr16:23636149

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA299704

rs_730881881

6 SubmittersRCV000227552 RCV000587887 RCV000454193

NM_024675.4(PALB2):c.212-2A>G

SNV
Germline

Chr16:23636336

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N
Fanconi anemia complementation group N
PALB2-related disorder
Hereditary breast ovarian cancer syndrome

Criteria Provided
Conflicting Classifications

CA299700

rs_730881879

13 SubmittersRCV000160830 RCV000206312 RCV000213220 RCV002498799 RCV001781505 RCV004739509 RCV004800300

NM_024675.4(PALB2):c.161A>G (p.Glu54Gly)

SNV
Germline

Chr16:23637900

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA299763

rs_730881898

5 SubmittersRCV000160859 RCV000212769 RCV000463943 RCV000780564

NM_024675.4(PALB2):c.109-2A>G

SNV
Germline

Chr16:23637954

Pathogenic/Likely pathogenic

Condition: not provided
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA299762

rs_730881897

9 SubmittersRCV000160858 RCV005016482 RCV000572657 RCV000803061

NM_024675.4(PALB2):c.43G>T (p.Glu15Ter)

SNV
Germline

Chr16:23641115

Pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA299713

rs_730881884

6 SubmittersRCV000160835 RCV000567534 RCV001036521

NM_024675.4(PALB2):c.-5G>T

SNV
Germline

Chr16:23641162

Conflicting classifications of pathogenicity

not specified
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA299687

rs_730881875

3 SubmittersRCV000160825 RCV000561746

NM_024675.4(PALB2):c.3545T>C (p.Val1182Ala)

SNV
Germline

Chr16:23603475

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA196999

rs_747149179

4 SubmittersRCV000166908 RCV000548591

NM_024675.4(PALB2):c.3244A>G (p.Ser1082Gly)

SNV
Germline

Chr16:23607970

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Condition: not provided

Criteria Provided
Conflicting Classifications

CA196312

rs_786203345

8 SubmittersRCV000166614 RCV000232382 RCV002505212 RCV004998351

NM_024675.4(PALB2):c.3114-5C>T

SNV
Germline

Chr16:23614096

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA198420

rs_753307725

6 SubmittersRCV000167480 RCV000934763 RCV001775654

NM_024675.4(PALB2):c.2986G>T (p.Glu996Ter)

SNV
Germline

Chr16:23622979

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Malignant tumor of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA197777

rs_786203775

6 SubmittersRCV000167226 RCV000227242 RCV000485825 RCV002271440

NM_024675.4(PALB2):c.2792T>G (p.Leu931Arg)

SNV
Germline

Chr16:23624051

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Breast-ovarian cancer, familial, susceptibility to, 5
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA196017

rs_773831304

16 SubmittersRCV000166492 RCV000408812 RCV000483646 RCV002298494 RCV003389046 RCV001354782

NM_024675.4(PALB2):c.2782G>A (p.Val928Met)

SNV
Germline

Chr16:23624061

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA192592

rs_771288520

3 SubmittersRCV000165137 RCV002516474

NM_024675.4(PALB2):c.2748+1G>T

SNV
Germline

Chr16:23626235

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA193676

rs_753153576

12 SubmittersRCV000165555 RCV000635768 RCV000487378 RCV003155927

NM_024675.4(PALB2):c.2662A>T (p.Ile888Leu)

SNV
Germline

Chr16:23626322

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA192991

rs_786202468

4 SubmittersRCV000165291 RCV000456550 RCV002284368

NM_024675.4(PALB2):c.2474G>C (p.Arg825Thr)

SNV
Germline

Chr16:23629680

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5
Endometrial carcinoma

Criteria Provided
Conflicting Classifications

CA192462

rs_146218439

13 SubmittersRCV000165079 RCV000236812 RCV000780569 RCV001086620 RCV005359498 RCV001256975

NM_024675.4(PALB2):c.2453T>C (p.Phe818Ser)

SNV
Germline

Chr16:23629701

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Hereditary cancer

Criteria Provided
Conflicting Classifications

CA186194

rs_370908330

7 SubmittersRCV000162394 RCV000476189 RCV004589674 RCV005235052

NM_024675.4(PALB2):c.2356C>T (p.His786Tyr)

SNV
Germline

Chr16:23629798

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
not specified
Condition: not provided
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA197222

rs_786203608

10 SubmittersRCV000166996 RCV000226421 RCV002505215 RCV003321534 RCV001566992 RCV003129793

NM_024675.4(PALB2):c.2344C>T (p.Pro782Ser)

SNV
Germline

Chr16:23629810

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Malignant tumor of breast
not specified
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA196135

rs_786203296

11 SubmittersRCV000166543 RCV000470017 RCV000478256 RCV001355915 RCV003479039 RCV002492670

NM_024675.4(PALB2):c.2336C>G (p.Ser779Ter)

SNV
Germline

Chr16:23629818

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Hereditary breast ovarian cancer syndrome
PALB2-related disorder
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA194883

rs_764509489

11 SubmittersRCV000457524 RCV000166057 RCV003226227 RCV004528915 RCV000480723

NM_024675.4(PALB2):c.2277A>G (p.Gln759=)

SNV
Germline

Chr16:23629877

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Fanconi anemia complementation group N
Breast and/or ovarian cancer
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA193209

rs_786202524

11 SubmittersRCV000165372 RCV000472744 RCV000614133 RCV001119745 RCV003150021 RCV004535111

NM_024675.4(PALB2):c.2228A>T (p.Tyr743Phe)

SNV
Germline

Chr16:23629926

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA191248

rs_141749524

2 SubmittersRCV000164551 RCV000698708

NM_024675.4(PALB2):c.2228A>G (p.Tyr743Cys)

SNV
Germline

Chr16:23629926

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
not specified
Hereditary breast ovarian cancer syndrome
Breast and/or ovarian cancer
Familial pancreatic carcinoma
Familial cancer of breast
Condition: not provided
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA189784

rs_141749524

13 SubmittersRCV000164010 RCV000781684 RCV001030648 RCV003150010 RCV005359455 RCV000197626 RCV000255110 RCV000296163

NM_024675.4(PALB2):c.2134G>C (p.Ala712Pro)

SNV
Germline

Chr16:23630020

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA194955

rs_765942523

5 SubmittersRCV000166087 RCV000459199 RCV002485027

NM_024675.4(PALB2):c.2100A>T (p.Ser700=)

SNV
Germline

Chr16:23630054

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Familial cancer of breast
not specified
Condition: not provided
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA190176

rs_757145884

10 SubmittersRCV000164155 RCV000347505 RCV000200038 RCV000611803 RCV001358505 RCV004539543

NM_024675.4(PALB2):c.2067G>A (p.Ser689=)

SNV
Germline

Chr16:23630087

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Fanconi anemia complementation group N
Condition: not provided
Carcinoma of colon
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA193263

rs_371149159

16 SubmittersRCV000165391 RCV000197495 RCV000420216 RCV001119747 RCV001284030 RCV001356268 RCV004535112

NM_024675.4(PALB2):c.1958G>A (p.Cys653Tyr)

SNV
Germline

Chr16:23630196

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA198426

rs_771246748

3 SubmittersRCV000167483 RCV000456974

NM_024675.4(PALB2):c.1930G>T (p.Gly644Ter)

SNV
Germline

Chr16:23630224

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA192870

rs_786202439

1 SubmittersRCV000165251

NM_024675.4(PALB2):c.1766C>T (p.Thr589Met)

SNV
Germline

Chr16:23630388

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Carcinoma of colon
Malignant tumor of breast
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA198251

rs_773340677

11 SubmittersRCV000167418 RCV000474329 RCV000479496 RCV001175052 RCV001030258 RCV001357624 RCV004739545

NM_024675.4(PALB2):c.1748T>C (p.Leu583Ser)

SNV
Germline

Chr16:23630406

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA195224

rs_587782151

7 SubmittersRCV000166198 RCV000464125 RCV000996241 RCV005230014 RCV005016500

NM_024675.4(PALB2):c.1691A>G (p.Lys564Arg)

SNV
Germline

Chr16:23630463

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA194670

rs_62625276

7 SubmittersRCV000165968 RCV000197146 RCV001030253

NM_024675.4(PALB2):c.1662A>G (p.Glu554=)

SNV
Germline

Chr16:23634884

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA193865

rs_786202692

9 SubmittersRCV000165629 RCV000462332 RCV001567936 RCV003491900

NM_024675.4(PALB2):c.1659C>G (p.His553Gln)

SNV
Germline

Chr16:23634887

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA196924

rs_370318597

4 SubmittersRCV000166875 RCV000547924 RCV001201201

NM_024675.4(PALB2):c.1599T>C (p.Thr533=)

SNV
Germline

Chr16:23634947

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
not specified
PALB2-related disorder
Condition: not provided
Familial pancreatic carcinoma

Criteria Provided
Conflicting Classifications

CA186523

rs_786201088

10 SubmittersRCV000162589 RCV000232866 RCV001121723 RCV001818362 RCV004544477 RCV001704155 RCV005359395

NM_024675.4(PALB2):c.1526G>A (p.Gly509Asp)

SNV
Germline

Chr16:23635020

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA195692

rs_786203176

5 SubmittersRCV000166375 RCV000458684 RCV000765273 RCV002228767

NM_024675.4(PALB2):c.1510G>A (p.Val504Ile)

SNV
Germline

Chr16:23635036

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA196712

rs_771846754

3 SubmittersRCV000166778 RCV000816945

NM_024675.4(PALB2):c.1454C>T (p.Thr485Ile)

SNV
Germline

Chr16:23635092

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Carcinoma of colon

Criteria Provided
Conflicting Classifications

CA193882

rs_786202699

5 SubmittersRCV000165637 RCV000205126 RCV000507136 RCV001030228

NM_024675.4(PALB2):c.1451T>A (p.Leu484Ter)

SNV
Germline

Chr16:23635095

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Generalized hypopigmentation
Basal cell carcinoma
Hereditary breast ovarian cancer syndrome
Familial cancer of breast
Malignant tumor of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA197580

rs_786203714

12 SubmittersRCV000167136 RCV000414940 RCV000587378 RCV001310142 RCV001356904 RCV001543564

NM_024675.4(PALB2):c.1421G>A (p.Ser474Asn)

SNV
Germline

Chr16:23635125

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA190537

rs_786201806

6 SubmittersRCV000164284 RCV000235242 RCV000693357

NM_024675.4(PALB2):c.1408A>G (p.Thr470Ala)

SNV
Germline

Chr16:23635138

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Inherited breast cancer and ovarian cancer
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA191289

rs_150636811

10 SubmittersRCV000164567 RCV000525404 RCV000480806 RCV002265643 RCV005237616 RCV005359480

NM_024675.4(PALB2):c.1379A>G (p.Gln460Arg)

SNV
Germline

Chr16:23635167

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Condition: not provided
Hereditary breast ovarian cancer syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
PALB2-related disorder
not specified

Criteria Provided
Conflicting Classifications

CA196834

rs_749494645

16 SubmittersRCV000166836 RCV000289282 RCV000483813 RCV001030716 RCV000989572 RCV005396492 RCV004739541 RCV000780567

NM_024675.4(PALB2):c.1273G>A (p.Val425Met)

SNV
Germline

Chr16:23635273

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Malignant tumor of breast
Condition: not provided
Breast and/or ovarian cancer
Hereditary breast ovarian cancer syndrome
PALB2-related disorder
not specified

Criteria Provided
Conflicting Classifications

CA197697

rs_576081828

13 SubmittersRCV000167189 RCV000205365 RCV001358598 RCV000236471 RCV003491915 RCV004689644 RCV004539565 RCV001030212

NM_024675.4(PALB2):c.1252A>G (p.Asn418Asp)

SNV
Germline

Chr16:23635294

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA194782

rs_786202943

7 SubmittersRCV000166018 RCV000228629 RCV001775647 RCV005016498

NM_024675.4(PALB2):c.1123C>A (p.Leu375Ile)

SNV
Germline

Chr16:23635423

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA196837

rs_373298267

13 SubmittersRCV000166837 RCV000198293 RCV000236203 RCV001420780 RCV004545875

NM_024675.4(PALB2):c.1097A>G (p.Asn366Ser)

SNV
Germline

Chr16:23635449

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA191737

rs_554849907

6 SubmittersRCV000164773 RCV000204324 RCV005054172 RCV004535105

NM_024675.4(PALB2):c.1093A>G (p.Arg365Gly)

SNV
Germline

Chr16:23635453

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA191954

rs_773001248

8 SubmittersRCV000164864 RCV000486708 RCV000205169 RCV002485020

NM_024675.4(PALB2):c.1030A>G (p.Asn344Asp)

SNV
Germline

Chr16:23635516

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA194420

rs_786202850

4 SubmittersRCV000165880 RCV000230594 RCV004692776

NM_024675.4(PALB2):c.980G>A (p.Cys327Tyr)

SNV
Germline

Chr16:23635566

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA193324

rs_786202550

5 SubmittersRCV000165411 RCV000460541 RCV001836740

NM_024675.4(PALB2):c.950C>T (p.Thr317Ile)

SNV
Germline

Chr16:23635596

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Malignant tumor of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA191811

rs_45548638

8 SubmittersRCV000164806 RCV000200449 RCV001357471 RCV000766544

NM_024675.4(PALB2):c.940C>T (p.Gln314Ter)

SNV
Germline

Chr16:23635606

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA197949

rs_786203821

9 SubmittersRCV000167296 RCV000463323 RCV000523563 RCV000586368

NM_024675.4(PALB2):c.829G>A (p.Asp277Asn)

SNV
Germline

Chr16:23635717

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Carcinoma of colon
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA195935

rs_778309339

9 SubmittersRCV000166462 RCV000235601 RCV000477600 RCV001030179 RCV001336120

NM_024675.4(PALB2):c.813T>A (p.Ser271Arg)

SNV
Germline

Chr16:23635733

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA195966

rs_786203246

9 SubmittersRCV000166472 RCV000556676 RCV001555224 RCV001193465

NM_024675.4(PALB2):c.788A>G (p.Glu263Gly)

SNV
Germline

Chr16:23635758

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA192260

rs_745553724

8 SubmittersRCV000164996 RCV000485489 RCV000233981 RCV005016493

NM_024675.4(PALB2):c.739A>G (p.Thr247Ala)

SNV
Germline

Chr16:23635807

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA195172

rs_786203040

6 SubmittersRCV000166174 RCV000459460 RCV002485029

NM_024675.4(PALB2):c.637G>C (p.Val213Leu)

SNV
Germline

Chr16:23635909

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA198128

rs_786203875

5 SubmittersRCV000167372 RCV000635925 RCV001193467 RCV002485041

NM_024675.4(PALB2):c.495C>T (p.Gly165=)

SNV
Germline

Chr16:23636051

Conflicting classifications of pathogenicity

not specified
Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Bile duct cancer

Criteria Provided
Conflicting Classifications

CA193911

rs_200937538

15 SubmittersRCV000444952 RCV000532734 RCV000679773 RCV000165654 RCV001119841 RCV001357741

NM_024675.4(PALB2):c.266A>G (p.Asp89Gly)

SNV
Germline

Chr16:23636280

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA190463

rs_786201790

2 SubmittersRCV000164258 RCV002517613

NM_024675.4(PALB2):c.101G>T (p.Arg34Leu)

SNV
Germline

Chr16:23638077

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA196241

rs_144944814

9 SubmittersRCV000166587 RCV000456690 RCV000520497 RCV002498826

NM_024675.4(PALB2):c.100C>T (p.Arg34Cys)

SNV
Germline

Chr16:23638078

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Inherited breast cancer and ovarian cancer

Criteria Provided
Conflicting Classifications

CA191499

rs_373483056

14 SubmittersRCV000164663 RCV000199940 RCV000236984 RCV002222417 RCV004808602

NM_024675.4(PALB2):c.36G>A (p.Glu12=)

SNV
Germline

Chr16:23641122

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA192309

rs_760609798

6 SubmittersRCV000165018 RCV000476001 RCV004998329

NM_024675.4(PALB2):c.3106G>C (p.Val1036Leu)

SNV
Germline

Chr16:23621369

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
not specified
Carcinoma of colon
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA334122

rs_756906403

12 SubmittersRCV000168000 RCV000479177 RCV000216674 RCV001731498 RCV001030381 RCV002485044

NM_024675.4(PALB2):c.2835-1G>A

SNV
Germline

Chr16:23623131

Pathogenic/Likely pathogenic

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
PALB2-related disorder

Criteria Provided
Multiple Submitters
No Conflicts

CA334206

rs_515726099

5 SubmittersRCV000168057 RCV000255033 RCV000454148 RCV004528920

NM_024675.4(PALB2):c.1659C>A (p.His553Gln)

SNV
Germline

Chr16:23634887

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA334554

rs_370318597

6 SubmittersRCV000519942 RCV000582233 RCV000168288

NM_024675.4(PALB2):c.1316G>T (p.Gly439Val)

SNV
Germline

Chr16:23635230

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA334035

rs_537258442

13 SubmittersRCV000167944 RCV000588409 RCV000565232 RCV000765276 RCV001818401

NM_024675.4(PALB2):c.1115G>C (p.Ser372Thr)

SNV
Germline

Chr16:23635431

Conflicting classifications of pathogenicity

Familial cancer of breast
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA334752

rs_786204243

4 SubmittersRCV000168425 RCV000765277 RCV000774638

NM_024675.4(PALB2):c.1096A>G (p.Asn366Asp)

SNV
Germline

Chr16:23635450

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Inherited breast cancer and ovarian cancer

Criteria Provided
Conflicting Classifications

CA334083

rs_786204080

6 SubmittersRCV000167975 RCV000774639 RCV004808606

NM_024675.4(PALB2):c.85A>G (p.Ser29Gly)

SNV
Germline

Chr16:23638093

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA333979

rs_776110440

5 SubmittersRCV000167900 RCV000217631 RCV002262763

NM_024675.4(PALB2):c.2505C>T (p.Ser835=)

SNV
Germline

Chr16:23629649

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Malignant tumor of breast
not specified

Criteria Provided
Conflicting Classifications

CA246241

rs_756502783

12 SubmittersRCV000575425 RCV001085109 RCV000724499 RCV001354928 RCV003321538

NM_024675.4(PALB2):c.3538A>G (p.Ile1180Val)

SNV
Germline

Chr16:23603482

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA335883

rs_863224788

10 SubmittersRCV000195715 RCV000216876 RCV000478251 RCV001251265 RCV002492923 RCV005396619

NM_024675.4(PALB2):c.3473A>G (p.His1158Arg)

SNV
Germline

Chr16:23603547

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast and/or ovarian cancer
PALB2-related disorder
Condition: not provided

Criteria Provided
Conflicting Classifications

CA338566

rs_45505500

9 SubmittersRCV000199321 RCV000217762 RCV001798672 RCV004739589 RCV004998415

NM_024675.4(PALB2):c.3448C>T (p.Leu1150Phe)

SNV
Germline

Chr16:23603572

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA337664

rs_863224787

6 SubmittersRCV000198123 RCV000776376 RCV001284322

NM_024675.4(PALB2):c.3260G>A (p.Ser1087Asn)

SNV
Germline

Chr16:23607954

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA336127

rs_863224786

2 SubmittersRCV000196033 RCV001019497

NM_024675.4(PALB2):c.3202-9C>T

SNV
Germline

Chr16:23608021

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Pancreatic cancer, susceptibility to, 3
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA336806

rs_757444247

7 SubmittersRCV000196913 RCV000579396 RCV001354308 RCV001711353 RCV001818478

NM_024675.4(PALB2):c.3103A>G (p.Ile1035Val)

SNV
Germline

Chr16:23621372

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Chordoma

Criteria Provided
Conflicting Classifications

CA336715

rs_863224783

10 SubmittersRCV000196785 RCV000220160 RCV001797063 RCV002266931

NM_024675.4(PALB2):c.2515-1G>C

SNV
Germline

Chr16:23629276

Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA337588

rs_587776417

5 SubmittersRCV000198016 RCV000580827 RCV000985889

NM_024675.4(PALB2):c.2506G>T (p.Val836Phe)

SNV
Germline

Chr16:23629648

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA335985

rs_536644825

5 SubmittersRCV000195841 RCV000584448 RCV001030312

NM_024675.4(PALB2):c.2360C>T (p.Thr787Ile)

SNV
Germline

Chr16:23629794

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Carcinoma of colon
not specified

Criteria Provided
Conflicting Classifications

CA337312

rs_201042302

14 SubmittersRCV000197564 RCV000216753 RCV000236931 RCV001030299 RCV004586620

NM_024675.4(PALB2):c.2176C>T (p.Pro726Ser)

SNV
Germline

Chr16:23629978

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA337127

rs_566813395

6 SubmittersRCV000197340 RCV000569353 RCV001775663 RCV005361158

NM_024675.4(PALB2):c.2140G>A (p.Asp714Asn)

SNV
Germline

Chr16:23630014

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial pancreatic carcinoma

Criteria Provided
Conflicting Classifications

CA335668

rs_45537237

7 SubmittersRCV000195423 RCV000562225 RCV003223619 RCV005361157

NM_024675.4(PALB2):c.1337A>T (p.Asp446Val)

SNV
Germline

Chr16:23635209

Conflicting classifications of pathogenicity

Familial cancer of breast
Retinoblastoma
Condition: not provided
Hereditary cancer-predisposing syndrome
not specified
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA339587

rs_146434474

12 SubmittersRCV000200861 RCV000761148 RCV000255070 RCV000562823 RCV001194137 RCV002492922 RCV004530198 RCV005600809

NM_024675.4(PALB2):c.985C>G (p.Leu329Val)

SNV
Germline

Chr16:23635561

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA336763

rs_863224792

3 SubmittersRCV000196873 RCV001030192 RCV005452958

NM_024675.4(PALB2):c.929G>A (p.Ser310Asn)

SNV
Germline

Chr16:23635617

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
not specified
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA336641

rs_370887726

9 SubmittersRCV000196709 RCV000480147 RCV000570793 RCV004689672 RCV004739590

NM_024675.4(PALB2):c.380A>G (p.His127Arg)

SNV
Germline

Chr16:23636166

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA338916

rs_863224789

6 SubmittersRCV000199860 RCV001804936 RCV001030147

NM_024675.4(PALB2):c.3073G>A (p.Ala1025Thr)

SNV
Germline

Chr16:23621402

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Fanconi anemia complementation group N
not specified
Breast and/or ovarian cancer
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA277851

rs_746872839

12 SubmittersRCV000202108 RCV000213208 RCV000479987 RCV001116750 RCV001174762 RCV003491950 RCV005396622

NM_024675.4(PALB2):c.3350+1G>A

SNV
Germline

Chr16:23607863

Pathogenic/Likely pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA348374

rs_864622192

3 SubmittersRCV000204129

NM_024675.4(PALB2):c.3331C>G (p.Pro1111Ala)

SNV
Germline

Chr16:23607883

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Condition: not provided
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Criteria Provided
Conflicting Classifications

CA350039

rs_864622193

10 SubmittersRCV000222857 RCV000205952 RCV001800527 RCV000587389 RCV002478727 RCV004764779

NM_024675.4(PALB2):c.3271C>T (p.Gln1091Ter)

SNV
Germline

Chr16:23607943

Pathogenic/Likely pathogenic

Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA350661

rs_864622138

5 SubmittersRCV000206656 RCV000708617 RCV004692825

NM_024675.4(PALB2):c.2834+2T>G

SNV
Germline

Chr16:23624007

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA349966

rs_864622481

1 SubmittersRCV000205865

NM_024675.4(PALB2):c.2561A>G (p.Asn854Ser)

SNV
Germline

Chr16:23629229

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA348183

rs_146455175

8 SubmittersRCV000203889 RCV000573572 RCV000679765

NM_024675.4(PALB2):c.1647C>A (p.His549Gln)

SNV
Germline

Chr16:23634899

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
Breast and/or ovarian cancer
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA348236

rs_747842085

11 SubmittersRCV000203956 RCV000219639 RCV000479905 RCV000766620 RCV001798683 RCV005396646

NM_024675.4(PALB2):c.1457A>T (p.Lys486Ile)

SNV
Germline

Chr16:23635089

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA349277

rs_864622291

4 SubmittersRCV000205091 RCV000780561 RCV001030229 RCV002390544

NM_024675.4(PALB2):c.761C>A (p.Ser254Ter)

SNV
Germline

Chr16:23635785

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA350807

rs_864622695

2 SubmittersRCV000206812 RCV002390551

NM_024675.4(PALB2):c.508A>G (p.Arg170Gly)

SNV
Germline

Chr16:23636038

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA349481

rs_864622622

8 SubmittersRCV000205323 RCV000215139 RCV000484020 RCV003114369

NM_024675.4(PALB2):c.398G>T (p.Ser133Ile)

SNV
Germline

Chr16:23636148

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA348953

rs_864622411

5 SubmittersRCV000204748 RCV000575642 RCV005016566 RCV005361185

NM_024675.4(PALB2):c.226A>G (p.Ile76Val)

SNV
Germline

Chr16:23636320

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Carcinoma of colon
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
not specified

Criteria Provided
Conflicting Classifications

CA348162

rs_541028076

8 SubmittersRCV000203860 RCV000223229 RCV000590079 RCV001030134 RCV005016565 RCV001526861

NM_024675.4(PALB2):c.149A>C (p.Lys50Thr)

SNV
Germline

Chr16:23637912

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome
Condition: not provided
Breast and/or ovarian cancer
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA349816

rs_763598472

13 SubmittersRCV000205692 RCV000236334 RCV000221595 RCV000656934 RCV003491955 RCV001357513

NM_024675.4(PALB2):c.109C>T (p.Arg37Cys)

SNV
Germline

Chr16:23637952

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
PALB2-related disorder
not specified

Criteria Provided
Conflicting Classifications

CA348301

rs_200048921

10 SubmittersRCV000204029 RCV000561601 RCV000485666 RCV004530229 RCV002247634

NM_024675.4(PALB2):c.1042C>T (p.Gln348Ter)

SNV
Germline

Chr16:23635504

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary breast ovarian cancer syndrome
Hereditary cancer-predisposing syndrome
Malignant tumor of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10575850

rs_375699023

10 SubmittersRCV000255651 RCV000409735 RCV000416712 RCV000568484 RCV001358472

NM_024675.4(PALB2):c.2755G>A (p.Val919Ile)

SNV
Germline

Chr16:23624088

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Breast and/or ovarian cancer
Chordoma
not specified

Criteria Provided
Conflicting Classifications

CA7963488

rs_775193384

10 SubmittersRCV000211057 RCV000454132 RCV000478723 RCV005016571 RCV003150103 RCV002266935 RCV002465567

NM_024675.4(PALB2):c.1478C>T (p.Pro493Leu)

SNV
Germline

Chr16:23635068

Conflicting classifications of pathogenicity

Familial cancer of breast
Pilocytic astrocytoma
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963704

rs_770965402

7 SubmittersRCV000211081 RCV000761143 RCV000217376 RCV001582721

NM_024675.4(PALB2):c.1194G>T (p.Val398=)

SNV
Germline

Chr16:23635352

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA10576114

rs_61755173

5 SubmittersRCV000211072 RCV002336588 RCV004998437

NM_024675.4(PALB2):c.3544G>C (p.Val1182Leu)

SNV
Germline

Chr16:23603476

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10579910

rs_876660474

2 SubmittersRCV000215738 RCV000802184

NM_024675.4(PALB2):c.3494C>T (p.Ser1165Leu)

SNV
Germline

Chr16:23603526

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Chordoma

Criteria Provided
Conflicting Classifications

CA7963328

rs_773829275

12 SubmittersRCV000220953 RCV002478804 RCV000485944 RCV000535759 RCV001121621 RCV002266936

NM_024675.4(PALB2):c.3412G>A (p.Ala1138Thr)

SNV
Germline

Chr16:23603608

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA7963343

rs_577651839

8 SubmittersRCV000215508 RCV000686283 RCV000759188 RCV005016592

NM_024675.4(PALB2):c.3392T>C (p.Ile1131Thr)

SNV
Germline

Chr16:23603628

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA10579918

rs_876658196

10 SubmittersRCV000215576 RCV000229527 RCV000590765 RCV005396705

NM_024675.4(PALB2):c.3358G>T (p.Glu1120Ter)

SNV
Germline

Chr16:23603662

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10579919

rs_876658773

4 SubmittersRCV000215626 RCV003454620

NM_024675.4(PALB2):c.3350G>A (p.Arg1117Lys)

SNV
Germline

Chr16:23607864

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Breast-ovarian cancer, familial, susceptibility to, 5
Hereditary breast ovarian cancer syndrome
Condition: not provided

Reviewed By Expert Panel

CA10579920

rs_876659859

9 SubmittersRCV000217139 RCV000533846 RCV002271470 RCV003315422 RCV002277578 RCV004998471

NM_024675.4(PALB2):c.3232T>A (p.Cys1078Ser)

SNV
Germline

Chr16:23607982

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Carcinoma of colon
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA10579924

rs_876659587

8 SubmittersRCV000214649 RCV000530258 RCV001030400 RCV001788088 RCV003230458

NM_024675.4(PALB2):c.3225T>A (p.Ser1075Arg)

SNV
Germline

Chr16:23607989

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA7963396

rs_202222149

7 SubmittersRCV000218610 RCV000466966 RCV002500726 RCV005396711

NM_024675.4(PALB2):c.3201+3A>C

SNV
Germline

Chr16:23614001

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10579928

rs_876660215

2 SubmittersRCV000216437 RCV001853618

NM_024675.4(PALB2):c.3165C>A (p.Tyr1055Ter)

SNV
Germline

Chr16:23614040

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA10579929

rs_876658157

4 SubmittersRCV000222632 RCV001857756 RCV004998440

NM_024675.4(PALB2):c.3114G>A (p.Trp1038Ter)

SNV
Germline

Chr16:23614091

Pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10579930

rs_778345761

4 SubmittersRCV000222262 RCV001030388 RCV001070907

NM_024675.4(PALB2):c.3113+5G>C

SNV
Germline

Chr16:23621357

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA10579931

rs_876659463

13 SubmittersRCV000214215 RCV000231026 RCV000255512 RCV005016593 RCV005416112

NM_024675.4(PALB2):c.3096G>C (p.Met1032Ile)

SNV
Germline

Chr16:23621379

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963436

rs_778705498

3 SubmittersRCV000217483 RCV001216363

NM_024675.4(PALB2):c.3061G>A (p.Gly1021Arg)

SNV
Germline

Chr16:23621414

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Breast and/or ovarian cancer
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963440

rs_143808171

8 SubmittersRCV000214675 RCV000558947 RCV002265691 RCV001798715 RCV003328567

NM_024675.4(PALB2):c.2978C>T (p.Thr993Met)

SNV
Germline

Chr16:23622987

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
not specified
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA7963457

rs_61756146

12 SubmittersRCV000213330 RCV000236936 RCV000544190 RCV002267960 RCV002478799 RCV005396720

NM_024675.4(PALB2):c.2968G>T (p.Glu990Ter)

SNV
Germline

Chr16:23622997

Pathogenic

Hereditary cancer-predisposing syndrome
Breast neoplasm
Condition: not provided
Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA10579941

rs_876659036

10 SubmittersRCV000219424 RCV000504617 RCV000657700 RCV000635907 RCV004796114 RCV005361290

NM_024675.4(PALB2):c.2835G>A (p.Arg945=)

SNV
Germline

Chr16:23623130

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10579948

rs_876659983

3 SubmittersRCV000217381 RCV000483812 RCV001320081

NM_024675.4(PALB2):c.2693G>A (p.Trp898Ter)

SNV
Germline

Chr16:23626291

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Breast and/or ovarian cancer

Criteria Provided
Multiple Submitters
No Conflicts

CA10579954

rs_876658983

6 SubmittersRCV000216899 RCV000478895 RCV002518293 RCV003491974

NM_024675.4(PALB2):c.2674G>T (p.Glu892Ter)

SNV
Germline

Chr16:23626310

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Inherited breast cancer and ovarian cancer

Criteria Provided
Multiple Submitters
No Conflicts

CA10579956

rs_45476495

6 SubmittersRCV000217992 RCV001045962 RCV005237756

NM_024675.4(PALB2):c.2667T>A (p.Thr889=)

SNV
Germline

Chr16:23626317

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10579957

rs_876659224

4 SubmittersRCV000216116 RCV001118199 RCV005090094

NM_024675.4(PALB2):c.2630G>A (p.Trp877Ter)

SNV
Germline

Chr16:23626354

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10579959

rs_876660678

3 SubmittersRCV000213186 RCV001064019

NM_024675.4(PALB2):c.2512C>G (p.Gln838Glu)

SNV
Germline

Chr16:23629642

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA10579963

rs_750650768

6 SubmittersRCV000213341 RCV000635607 RCV002478788 RCV003223625

NM_024675.4(PALB2):c.2506G>C (p.Val836Leu)

SNV
Germline

Chr16:23629648

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
B lymphoblastic leukemia lymphoma with t(12
21)(p13
q22)
TEL-AML1 (ETV6-RUNX1)
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA7963565

rs_536644825

6 SubmittersRCV000215537 RCV000687946 RCV000761094 RCV002494591

NM_024675.4(PALB2):c.2506G>A (p.Val836Ile)

SNV
Germline

Chr16:23629648

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
not specified
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA7963564

rs_536644825

12 SubmittersRCV000214970 RCV000586837 RCV000457210 RCV001420721 RCV005016588 RCV005361295

NM_024675.4(PALB2):c.2448C>G (p.Phe816Leu)

SNV
Germline

Chr16:23629706

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA10579970

rs_876659879

4 SubmittersRCV000215749 RCV000635843 RCV002247661

NM_024675.4(PALB2):c.2437A>G (p.Ile813Val)

SNV
Germline

Chr16:23629717

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA10579971

rs_766396469

2 SubmittersRCV000216460

NM_024675.4(PALB2):c.2167A>T (p.Met723Leu)

SNV
Germline

Chr16:23629987

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA10579981

rs_876660336

5 SubmittersRCV000217611 RCV000467128 RCV003153509 RCV005016605

NM_024675.4(PALB2):c.2167A>G (p.Met723Val)

SNV
Germline

Chr16:23629987

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10579982

rs_876660336

2 SubmittersRCV000214669 RCV001350792

NM_024675.4(PALB2):c.2147A>G (p.Asn716Ser)

SNV
Germline

Chr16:23630007

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Papillary thyroid carcinoma
Condition: not provided
not specified
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA7963618

rs_148335539

8 SubmittersRCV000214302 RCV000458608 RCV000761167 RCV001567281 RCV002271471 RCV004532798

NM_024675.4(PALB2):c.2108T>G (p.Leu703Ter)

SNV
Germline

Chr16:23630046

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA7963621

rs_752592662

3 SubmittersRCV000223583 RCV001221815

NM_024675.4(PALB2):c.1919C>A (p.Ser640Ter)

SNV
Germline

Chr16:23630235

Pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Multiple Submitters
No Conflicts

CA7963646

rs_760094988

10 SubmittersRCV000214899 RCV000479396 RCV000545701 RCV005016586

NM_024675.4(PALB2):c.1918T>G (p.Ser640Ala)

SNV
Germline

Chr16:23630236

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
not specified

Criteria Provided
Conflicting Classifications

CA10579991

rs_876659058

7 SubmittersRCV000221223 RCV000635882 RCV002478798 RCV002509316

NM_024675.4(PALB2):c.1918T>A (p.Ser640Thr)

SNV
Germline

Chr16:23630236

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA10579992

rs_876659058

2 SubmittersRCV000221530 RCV003133189

NM_024675.4(PALB2):c.1804C>G (p.Gln602Glu)

SNV
Germline

Chr16:23630350

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10579997

rs_876660475

3 SubmittersRCV000218759 RCV000538187

NM_024675.4(PALB2):c.1767G>A (p.Thr589=)

SNV
Germline

Chr16:23630387

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Familial cancer of breast
not specified
Breast-ovarian cancer, familial, susceptibility to, 5
PALB2-related disorder
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963663

rs_769849072

13 SubmittersRCV000217926 RCV001121719 RCV000457514 RCV000436798 RCV005365148 RCV004532777 RCV002478785

NM_024675.4(PALB2):c.1744T>C (p.Ser582Pro)

SNV
Germline

Chr16:23630410

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10579999

rs_876659597

2 SubmittersRCV000214800 RCV001316625

NM_024675.4(PALB2):c.1732A>G (p.Ser578Gly)

SNV
Germline

Chr16:23630422

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA7963665

rs_764023822

7 SubmittersRCV000217898 RCV000464403 RCV000985887 RCV001030256 RCV005361246

NM_024675.4(PALB2):c.1702C>A (p.Gln568Lys)

SNV
Germline

Chr16:23630452

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
PALB2-related disorder
not specified

Criteria Provided
Conflicting Classifications

CA10580001

rs_876659354

7 SubmittersRCV000214422 RCV000818865 RCV002494593 RCV004541351 RCV004701288

NM_024675.4(PALB2):c.1694G>A (p.Ser565Asn)

SNV
Germline

Chr16:23630460

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA10580002

rs_876659914

5 SubmittersRCV000214165 RCV000536671 RCV001753674 RCV004526647

NM_024675.4(PALB2):c.1588C>T (p.Leu530Phe)

SNV
Germline

Chr16:23634958

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10580006

rs_876659671

3 SubmittersRCV000218879 RCV000635734

NM_024675.4(PALB2):c.1573G>T (p.Asp525Tyr)

SNV
Germline

Chr16:23634973

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10580007

rs_876659074

2 SubmittersRCV000219759 RCV001857775

NM_024675.4(PALB2):c.1540G>A (p.Gly514Arg)

SNV
Germline

Chr16:23635006

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA7963698

rs_756778249

12 SubmittersRCV000214985 RCV000589880 RCV000989570 RCV001027798 RCV003224228

NM_024675.4(PALB2):c.1456A>G (p.Lys486Glu)

SNV
Germline

Chr16:23635090

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA10580008

rs_876658949

3 SubmittersRCV000215703 RCV000811638 RCV001570464

NM_024675.4(PALB2):c.1378C>T (p.Gln460Ter)

SNV
Germline

Chr16:23635168

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10580012

rs_876658166

4 SubmittersRCV000222117 RCV001853499

NM_024675.4(PALB2):c.1079A>G (p.Asp360Gly)

SNV
Germline

Chr16:23635467

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA10580022

rs_876659751

8 SubmittersRCV000220824 RCV000679759 RCV000459883 RCV002500734

NM_024675.4(PALB2):c.1072C>T (p.Pro358Ser)

SNV
Germline

Chr16:23635474

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA10580023

rs_876660876

6 SubmittersRCV000220349 RCV000235363 RCV000466160 RCV002494599

NM_024675.4(PALB2):c.1052C>A (p.Thr351Lys)

SNV
Germline

Chr16:23635494

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA10580024

rs_876658656

5 SubmittersRCV000218423 RCV000531194 RCV005016578

NM_024675.4(PALB2):c.908T>C (p.Leu303Pro)

SNV
Germline

Chr16:23635638

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963747

rs_774057025

5 SubmittersRCV000216402 RCV000822728 RCV001284671

NM_024675.4(PALB2):c.902A>G (p.Asp301Gly)

SNV
Germline

Chr16:23635644

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Pancreatic cancer, susceptibility to, 3
not specified

Criteria Provided
Conflicting Classifications

CA7963748

rs_759014440

8 SubmittersRCV000215213 RCV000461086 RCV000478906 RCV001354911 RCV004800343

NM_024675.4(PALB2):c.844A>G (p.Arg282Gly)

SNV
Germline

Chr16:23635702

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast and/or ovarian cancer

Criteria Provided
Conflicting Classifications

CA7963752

rs_45447991

9 SubmittersRCV000220267 RCV000462094 RCV000759905 RCV003491976

NM_024675.4(PALB2):c.826C>T (p.His276Tyr)

SNV
Germline

Chr16:23635720

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10580030

rs_876658815

2 SubmittersRCV000215431 RCV000544750

NM_024675.4(PALB2):c.773G>A (p.Ser258Asn)

SNV
Germline

Chr16:23635773

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963758

rs_371289600

4 SubmittersRCV000215658 RCV000635854 RCV002485415

NM_024675.4(PALB2):c.619C>T (p.Pro207Ser)

SNV
Germline

Chr16:23635927

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10580036

rs_374090568

2 SubmittersRCV000214926 RCV001370562

NM_024675.4(PALB2):c.595C>T (p.Leu199Phe)

SNV
Germline

Chr16:23635951

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10580037

rs_876660851

3 SubmittersRCV000216403 RCV003765443

NM_024675.4(PALB2):c.583A>G (p.Ile195Val)

SNV
Germline

Chr16:23635963

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA7963779

rs_760784181

8 SubmittersRCV000215618 RCV001030160 RCV001234307 RCV005016591 RCV005365161

NM_024675.4(PALB2):c.541G>T (p.Glu181Ter)

SNV
Germline

Chr16:23636005

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA10580039

rs_864622280

4 SubmittersRCV000219378 RCV001060848 RCV005237732

NM_024675.4(PALB2):c.347T>A (p.Leu116Ter)

SNV
Germline

Chr16:23636199

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA10580044

rs_876660465

5 SubmittersRCV000223009 RCV000709748 RCV003227721

NM_024675.4(PALB2):c.338C>G (p.Pro113Arg)

SNV
Germline

Chr16:23636208

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963798

rs_374425261

3 SubmittersRCV000219266 RCV000552379

NM_024675.4(PALB2):c.308G>A (p.Gly103Glu)

SNV
Germline

Chr16:23636238

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA10580046

rs_876660794

2 SubmittersRCV000222248 RCV001854715

NM_024675.4(PALB2):c.229T>C (p.Cys77Arg)

SNV
Germline

Chr16:23636317

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA7963811

rs_760045493

10 SubmittersRCV000222033 RCV000472473 RCV000485885 RCV001818541 RCV005361343

NM_024675.4(PALB2):c.154G>A (p.Val52Ile)

SNV
Germline

Chr16:23637907

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA10580051

rs_876659444

2 SubmittersRCV000215013 RCV000482119

NM_024675.4(PALB2):c.115C>T (p.Gln39Ter)

SNV
Germline

Chr16:23637946

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10580053

rs_876659319

4 SubmittersRCV000223492 RCV000551161

NM_024675.4(PALB2):c.48+2T>G

SNV
Germline

Chr16:23641108

Likely pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA10580057

rs_876659679

1 SubmittersRCV000221819

NM_024675.4(PALB2):c.3420G>A (p.Trp1140Ter)

SNV
Germline

Chr16:23603600

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA10583349

rs_878855118

2 SubmittersRCV000226507 RCV004020882

NM_024675.4(PALB2):c.2964A>G (p.Gln988=)

SNV
Germline

Chr16:23623001

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA7963460

rs_777244673

6 SubmittersRCV000229549 RCV000563128 RCV000759903 RCV001192741 RCV004725117

NM_024675.4(PALB2):c.2840T>C (p.Leu947Ser)

SNV
Germline

Chr16:23623125

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Inherited breast cancer and ovarian cancer
not specified
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA7963465

rs_45464500

10 SubmittersRCV000229185 RCV000564890 RCV000587839 RCV005055099 RCV005238770 RCV005003582

NM_024675.4(PALB2):c.2624T>C (p.Met875Thr)

SNV
Germline

Chr16:23626360

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA10583359

rs_878855110

3 SubmittersRCV000231157 RCV000780566 RCV004649110

NM_024675.4(PALB2):c.2594C>G (p.Ser865Ter)

SNV
Germline

Chr16:23626390

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA10583360

rs_746604683

3 SubmittersRCV000234617 RCV003352808

NM_024675.4(PALB2):c.2509G>T (p.Glu837Ter)

SNV
Germline

Chr16:23629645

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Pancreatic cancer, susceptibility to, 3
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA10583361

rs_587778587

7 SubmittersRCV000227927 RCV000454198 RCV000235331 RCV001030314 RCV001193462

NM_024675.4(PALB2):c.2201C>A (p.Thr734Asn)

SNV
Germline

Chr16:23629953

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Condition: not provided
not specified
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA10583365

rs_878855107

17 SubmittersRCV000233965 RCV000569446 RCV001119746 RCV001566044 RCV001820767 RCV002487088 RCV004739637 RCV005361461

NM_024675.4(PALB2):c.2066C>T (p.Ser689Leu)

SNV
Germline

Chr16:23630088

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA7963627

rs_749602688

6 SubmittersRCV000228021 RCV001030274 RCV000774634 RCV004541455

NM_024675.4(PALB2):c.1753G>A (p.Asp585Asn)

SNV
Germline

Chr16:23630401

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA10583370

rs_878855102

5 SubmittersRCV000227668 RCV000773064 RCV002277593

NM_024675.4(PALB2):c.1463G>T (p.Ser488Ile)

SNV
Germline

Chr16:23635083

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA7963705

rs_767926590

8 SubmittersRCV000226177 RCV000564692 RCV000589383 RCV002487087

NM_024675.4(PALB2):c.1369G>T (p.Glu457Ter)

SNV
Germline

Chr16:23635177

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10583374

rs_878855099

2 SubmittersRCV000231944

NM_024675.4(PALB2):c.1226A>G (p.Tyr409Cys)

SNV
Germline

Chr16:23635320

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Hereditary cancer

Criteria Provided
Conflicting Classifications

CA10583375

rs_878855097

7 SubmittersRCV000230943 RCV000709387 RCV000985884 RCV003492015

NM_024675.4(PALB2):c.365A>G (p.Asp122Gly)

SNV
Germline

Chr16:23636181

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA10583383

rs_866367185

4 SubmittersRCV000232654 RCV001189069 RCV004721317

NM_024675.4(PALB2):c.212-3C>T

SNV
Germline

Chr16:23636337

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA10583385

rs_878855106

3 SubmittersRCV000228404 RCV000569563

NM_024675.4(PALB2):c.79G>T (p.Glu27Ter)

SNV
Germline/somatic

Chr16:23638099

Pathogenic/Likely pathogenic

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Malignant tumor of breast
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Fanconi anemia complementation group N
Lung cancer
PALB2-related disorder

Criteria Provided
Multiple Submitters
No Conflicts

CA10583387

rs_878855122

16 SubmittersRCV000228882 RCV000255635 RCV000454231 RCV001175093 RCV002500815 RCV003485568 RCV002282082 RCV004532964

NM_024675.4(PALB2):c.48+7G>C

SNV
Germline

Chr16:23641103

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA7963885

rs_190626072

10 SubmittersRCV000230746 RCV000580140 RCV000433452 RCV000586925 RCV004541457

NM_024675.4(PALB2):c.7G>T (p.Glu3Ter)

SNV
Germline

Chr16:23641151

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Reviewed By Expert Panel

CA10583388

rs_878855123

8 SubmittersRCV000231797 RCV000582525 RCV000657770

NM_024675.4(PALB2):c.2T>C (p.Met1Thr)

SNV
Germline

Chr16:23641156

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA7963891

rs_756519825

4 SubmittersRCV000230496 RCV002436040

NM_024675.4(PALB2):c.3492G>A (p.Trp1164Ter)

SNV
Germline

Chr16:23603528

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA10584499

rs_587782217

8 SubmittersRCV000235984 RCV000662671 RCV001020433

NM_024675.4(PALB2):c.3491G>A (p.Trp1164Ter)

SNV
Germline

Chr16:23603529

Pathogenic/Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10584500

rs_879254113

6 SubmittersRCV000235914 RCV000454361 RCV000477362

NM_024675.4(PALB2):c.3436C>G (p.Gln1146Glu)

SNV
Germline

Chr16:23603584

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA10584501

rs_879254033

4 SubmittersRCV000236192 RCV001854872 RCV001183519

NM_024675.4(PALB2):c.2996+5G>T

SNV
Germline

Chr16:23622964

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
PALB2-related disorder
not specified

Criteria Provided
Conflicting Classifications

CA10584507

rs_879254193

11 SubmittersRCV000468560 RCV000562437 RCV000587970 RCV004541468 RCV005238783

NM_024675.4(PALB2):c.2860G>T (p.Glu954Ter)

SNV
Germline

Chr16:23623105

Pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10584509

rs_879254015

2 SubmittersRCV000235480 RCV001854860

NM_024675.4(PALB2):c.2435C>T (p.Pro812Leu)

SNV
Germline

Chr16:23629719

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Malignant tumor of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA7963575

rs_774502617

9 SubmittersRCV000235316 RCV000635929 RCV000575251 RCV001357974 RCV002494681 RCV003330604

NM_024675.4(PALB2):c.2197A>G (p.Thr733Ala)

SNV
Germline

Chr16:23629957

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA10584511

rs_879254051

7 SubmittersRCV000236085 RCV000470751 RCV000571493 RCV002487097 RCV005230178

NM_024675.4(PALB2):c.2148T>A (p.Asn716Lys)

SNV
Germline

Chr16:23630006

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA7963617

rs_770145849

7 SubmittersRCV000236038 RCV000464776 RCV000574979 RCV002479940

NM_024675.4(PALB2):c.2066C>A (p.Ser689Ter)

SNV
Germline

Chr16:23630088

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA10584512

rs_749602688

3 SubmittersRCV000236381 RCV003454716 RCV002418041

NM_024675.4(PALB2):c.2053A>C (p.Lys685Gln)

SNV
Germline

Chr16:23630101

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA10584513

rs_876660397

5 SubmittersRCV000235440 RCV001854851 RCV000566295

NM_024675.4(PALB2):c.1861C>A (p.Pro621Thr)

SNV
Germline

Chr16:23630293

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA7963654

rs_756116550

10 SubmittersRCV000235273 RCV000454184 RCV000989565 RCV001192764

NM_024675.4(PALB2):c.668T>C (p.Ile223Thr)

SNV
Germline

Chr16:23635878

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA7963771

rs_150517167

8 SubmittersRCV000236902 RCV000635688 RCV000572381 RCV001193466

NM_024675.4(PALB2):c.472C>T (p.Gln158Ter)

SNV
Germline

Chr16:23636074

Pathogenic/Likely pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10584523

rs_879254197

3 SubmittersRCV000237059 RCV001382726

NM_024675.4(PALB2):c.398G>A (p.Ser133Asn)

SNV
Germline

Chr16:23636148

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA10584524

rs_864622411

5 SubmittersRCV000235826 RCV000691656 RCV000780568 RCV000570939

NM_024675.4(PALB2):c.205C>T (p.His69Tyr)

SNV
Germline

Chr16:23637856

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA10584525

rs_879253891

8 SubmittersRCV000236918 RCV000575557 RCV000823428 RCV000781688 RCV002494677

NM_024675.4(PALB2):c.155T>C (p.Val52Ala)

SNV
Germline

Chr16:23637906

Conflicting classifications of pathogenicity

Breast neoplasm
Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963833

rs_373970237

8 SubmittersRCV000417330 RCV000235666 RCV000462987 RCV000568339

NM_024675.4(PALB2):c.1A>G (p.Met1Val)

SNV
Germline

Chr16:23641157

Pathogenic/Likely pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA10584527

rs_879254144

5 SubmittersRCV000237093 RCV000696235 RCV002418043

NM_024675.4(PALB2):c.3234T>A (p.Cys1078Ter)

SNV
Germline

Chr16:23607980

Pathogenic/Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10588601

rs_886039634

6 SubmittersRCV000254975 RCV001525205 RCV001855013

NM_024675.4(PALB2):c.3114-1G>A

SNV
Germline

Chr16:23614092

Pathogenic/Likely pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Multiple Submitters
No Conflicts

CA10588602

rs_886039619

6 SubmittersRCV000255848 RCV000551424 RCV000569707 RCV005361500

NM_024675.4(PALB2):c.2996+1G>T

SNV
Germline

Chr16:23622968

Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10588605

rs_886039626

3 SubmittersRCV000255151 RCV001017834 RCV001379452

NM_024675.4(PALB2):c.2835-2A>C

SNV
Germline

Chr16:23623132

Likely pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10588606

rs_886039613

2 SubmittersRCV000256178 RCV003454780

NM_024675.4(PALB2):c.2514+1G>C

SNV
Germline

Chr16:23629639

Likely pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA10588607

rs_886039729

5 SubmittersRCV000255296 RCV001229856 RCV002429197

NM_024675.4(PALB2):c.2368C>T (p.Gln790Ter)

SNV
Germline

Chr16:23629786

Pathogenic/Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Fanconi anemia
Hereditary cancer
Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA10588608

rs_886039480

11 SubmittersRCV000255054 RCV000454204 RCV000509375 RCV000552634 RCV003155937

NM_024675.4(PALB2):c.1496T>A (p.Leu499Ter)

SNV
Germline

Chr16:23635050

Pathogenic/Likely pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10588610

rs_886039620

2 SubmittersRCV000254924 RCV001390098

NM_024675.4(PALB2):c.1424C>G (p.Ser475Ter)

SNV
Germline

Chr16:23635122

Pathogenic/Likely pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA10588611

rs_886039479

4 SubmittersRCV000255228 RCV001066196 RCV002392782

NM_024675.4(PALB2):c.421C>T (p.Gln141Ter)

SNV
Germline

Chr16:23636125

Pathogenic/Likely pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10588614

rs_886039686

3 SubmittersRCV000256010 RCV003454783

NM_024675.4(PALB2):c.178C>T (p.Gln60Ter)

SNV
Germline

Chr16:23637883

Pathogenic/Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA10588615

rs_886039747

4 SubmittersRCV000255924 RCV001013160 RCV002518769

NM_024675.4(PALB2):c.3202-1G>A

SNV
Germline

Chr16:23608013

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Multiple Submitters
No Conflicts

CA16042147

rs_515726111

10 SubmittersRCV000409659 RCV001019201 RCV003493565 RCV002481267

NM_024675.4(PALB2):c.2748+1G>C

SNV
Germline

Chr16:23626235

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA16042148

rs_753153576

5 SubmittersRCV000409294 RCV001176291 RCV003315425 RCV003477909

NM_024675.4(PALB2):c.2576C>A (p.Ser859Ter)

SNV
Germline

Chr16:23629214

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA16042149

rs_1057517539

4 SubmittersRCV000410429 RCV000454290

NM_024675.4(PALB2):c.3G>A (p.Met1Ile)

SNV
Germline

Chr16:23641155

Pathogenic/Likely pathogenic

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA16042152

rs_1057517585

8 SubmittersRCV000410696 RCV000505935 RCV000567207 RCV004698787

NM_024675.4(PALB2):c.1448C>G (p.Ser483Ter)

SNV
Germline

Chr16:23635098

Pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA16607001

rs_1057520736

2 SubmittersRCV000421638 RCV001525971

NM_024675.4(PALB2):c.1746C>T (p.Ser582=)

SNV
Germline

Chr16:23630408

Conflicting classifications of pathogenicity

not specified
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA16607213

rs_1057520985

6 SubmittersRCV000430741 RCV000775902 RCV001490679 RCV003477918

NM_024675.4(PALB2):c.1685-14T>A

SNV
Germline

Chr16:23630483

Conflicting classifications of pathogenicity

not specified
Familial cancer of breast
PALB2-related cancer predisposition
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963670

rs_780772404

6 SubmittersRCV000443095 RCV000663142 RCV005355771 RCV003584602

NM_024675.4(PALB2):c.1438A>T (p.Lys480Ter)

SNV
Germline

Chr16:23635108

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA16607220

rs_1057520653

6 SubmittersRCV000424678 RCV001390153 RCV005384711

NM_024675.4(PALB2):c.66A>G (p.Ala22=)

SNV
Germline

Chr16:23638112

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA16607223

rs_1057520982

6 SubmittersRCV000923663 RCV000569467 RCV001119846 RCV001456862

NM_024675.4(PALB2):c.2992G>A (p.Gly998Arg)

SNV
Germline

Chr16:23622973

Conflicting classifications of pathogenicity

not specified
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA16607334

rs_1039184417

4 SubmittersRCV000442850 RCV000775926 RCV001046244

NM_024675.4(PALB2):c.1685-1G>C

SNV
Germline

Chr16:23630470

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16607339

rs_1057520645

6 SubmittersRCV000431972 RCV001055212 RCV002411312

NM_024675.4(PALB2):c.2993G>C (p.Gly998Ala)

SNV
Germline

Chr16:23622972

Conflicting classifications of pathogenicity

not specified
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA16608106

rs_45551636

4 SubmittersRCV000425596 RCV000775893 RCV001038066

NM_024675.4(PALB2):c.1611G>A (p.Ser537=)

SNV
Germline

Chr16:23634935

Conflicting classifications of pathogenicity

Familial cancer of breast
Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
not specified

Criteria Provided
Conflicting Classifications

CA7963693

rs_730881874

10 SubmittersRCV000989569 RCV001121721 RCV000572139 RCV001703482 RCV005355718 RCV005407090

NM_024675.4(PALB2):c.1424C>A (p.Ser475Ter)

SNV
Germline

Chr16:23635122

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA16608121

rs_886039479

3 SubmittersRCV000436797 RCV003449055 RCV005384712

NM_024675.4(PALB2):c.3464C>G (p.Ser1155Cys)

SNV
Germline

Chr16:23603556

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963332

rs_755609496

5 SubmittersRCV000454280 RCV000529716 RCV000480681

NM_024675.4(PALB2):c.3202-2A>C

SNV
Germline

Chr16:23608014

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA16609588

rs_1060499827

4 SubmittersRCV000454196 RCV000576715

NM_024675.4(PALB2):c.2748+2T>C

SNV
Germline

Chr16:23626234

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA16609594

rs_1060499821

2 SubmittersRCV000454214 RCV003449105

NM_024675.4(PALB2):c.2473A>G (p.Arg825Gly)

SNV
Germline

Chr16:23629681

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963569

rs_745747228

4 SubmittersRCV000454362 RCV000764048 RCV001861653

NM_024675.4(PALB2):c.1039G>T (p.Glu347Ter)

SNV
Germline

Chr16:23635507

Pathogenic

Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA16609602

rs_1060499812

5 SubmittersRCV000454356 RCV003315427 RCV003239290

NM_024675.4(PALB2):c.931A>T (p.Lys311Ter)

SNV
Germline

Chr16:23635615

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA16609604

rs_1060499831

3 SubmittersRCV000454180 RCV003476020

NM_024675.4(PALB2):c.108+1G>A

SNV
Germline

Chr16:23638069

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Pancreatic cancer, susceptibility to, 3
Breast cancer, susceptibility to

Criteria Provided
Multiple Submitters
No Conflicts

CA16609606

rs_1060499814

12 SubmittersRCV000454354 RCV000466548 RCV000484652 RCV001258109

NM_024675.4(PALB2):c.106C>T (p.Gln36Ter)

SNV
Germline

Chr16:23638072

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Multiple Submitters
No Conflicts

CA16609607

rs_757369748

7 SubmittersRCV000454301 RCV001380280 RCV000657579 RCV000763378

NM_024675.4(PALB2):c.3508C>A (p.His1170Asn)

SNV
Germline

Chr16:23603512

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16614807

rs_200283306

3 SubmittersRCV000459786 RCV001192088

NM_024675.4(PALB2):c.3035C>T (p.Thr1012Ile)

SNV
Germline

Chr16:23621440

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA7963444

rs_761032954

12 SubmittersRCV000575045 RCV000479556 RCV000475841 RCV005018786

NM_024675.4(PALB2):c.2940C>T (p.Ser980=)

SNV
Germline

Chr16:23623025

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA7963464

rs_766049739

7 SubmittersRCV000461224 RCV000580627 RCV001712437 RCV005355903

NM_024675.4(PALB2):c.2834+3A>G

SNV
Germline

Chr16:23624006

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16614824

rs_1060502766

2 SubmittersRCV000474406 RCV001016728

NM_024675.4(PALB2):c.1553C>G (p.Ser518Ter)

SNV
Germline

Chr16:23634993

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
PALB2-related disorder

Criteria Provided
Multiple Submitters
No Conflicts

CA16614852

rs_1060502805

5 SubmittersRCV000469612 RCV001012094 RCV004529598

NM_024675.4(PALB2):c.2749-1G>C

SNV
Germline

Chr16:23624095

Likely pathogenic

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA16614853

rs_1060502804

3 SubmittersRCV000461242 RCV002509392 RCV005452993

NM_024675.4(PALB2):c.1537A>G (p.Thr513Ala)

SNV
Germline

Chr16:23635009

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Carcinoma of colon

Criteria Provided
Conflicting Classifications

CA16614855

rs_1060502741

7 SubmittersRCV000474363 RCV000575626 RCV000587874 RCV002480416 RCV001030235

NM_024675.4(PALB2):c.2730T>A (p.Tyr910Ter)

SNV
Germline

Chr16:23626254

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA16614856

rs_995629797

9 SubmittersRCV000459119 RCV000568217 RCV002489062 RCV000657580

NM_024675.4(PALB2):c.2677G>T (p.Asp893Tyr)

SNV
Germline

Chr16:23626307

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963508

rs_765077104

8 SubmittersRCV000457988 RCV001016287 RCV003991027 RCV005243235

NM_024675.4(PALB2):c.1383T>A (p.Ser461Arg)

SNV
Germline

Chr16:23635163

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA7963711

rs_768482110

8 SubmittersRCV000470251 RCV000781681 RCV000568070 RCV000679760 RCV002481444

NM_024675.4(PALB2):c.1084C>G (p.Leu362Val)

SNV
Germline

Chr16:23635462

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16614861

rs_1060502758

2 SubmittersRCV000475695 RCV000572723

NM_024675.4(PALB2):c.880A>G (p.Lys294Glu)

SNV
Germline

Chr16:23635666

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963750

rs_753676934

5 SubmittersRCV000468876 RCV000574047 RCV002223850

NM_024675.4(PALB2):c.2514+8C>T

SNV
Germline

Chr16:23629632

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA16614865

rs_1060504706

4 SubmittersRCV000470502 RCV004017633 RCV004740248

NM_024675.4(PALB2):c.2389C>A (p.Gln797Lys)

SNV
Germline

Chr16:23629765

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA16614866

rs_1060502768

4 SubmittersRCV000476517 RCV000567346 RCV003318580

NM_024675.4(PALB2):c.2188A>G (p.Ile730Val)

SNV
Germline

Chr16:23629966

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
not specified
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA16614873

rs_1060502735

8 SubmittersRCV000468216 RCV000479293 RCV000563382 RCV001199879 RCV001354437

NM_024675.4(PALB2):c.304G>A (p.Val102Ile)

SNV
Germline

Chr16:23636242

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963803

rs_778573607

6 SubmittersRCV000465446 RCV000562562 RCV003332178

NM_024675.4(PALB2):c.45A>G (p.Glu15=)

SNV
Germline

Chr16:23641113

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Familial pancreatic carcinoma
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16614880

rs_1060504718

6 SubmittersRCV000828254 RCV001085519 RCV005355905 RCV003168912

NM_024675.4(PALB2):c.1435C>T (p.Gln479Ter)

SNV
Germline

Chr16:23635111

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA16614893

rs_1060502761

2 SubmittersRCV000463150 RCV001011563

NM_024675.4(PALB2):c.1217C>T (p.Ala406Val)

SNV
Germline

Chr16:23635329

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA16614898

rs_1060502757

8 SubmittersRCV000463216 RCV000569051 RCV001561387 RCV002481447

NM_024675.4(PALB2):c.1144A>C (p.Ser382Arg)

SNV
Germline

Chr16:23635402

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16614900

rs_1060502737

3 SubmittersRCV000476970 RCV000775933

NM_024675.4(PALB2):c.3391A>G (p.Ile1131Val)

SNV
Germline

Chr16:23603629

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
not specified

Criteria Provided
Conflicting Classifications

CA7963344

rs_774517454

7 SubmittersRCV000456527 RCV000589068 RCV000771464 RCV005355850 RCV004596198

NM_024675.4(PALB2):c.3351-2A>G

SNV
Germline

Chr16:23603671

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA16615066

rs_1060502764

5 SubmittersRCV000466376 RCV001020064 RCV004721374

NM_024675.4(PALB2):c.3256C>G (p.Arg1086Gly)

SNV
Germline

Chr16:23607958

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
not specified
Hereditary breast ovarian cancer syndrome
Familial pancreatic carcinoma

Criteria Provided
Conflicting Classifications

CA16615072

rs_587776527

6 SubmittersRCV000461441 RCV000773077 RCV003319358 RCV003321613 RCV005355852

NM_024675.4(PALB2):c.2835-3T>C

SNV
Germline

Chr16:23623133

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA16615078

rs_1060502795

4 SubmittersRCV000468775 RCV001016565 RCV004596199

NM_024675.4(PALB2):c.2711G>A (p.Trp904Ter)

SNV
Germline

Chr16:23626273

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA16615083

rs_1060502726

7 SubmittersRCV000465081 RCV000566729 RCV000522916 RCV005355847

NM_024675.4(PALB2):c.2328C>A (p.Phe776Leu)

SNV
Germline

Chr16:23629826

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA16615088

rs_45508997

4 SubmittersRCV000469475 RCV004943901 RCV005398628

NM_024675.4(PALB2):c.2303G>C (p.Cys768Ser)

SNV
Germline

Chr16:23629851

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16615091

rs_1060502770

3 SubmittersRCV000471672 RCV001015017

NM_024675.4(PALB2):c.1696C>T (p.Arg566Cys)

SNV
Germline

Chr16:23630458

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA7963668

rs_746582620

10 SubmittersRCV000461240 RCV000586825 RCV000563652 RCV002481446

NM_024675.4(PALB2):c.1366G>T (p.Glu456Ter)

SNV
Germline

Chr16:23635180

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA16615101

rs_1060502785

3 SubmittersRCV000472293

NM_024675.4(PALB2):c.1103A>G (p.Asn368Ser)

SNV
Germline

Chr16:23635443

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA16615103

rs_1060502799

4 SubmittersRCV000469658 RCV000563832 RCV003153633

NM_024675.4(PALB2):c.727A>C (p.Thr243Pro)

SNV
Germline

Chr16:23635819

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA16615106

rs_1060502747

4 SubmittersRCV000464943 RCV000567643 RCV001848813

NM_024675.4(PALB2):c.602G>A (p.Ser201Asn)

SNV
Germline

Chr16:23635944

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16615115

rs_1060502790

2 SubmittersRCV000476599 RCV004943900

NM_024675.4(PALB2):c.206A>T (p.His69Leu)

SNV
Germline

Chr16:23637855

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA16615126

rs_749443090

8 SubmittersRCV000476673 RCV000485056 RCV000569594 RCV005018787

NM_024675.4(PALB2):c.127A>G (p.Lys43Glu)

SNV
Germline

Chr16:23637934

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA7963836

rs_765125459

11 SubmittersRCV000474623 RCV000580520 RCV000485071 RCV002481445

NM_024675.4(PALB2):c.2725C>G (p.Leu909Val)

SNV
Germline

Chr16:23626259

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16615221

rs_1060502739

3 SubmittersRCV000463483 RCV000572861

NM_024675.4(PALB2):c.2587-2A>C

SNV
Germline

Chr16:23626399

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16615225

rs_1060502787

3 SubmittersRCV000460478 RCV002429521

NM_024675.4(PALB2):c.2438T>C (p.Ile813Thr)

SNV
Germline

Chr16:23629716

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA7963573

rs_763191051

9 SubmittersRCV000476976 RCV000588415 RCV000564912 RCV004533194

NM_024675.4(PALB2):c.2375C>G (p.Ser792Ter)

SNV
Germline

Chr16:23629779

Pathogenic/Likely pathogenic

Familial cancer of breast
Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA16615240

rs_1060502748

5 SubmittersRCV000457054 RCV001813781 RCV004649161

NM_024675.4(PALB2):c.1492G>A (p.Asp498Asn)

SNV
Germline

Chr16:23635054

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA16615265

rs_75023630

4 SubmittersRCV000466463 RCV000572623 RCV002496776

NM_024675.4(PALB2):c.1343G>A (p.Ser448Asn)

SNV
Germline

Chr16:23635203

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA16615266

rs_956172059

5 SubmittersRCV000464002 RCV000564122 RCV000486431

NM_024675.4(PALB2):c.1213C>G (p.Pro405Ala)

SNV
Germline

Chr16:23635333

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast and/or ovarian cancer
PALB2-related disorder
Ovarian cancer
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA7963723

rs_545119348

9 SubmittersRCV000456874 RCV000561159 RCV003492059 RCV004529596 RCV003153632 RCV005355849

NM_024675.4(PALB2):c.1048C>T (p.Gln350Ter)

SNV
Germline

Chr16:23635498

Pathogenic

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA16615273

rs_1060502788

5 SubmittersRCV000476491 RCV000520926 RCV002402280

NM_024675.4(PALB2):c.661G>A (p.Val221Ile)

SNV
Germline

Chr16:23635885

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary breast ovarian cancer syndrome
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16615301

rs_1060502773

7 SubmittersRCV000462286 RCV003324751 RCV005355851 RCV000569599

NM_024675.4(PALB2):c.510A>C (p.Arg170Ser)

SNV
Germline

Chr16:23636036

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Condition: not provided

Criteria Provided
Conflicting Classifications

CA16615302

rs_1060502796

5 SubmittersRCV000474642 RCV000571001 RCV001294231 RCV003477982

NM_024675.4(PALB2):c.3421G>A (p.Asp1141Asn)

SNV
Germline

Chr16:23603599

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA16620112

rs_1064795975

3 SubmittersRCV000480747 RCV004943925 RCV002525917

NM_024675.4(PALB2):c.3122A>C (p.Lys1041Thr)

SNV
Germline

Chr16:23614083

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963418

rs_781663559

6 SubmittersRCV000478421 RCV000635632 RCV000708730

NM_024675.4(PALB2):c.3114-6T>C

SNV
Germline

Chr16:23614097

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA16620116

rs_1064794886

3 SubmittersRCV000482960 RCV001078733

NM_024675.4(PALB2):c.3054G>T (p.Glu1018Asp)

SNV
Germline

Chr16:23621421

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
not specified

Criteria Provided
Conflicting Classifications

CA16620118

rs_183489969

7 SubmittersRCV000481068 RCV000561822 RCV000694700 RCV001030372 RCV002268123

NM_024675.4(PALB2):c.2875G>T (p.Val959Leu)

SNV
Germline

Chr16:23623090

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA16620123

rs_1064793658

4 SubmittersRCV000484497 RCV000562675 RCV001865437

NM_024675.4(PALB2):c.2836G>A (p.Ala946Thr)

SNV
Germline

Chr16:23623129

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16620124

rs_878855113

3 SubmittersRCV000484044 RCV001305631 RCV004943923

NM_024675.4(PALB2):c.2614G>A (p.Val872Met)

SNV
Germline

Chr16:23626370

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16620129

rs_1064793628

4 SubmittersRCV000484695 RCV000696384 RCV004659056

NM_024675.4(PALB2):c.2422G>A (p.Gly808Arg)

SNV
Germline

Chr16:23629732

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA16620133

rs_1064795507

5 SubmittersRCV000698122 RCV000775954 RCV000486954

NM_024675.4(PALB2):c.2411C>T (p.Ser804Phe)

SNV
Germline

Chr16:23629743

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA7963582

rs_149836639

7 SubmittersRCV000481392 RCV000581656 RCV000635655 RCV002475930

NM_024675.4(PALB2):c.2340C>T (p.Gly780=)

SNV
Germline

Chr16:23629814

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA16620134

rs_1064794853

4 SubmittersRCV000485867 RCV000814645 RCV004943920

NM_024675.4(PALB2):c.2326T>C (p.Phe776Leu)

SNV
Germline

Chr16:23629828

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963593

rs_764925691

7 SubmittersRCV000486202 RCV000662841 RCV001015195

NM_024675.4(PALB2):c.1600T>G (p.Ser534Ala)

SNV
Germline

Chr16:23634946

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Chordoma

Criteria Provided
Conflicting Classifications

CA16620143

rs_1064793824

5 SubmittersRCV000484915 RCV000689372 RCV001012375 RCV002266967

NM_024675.4(PALB2):c.1491T>G (p.Asn497Lys)

SNV
Germline

Chr16:23635055

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963703

rs_374707677

3 SubmittersRCV000635954 RCV000486048 RCV001011852

NM_024675.4(PALB2):c.1463G>C (p.Ser488Thr)

SNV
Germline

Chr16:23635083

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA16620145

rs_767926590

5 SubmittersRCV000486572 RCV000538747 RCV002395159 RCV003315431

NM_024675.4(PALB2):c.1337A>G (p.Asp446Gly)

SNV
Germline

Chr16:23635209

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963717

rs_146434474

3 SubmittersRCV000478568 RCV001010834 RCV000798423

NM_024675.4(PALB2):c.1179A>G (p.Lys393=)

SNV
Germline

Chr16:23635367

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA16620151

rs_976340416

5 SubmittersRCV000480231 RCV000567685 RCV001396731

NM_024675.4(PALB2):c.769G>C (p.Gly257Arg)

SNV
Germline

Chr16:23635777

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA16620155

rs_587780824

3 SubmittersRCV000485497 RCV002402401 RCV003607293

NM_024675.4(PALB2):c.742G>C (p.Val248Leu)

SNV
Germline

Chr16:23635804

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA16620157

rs_572102702

4 SubmittersRCV000478004 RCV000635771 RCV002383910 RCV005355924

NM_024675.4(PALB2):c.163C>T (p.Gln55Ter)

SNV
Germline

Chr16:23637898

Pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA16620162

rs_1064793772

2 SubmittersRCV000482275 RCV003168945

NM_024675.4(PALB2):c.108+9A>G

SNV
Germline

Chr16:23638061

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA16620164

rs_1064795783

2 SubmittersRCV000482406 RCV001495481

NM_024675.4(PALB2):c.20A>G (p.Lys7Arg)

SNV
Germline

Chr16:23641138

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
not specified
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA16620166

rs_947155109

10 SubmittersRCV000702590 RCV000483460 RCV000571040 RCV003226305 RCV004527591

NM_024675.4(PALB2):c.643G>T (p.Glu215Ter)

SNV
Germline

Chr16:23635903

Pathogenic

Breast neoplasm
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395136539

rs_1555461693

2 SubmittersRCV000504603 RCV001385716

NM_024675.4(PALB2):c.62T>G (p.Leu21Ter)

SNV
Germline

Chr16:23638116

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA7963863

rs_769240800

9 SubmittersRCV000507280 RCV000535566 RCV000575810

NM_024675.4(PALB2):c.3324C>A (p.Tyr1108Ter)

SNV
Germline

Chr16:23607890

Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395139372

rs_1218512317

2 SubmittersRCV000523756 RCV003362812

NM_024675.4(PALB2):c.1685-2A>G

SNV
Germline

Chr16:23630471

Likely pathogenic

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related disorder
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA7963669

rs_754660432

6 SubmittersRCV000519126 RCV000568799 RCV001037839 RCV004527630 RCV005411471

NM_024675.4(PALB2):c.119G>A (p.Arg40Lys)

SNV
Germline

Chr16:23637942

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA279501900

rs_573118236

5 SubmittersRCV000523351 RCV001063588 RCV000774647 RCV003446134

NM_024675.4(PALB2):c.2596G>T (p.Gly866Cys)

SNV
Germline

Chr16:23626388

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA7963516

rs_780415750

5 SubmittersRCV000536489 RCV000759899 RCV001187392 RCV004596242

NM_024675.4(PALB2):c.2017G>A (p.Glu673Lys)

SNV
Germline

Chr16:23630137

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395127047

rs_1236182341

3 SubmittersRCV000540647 RCV000569513

NM_024675.4(PALB2):c.1643C>T (p.Ser548Leu)

SNV
Germline

Chr16:23634903

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395130164

rs_1241049372

3 SubmittersRCV000547156 RCV000571222 RCV002259347

NM_024675.4(PALB2):c.1133C>T (p.Pro378Leu)

SNV
Germline

Chr16:23635413

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395133627

rs_1442895662

4 SubmittersRCV000526864 RCV002448657 RCV002293450

NM_024675.4(PALB2):c.1004A>G (p.Asn335Ser)

SNV
Germline

Chr16:23635542

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395134568

rs_1368473544

4 SubmittersRCV000554257 RCV000777235 RCV004719858

NM_024675.4(PALB2):c.223A>T (p.Lys75Ter)

SNV
Germline

Chr16:23636323

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA395138968

rs_1555461875

9 SubmittersRCV000557714 RCV001014881 RCV001008028 RCV005357565

NM_024675.4(PALB2):c.3436C>T (p.Gln1146Ter)

SNV
Germline

Chr16:23603584

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395138158

rs_879254033

3 SubmittersRCV000533343 RCV002456088

NM_024675.4(PALB2):c.3324C>G (p.Tyr1108Ter)

SNV
Germline

Chr16:23607890

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395139370

rs_1218512317

7 SubmittersRCV000550532 RCV001019991 RCV004592566

NM_024675.4(PALB2):c.3476G>T (p.Trp1159Leu)

SNV
Germline

Chr16:23603544

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Condition: not provided

Criteria Provided
Conflicting Classifications

CA279524947

rs_587782050

6 SubmittersRCV000547300 RCV000564987 RCV003317262 RCV003329296

NM_024675.4(PALB2):c.2821A>G (p.Ile941Val)

SNV
Germline

Chr16:23624022

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA7963481

rs_778602038

9 SubmittersRCV000534984 RCV000759902 RCV000572648 RCV005004225

NM_024675.4(PALB2):c.2515-3C>T

SNV
Germline

Chr16:23629278

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA279491568

rs_957106428

4 SubmittersRCV000543762 RCV001015746 RCV001775854

NM_024675.4(PALB2):c.2290A>G (p.Lys764Glu)

SNV
Germline

Chr16:23629864

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963599

rs_573744591

3 SubmittersRCV000551829 RCV000771302

NM_024675.4(PALB2):c.1765A>G (p.Thr589Ala)

SNV
Germline

Chr16:23630389

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395128203

rs_1437053825

4 SubmittersRCV000550043 RCV001013028 RCV003478137

NM_024675.4(PALB2):c.1471G>A (p.Ala491Thr)

SNV
Germline

Chr16:23635075

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA279498326

rs_577969558

5 SubmittersRCV000555891 RCV000563308 RCV001545090

NM_024675.4(PALB2):c.1082C>G (p.Thr361Ser)

SNV
Germline

Chr16:23635464

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395133936

rs_1345668733

2 SubmittersRCV000557004 RCV005384760

NM_024675.4(PALB2):c.1061C>G (p.Ser354Cys)

SNV
Germline

Chr16:23635485

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395134068

rs_1555461474

2 SubmittersRCV000532399 RCV005384759

NM_024675.4(PALB2):c.1066A>G (p.Lys356Glu)

SNV
Germline

Chr16:23635480

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified
Familial pancreatic carcinoma
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395134035

rs_1202130508

9 SubmittersRCV000544610 RCV000575442 RCV001174761 RCV005357564 RCV001538610

NM_024675.4(PALB2):c.931A>G (p.Lys311Glu)

SNV
Germline

Chr16:23635615

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395135258

rs_1060499831

5 SubmittersRCV000528073 RCV000564202 RCV001584261

NM_024675.4(PALB2):c.935G>A (p.Ser312Asn)

SNV
Germline

Chr16:23635611

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395135226

rs_1407319475

4 SubmittersRCV000553560 RCV000567058 RCV001800745

NM_024675.4(PALB2):c.892G>A (p.Val298Ile)

SNV
Germline

Chr16:23635654

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA395135620

rs_1060502765

5 SubmittersRCV000551680 RCV000563746 RCV001800744 RCV005357568

NM_024675.4(PALB2):c.828C>T (p.His276=)

SNV
Germline

Chr16:23635718

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Familial ovarian cancer
Fanconi anemia complementation group N
Malignant tumor of breast

Criteria Provided
Conflicting Classifications

CA279499381

rs_911713488

9 SubmittersRCV000557022 RCV000567452 RCV001171908 RCV001357885 RCV001118311 RCV001354533

NM_024675.4(PALB2):c.718C>A (p.Pro240Thr)

SNV
Germline

Chr16:23635828

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA7963768

rs_757567654

5 SubmittersRCV000530439 RCV000568617 RCV001030167 RCV001118312

NM_024675.4(PALB2):c.566G>T (p.Arg189Ile)

SNV
Germline

Chr16:23635980

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963780

rs_764180110

3 SubmittersRCV000535087 RCV001189068

NM_024675.4(PALB2):c.406A>T (p.Ser136Cys)

SNV
Germline

Chr16:23636140

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA7963796

rs_144496685

5 SubmittersRCV000542390 RCV001021800 RCV004525963

NM_024675.4(PALB2):c.3394T>C (p.Leu1132=)

SNV
Germline

Chr16:23603626

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA494173743

rs_1282821765

7 SubmittersRCV000528385 RCV000602592 RCV001121623 RCV001020184 RCV001796099

NM_024675.4(PALB2):c.2452T>C (p.Phe818Leu)

SNV
Germline

Chr16:23629702

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395124159

rs_1555460328

3 SubmittersRCV000546200 RCV001180795

NM_024675.4(PALB2):c.1702C>T (p.Gln568Ter)

SNV
Germline

Chr16:23630452

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395128442

rs_876659354

3 SubmittersRCV000549307 RCV002413486

NM_024675.4(PALB2):c.1507G>C (p.Ala503Pro)

SNV
Germline

Chr16:23635039

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395131030

rs_1555461243

5 SubmittersRCV000540105 RCV000579884 RCV001755821

NM_024675.4(PALB2):c.1458A>G (p.Lys486=)

SNV
Germline

Chr16:23635088

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA494461445

rs_1555461270

4 SubmittersRCV000526724 RCV000985885 RCV004943959

NM_024675.4(PALB2):c.1192G>A (p.Val398Met)

SNV
Germline

Chr16:23635354

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963726

rs_769097541

5 SubmittersRCV000553689 RCV000771520 RCV001030202

NM_024675.4(PALB2):c.1165C>G (p.Leu389Val)

SNV
Germline

Chr16:23635381

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395133462

rs_1555461427

4 SubmittersRCV000552765 RCV000777229 RCV003236811

NM_024675.4(PALB2):c.290C>A (p.Ser97Tyr)

SNV
Germline

Chr16:23636256

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963804

rs_776902295

3 SubmittersRCV000554765 RCV000580967

NM_024675.4(PALB2):c.3165C>G (p.Tyr1055Ter)

SNV
Germline

Chr16:23614040

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395141266

rs_876658157

3 SubmittersRCV000565155 RCV003451225

NM_024675.4(PALB2):c.2920A>G (p.Lys974Glu)

SNV
Germline

Chr16:23623045

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395144193

rs_1418709183

5 SubmittersRCV000568691 RCV000817606 RCV002491131 RCV003128630

NM_024675.4(PALB2):c.3500C>T (p.Thr1167Ile)

SNV
Germline

Chr16:23603520

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA395137900

rs_1308784980

8 SubmittersRCV000571848 RCV000635737 RCV000756459 RCV005018978

NM_024675.4(PALB2):c.2580G>T (p.Glu860Asp)

SNV
Germline

Chr16:23629210

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA395123652

rs_1348398121

5 SubmittersRCV000562114 RCV000704755 RCV005357695

NM_024675.4(PALB2):c.2509G>C (p.Glu837Gln)

SNV
Germline

Chr16:23629645

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395123935

rs_587778587

4 SubmittersRCV000566274 RCV001305394 RCV004592701

NM_024675.4(PALB2):c.2953T>C (p.Ser985Pro)

SNV
Germline

Chr16:23623012

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963462

rs_139726856

4 SubmittersRCV000572069 RCV000635674

NM_024675.4(PALB2):c.2858A>G (p.Asp953Gly)

SNV
Germline

Chr16:23623107

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395144455

rs_1555459583

5 SubmittersRCV000564938 RCV000814534 RCV003478226

NM_024675.4(PALB2):c.2245G>T (p.Glu749Ter)

SNV
Germline

Chr16:23629909

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Multiple Submitters
No Conflicts

CA395125490

rs_1555460431

5 SubmittersRCV000568921 RCV001242094 RCV003338667

NM_024675.4(PALB2):c.2218C>T (p.Gln740Ter)

SNV
Germline

Chr16:23629936

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395125558

rs_1555460445

7 SubmittersRCV000567438 RCV000989559 RCV000587693 RCV003318598

NM_024675.4(PALB2):c.2787T>G (p.Tyr929Ter)

SNV
Germline

Chr16:23624056

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395145066

rs_876660669

1 SubmittersRCV000568858

NM_024675.4(PALB2):c.2749-2A>C

SNV
Germline

Chr16:23624096

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395145283

rs_1555459747

3 SubmittersRCV000574502 RCV001858134

NM_024675.4(PALB2):c.1945A>T (p.Lys649Ter)

SNV
Germline

Chr16:23630209

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395127417

rs_1555460579

4 SubmittersRCV000563292 RCV001224726

NM_024675.4(PALB2):c.3350+4A>C

SNV
Germline

Chr16:23607860

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA658658454

rs_180177136

2 SubmittersRCV000565846 RCV000701534

NM_024675.4(PALB2):c.3201G>A (p.Met1067Ile)

SNV
Germline

Chr16:23614004

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395141087

rs_1555458809

4 SubmittersRCV000561229 RCV000635884

NM_024675.4(PALB2):c.3091A>G (p.Ile1031Val)

SNV
Germline

Chr16:23621384

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963438

rs_757946618

2 SubmittersRCV000561086

NM_024675.4(PALB2):c.2221G>A (p.Gly741Ser)

SNV
Germline

Chr16:23629933

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395125550

rs_1555460440

5 SubmittersRCV000565945 RCV000690008 RCV001030287

NM_024675.4(PALB2):c.1783G>A (p.Asp595Asn)

SNV
Germline

Chr16:23630371

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395128128

rs_1555460653

2 SubmittersRCV000561858 RCV000804639

NM_024675.4(PALB2):c.2026A>C (p.Ile676Leu)

SNV
Germline

Chr16:23630128

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963636

rs_761478794

6 SubmittersRCV000563462 RCV000764049 RCV000989562

NM_024675.4(PALB2):c.2748+1G>A

SNV
Germline

Chr16:23626235

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Multiple Submitters
No Conflicts

CA279488993

rs_753153576

8 SubmittersRCV000563623 RCV001234382 RCV000985891 RCV005018988

NM_024675.4(PALB2):c.1684+1G>T

SNV
Germline

Chr16:23634861

Likely pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395129863

rs_1555461148

4 SubmittersRCV000572683 RCV002221556 RCV003485609

NM_024675.4(PALB2):c.2632G>T (p.Glu878Ter)

SNV
Germline

Chr16:23626352

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395122165

rs_1555459999

4 SubmittersRCV000561696 RCV000635833 RCV001030334

NM_024675.4(PALB2):c.1660G>A (p.Glu554Lys)

SNV
Germline

Chr16:23634886

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA7963687

rs_377486858

5 SubmittersRCV000565852 RCV001053537 RCV001584375 RCV005231088

NM_024675.4(PALB2):c.2461A>T (p.Asn821Tyr)

SNV
Germline

Chr16:23629693

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA279492004

rs_958566673

7 SubmittersRCV000561459 RCV001240791 RCV003151105

NM_024675.4(PALB2):c.1506G>C (p.Lys502Asn)

SNV
Germline

Chr16:23635040

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963701

rs_371142570

4 SubmittersRCV000563604 RCV000691734

NM_024675.4(PALB2):c.2402A>G (p.Asp801Gly)

SNV
Germline

Chr16:23629752

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395124448

rs_1555460348

3 SubmittersRCV000563156 RCV001306017

NM_024675.4(PALB2):c.1327A>T (p.Lys443Ter)

SNV
Germline

Chr16:23635219

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395132293

rs_1555461339

3 SubmittersRCV000574863 RCV000814465

NM_024675.4(PALB2):c.2234A>G (p.Lys745Arg)

SNV
Germline

Chr16:23629920

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Carcinoma of colon
Condition: not provided
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA7963609

rs_142343372

9 SubmittersRCV000566180 RCV000689640 RCV001030288 RCV001775883 RCV002491122

NM_024675.4(PALB2):c.1675C>T (p.Gln559Ter)

SNV
Germline

Chr16:23634871

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Gastric cancer

Criteria Provided
Multiple Submitters
No Conflicts

CA395129920

rs_1555461154

8 SubmittersRCV000566479 RCV000989568 RCV001800773 RCV003159958

NM_024675.4(PALB2):c.2042A>C (p.Lys681Thr)

SNV
Germline

Chr16:23630112

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395126889

rs_1555460514

3 SubmittersRCV000570278 RCV001035439

NM_024675.4(PALB2):c.1994A>T (p.Asp665Val)

SNV
Germline

Chr16:23630160

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395127211

rs_1555460531

3 SubmittersRCV000563467 RCV001324301

NM_024675.4(PALB2):c.1833C>A (p.Asp611Glu)

SNV
Germline

Chr16:23630321

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963656

rs_779184831

8 SubmittersRCV000575169 RCV000586706 RCV000801789

NM_024675.4(PALB2):c.481G>C (p.Asp161His)

SNV
Germline

Chr16:23636065

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963788

rs_769841151

6 SubmittersRCV000566918 RCV000817677 RCV002268179 RCV003318597

NM_024675.4(PALB2):c.371C>T (p.Thr124Ile)

SNV
Germline

Chr16:23636175

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA279500159

rs_45457297

4 SubmittersRCV000562435 RCV000693977 RCV003235296 RCV004689798

NM_024675.4(PALB2):c.1012C>A (p.Pro338Thr)

SNV
Germline

Chr16:23635534

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395134450

rs_560853558

2 SubmittersRCV000566139 RCV001858211

NM_024675.4(PALB2):c.1243A>C (p.Ser415Arg)

SNV
Germline

Chr16:23635303

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395132937

rs_1555461376

2 SubmittersRCV000570108 RCV001039556

NM_024675.4(PALB2):c.854C>G (p.Ser285Ter)

SNV
Germline

Chr16:23635692

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395135849

rs_180177094

1 SubmittersRCV000561198

NM_024675.4(PALB2):c.1176A>G (p.Glu392=)

SNV
Germline

Chr16:23635370

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA494461843

rs_1555461423

5 SubmittersRCV000570728 RCV001423280 RCV003321674

NM_024675.4(PALB2):c.808A>G (p.Ser270Gly)

SNV
Germline

Chr16:23635738

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395136000

rs_1347076714

5 SubmittersRCV000563900 RCV000807027 RCV000985895

NM_024675.4(PALB2):c.43G>A (p.Glu15Lys)

SNV
Germline

Chr16:23641115

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395141028

rs_730881884

4 SubmittersRCV000571125 RCV000635761 RCV004800469

NM_024675.4(PALB2):c.22C>T (p.Pro8Ser)

SNV
Germline

Chr16:23641136

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395141151

rs_876660586

2 SubmittersRCV000575831 RCV001858135

NM_024675.4(PALB2):c.736A>T (p.Thr246Ser)

SNV
Germline

Chr16:23635810

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395136241

rs_1555461659

5 SubmittersRCV000567314 RCV000699347 RCV001775886

NM_024675.4(PALB2):c.560C>A (p.Pro187His)

SNV
Germline

Chr16:23635986

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5
Hereditary cancer

Criteria Provided
Conflicting Classifications

CA7963781

rs_371582757

11 SubmittersRCV000563795 RCV000635903 RCV002476221 RCV003448324 RCV003492103

NM_024675.4(PALB2):c.509G>C (p.Arg170Thr)

SNV
Germline

Chr16:23636037

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA279499902

rs_898765598

7 SubmittersRCV000564267 RCV000818311 RCV001030155

NM_024675.4(PALB2):c.193C>G (p.Pro65Ala)

SNV
Germline

Chr16:23637868

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395139040

rs_1229828972

2 SubmittersRCV000564430 RCV000704290

NM_024675.4(PALB2):c.850A>G (p.Thr284Ala)

SNV
Germline

Chr16:23635696

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395135866

rs_1555461584

4 SubmittersRCV000575140 RCV001030183 RCV003607310

NM_024675.4(PALB2):c.682C>T (p.Gln228Ter)

SNV
Germline

Chr16:23635864

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Reviewed By Expert Panel

CA395136420

rs_1327399690

5 SubmittersRCV000573011 RCV000635756 RCV003987611

NM_024675.4(PALB2):c.280G>C (p.Glu94Gln)

SNV
Germline

Chr16:23636266

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395138842

rs_45602040

2 SubmittersRCV000566283 RCV001853787

NM_024675.4(PALB2):c.233T>C (p.Val78Ala)

SNV
Germline

Chr16:23636313

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395138944

rs_1313634930

4 SubmittersRCV000575076 RCV001044744

NM_024675.4(PALB2):c.7G>A (p.Glu3Lys)

SNV
Germline

Chr16:23641151

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395141243

rs_878855123

2 SubmittersRCV000561851 RCV001064138

NM_024675.4(PALB2):c.3130C>T (p.Gln1044Ter)

SNV
Germline

Chr16:23614075

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395141418

rs_766394024

5 SubmittersRCV000565870 RCV000700246 RCV003155951

NM_024675.4(PALB2):c.2834+1G>C

SNV
Germline

Chr16:23624008

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395144749

rs_587776419

3 SubmittersRCV000569964 RCV001858210 RCV003320696

NM_024675.4(PALB2):c.2512C>T (p.Gln838Ter)

SNV
Germline

Chr16:23629642

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395123923

rs_750650768

6 SubmittersRCV000561038 RCV001053672 RCV001553686

NM_024675.4(PALB2):c.2503T>A (p.Ser835Thr)

SNV
Germline

Chr16:23629651

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395123952

rs_1343435250

2 SubmittersRCV000562867 RCV001858209

NM_024675.4(PALB2):c.2494C>T (p.His832Tyr)

SNV
Germline

Chr16:23629660

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA279491908

rs_901786175

4 SubmittersRCV000568602 RCV000635698 RCV001174939

NM_024675.4(PALB2):c.1883A>C (p.Lys628Thr)

SNV
Germline

Chr16:23630271

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA279493367

rs_954390684

6 SubmittersRCV000570203 RCV000706639 RCV001584379 RCV004800473

NM_024675.4(PALB2):c.1784A>G (p.Asp595Gly)

SNV
Germline

Chr16:23630370

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395128119

rs_1555460652

2 SubmittersRCV000571419 RCV000812280

NM_024675.4(PALB2):c.1648A>T (p.Lys550Ter)

SNV
Germline

Chr16:23634898

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395130127

rs_1555461178

3 SubmittersRCV000569937 RCV001853819

NM_024675.4(PALB2):c.1562C>T (p.Thr521Ile)

SNV
Germline

Chr16:23634984

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395130739

rs_1555461218

2 SubmittersRCV000571175 RCV001304806

NM_024675.4(PALB2):c.1377C>A (p.Asp459Glu)

SNV
Germline

Chr16:23635169

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963712

rs_771002573

3 SubmittersRCV000564673 RCV001218569

NM_024675.4(PALB2):c.1292G>A (p.Ser431Asn)

SNV
Germline

Chr16:23635254

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA395132501

rs_1555461357

4 SubmittersRCV000561985 RCV000635950 RCV000780557

NM_024675.4(PALB2):c.1141C>T (p.Leu381Phe)

SNV
Germline

Chr16:23635405

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395133592

rs_1555461435

2 SubmittersRCV000566800 RCV001239808

NM_024675.4(PALB2):c.814G>T (p.Glu272Ter)

SNV
Germline

Chr16:23635732

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395135986

rs_515726127

1 SubmittersRCV000562700

NM_024675.4(PALB2):c.505C>G (p.Leu169Val)

SNV
Germline

Chr16:23636041

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395137027

rs_180177086

2 SubmittersRCV000575213 RCV001345557

NM_024675.4(PALB2):c.349C>A (p.Pro117Thr)

SNV
Germline

Chr16:23636197

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA395137687

rs_1413238389

6 SubmittersRCV000567477 RCV000684939 RCV003237929 RCV003444602

NM_024675.4(PALB2):c.187C>G (p.Leu63Val)

SNV
Germline

Chr16:23637874

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963829

rs_730881899

2 SubmittersRCV000575025 RCV001858327

NM_024675.4(PALB2):c.90G>A (p.Lys30=)

SNV
Germline

Chr16:23638088

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA494167972

rs_515726130

4 SubmittersRCV000566824 RCV001444109 RCV003478215

NM_024675.4(PALB2):c.48+1G>A

SNV
Germline

Chr16:23641109

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395140998

rs_515726118

5 SubmittersRCV000561202 RCV000635645 RCV000708619

NM_024675.4(PALB2):c.866T>A (p.Leu289Ter)

SNV
Unknown

Chr16:23635680

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395135804

rs_1555461574

2 SubmittersRCV000576557

NM_024675.4(PALB2):c.1538C>T (p.Thr513Ile)

SNV
Germline

Chr16:23635008

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963699

rs_778890869

5 SubmittersRCV000580586 RCV000635783 RCV001030236

NM_024675.4(PALB2):c.3379T>C (p.Cys1127Arg)

SNV
Germline

Chr16:23603641

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Ovarian cancer
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Hereditary breast ovarian cancer syndrome

Criteria Provided
Conflicting Classifications

CA7963346

rs_767830005

11 SubmittersRCV000579960 RCV000701458 RCV001030414 RCV003153752 RCV005019004 RCV005367434

NM_024675.4(PALB2):c.1684+11A>G

SNV
Germline

Chr16:23634851

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963684

rs_201368043

3 SubmittersRCV000580824 RCV001121720 RCV001860051

NM_024675.4(PALB2):c.109-12T>A

SNV
Germline

Chr16:23637964

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
PALB2-related cancer predisposition
Fanconi anemia complementation group N

Criteria Provided
Multiple Submitters
No Conflicts

CA7963843

rs_774949203

8 SubmittersRCV000579887 RCV000794723 RCV001030120 RCV005357727 RCV003133384

NM_024675.4(PALB2):c.2500C>T (p.His834Tyr)

SNV
Germline

Chr16:23629654

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395123962

rs_1555460308

3 SubmittersRCV000579392 RCV001853887

NM_024675.4(PALB2):c.1772C>A (p.Pro591Gln)

SNV
Germline

Chr16:23630382

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963662

rs_761773470

4 SubmittersRCV000581038 RCV000809631

NM_024675.4(PALB2):c.3067C>T (p.Gln1023Ter)

SNV
Germline

Chr16:23621408

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395142961

rs_1555459386

3 SubmittersRCV000584638 RCV000803999 RCV001269180

NM_024675.4(PALB2):c.211+1G>A

SNV
Germline

Chr16:23637849

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA395139005

rs_1555462026

8 SubmittersRCV000581906 RCV000989582 RCV002466544 RCV005357759

NM_024675.4(PALB2):c.3166C>T (p.Gln1056Ter)

SNV
Germline

Chr16:23614039

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Gastric cancer
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA279530832

rs_1021662947

7 SubmittersRCV000581301 RCV001038568 RCV003159983 RCV005256644

NM_024675.4(PALB2):c.2996+14T>G

SNV
Germline

Chr16:23622955

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Familial cancer of breast
PALB2-related cancer predisposition

Criteria Provided
Conflicting Classifications

CA621661650

rs_1407045774

4 SubmittersRCV000583916 RCV001116751 RCV002061896 RCV005357760

NM_024675.4(PALB2):c.1227T>C (p.Tyr409=)

SNV
Germline

Chr16:23635319

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
not specified
Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494461670

rs_1555461386

8 SubmittersRCV000581501 RCV000600139 RCV000759892 RCV001451262

NM_024675.4(PALB2):c.1148T>C (p.Leu383Pro)

SNV
Germline

Chr16:23635398

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395133557

rs_1555461432

2 SubmittersRCV000584423

NM_024675.4(PALB2):c.3350+2C>G

SNV
Germline

Chr16:23607862

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395139182

rs_1555458171

5 SubmittersRCV000582943 RCV001361268

NM_024675.4(PALB2):c.3113+17G>T

SNV
Germline

Chr16:23621345

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
not specified
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA621356238

rs_1451806881

4 SubmittersRCV000581411 RCV000609993 RCV001853933

NM_024675.4(PALB2):c.2515-7T>G

SNV
Germline

Chr16:23629282

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA658683922

rs_1555460231

3 SubmittersRCV000582208 RCV002530804

NM_024675.4(PALB2):c.-10C>T

SNV
Germline

Chr16:23641167

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
PALB2-related cancer predisposition

Criteria Provided
Conflicting Classifications

CA279505441

rs_1038099508

6 SubmittersRCV000583508 RCV001712601 RCV005357758

NM_024675.4(PALB2):c.1301A>C (p.Asp434Ala)

SNV
Germline

Chr16:23635245

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963721

rs_757972600

3 SubmittersRCV000581417 RCV001345251

NM_024675.4(PALB2):c.303T>G (p.Asp101Glu)

SNV
Germline

Chr16:23636243

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
not specified
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA395138797

rs_1417779335

5 SubmittersRCV000583166 RCV001800806 RCV003133386 RCV005019008

NM_024675.4(PALB2):c.2749-1G>T

SNV
Germline

Chr16:23624095

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA16609292

rs_1060502804

4 SubmittersRCV000581632 RCV000824261

NM_024675.4(PALB2):c.2673C>A (p.Cys891Ter)

SNV
Germline

Chr16:23626311

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395122040

rs_78179744

5 SubmittersRCV000582849 RCV002529275

NM_024675.4(PALB2):c.2464C>T (p.Gln822Ter)

SNV
Germline

Chr16:23629690

Pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395124102

rs_1555460323

5 SubmittersRCV000581596 RCV002268211 RCV003451307

NM_024675.4(PALB2):c.2437A>C (p.Ile813Leu)

SNV
Germline

Chr16:23629717

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963574

rs_766396469

4 SubmittersRCV000584188 RCV000699252 RCV001567582

NM_024675.4(PALB2):c.1940A>T (p.His647Leu)

SNV
Germline

Chr16:23630214

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA395127436

rs_1055533509

5 SubmittersRCV000582747 RCV000695699 RCV001755976 RCV002282244

NM_024675.4(PALB2):c.1685-7T>G

SNV
Germline

Chr16:23630476

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified

Criteria Provided
Conflicting Classifications

CA658683933

rs_1555460705

5 SubmittersRCV000582581 RCV000663169 RCV004767419

NM_024675.4(PALB2):c.1597A>G (p.Thr533Ala)

SNV
Germline

Chr16:23634949

Conflicting classifications of pathogenicity

Breast carcinoma
Familial cancer of breast
Malignant tumor of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395130540

rs_1393117824

6 SubmittersRCV000626962 RCV000815815 RCV001356890 RCV003478331 RCV001012327

NM_024675.4(PALB2):c.3523C>T (p.Gln1175Ter)

SNV
Germline

Chr16:23603497

Pathogenic

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395137833

rs_1555457841

5 SubmittersRCV000635687 RCV001702535 RCV002334080

NM_024675.4(PALB2):c.2834+5G>A

SNV
Germline

Chr16:23624004

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA7963478

rs_570455216

5 SubmittersRCV000635658 RCV001016729 RCV004723006

NM_024675.4(PALB2):c.2694G>A (p.Trp898Ter)

SNV
Germline

Chr16:23626290

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395121972

rs_1555459949

2 SubmittersRCV000635736

NM_024675.4(PALB2):c.2650G>T (p.Glu884Ter)

SNV
Germline

Chr16:23626334

Pathogenic

Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395122125

rs_1304351755

7 SubmittersRCV000635848 RCV005416117 RCV000760341

NM_024675.4(PALB2):c.2345C>A (p.Pro782Gln)

SNV
Germline

Chr16:23629809

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963590

rs_772095244

3 SubmittersRCV000635803 RCV002424398

NM_024675.4(PALB2):c.3494C>A (p.Ser1165Ter)

SNV
Germline

Chr16:23603526

Pathogenic/Likely pathogenic

Breast and/or ovarian cancer
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395137923

rs_773829275

5 SubmittersRCV001270994 RCV000635924 RCV003303005

NM_024675.4(PALB2):c.2989G>T (p.Asp997Tyr)

SNV
Germline

Chr16:23622976

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395143864

rs_1555459513

6 SubmittersRCV000776383 RCV000635883 RCV001192766 RCV004721509

NM_024675.4(PALB2):c.157G>A (p.Glu53Lys)

SNV
Germline

Chr16:23637904

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395139231

rs_1184603042

5 SubmittersRCV000635779 RCV000709389

NM_024675.4(PALB2):c.2748+8G>A

SNV
Germline

Chr16:23626228

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA621661861

rs_1188895680

4 SubmittersRCV000636047 RCV001182085 RCV005357839

NM_024675.4(PALB2):c.2587-7G>A

SNV
Germline

Chr16:23626404

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA279489186

rs_932395531

4 SubmittersRCV000635604 RCV003584684 RCV001558518

NM_024675.4(PALB2):c.1984A>T (p.Lys662Ter)

SNV
Germline

Chr16:23630170

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395127256

rs_1555460533

4 SubmittersRCV000635787 RCV001190673

NM_024675.4(PALB2):c.1685-3T>C

SNV
Germline

Chr16:23630472

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA658798577

rs_1254059410

5 SubmittersRCV000635992 RCV003128674 RCV002404773

NM_024675.4(PALB2):c.1448C>A (p.Ser483Ter)

SNV
Germline

Chr16:23635098

Pathogenic

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395131234

rs_1057520736

4 SubmittersRCV000635841 RCV001591416 RCV002388041

NM_024675.4(PALB2):c.932A>G (p.Lys311Arg)

SNV
Germline

Chr16:23635614

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA7963744

rs_755129205

5 SubmittersRCV000635946 RCV001030189 RCV001019174 RCV001194138

NM_024675.4(PALB2):c.2267G>A (p.Cys756Tyr)

SNV
Germline

Chr16:23629887

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA279492499

rs_925044785

8 SubmittersRCV000635807 RCV001014983 RCV001030292 RCV003133422

NM_024675.4(PALB2):c.926T>G (p.Ile309Arg)

SNV
Germline

Chr16:23635620

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA279499141

rs_201588519

3 SubmittersRCV000635796 RCV001189067

NM_024675.4(PALB2):c.846A>T (p.Arg282Ser)

SNV
Germline

Chr16:23635700

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395135882

rs_1555461587

3 SubmittersRCV000635901 RCV002448970

NM_024675.4(PALB2):c.2968G>C (p.Glu990Gln)

SNV
Germline

Chr16:23622997

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395143969

rs_876659036

3 SubmittersRCV000635602 RCV001796150 RCV002438681

NM_024675.4(PALB2):c.2869A>T (p.Lys957Ter)

SNV
Germline

Chr16:23623096

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395144397

rs_515726103

1 SubmittersRCV000635650

NM_024675.4(PALB2):c.1607T>C (p.Leu536Pro)

SNV
Germline

Chr16:23634939

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395130490

rs_1555461198

3 SubmittersRCV000635825 RCV003233767 RCV004649235

NM_024675.4(PALB2):c.109-5T>C

SNV
Germline

Chr16:23637957

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963841

rs_749299119

7 SubmittersRCV001030121 RCV001017270 RCV001706691

NM_024675.4(PALB2):c.3441T>A (p.Cys1147Ter)

SNV
Germline

Chr16:23603579

Pathogenic/Likely pathogenic

Familial cancer of breast
Condition: not provided
Malignant tumor of breast
PALB2-related disorder
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA395138136

rs_1555457867

10 SubmittersRCV001213219 RCV000657758 RCV004526734 RCV004740390 RCV002458171 RCV005019096

NM_024675.4(PALB2):c.3425T>A (p.Leu1142Ter)

SNV
Germline

Chr16:23603595

Pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395138197

rs_1555457878

2 SubmittersRCV000657760 RCV001234062

NM_024675.4(PALB2):c.1288C>T (p.Gln430Ter)

SNV
Germline

Chr16:23635258

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395132531

rs_1555461358

5 SubmittersRCV000657764 RCV000662965 RCV002386129

NM_024675.4(PALB2):c.475G>T (p.Glu159Ter)

SNV
Germline

Chr16:23636071

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395137122

rs_1555461788

3 SubmittersRCV000662619

NM_024675.4(PALB2):c.212-2A>T

SNV
Unknown

Chr16:23636336

Likely pathogenic

Familial cancer of breast

No Assertion Criteria Provided

CA395139000

rs_730881879

1 SubmittersRCV000662995

NM_024675.4(PALB2):c.778C>T (p.Gln260Ter)

SNV
Germline

Chr16:23635768

Pathogenic

Neuroendocrine tumor of pancreas
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395136081

rs_1555461627

5 SubmittersRCV000677896 RCV003453394 RCV002406519

NM_024675.4(PALB2):c.2515-11T>C

SNV
Germline

Chr16:23629286

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963546

rs_780521904

6 SubmittersRCV000679764 RCV000771301 RCV002066995

NM_024675.4(PALB2):c.1991T>G (p.Met664Arg)

SNV
Germline

Chr16:23630163

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395127223

rs_945657254

3 SubmittersRCV001013949 RCV000679762 RCV000801768

NM_024675.4(PALB2):c.3340C>T (p.Gln1114Ter)

SNV
Germline

Chr16:23607874

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395139278

rs_1567206756

5 SubmittersRCV000700359 RCV000708618

NM_024675.4(PALB2):c.3262C>T (p.Pro1088Ser)

SNV
Germline

Chr16:23607952

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395139751

rs_1060502777

2 SubmittersRCV000691622 RCV001019527

NM_024675.4(PALB2):c.2540C>G (p.Ser847Cys)

SNV
Germline

Chr16:23629250

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA395123812

rs_1567216902

4 SubmittersRCV000686106 RCV001015881 RCV002485597

NM_024675.4(PALB2):c.97G>C (p.Ala33Pro)

SNV
Germline

Chr16:23638081

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Criteria Provided
Conflicting Classifications

CA395139652

rs_747302288

2 SubmittersRCV000689943 RCV003483707

NM_024675.4(PALB2):c.3350+6T>C

SNV
Germline

Chr16:23607858

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA891843570

rs_1567206733

1 SubmittersRCV000704793

NM_024675.4(PALB2):c.2515-1G>A

SNV
Germline

Chr16:23629276

Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Pancreatic cancer, susceptibility to, 3
Breast cancer, susceptibility to

Criteria Provided
Multiple Submitters
No Conflicts

CA395123879

rs_587776417

5 SubmittersRCV000707120 RCV001015744 RCV001258101

NM_024675.4(PALB2):c.1150G>A (p.Glu384Lys)

SNV
Germline

Chr16:23635396

Conflicting classifications of pathogenicity

Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395133552

rs_1567221497

4 SubmittersRCV000693232 RCV002493183 RCV001181141

NM_024675.4(PALB2):c.938G>A (p.Gly313Asp)

SNV
Germline

Chr16:23635608

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395135187

rs_1555461531

2 SubmittersRCV000704478 RCV005463103

NM_024675.4(PALB2):c.113C>T (p.Ala38Val)

SNV
Germline

Chr16:23637948

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Ovarian cancer
Pancreatic cancer, susceptibility to, 3
Familial cancer of breast
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA7963837

rs_371875379

5 SubmittersRCV000694173 RCV000774648 RCV003153807 RCV002477574

NM_024675.4(PALB2):c.3037A>G (p.Ile1013Val)

SNV
Germline

Chr16:23621438

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395143060

rs_1567212950

4 SubmittersRCV000695855 RCV001030369 RCV002507213 RCV003362904

NM_024675.4(PALB2):c.2698G>C (p.Ala900Pro)

SNV
Germline

Chr16:23626286

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395121953

rs_1555459946

4 SubmittersRCV000691295 RCV001016341 RCV001729686

NM_024675.4(PALB2):c.2273C>T (p.Pro758Leu)

SNV
Germline

Chr16:23629881

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA7963603

rs_746117401

6 SubmittersRCV000700574 RCV001284196 RCV002442498 RCV004527749

NM_024675.4(PALB2):c.1006A>C (p.Asn336His)

SNV
Germline

Chr16:23635540

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA395134551

rs_1060502774

5 SubmittersRCV000701789 RCV000985881 RCV002422574 RCV003479202

NM_024675.4(PALB2):c.3342G>C (p.Gln1114His)

SNV
Germline

Chr16:23607872

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395139263

rs_1567206753

3 SubmittersRCV000707157 RCV000776589

NM_024675.4(PALB2):c.2645G>T (p.Cys882Phe)

SNV
Germline

Chr16:23626339

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395122138

rs_45486906

3 SubmittersRCV000704896 RCV001184091

NM_024675.4(PALB2):c.2813A>G (p.Asn938Ser)

SNV
Germline

Chr16:23624030

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395144893

rs_1567214357

5 SubmittersRCV000708729 RCV000802486 RCV002298749

NM_024675.4(PALB2):c.1152A>G (p.Glu384=)

SNV
Germline

Chr16:23635394

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494461920

rs_1567221490

3 SubmittersRCV000708727 RCV005422950

NM_024675.4(PALB2):c.868G>T (p.Glu290Ter)

SNV
Germline

Chr16:23635678

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395135793

rs_1567222143

4 SubmittersRCV000708621 RCV000794070

NM_024675.4(PALB2):c.49-1G>A

SNV
Germline

Chr16:23638130

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395140039

rs_1440838364

4 SubmittersRCV000708620 RCV005092051

NM_024675.4(PALB2):c.2587-1G>C

SNV
Germline

Chr16:23626398

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA7963519

rs_761214886

7 SubmittersRCV000709380 RCV000989555 RCV001759427 RCV005357957

NM_024675.4(PALB2):c.50T>G (p.Leu17Ter)

SNV
Germline

Chr16:23638128

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395140021

rs_1567224232

4 SubmittersRCV000709390 RCV000989583

NM_024675.4(PALB2):c.2192T>G (p.Leu731Ter)

SNV
Germline

Chr16:23629962

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395125606

rs_1567217898

6 SubmittersRCV000755035 RCV001855858 RCV001354086

NM_024675.4(PALB2):c.1919C>G (p.Ser640Ter)

SNV
Germline

Chr16:23630235

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395127515

rs_760094988

5 SubmittersRCV000756460 RCV003453539 RCV002406678

NM_024675.4(PALB2):c.1941T>C (p.His647=)

SNV
Germline

Chr16:23630213

Conflicting classifications of pathogenicity

Condition: not provided
not specified
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963643

rs_745467835

5 SubmittersRCV000759182 RCV000781683 RCV001080752 RCV002406684

NM_024675.4(PALB2):c.1673T>C (p.Ile558Thr)

SNV
Germline

Chr16:23634873

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963686

rs_766583287

4 SubmittersRCV000759897 RCV001340380 RCV003166013

NM_024675.4(PALB2):c.1046A>C (p.Asn349Thr)

SNV
Germline

Chr16:23635500

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395134191

rs_1567221740

3 SubmittersRCV000759891 RCV000806524 RCV003279043

NM_024675.4(PALB2):c.613G>T (p.Glu205Ter)

SNV
Germline

Chr16:23635933

Likely pathogenic

Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395136640

rs_1567222636

2 SubmittersRCV000759192

NM_024675.4(PALB2):c.379C>T (p.His127Tyr)

SNV
Germline

Chr16:23636167

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA279500141

rs_1056494105

4 SubmittersRCV000759189 RCV001021174 RCV002533132

NM_024675.4(PALB2):c.48+10G>A

SNV
Germline

Chr16:23641100

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
PALB2-related cancer predisposition

Criteria Provided
Conflicting Classifications

CA913190540

rs_1311681895

4 SubmittersRCV000759190 RCV001472512 RCV005367536

NM_024675.4(PALB2):c.2866G>T (p.Glu956Ter)

SNV
Germline

Chr16:23623099

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395144411

rs_1219715328

4 SubmittersRCV000772898 RCV001388158

NM_024675.4(PALB2):c.2522C>T (p.Thr841Ile)

SNV
Germline

Chr16:23629268

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395123851

rs_1373085553

3 SubmittersRCV000773403 RCV003768340

NM_024675.4(PALB2):c.2336C>T (p.Ser779Leu)

SNV
Germline

Chr16:23629818

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Fanconi anemia complementation group N
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA395124994

rs_764509489

4 SubmittersRCV000773204 RCV000819396 RCV002507340

NM_024675.4(PALB2):c.1997C>T (p.Thr666Ile)

SNV
Germline

Chr16:23630157

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Familial cancer of breast
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA395127183

rs_1567218311

5 SubmittersRCV000777409 RCV001869122 RCV002477779 RCV005358024

NM_024675.4(PALB2):c.1878A>G (p.Lys626=)

SNV
Germline

Chr16:23630276

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494461216

rs_1567218624

3 SubmittersRCV000774266 RCV001468975

NM_024675.4(PALB2):c.1673T>G (p.Ile558Ser)

SNV
Germline

Chr16:23634873

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395129930

rs_766583287

2 SubmittersRCV000774306

NM_024675.4(PALB2):c.1536C>A (p.Tyr512Ter)

SNV
Germline

Chr16:23635010

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395130912

rs_1567220802

5 SubmittersRCV000820180 RCV000773666 RCV001030234

NM_024675.4(PALB2):c.1430C>A (p.Thr477Asn)

SNV
Germline

Chr16:23635116

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395131289

rs_1567221020

3 SubmittersRCV000771646 RCV000817099

NM_024675.4(PALB2):c.1376A>G (p.Asp459Gly)

SNV
Germline

Chr16:23635170

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA279498431

rs_1031787378

4 SubmittersRCV000776558 RCV001030219

NM_024675.4(PALB2):c.352A>G (p.Ile118Val)

SNV
Germline

Chr16:23636194

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395137667

rs_1567223015

3 SubmittersRCV000772634 RCV001064113

NM_024675.4(PALB2):c.341G>A (p.Gly114Glu)

SNV
Germline

Chr16:23636205

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395137738

rs_1567223045

3 SubmittersRCV000774983 RCV003607351

NM_024675.4(PALB2):c.289T>C (p.Ser97Pro)

SNV
Germline

Chr16:23636257

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395138822

rs_1456296764

4 SubmittersRCV000775252 RCV001344073 RCV003166052

NM_024675.4(PALB2):c.73A>T (p.Lys25Ter)

SNV
Germline

Chr16:23638105

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395139806

rs_1248579792

6 SubmittersRCV000772890 RCV001030115 RCV003155956

NM_024675.4(PALB2):c.22C>A (p.Pro8Thr)

SNV
Germline

Chr16:23641136

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA395141153

rs_876660586

4 SubmittersRCV000773884 RCV001209051 RCV005367544

NM_024675.4(PALB2):c.2515-14T>A

SNV
Germline

Chr16:23629289

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963547

rs_752108348

3 SubmittersRCV000774629 RCV002061094

NM_024675.4(PALB2):c.1685-1G>A

SNV
Germline

Chr16:23630470

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395128493

rs_1057520645

3 SubmittersRCV000773053 RCV001064056

NM_024675.4(PALB2):c.3201+4A>G

SNV
Germline

Chr16:23614000

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA621354618

rs_1226634357

3 SubmittersRCV000774968 RCV001304942

NM_024675.4(PALB2):c.2587-9T>C

SNV
Germline

Chr16:23626406

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA494161343

rs_1567215613

4 SubmittersRCV000777528 RCV001050389 RCV003478478

NM_024675.4(PALB2):c.1685-10T>C

SNV
Germline

Chr16:23630479

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Hereditary cancer

Criteria Provided
Conflicting Classifications

CA913188779

rs_1567219034

4 SubmittersRCV000774865 RCV001491198 RCV005231318

NM_024675.4(PALB2):c.3201+5G>T

SNV
Germline

Chr16:23613999

Likely pathogenic

Hereditary breast ovarian cancer syndrome

Criteria Provided
Single Submitter

CA915949160

rs_1597073208

1 SubmittersRCV000845286

NM_024675.4(PALB2):c.2759T>G (p.Leu920Ter)

SNV
Germline

Chr16:23624084

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395145235

rs_1567214493

4 SubmittersRCV000780562 RCV002440616

NM_024675.4(PALB2):c.2616G>T (p.Val872=)

SNV
Germline

Chr16:23626368

Conflicting classifications of pathogenicity

not specified
Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494161299

rs_1567215519

6 SubmittersRCV000780565 RCV000878247 RCV002440617 RCV001078566

NM_024675.4(PALB2):c.2012T>G (p.Leu671Ter)

SNV
Germline

Chr16:23630142

Pathogenic/Likely pathogenic

Familial cancer of breast
Malignant tumor of breast
Hereditary cancer-predisposing syndrome
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA7963637

rs_755263466

7 SubmittersRCV000780570 RCV001355597 RCV002422668 RCV003155957

NM_024675.4(PALB2):c.1121T>C (p.Ile374Thr)

SNV
Germline

Chr16:23635425

Conflicting classifications of pathogenicity

not specified
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395133702

rs_1567221558

4 SubmittersRCV000781685 RCV000794017 RCV001009887

NM_024675.4(PALB2):c.761C>G (p.Ser254Ter)

SNV
Germline

Chr16:23635785

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Uterine corpus cancer

Criteria Provided
Multiple Submitters
No Conflicts

CA395136152

rs_864622695

4 SubmittersRCV000780563 RCV001026625 RCV003128160

NC_000016.10:g.23626399T>C

SNV
Germline

Chr16:23626399

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395122290

rs_1060502787

2 SubmittersRCV002026378

NM_024675.4(PALB2):c.2514+2T>C

SNV
Germline

Chr16:23629638

Pathogenic

Condition: not provided

No Assertion Criteria Provided

CA395123908

rs_1343145658

2 SubmittersRCV000786800

NM_024675.4(PALB2):c.2768T>G (p.Val923Gly)

SNV
Germline

Chr16:23624075

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395145174

rs_1597082876

2 SubmittersRCV000993768

NM_024675.4(PALB2):c.3477G>A (p.Trp1159Ter)

SNV
Germline

Chr16:23603543

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395137993

rs_1597061983

3 SubmittersRCV000811935 RCV004028753

NM_024675.4(PALB2):c.3277A>G (p.Ile1093Val)

SNV
Germline

Chr16:23607937

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395139636

rs_1597066812

3 SubmittersRCV000792136 RCV004027409

NM_024675.4(PALB2):c.2942G>A (p.Ser981Asn)

SNV
Germline

Chr16:23623023

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395144102

rs_1597081224

2 SubmittersRCV000805772 RCV005401618

NM_024675.4(PALB2):c.2773G>A (p.Val925Met)

SNV
Germline

Chr16:23624070

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395145141

rs_180177125

2 SubmittersRCV000807391 RCV004028613

NM_024675.4(PALB2):c.2749G>A (p.Val917Ile)

SNV
Germline

Chr16:23624094

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
PALB2-related disorder
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395145267

rs_753767237

4 SubmittersRCV000815988 RCV001016480 RCV004545803 RCV005251230

NM_024675.4(PALB2):c.2566C>T (p.Gln856Ter)

SNV
Germline

Chr16:23629224

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA7963540

rs_770996884

6 SubmittersRCV000816115 RCV001015972

NM_024675.4(PALB2):c.2422G>T (p.Gly808Ter)

SNV
Germline

Chr16:23629732

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395124318

rs_1064795507

1 SubmittersRCV000804000

NM_024675.4(PALB2):c.2329G>T (p.Asp777Tyr)

SNV
Germline

Chr16:23629825

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395125061

rs_148026749

2 SubmittersRCV000811967 RCV001015206

NM_024675.4(PALB2):c.2218C>G (p.Gln740Glu)

SNV
Germline

Chr16:23629936

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395125557

rs_1555460445

3 SubmittersRCV000813235 RCV001805889

NM_024675.4(PALB2):c.1781G>A (p.Arg594Lys)

SNV
Germline

Chr16:23630373

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395128146

rs_1597091217

3 SubmittersRCV000794250 RCV001524353

NM_024675.4(PALB2):c.1779T>C (p.His593=)

SNV
Germline

Chr16:23630375

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA494461386

rs_1475548158

3 SubmittersRCV000808278 RCV001013149

NM_024675.4(PALB2):c.1647C>G (p.His549Gln)

SNV
Germline

Chr16:23634899

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395130140

rs_747842085

2 SubmittersRCV000812545

NM_024675.4(PALB2):c.1522C>T (p.Pro508Ser)

SNV
Germline

Chr16:23635024

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395130967

rs_1597095773

2 SubmittersRCV000808247 RCV001012001

NM_024675.4(PALB2):c.1432T>C (p.Ser478Pro)

SNV
Germline

Chr16:23635114

Conflicting classifications of pathogenicity

Familial cancer of breast
not specified
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395131285

rs_1597096071

3 SubmittersRCV000796364 RCV002249510 RCV002388440

NM_024675.4(PALB2):c.1129C>T (p.Gln377Ter)

SNV
Germline

Chr16:23635417

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA279498785

rs_929474806

5 SubmittersRCV002325498 RCV000792959

NM_024675.4(PALB2):c.1010T>A (p.Leu337Ter)

SNV
Germline

Chr16:23635536

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395134478

rs_45494092

2 SubmittersRCV000794532 RCV004027491

NM_024675.4(PALB2):c.512T>A (p.Leu171Ter)

SNV
Germline

Chr16:23636034

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395137012

rs_876658979

2 SubmittersRCV000798117 RCV004944161

NM_024675.4(PALB2):c.254A>G (p.Lys85Arg)

SNV
Germline

Chr16:23636292

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395138897

rs_1597099769

3 SubmittersRCV001030139 RCV004944140 RCV000791662

NM_024675.4(PALB2):c.212-2A>C

SNV
Germline

Chr16:23636336

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395138999

rs_730881879

6 SubmittersRCV000793896 RCV001268209 RCV002422689

NM_024675.4(PALB2):c.3113+5G>A

SNV
Germline

Chr16:23621357

Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA915949162

rs_876659463

3 SubmittersRCV000821488 RCV002319908 RCV005231391

NM_024675.4(PALB2):c.211+1G>T

SNV
Germline

Chr16:23637849

Pathogenic/Likely pathogenic

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395139004

rs_1555462026

8 SubmittersRCV000806217 RCV001291546 RCV004944181 RCV005092410

NM_024675.4(PALB2):c.-1G>C

SNV
Germline

Chr16:23641158

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA915949148

rs_1341292125

3 SubmittersRCV000827093 RCV004029200 RCV005432454

NM_024675.4(PALB2):c.2202T>C (p.Thr734=)

SNV
Germline

Chr16:23629952

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA494461110

rs_1278216949

4 SubmittersRCV001499662 RCV003478554 RCV002427183

NM_024675.4(PALB2):c.1621A>C (p.Arg541=)

SNV
Germline

Chr16:23634925

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA494461352

rs_1597095457

5 SubmittersRCV001407327 RCV001805944 RCV000966551

NM_024675.4(PALB2):c.1919C>T (p.Ser640Leu)

SNV
Germline

Chr16:23630235

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395127513

rs_760094988

4 SubmittersRCV000985888 RCV003473528 RCV004030102

NM_024675.4(PALB2):c.1566A>G (p.Pro522=)

SNV
Germline

Chr16:23634980

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494461275

rs_1597095620

5 SubmittersRCV000985886 RCV001186186 RCV001495441

NM_024675.4(PALB2):c.1917G>T (p.Glu639Asp)

SNV
Germline

Chr16:23630237

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395127520

rs_1597090787

2 SubmittersRCV000989564

NM_024675.4(PALB2):c.3469C>T (p.Gln1157Ter)

SNV
Germline

Chr16:23603551

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Malignant tumor of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395138028

rs_1597062038

7 SubmittersRCV001020375 RCV001860983 RCV003226417

NM_024675.4(PALB2):c.3460G>A (p.Val1154Ile)

SNV
Germline

Chr16:23603560

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395138067

rs_1597062059

2 SubmittersRCV001020361 RCV005093195

NM_024675.4(PALB2):c.3415A>G (p.Ile1139Val)

SNV
Germline

Chr16:23603605

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial ovarian cancer
Familial cancer of breast
Condition: not provided
not specified

Criteria Provided
Conflicting Classifications

CA395138220

rs_1249960937

6 SubmittersRCV001020240 RCV001356031 RCV001361922 RCV004588497 RCV004702583

NM_024675.4(PALB2):c.3395T>A (p.Leu1132Ter)

SNV
Germline

Chr16:23603625

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395138260

rs_1597062296

3 SubmittersRCV001020185 RCV003455110

NM_024675.4(PALB2):c.2824A>T (p.Arg942Ter)

SNV
Germline

Chr16:23624019

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395144821

rs_757055720

1 SubmittersRCV001016698

NM_024675.4(PALB2):c.2736G>A (p.Trp912Ter)

SNV
Germline

Chr16:23626248

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395121841

rs_1555459925

5 SubmittersRCV001016442 RCV001234330 RCV005232052

NM_024675.4(PALB2):c.2389C>T (p.Gln797Ter)

SNV
Germline

Chr16:23629765

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395124573

rs_1060502768

5 SubmittersRCV001015370 RCV002549416

NM_024675.4(PALB2):c.2123T>A (p.Leu708Ter)

SNV
Germline

Chr16:23630031

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395125753

rs_1597090059

2 SubmittersRCV001014530 RCV003455085

NM_024675.4(PALB2):c.2099C>G (p.Ser700Ter)

SNV
Germline

Chr16:23630055

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395125797

rs_1597090146

1 SubmittersRCV001014427

NM_024675.4(PALB2):c.2078A>T (p.His693Leu)

SNV
Germline

Chr16:23630076

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395126578

rs_587780208

3 SubmittersRCV001014348 RCV001047310 RCV003478620

NM_024675.4(PALB2):c.1915G>T (p.Glu639Ter)

SNV
Germline

Chr16:23630239

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395127528

rs_1555460592

2 SubmittersRCV001013686 RCV003455079

NM_024675.4(PALB2):c.1882A>T (p.Lys628Ter)

SNV
Germline

Chr16:23630272

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395127646

rs_1597090894

2 SubmittersRCV001013510 RCV001380164

NM_024675.4(PALB2):c.1653T>G (p.Tyr551Ter)

SNV
Germline

Chr16:23634893

Pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395130088

rs_118203997

4 SubmittersRCV001012602 RCV001284026 RCV001860714

NM_024675.4(PALB2):c.1643C>G (p.Ser548Ter)

SNV
Germline

Chr16:23634903

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395130162

rs_1241049372

3 SubmittersRCV001012547 RCV001047370

NM_024675.4(PALB2):c.1622G>A (p.Arg541Lys)

SNV
Germline

Chr16:23634924

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395130342

rs_1597095450

3 SubmittersRCV001012445 RCV001358872

NM_024675.4(PALB2):c.1586C>T (p.Pro529Leu)

SNV
Germline

Chr16:23634960

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395130604

rs_1597095559

2 SubmittersRCV001012296 RCV001323085

NM_024675.4(PALB2):c.1451T>G (p.Leu484Ter)

SNV
Germline

Chr16:23635095

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Hereditary breast ovarian cancer syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395131225

rs_786203714

2 SubmittersRCV001011656 RCV001030651

NM_024675.4(PALB2):c.1384G>T (p.Glu462Ter)

SNV
Germline

Chr16:23635162

Pathogenic/Likely pathogenic

Hereditary breast ovarian cancer syndrome
Hereditary cancer-predisposing syndrome
Gastric cancer
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395131383

rs_1597096243

4 SubmittersRCV001030652 RCV001011273 RCV003160174 RCV001030221

NM_024675.4(PALB2):c.1163C>T (p.Pro388Leu)

SNV
Germline

Chr16:23635383

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395133468

rs_1597096898

2 SubmittersRCV001010064 RCV001232223

NM_024675.4(PALB2):c.1117G>T (p.Glu373Ter)

SNV
Germline

Chr16:23635429

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395133728

rs_1597097072

3 SubmittersRCV001017382 RCV001383301

NM_024675.4(PALB2):c.1010T>G (p.Leu337Ter)

SNV
Germline

Chr16:23635536

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Malignant tumor of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA16622082

rs_45494092

4 SubmittersRCV001016993 RCV001057150 RCV004689957

NM_024675.4(PALB2):c.833T>A (p.Leu278Gln)

SNV
Germline

Chr16:23635713

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N

Criteria Provided
Conflicting Classifications

CA7963755

rs_200843485

3 SubmittersRCV001017584 RCV005004485

NM_024675.4(PALB2):c.809G>A (p.Ser270Asn)

SNV
Germline

Chr16:23635737

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395135998

rs_1597098223

2 SubmittersRCV001027172 RCV001045831

NM_024675.4(PALB2):c.712A>T (p.Arg238Ter)

SNV
Germline

Chr16:23635834

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395136336

rs_779278389

3 SubmittersRCV001026070 RCV001242112

NM_024675.4(PALB2):c.388C>T (p.His130Tyr)

SNV
Germline

Chr16:23636158

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Fanconi anemia complementation group N
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395137451

rs_1555461809

5 SubmittersRCV001021365 RCV001030148 RCV001119842 RCV001861018

NM_024675.4(PALB2):c.343G>T (p.Gly115Ter)

SNV
Germline

Chr16:23636203

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395137728

rs_1597099523

3 SubmittersRCV001020314 RCV001070132

NM_024675.4(PALB2):c.34G>C (p.Glu12Gln)

SNV
Germline

Chr16:23641124

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963887

rs_765520187

2 SubmittersRCV001020465 RCV002551827

NM_024675.4(PALB2):c.3351-1G>C

SNV
Germline

Chr16:23603670

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395138433

rs_1597062406

2 SubmittersRCV001020063 RCV003455108

NM_024675.4(PALB2):c.3202-4T>C

SNV
Germline

Chr16:23608016

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA915949159

rs_1597067067

4 SubmittersRCV001019202 RCV001284320 RCV001411007

NM_024675.4(PALB2):c.3113+1G>A

SNV
Germline

Chr16:23621361

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395142752

rs_1597079557

3 SubmittersRCV001018702 RCV002550843

NM_024675.4(PALB2):c.2997-1G>A

SNV
Germline

Chr16:23621479

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963447

rs_754465466

4 SubmittersRCV001017865 RCV003455099

NM_024675.4(PALB2):c.2834+2T>C

SNV
Germline

Chr16:23624007

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Gastric cancer
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395144743

rs_864622481

7 SubmittersRCV001016727 RCV001030347 RCV003160177 RCV005236531 RCV005401689 RCV001860839

NM_024675.4(PALB2):c.212-5C>T

SNV
Germline

Chr16:23636339

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA915949138

rs_1597099922

2 SubmittersRCV001014540 RCV005423766

NM_024675.4(PALB2):c.109-2A>C

SNV
Germline

Chr16:23637954

Likely pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395139505

rs_730881897

1 SubmittersRCV001017254

NM_024675.4(PALB2):c.2242A>G (p.Thr748Ala)

SNV
Germline

Chr16:23629912

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395125498

rs_1279823900

3 SubmittersRCV001030290 RCV002427473 RCV005093298

NM_024675.4(PALB2):c.2083A>T (p.Lys695Ter)

SNV
Germline

Chr16:23630071

Pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395125847

rs_1567218141

3 SubmittersRCV001030276 RCV003455145

NM_024675.4(PALB2):c.1972G>T (p.Glu658Ter)

SNV
Germline

Chr16:23630182

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395127308

rs_1555460542

4 SubmittersRCV001030273 RCV004030912

NM_024675.4(PALB2):c.1907A>G (p.Glu636Gly)

SNV
Germline

Chr16:23630247

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395127557

rs_1966863975

3 SubmittersRCV001030267 RCV004030911 RCV003607397

NM_024675.4(PALB2):c.1837C>T (p.Gln613Ter)

SNV
Germline

Chr16:23630317

Pathogenic

Condition: not provided
Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395127879

rs_1966865214

6 SubmittersRCV001030263 RCV003455144 RCV004577541 RCV003584801

NM_024675.4(PALB2):c.1786G>T (p.Gly596Ter)

SNV
Germline

Chr16:23630368

Pathogenic

Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395128111

rs_1966866081

4 SubmittersRCV001030260 RCV004702588

NM_024675.4(PALB2):c.1411G>C (p.Gly471Arg)

SNV
Germline

Chr16:23635135

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395131328

rs_1966970790

3 SubmittersRCV001030224 RCV004659289 RCV003607396

NM_024675.4(PALB2):c.812G>A (p.Ser271Asn)

SNV
Germline

Chr16:23635734

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395135989

rs_1167051191

4 SubmittersRCV001030177 RCV002416312 RCV003607394

NM_024675.4(PALB2):c.746C>T (p.Pro249Leu)

SNV
Germline

Chr16:23635800

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963764

rs_759810283

4 SubmittersRCV001030171 RCV002391085

NM_024675.4(PALB2):c.538G>T (p.Glu180Ter)

SNV
Germline

Chr16:23636008

Pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395136914

rs_750782778

3 SubmittersRCV001030156 RCV003607393

NM_024675.4(PALB2):c.227T>C (p.Ile76Thr)

SNV
Germline

Chr16:23636319

Conflicting classifications of pathogenicity

Carcinoma of colon
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395138956

rs_1967061407

3 SubmittersRCV001030135 RCV001862432 RCV004030909

NM_024675.4(PALB2):c.3161C>T (p.Ser1054Phe)

SNV
Germline

Chr16:23614044

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395141281

rs_1227213725

2 SubmittersRCV001045819 RCV002320261

NM_024675.4(PALB2):c.3028G>T (p.Glu1010Ter)

SNV
Germline

Chr16:23621447

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395143098

rs_1966771907

3 SubmittersRCV001064157 RCV002436654

NM_024675.4(PALB2):c.2485C>T (p.Gln829Ter)

SNV
Germline

Chr16:23629669

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395124018

rs_1966855759

3 SubmittersRCV001048640 RCV003283899

NM_024675.4(PALB2):c.1988G>A (p.Arg663His)

SNV
Germline

Chr16:23630166

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA395127231

rs_1462734899

3 SubmittersRCV001061994 RCV002418525 RCV003323791

NM_024675.4(PALB2):c.1568C>G (p.Ala523Gly)

SNV
Germline

Chr16:23634978

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395130717

rs_1966956742

2 SubmittersRCV001071418 RCV004030790

NM_024675.4(PALB2):c.1553C>A (p.Ser518Ter)

SNV
Germline

Chr16:23634993

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome
PALB2-related disorder

Criteria Provided
Multiple Submitters
No Conflicts

CA395130804

rs_1060502805

4 SubmittersRCV001044695 RCV002400256 RCV004740549

NM_024675.4(PALB2):c.1480A>G (p.Thr494Ala)

SNV
Germline

Chr16:23635066

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Hereditary cancer

Criteria Provided
Conflicting Classifications

CA395131134

rs_1555461258

4 SubmittersRCV001051470 RCV002393258 RCV004702605

NM_024675.4(PALB2):c.1315G>A (p.Gly439Arg)

SNV
Germline

Chr16:23635231

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963720

rs_764750338

2 SubmittersRCV001057203 RCV004944821

NM_024675.4(PALB2):c.1002C>A (p.Tyr334Ter)

SNV
Germline

Chr16:23635544

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395134596

rs_1967002667

3 SubmittersRCV001055176 RCV003283917

NM_024675.4(PALB2):c.647T>C (p.Ile216Thr)

SNV
Germline

Chr16:23635899

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395136523

rs_1967031858

2 SubmittersRCV001039734 RCV004944785

NM_024675.4(PALB2):c.568T>A (p.Ser190Thr)

SNV
Germline

Chr16:23635978

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395136806

rs_1967037502

2 SubmittersRCV001041617 RCV002348354

NM_024675.4(PALB2):c.485G>C (p.Cys162Ser)

SNV
Germline

Chr16:23636061

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395137099

rs_1555461779

3 SubmittersRCV001050370 RCV001191985

NM_024675.4(PALB2):c.483C>G (p.Asp161Glu)

SNV
Germline

Chr16:23636063

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA279499946

rs_371627753

3 SubmittersRCV001054073 RCV002479328 RCV002339272

NM_024675.4(PALB2):c.398G>C (p.Ser133Thr)

SNV
Germline

Chr16:23636148

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Chordoma

Criteria Provided
Conflicting Classifications

CA395137415

rs_864622411

4 SubmittersRCV001038666 RCV001178878 RCV002267068

NM_024675.4(PALB2):c.290C>T (p.Ser97Phe)

SNV
Germline

Chr16:23636256

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395138819

rs_776902295

2 SubmittersRCV001048724

NM_024675.4(PALB2):c.211+2T>C

SNV
Germline

Chr16:23637848

Likely pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395139002

rs_1967098495

1 SubmittersRCV001036628

NM_024675.4(PALB2):c.2514+1G>A

SNV
Germline

Chr16:23629639

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395123914

rs_886039729

4 SubmittersRCV001187628 RCV001069194

NM_024675.4(PALB2):c.48+1G>T

SNV
Germline

Chr16:23641109

Pathogenic/Likely pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395140996

rs_515726118

3 SubmittersRCV001091643 RCV001377904

NM_024675.4(PALB2):c.3402T>A (p.Ser1134=)

SNV
Germline

Chr16:23603618

Conflicting classifications of pathogenicity

Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494173722

rs_1966403904

4 SubmittersRCV001121622 RCV001526131 RCV001201577

NM_024675.4(PALB2):c.*10A>T

SNV
Germline

Chr16:23603449

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA913188696

rs_1966394024

2 SubmittersRCV001180161 RCV005428093

NM_024675.4(PALB2):c.2872C>T (p.Gln958Ter)

SNV
Germline

Chr16:23623093

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395144382

rs_1567213829

2 SubmittersRCV001386173 RCV001179792

NM_024675.4(PALB2):c.2535T>C (p.Pro845=)

SNV
Germline

Chr16:23629255

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
not specified
Condition: not provided

Criteria Provided
Conflicting Classifications

CA494163498

rs_1567216906

6 SubmittersRCV001181274 RCV002559781 RCV004596416 RCV003478712

NM_024675.4(PALB2):c.2360C>G (p.Thr787Ser)

SNV
Germline

Chr16:23629794

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA279492250

rs_201042302

3 SubmittersRCV001180223 RCV001218280

NM_024675.4(PALB2):c.2278C>A (p.Leu760Ile)

SNV
Germline

Chr16:23629876

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963601

rs_769634658

3 SubmittersRCV001180225 RCV001244487

NM_024675.4(PALB2):c.2265C>A (p.Cys755Ter)

SNV
Germline

Chr16:23629889

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395125417

rs_1966858159

1 SubmittersRCV001188618

NM_024675.4(PALB2):c.1364A>T (p.Asn455Ile)

SNV
Germline

Chr16:23635182

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395131471

rs_587781824

2 SubmittersRCV001175887

NM_024675.4(PALB2):c.1352T>A (p.Leu451Ter)

SNV
Germline

Chr16:23635194

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395131526

rs_1966974831

1 SubmittersRCV001177020

NM_024675.4(PALB2):c.1253A>G (p.Asn418Ser)

SNV
Germline

Chr16:23635293

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395132874

rs_1784498384

3 SubmittersRCV001184627 RCV001300771

NM_024675.4(PALB2):c.1181A>T (p.His394Leu)

SNV
Germline

Chr16:23635365

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963729

rs_762430363

4 SubmittersRCV001184922 RCV001359927

NM_024675.4(PALB2):c.503C>G (p.Ser168Ter)

SNV
Germline

Chr16:23636043

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395137032

rs_515726122

4 SubmittersRCV001187410 RCV003449610

NM_024675.4(PALB2):c.236A>G (p.Tyr79Cys)

SNV
Germline

Chr16:23636310

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395138939

rs_766710382

2 SubmittersRCV001191364

NM_024675.4(PALB2):c.37G>T (p.Glu13Ter)

SNV
Germline

Chr16:23641121

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395141056

rs_373287455

2 SubmittersRCV002555489 RCV001178653

NM_024675.4(PALB2):c.2997-2A>T

SNV
Germline

Chr16:23621480

Likely pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395143249

rs_1555459421

1 SubmittersRCV001188593

NM_024675.4(PALB2):c.2749-15C>G

SNV
Germline

Chr16:23624109

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA913188718

rs_1567214528

2 SubmittersRCV001188503 RCV002559151

NM_024675.4(PALB2):c.212-1G>A

SNV
Germline

Chr16:23636335

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395138998

rs_1597099910

4 SubmittersRCV001180262 RCV001875981

NM_024675.4(PALB2):c.2997-15C>A

SNV
Germline

Chr16:23621493

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA1139664575

rs_1966773679

2 SubmittersRCV001192051 RCV002069179

NM_024675.4(PALB2):c.3351-10A>T

SNV
Germline

Chr16:23603679

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA913188700

rs_1057517611

2 SubmittersRCV001189248 RCV002560044

NM_024675.4(PALB2):c.2586+8G>T

SNV
Germline

Chr16:23629196

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA913188730

rs_1060504708

3 SubmittersRCV001176656 RCV005093770

NM_024675.4(PALB2):c.2514+5A>G

SNV
Germline

Chr16:23629635

Conflicting classifications of pathogenicity

not specified
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA1139664588

rs_1966855329

2 SubmittersRCV001192770 RCV005428132

NM_024675.4(PALB2):c.2383C>G (p.Gln795Glu)

SNV
Germline

Chr16:23629771

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395124613

rs_1966856854

3 SubmittersRCV001196352 RCV003293986

NM_024675.4(PALB2):c.3251C>A (p.Ser1084Ter)

SNV
Germline

Chr16:23607963

Likely pathogenic

Malignant tumor of breast
Familial cancer of breast

Criteria Provided
Single Submitter

CA395139820

rs_62625271

2 SubmittersRCV001201230 RCV003485687

NM_024675.4(PALB2):c.2749-5T>C

SNV
Germline

Chr16:23624099

Conflicting classifications of pathogenicity

not specified
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494181324

rs_1966828330

2 SubmittersRCV001201202 RCV005428134

NM_024675.4(PALB2):c.3425T>G (p.Leu1142Ter)

SNV
Germline

Chr16:23603595

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395138193

rs_1555457878

3 SubmittersRCV001215359 RCV002451471

NM_024675.4(PALB2):c.181C>T (p.Gln61Ter)

SNV
Germline

Chr16:23637880

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395139085

rs_1967100637

2 SubmittersRCV001202645

NM_024675.4(PALB2):c.3202-2A>G

SNV
Germline

Chr16:23608014

Pathogenic/Likely pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395140148

rs_1060499827

2 SubmittersRCV001207886

NM_024675.4(PALB2):c.2587-8T>G

SNV
Germline

Chr16:23626405

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Condition: not provided
PALB2-related cancer predisposition
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA1139664582

rs_1489345430

5 SubmittersRCV001212825 RCV003584848 RCV004783916 RCV005359946 RCV004740615

NM_024675.4(PALB2):c.2586+1G>T

SNV
Germline

Chr16:23629203

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395123602

rs_1375713365

1 SubmittersRCV001221542

NM_024675.4(PALB2):c.3307G>T (p.Val1103Leu)

SNV
Germline

Chr16:23607907

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395139465

rs_201657283

2 SubmittersRCV001228456 RCV005384993

NM_024675.4(PALB2):c.1769C>T (p.Ala590Val)

SNV
Germline

Chr16:23630385

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395128187

rs_1966866430

2 SubmittersRCV001234776 RCV004659430

NM_024675.4(PALB2):c.1497G>T (p.Leu499Phe)

SNV
Germline

Chr16:23635049

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395131062

rs_748315431

2 SubmittersRCV001233619 RCV002393582

NM_024675.4(PALB2):c.1227T>A (p.Tyr409Ter)

SNV
Germline

Chr16:23635319

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395133079

rs_1555461386

5 SubmittersRCV001229056 RCV001526202

NM_024675.4(PALB2):c.1115G>A (p.Ser372Asn)

SNV
Germline

Chr16:23635431

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395133748

rs_786204243

2 SubmittersRCV003365269 RCV001227673

NM_024675.4(PALB2):c.1411G>A (p.Gly471Arg)

SNV
Germline

Chr16:23635135

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395131327

rs_1966970790

2 SubmittersRCV001244884 RCV004944949

NM_024675.4(PALB2):c.577A>G (p.Thr193Ala)

SNV
Germline

Chr16:23635969

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA395136777

rs_1967037000

3 SubmittersRCV001244167 RCV002357041 RCV003493830

NM_024675.4(PALB2):c.2749-1G>A

SNV
Germline

Chr16:23624095

Likely pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395145276

rs_1060502804

1 SubmittersRCV001238219

NM_024675.4(PALB2):c.2996+2T>C

SNV
Germline

Chr16:23622967

Likely pathogenic

Hereditary breast ovarian cancer syndrome
Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395143815

rs_1966797789

4 SubmittersRCV001269178 RCV001377139 RCV003478760 RCV005403011

NM_024675.4(PALB2):c.2878C>T (p.Leu960=)

SNV
Germline

Chr16:23623087

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494180493

rs_1966803657

2 SubmittersRCV001284199 RCV002069504

NM_024675.4(PALB2):c.2136G>T (p.Ala712=)

SNV
Germline

Chr16:23630018

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494461158

rs_905951607

3 SubmittersRCV001284031 RCV003584878 RCV005423955

NM_024675.4(PALB2):c.108+2T>C

SNV
Germline

Chr16:23638068

Likely pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395139559

rs_2142459705

1 SubmittersRCV001523835

NM_024675.4(PALB2):c.1012C>T (p.Pro338Ser)

SNV
Germline

Chr16:23635534

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395134436

rs_560853558

2 SubmittersRCV002350539 RCV001300197

NM_024675.4(PALB2):c.1556C>A (p.Ala519Asp)

SNV
Germline

Chr16:23634990

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395130790

rs_1340452845

2 SubmittersRCV001317568 RCV002402884

NM_024675.4(PALB2):c.2707G>A (p.Ala903Thr)

SNV
Germline

Chr16:23626277

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395121924

rs_1324636666

2 SubmittersRCV001340061 RCV002438773

NM_024675.4(PALB2):c.1745C>T (p.Ser582Phe)

SNV
Germline

Chr16:23630409

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA279493666

rs_865777690

2 SubmittersRCV001350098 RCV004651609

NM_024675.4(PALB2):c.1685-2A>C

SNV
Germline

Chr16:23630471

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395128498

rs_754660432

2 SubmittersRCV001346019 RCV002412087

NM_024675.4(PALB2):c.1307A>G (p.Lys436Arg)

SNV
Germline

Chr16:23635239

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395132422

rs_1966977995

2 SubmittersRCV001342671 RCV005385046

NM_024675.4(PALB2):c.1196C>T (p.Pro399Leu)

SNV
Germline

Chr16:23635350

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395133260

rs_776115183

2 SubmittersRCV001352366 RCV003284250

NM_024675.4(PALB2):c.923C>T (p.Ala308Val)

SNV
Germline

Chr16:23635623

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395135308

rs_1967009067

2 SubmittersRCV001347591 RCV004651601

NM_024675.4(PALB2):c.592C>T (p.His198Tyr)

SNV
Germline

Chr16:23635954

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395136723

rs_1967036024

2 SubmittersRCV001338145 RCV002357177

NM_024675.4(PALB2):c.553A>G (p.Lys185Glu)

SNV
Germline

Chr16:23635993

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395136852

rs_1967038738

2 SubmittersRCV001342754 RCV004945035

NM_024675.4(PALB2):c.385C>T (p.Pro129Ser)

SNV
Germline

Chr16:23636161

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA395137461

rs_1174443228

3 SubmittersRCV001351434 RCV004036654 RCV005361554

NM_024675.4(PALB2):c.3351G>A (p.Arg1117=)

SNV
Germline

Chr16:23603669

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA494173844

rs_1966406887

2 SubmittersRCV001362324 RCV004036835

NM_024675.4(PALB2):c.2348C>T (p.Ala783Val)

SNV
Germline

Chr16:23629806

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395124890

rs_1473991269

2 SubmittersRCV001373883 RCV004037588

NM_024675.4(PALB2):c.557A>G (p.Asn186Ser)

SNV
Germline

Chr16:23635989

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395136839

rs_587782164

2 SubmittersRCV001371738 RCV004037514

NM_024675.4(PALB2):c.2749-2A>G

SNV
Germline

Chr16:23624096

Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395145280

rs_1555459747

2 SubmittersRCV001379740 RCV002438885

NM_024675.4(PALB2):c.3351-1G>A

SNV
Germline

Chr16:23603670

Pathogenic/Likely pathogenic

Familial cancer of breast
Fanconi anemia complementation group N
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Multiple Submitters
No Conflicts

CA395138431

rs_1597062406

2 SubmittersRCV001385043 RCV005014535

NM_024675.4(PALB2):c.3058C>T (p.Gln1020Ter)

SNV
Germline

Chr16:23621417

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395143007

rs_2142327117

3 SubmittersRCV001380135 RCV002447506

NM_024675.4(PALB2):c.2631G>A (p.Trp877Ter)

SNV
Germline

Chr16:23626353

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395122169

rs_2142355636

1 SubmittersRCV001387638

NM_024675.4(PALB2):c.2041A>T (p.Lys681Ter)

SNV
Germline

Chr16:23630113

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395126895

rs_2142382651

1 SubmittersRCV001388172

NM_024675.4(PALB2):c.880A>T (p.Lys294Ter)

SNV
Germline

Chr16:23635666

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395135745

rs_753676934

3 SubmittersRCV001388498 RCV002377576

NM_024675.4(PALB2):c.691A>T (p.Lys231Ter)

SNV
Germline

Chr16:23635855

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395136399

rs_2142437289

1 SubmittersRCV001388611

NM_024675.4(PALB2):c.2733C>T (p.Thr911=)

SNV
Germline

Chr16:23626251

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA494161170

rs_1555459927

4 SubmittersRCV001464417 RCV003365410 RCV005408916

NM_024675.4(PALB2):c.2806T>C (p.Leu936=)

SNV
Germline

Chr16:23624037

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA494181112

rs_2142343280

4 SubmittersRCV001492152 RCV003225187 RCV005453304

NM_024675.4(PALB2):c.2595A>G (p.Ser865=)

SNV
Germline

Chr16:23626389

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494161328

rs_1597085400

3 SubmittersRCV001496554

NM_024675.4(PALB2):c.567A>G (p.Arg189=)

SNV
Germline

Chr16:23635979

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA494461778

rs_1597098858

2 SubmittersRCV001493501 RCV003584967

NM_024675.4(PALB2):c.349C>T (p.Pro117Ser)

SNV
Germline

Chr16:23636197

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395137693

rs_1413238389

3 SubmittersRCV001759141 RCV001885094 RCV004945712

NM_024675.4(PALB2):c.2275C>T (p.Gln759Ter)

SNV
Germline

Chr16:23629879

Pathogenic

Condition: not provided
Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395125377

rs_515726083

4 SubmittersRCV003237611 RCV003451919 RCV005416128 RCV004040750

NM_024675.4(PALB2):c.1188C>A (p.Cys396Ter)

SNV
Germline

Chr16:23635358

Pathogenic

Fanconi anemia complementation group N
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395133305

rs_587780817

3 SubmittersRCV001784795 RCV003316849

NM_024675.4(PALB2):c.3114-1G>C

SNV
Germline

Chr16:23614092

Likely pathogenic

Breast and/or ovarian cancer

Criteria Provided
Single Submitter

CA395141522

rs_886039619

1 SubmittersRCV001799366

NM_024675.4(PALB2):c.1799T>G (p.Leu600Ter)

SNV
Germline

Chr16:23630355

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395128055

rs_1966865838

3 SubmittersRCV001805610 RCV001869552

NM_024675.4(PALB2):c.652G>T (p.Glu218Ter)

SNV
Germline

Chr16:23635894

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395136492

rs_2142438340

2 SubmittersRCV001872563

NM_024675.4(PALB2):c.1352T>G (p.Leu451Ter)

SNV
Germline

Chr16:23635194

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395131522

rs_1966974831

1 SubmittersRCV001941648

NM_024675.4(PALB2):c.2383C>T (p.Gln795Ter)

SNV
Germline

Chr16:23629771

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395124615

rs_1966856854

2 SubmittersRCV001960567 RCV004044362

NM_024675.4(PALB2):c.1187G>A (p.Cys396Tyr)

SNV
Germline

Chr16:23635359

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395133312

rs_2142423374

2 SubmittersRCV002015186 RCV005455486

NM_024675.4(PALB2):c.1383T>G (p.Ser461Arg)

SNV
Germline

Chr16:23635163

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395131385

rs_768482110

2 SubmittersRCV001889281 RCV002386668

NM_024675.4(PALB2):c.3101A>G (p.Asn1034Ser)

SNV
Germline

Chr16:23621374

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395142818

rs_2142326183

3 SubmittersRCV002047098 RCV002324229

NM_024675.4(PALB2):c.49-1123C>G

SNV
Germline

Chr16:23639252

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA2573152327

rs_2142467185

2 SubmittersRCV001995273 RCV005455469

NM_024675.4(PALB2):c.758T>G (p.Leu253Arg)

SNV
Germline

Chr16:23635788

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395136164

rs_2142435363

2 SubmittersRCV001944518 RCV004651758

NM_024675.4(PALB2):c.787G>T (p.Glu263Ter)

SNV
Germline

Chr16:23635759

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395136048

rs_2142434483

2 SubmittersRCV001896468 RCV005382241

NM_024675.4(PALB2):c.209C>G (p.Ser70Ter)

SNV
Germline

Chr16:23637852

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395139011

rs_763745734

2 SubmittersRCV002042347

NM_024675.4(PALB2):c.84C>A (p.Tyr28Ter)

SNV
Germline

Chr16:23638094

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395139725

rs_761533286

1 SubmittersRCV002044551

NM_024675.4(PALB2):c.2146A>G (p.Asn716Asp)

SNV
Germline

Chr16:23630008

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395125704

rs_2142379886

2 SubmittersRCV001919455 RCV004656741

NM_024675.4(PALB2):c.1021G>T (p.Glu341Ter)

SNV
Germline

Chr16:23635525

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395134370

rs_2142428256

2 SubmittersRCV001954902 RCV002407093

NM_024675.4(PALB2):c.1967C>T (p.Pro656Leu)

SNV
Germline

Chr16:23630187

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA279493140

rs_370360082

2 SubmittersRCV001895058 RCV004945759

NM_024675.4(PALB2):c.665T>A (p.Leu222Ter)

SNV
Germline

Chr16:23635881

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395136454

rs_2142437926

1 SubmittersRCV001946504

NM_024675.4(PALB2):c.84C>G (p.Tyr28Ter)

SNV
Germline

Chr16:23638094

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395139726

rs_761533286

1 SubmittersRCV001941952

NM_024675.4(PALB2):c.3180T>A (p.Cys1060Ter)

SNV
Germline

Chr16:23614025

Pathogenic/Likely pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395141184

rs_2142298948

3 SubmittersRCV001941626

NM_024675.4(PALB2):c.1804C>T (p.Gln602Ter)

SNV
Germline

Chr16:23630350

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395128029

rs_876660475

4 SubmittersRCV001970218 RCV002407185

NM_024675.4(PALB2):c.2350A>T (p.Lys784Ter)

SNV
Germline

Chr16:23629804

Pathogenic/Likely pathogenic

Familial cancer of breast
Fanconi anemia complementation group N
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395124880

rs_1833331932

4 SubmittersRCV001970020 RCV003130638 RCV004044375

NM_024675.4(PALB2):c.1675C>G (p.Gln559Glu)

SNV
Germline

Chr16:23634871

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395129922

rs_1555461154

2 SubmittersRCV001885824 RCV004656699

NM_024675.4(PALB2):c.433A>G (p.Ser145Gly)

SNV
Germline

Chr16:23636113

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395137290

rs_2142443524

2 SubmittersRCV002030553 RCV002331572

NM_024675.4(PALB2):c.821C>T (p.Thr274Ile)

SNV
Germline

Chr16:23635725

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA279499394

rs_867994747

2 SubmittersRCV001931483 RCV004945812

NM_024675.4(PALB2):c.30C>G (p.Ser10Arg)

SNV
Germline

Chr16:23641128

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA7963889

rs_758500749

2 SubmittersRCV002019440 RCV003355751

NM_024675.4(PALB2):c.535C>T (p.Gln179Ter)

SNV
Germline

Chr16:23636011

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395136927

rs_730881903

4 SubmittersRCV001963210 RCV004945838

NM_024675.4(PALB2):c.2014G>T (p.Glu672Ter)

SNV
Germline

Chr16:23630140

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395127066

rs_45532440

1 SubmittersRCV001992625

NM_024675.4(PALB2):c.3456A>G (p.Pro1152=)

SNV
Germline

Chr16:23603564

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Fanconi anemia complementation group N
Pancreatic cancer, susceptibility to, 3

Criteria Provided
Conflicting Classifications

CA494173610

rs_2142253411

3 SubmittersRCV002164567 RCV002454557 RCV005397333

NM_024675.4(PALB2):c.477G>A (p.Glu159=)

SNV
Germline

Chr16:23636069

Conflicting classifications of pathogenicity

Familial cancer of breast
Condition: not provided
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA494461950

rs_1163253431

6 SubmittersRCV002159422 RCV002479850 RCV003585196 RCV005361938

NM_024675.4(PALB2):c.58A>T (p.Lys20Ter)

SNV
Germline

Chr16:23638120

Pathogenic/Likely pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395139930

rs_2142461082

2 SubmittersRCV002223100

NM_024675.4(PALB2):c.2586+30G>A

SNV
Germline

Chr16:23629174

Conflicting classifications of pathogenicity

Hereditary breast ovarian cancer syndrome
not specified

Criteria Provided
Conflicting Classifications

CA7963533

rs_769118926

2 SubmittersRCV002226282 RCV004596528

NM_024675.4(PALB2):c.3351-7C>T

SNV
Germline

Chr16:23603676

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA1139532234

rs_2142255767

2 SubmittersRCV002272685

NM_024675.4(PALB2):c.758T>C (p.Leu253Pro)

SNV
Germline

Chr16:23635788

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395136166

rs_2142435363

2 SubmittersRCV002288318 RCV002391399

NM_024675.4(PALB2):c.47A>C (p.Lys16Thr)

SNV
Germline

Chr16:23641111

Likely pathogenic

Hereditary breast ovarian cancer syndrome
Condition: not provided

Criteria Provided
Single Submitter

CA395141005

rs_1064795514

2 SubmittersRCV003156021 RCV004697206

NM_024675.4(PALB2):c.454A>T (p.Lys152Ter)

SNV
Germline

Chr16:23636092

Pathogenic

Hereditary breast ovarian cancer syndrome
Familial cancer of breast

Criteria Provided
Single Submitter

CA395137206

rs_2506511810

2 SubmittersRCV003156022 RCV003454093

NM_024675.4(PALB2):c.3351-2A>T

SNV
Germline

Chr16:23603671

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Hereditary breast ovarian cancer syndrome
Condition: not provided

Criteria Provided
Conflicting Classifications

CA395138435

rs_1060502764

3 SubmittersRCV002325724 RCV003156024 RCV004809809

NM_024675.4(PALB2):c.3380G>A (p.Cys1127Tyr)

SNV
Germline

Chr16:23603640

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA7963345

rs_759944815

2 SubmittersRCV002451830 RCV003607453

NM_024675.4(PALB2):c.3350+2C>T

SNV
Germline

Chr16:23607862

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395139174

rs_1555458171

2 SubmittersRCV002320978 RCV004047797

NM_024675.4(PALB2):c.1157C>T (p.Thr386Ile)

SNV
Germline

Chr16:23635389

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395133493

rs_876660840

2 SubmittersRCV003500713 RCV002355558

NM_024675.4(PALB2):c.1174G>T (p.Glu392Ter)

SNV
Germline

Chr16:23635372

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395133413

rs_2142423775

1 SubmittersRCV002333831

NM_024675.4(PALB2):c.3315G>A (p.Val1105=)

SNV
Germline

Chr16:23607899

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494175510

rs_2142271728

3 SubmittersRCV002454725 RCV003500705

NM_024675.4(PALB2):c.3113+1G>C

SNV
Germline

Chr16:23621361

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395142751

rs_1597079557

2 SubmittersRCV002326111 RCV003454100

NM_024675.4(PALB2):c.358A>G (p.Arg120Gly)

SNV
Germline

Chr16:23636188

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395137623

rs_2142445228

2 SubmittersRCV002339826 RCV005096322

NM_024675.4(PALB2):c.376G>A (p.Glu126Lys)

SNV
Germline

Chr16:23636170

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Conflicting Classifications

CA7963797

rs_577006107

3 SubmittersRCV002363862 RCV003500711 RCV003478969

NM_024675.4(PALB2):c.1273G>C (p.Val425Leu)

SNV
Germline

Chr16:23635273

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395132638

rs_576081828

2 SubmittersRCV002378893 RCV005097317

NM_024675.4(PALB2):c.703A>G (p.Thr235Ala)

SNV
Germline

Chr16:23635843

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395136368

rs_2142436855

2 SubmittersRCV002364948 RCV003607481

NM_024675.4(PALB2):c.1257C>A (p.Cys419Ter)

SNV
Germline

Chr16:23635289

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395132823

rs_786201086

1 SubmittersRCV002419503

NM_024675.4(PALB2):c.934A>T (p.Ser312Cys)

SNV
Germline

Chr16:23635612

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395135229

rs_1401541483

2 SubmittersRCV002371687 RCV003774174

NM_024675.4(PALB2):c.1725G>A (p.Trp575Ter)

SNV
Germline

Chr16:23630429

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395128363

rs_2142390682

3 SubmittersRCV002399116 RCV003454280

NM_024675.4(PALB2):c.1879G>C (p.Val627Leu)

SNV
Germline

Chr16:23630275

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395127657

rs_1567218614

2 SubmittersRCV002415264 RCV003774539

NM_024675.4(PALB2):c.1894G>T (p.Glu632Ter)

SNV
Germline

Chr16:23630260

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395127604

rs_2142386640

1 SubmittersRCV002408081

NM_024675.4(PALB2):c.1603A>G (p.Ser535Gly)

SNV
Germline

Chr16:23634943

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
not specified

Criteria Provided
Conflicting Classifications

CA395130513

rs_2142411421

3 SubmittersRCV002398735 RCV003321942

NM_024675.4(PALB2):c.1969G>T (p.Glu657Ter)

SNV
Germline

Chr16:23630185

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395127323

rs_2142384677

1 SubmittersRCV002423443

NM_024675.4(PALB2):c.2635A>T (p.Arg879Ter)

SNV
Germline

Chr16:23626349

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395122158

rs_1555459994

2 SubmittersRCV002428590 RCV003336742

NM_024675.4(PALB2):c.1A>C (p.Met1Leu)

SNV
Germline

Chr16:23641157

Likely pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395141291

rs_879254144

1 SubmittersRCV002417103

NM_024675.4(PALB2):c.2297C>G (p.Ser766Ter)

SNV
Germline

Chr16:23629857

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395125283

rs_1555460410

2 SubmittersRCV002446269 RCV003098785

NM_024675.4(PALB2):c.2T>G (p.Met1Arg)

SNV
Germline

Chr16:23641156

Pathogenic/Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395141286

rs_756519825

4 SubmittersRCV002435654 RCV003102964 RCV004999767

NM_024675.4(PALB2):c.2T>A (p.Met1Lys)

SNV
Germline

Chr16:23641156

Pathogenic

Gastric cancer

No Assertion Criteria Provided

CA395141289

rs_756519825

1 SubmittersRCV003164576

NM_024675.4(PALB2):c.2586+1G>A

SNV
Germline

Chr16:23629203

Pathogenic/Likely pathogenic

Familial cancer of breast
Condition: not provided

Criteria Provided
Multiple Submitters
No Conflicts

CA395123610

rs_1375713365

3 SubmittersRCV003064332 RCV003321970

NM_024675.4(PALB2):c.3114-239A>T

SNV
Germline

Chr16:23614330

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA2580091263

rs_2506269944

2 SubmittersRCV003075381 RCV004071807

NM_024675.4(PALB2):c.2587-15T>C

SNV
Germline

Chr16:23626412

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA2575946419

rs_2142356956

2 SubmittersRCV003080810

NM_024675.4(PALB2):c.2717G>A (p.Trp906Ter)

SNV
Germline

Chr16:23626267

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395121884

rs_2142353580

2 SubmittersRCV002611968

NM_024675.4(PALB2):c.1255T>C (p.Cys419Arg)

SNV
Germline

Chr16:23635291

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395132854

rs_2142421373

2 SubmittersRCV002717256 RCV004067773

NM_024675.4(PALB2):c.3202-9C>A

SNV
Germline

Chr16:23608021

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA2213428981

rs_757444247

2 SubmittersRCV002736157 RCV005251328

NM_024675.4(PALB2):c.182A>T (p.Gln61Leu)

SNV
Germline

Chr16:23637879

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395139076

rs_1354687901

2 SubmittersRCV002785728 RCV004946046

NM_024675.4(PALB2):c.1858G>T (p.Gly620Ter)

SNV
Germline

Chr16:23630296

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395127751

rs_777940379

2 SubmittersRCV002807323

NM_024675.4(PALB2):c.2277A>T (p.Gln759His)

SNV
Germline

Chr16:23629877

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395125368

rs_786202524

2 SubmittersRCV002856618 RCV005455611

NM_024675.4(PALB2):c.48+8G>C

SNV
Germline

Chr16:23641102

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA2580091243

rs_2142480527

2 SubmittersRCV002833664

NM_024675.4(PALB2):c.962T>G (p.Leu321Ter)

SNV
Germline

Chr16:23635584

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395134962

rs_2142429833

2 SubmittersRCV002857111

NM_024675.4(PALB2):c.715A>T (p.Arg239Ter)

SNV
Germline

Chr16:23635831

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395136320

rs_1967026821

1 SubmittersRCV002872244

NM_024675.4(PALB2):c.1536C>G (p.Tyr512Ter)

SNV
Germline

Chr16:23635010

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395130911

rs_1567220802

2 SubmittersRCV002898881

NM_024675.4(PALB2):c.1684+2T>A

SNV
Germline

Chr16:23634860

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395129858

rs_2142409238

2 SubmittersRCV002913112 RCV003367903

NM_024675.4(PALB2):c.1490A>G (p.Asn497Ser)

SNV
Germline

Chr16:23635056

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395131096

rs_1966962812

2 SubmittersRCV002947546 RCV004067106

NM_024675.4(PALB2):c.1549A>T (p.Lys517Ter)

SNV
Germline

Chr16:23634997

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395130831

rs_2506473795

1 SubmittersRCV002954240

NM_024675.4(PALB2):c.2578G>T (p.Glu860Ter)

SNV
Germline

Chr16:23629212

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395123667

rs_1966853670

2 SubmittersRCV002958045 RCV003367916

NM_024675.4(PALB2):c.3303C>T (p.Leu1101=)

SNV
Germline

Chr16:23607911

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494175553

rs_2506215064

2 SubmittersRCV003032076

NM_024675.4(PALB2):c.2555C>T (p.Pro852Leu)

SNV
Germline

Chr16:23629235

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395123750

rs_2142368283

2 SubmittersRCV003023810 RCV004654098

NM_024675.4(PALB2):c.3004G>T (p.Glu1002Ter)

SNV
Germline

Chr16:23621471

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395143203

rs_2142328421

2 SubmittersRCV003047180

NM_024675.4(PALB2):c.2058G>C (p.Arg686Ser)

SNV
Germline

Chr16:23630096

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395126761

rs_771376636

2 SubmittersRCV003127146 RCV004245979

NM_024675.4(PALB2):c.854C>A (p.Ser285Ter)

SNV
Unknown

Chr16:23635692

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395135850

rs_180177094

1 SubmittersRCV003140367

NM_024675.4(PALB2):c.27C>T (p.Leu9=)

SNV
Germline

Chr16:23641131

Conflicting classifications of pathogenicity

Pancreatic cancer, susceptibility to, 3
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494168470

rs_749298208

2 SubmittersRCV003142288 RCV005422268

NM_024675.4(PALB2):c.280G>T (p.Glu94Ter)

SNV
Germline

Chr16:23636266

Pathogenic

Hereditary cancer-predisposing syndrome
Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395138843

rs_45602040

3 SubmittersRCV003182763 RCV003228144 RCV005425115

NM_024675.4(PALB2):c.3254T>A (p.Leu1085Ter)

SNV
Germline

Chr16:23607960

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395139801

rs_780524136

1 SubmittersRCV003182764

NM_024675.4(PALB2):c.2514+1G>T

SNV
Germline

Chr16:23629639

Likely pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395123913

rs_886039729

1 SubmittersRCV003182766

NM_024675.4(PALB2):c.2038G>T (p.Gly680Ter)

SNV
Germline

Chr16:23630116

Pathogenic/Likely pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395126914

rs_1223755856

3 SubmittersRCV003229332 RCV003455782

NM_024675.4(PALB2):c.3457C>G (p.Pro1153Ala)

SNV
Germline

Chr16:23603563

Conflicting classifications of pathogenicity

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395138078

rs_1966399624

3 SubmittersRCV003230139 RCV003607576 RCV004285639

NM_024675.4(PALB2):c.2995G>T (p.Gly999Ter)

SNV
Germline

Chr16:23622970

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395143834

rs_1269970394

3 SubmittersRCV003311306 RCV003455792

NM_024675.4(PALB2):c.1560C>A (p.Cys520Ter)

SNV
Unknown

Chr16:23634986

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395130763

rs_2142412586

1 SubmittersRCV003316918

NM_024675.4(PALB2):c.108+2T>G

SNV
Germline

Chr16:23638068

Pathogenic/Likely pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395139553

rs_2142459705

2 SubmittersRCV003316941

NM_024675.4(PALB2):c.874C>T (p.Gln292Ter)

SNV
Germline

Chr16:23635672

Pathogenic

Hereditary breast ovarian cancer syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395135773

rs_1335897946

3 SubmittersRCV003317953 RCV003455798

NM_024675.4(PALB2):c.2835-1G>T

SNV
Germline

Chr16:23623131

Likely pathogenic

Familial cancer of breast

No Assertion Criteria Provided

CA395144549

rs_515726099

1 SubmittersRCV003485910

NM_024675.4(PALB2):c.373C>T (p.Gln125Ter)

SNV
Germline

Chr16:23636173

Pathogenic/Likely pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395137513

rs_2142444897

3 SubmittersRCV003485911

NM_024675.4(PALB2):c.1543A>T (p.Lys515Ter)

SNV
Germline

Chr16:23635003

Pathogenic

Condition: not provided
Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395130869

rs_1188755325

3 SubmittersRCV003326936 RCV003455801 RCV003585380

NM_024675.4(PALB2):c.1135A>T (p.Lys379Ter)

SNV
Germline

Chr16:23635411

Pathogenic

Condition: not provided

Criteria Provided
Single Submitter

CA395133619

rs_2142424902

1 SubmittersRCV003328908

NM_024675.4(PALB2):c.991G>T (p.Glu331Ter)

SNV
Germline

Chr16:23635555

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395134714

rs_878855126

2 SubmittersRCV003336888

NM_024675.4(PALB2):c.191C>A (p.Ser64Ter)

SNV
Unknown

Chr16:23637870

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395139044

rs_1567223942

1 SubmittersRCV003335750

NM_024675.4(PALB2):c.2835-2A>G

SNV
Germline

Chr16:23623132

Likely pathogenic

Fanconi anemia complementation group N
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395144551

rs_886039613

2 SubmittersRCV003340766 RCV003455803

NM_024675.4(PALB2):c.1740T>G (p.Tyr580Ter)

SNV
Germline

Chr16:23630414

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395128296

rs_2142390387

2 SubmittersRCV003455810 RCV003360869

NM_024675.4(PALB2):c.109-2A>T

SNV
Unknown

Chr16:23637954

Likely pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395139502

rs_730881897

2 SubmittersRCV003450443

NM_024675.4(PALB2):c.49-2A>G

SNV
Germline

Chr16:23638131

Conflicting classifications of pathogenicity

Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395140049

rs_786203245

2 SubmittersRCV003476607

NM_024675.4(PALB2):c.532G>T (p.Glu178Ter)

SNV
Unknown

Chr16:23636014

Pathogenic/Likely pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395136941

rs_1597098960

2 SubmittersRCV003450476

NM_024675.4(PALB2):c.2834+2T>A

SNV
Germline

Chr16:23624007

Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395144747

rs_864622481

3 SubmittersRCV003450451 RCV004364752

NM_024675.4(PALB2):c.1610C>A (p.Ser537Ter)

SNV
Germline

Chr16:23634936

Pathogenic/Likely pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395130459

rs_142103232

3 SubmittersRCV003452234

NM_024675.4(PALB2):c.2587-1G>A

SNV
Unknown

Chr16:23626398

Likely pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395122286

rs_761214886

1 SubmittersRCV003450440

NM_024675.4(PALB2):c.2997-2A>G

SNV
Unknown

Chr16:23621480

Likely pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395143252

rs_1555459421

1 SubmittersRCV003450441

NM_024675.4(PALB2):c.2748+2T>A

SNV
Unknown

Chr16:23626234

Likely pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395121812

rs_1060499821

1 SubmittersRCV003450442

NM_024675.4(PALB2):c.109-1G>A

SNV
Germline

Chr16:23637953

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395139500

rs_2142458017

3 SubmittersRCV003450444 RCV005455798

NM_024675.4(PALB2):c.3350+2C>A

SNV
Germline

Chr16:23607862

Likely pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395139184

rs_1555458171

2 SubmittersRCV005403315 RCV003450445

NM_024675.4(PALB2):c.3114-2A>G

SNV
Germline

Chr16:23614093

Likely pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395141527

rs_2142300348

2 SubmittersRCV003450447

NM_024675.4(PALB2):c.3G>T (p.Met1Ile)

SNV
Unknown

Chr16:23641155

Likely pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395141271

rs_1057517585

1 SubmittersRCV003450448

NM_024675.4(PALB2):c.3201+1G>A

SNV
Germline

Chr16:23614003

Pathogenic/Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395141079

rs_587776423

3 SubmittersRCV003450450 RCV004943042

NM_024675.4(PALB2):c.3113G>C (p.Trp1038Ser)

SNV
Unknown

Chr16:23621362

Likely pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395142753

rs_180177132

1 SubmittersRCV003450453

NM_024675.4(PALB2):c.1592T>A (p.Leu531Ter)

SNV
Unknown

Chr16:23634954

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA279498153

rs_540962715

1 SubmittersRCV003450461

NM_024675.4(PALB2):c.2068C>T (p.Gln690Ter)

SNV
Unknown

Chr16:23630086

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395126666

rs_1555460505

1 SubmittersRCV003450464

NM_024675.4(PALB2):c.3010C>T (p.Gln1004Ter)

SNV
Germline

Chr16:23621465

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395143174

rs_2142328321

3 SubmittersRCV003585399 RCV003450466

NM_024675.4(PALB2):c.412G>T (p.Glu138Ter)

SNV
Unknown

Chr16:23636134

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395137362

rs_1967048357

1 SubmittersRCV003450467

NM_024675.4(PALB2):c.313G>T (p.Glu105Ter)

SNV
Unknown

Chr16:23636233

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395138778

rs_1307895700

1 SubmittersRCV003450471

NM_024675.4(PALB2):c.55G>T (p.Glu19Ter)

SNV
Unknown

Chr16:23638123

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395139966

rs_2142461160

1 SubmittersRCV003450472

NM_024675.4(PALB2):c.2444C>G (p.Ser815Ter)

SNV
Unknown

Chr16:23629710

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395124200

rs_879254068

1 SubmittersRCV003450475

NM_024675.4(PALB2):c.2735G>A (p.Trp912Ter)

SNV
Germline

Chr16:23626249

Pathogenic

Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395121842

rs_2142353165

2 SubmittersRCV003450477

NM_024675.4(PALB2):c.470C>A (p.Ser157Ter)

SNV
Unknown

Chr16:23636076

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395137141

rs_749078410

1 SubmittersRCV003450478

NM_024675.4(PALB2):c.1414C>T (p.Gln472Ter)

SNV
Germline

Chr16:23635132

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395131320

rs_2142416694

2 SubmittersRCV004943043 RCV003450479

NM_024675.4(PALB2):c.3238A>T (p.Lys1080Ter)

SNV
Unknown

Chr16:23607976

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395139942

rs_1966511830

1 SubmittersRCV003450480

NM_024675.4(PALB2):c.1582G>T (p.Glu528Ter)

SNV
Unknown

Chr16:23634964

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395130634

rs_1966955447

1 SubmittersRCV003450487

NM_024675.4(PALB2):c.268G>T (p.Glu90Ter)

SNV
Germline

Chr16:23636278

Pathogenic

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

CA395138867

rs_2142447291

2 SubmittersRCV004943044 RCV003450489

NM_024675.4(PALB2):c.1892C>G (p.Ser631Ter)

SNV
Unknown

Chr16:23630262

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395127611

rs_2142386665

1 SubmittersRCV003450493

NM_024675.4(PALB2):c.964G>T (p.Glu322Ter)

SNV
Unknown

Chr16:23635582

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395134933

rs_1597097656

1 SubmittersRCV003450497

NM_024675.4(PALB2):c.1948G>T (p.Glu650Ter)

SNV
Unknown

Chr16:23630206

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395127403

rs_1597090662

1 SubmittersRCV003450500

NM_024675.4(PALB2):c.33T>A (p.Cys11Ter)

SNV
Unknown

Chr16:23641125

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395141083

rs_2142481060

1 SubmittersRCV003450503

NM_024675.4(PALB2):c.3419G>A (p.Trp1140Ter)

SNV
Unknown

Chr16:23603601

Pathogenic/Likely pathogenic

Familial cancer of breast
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Multiple Submitters
No Conflicts

CA395138212

rs_1060502809

2 SubmittersRCV003450504 RCV004560172

NM_024675.4(PALB2):c.3139A>T (p.Lys1047Ter)

SNV
Unknown

Chr16:23614066

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395141365

rs_2506266710

1 SubmittersRCV003452231

NM_024675.4(PALB2):c.2297C>A (p.Ser766Ter)

SNV
Unknown

Chr16:23629857

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395125285

rs_1555460410

1 SubmittersRCV003452239

NM_024675.4(PALB2):c.2658T>A (p.Cys886Ter)

SNV
Unknown

Chr16:23626326

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395122097

rs_2142354911

1 SubmittersRCV003452246

NM_024675.4(PALB2):c.3119T>A (p.Leu1040Ter)

SNV
Unknown

Chr16:23614086

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395141477

rs_2142300225

1 SubmittersRCV003452255

NM_024675.4(PALB2):c.1002C>G (p.Tyr334Ter)

SNV
Unknown

Chr16:23635544

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395134614

rs_1967002667

1 SubmittersRCV003452262

NM_024675.4(PALB2):c.3241G>T (p.Glu1081Ter)

SNV
Unknown

Chr16:23607973

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395139906

rs_2142273676

1 SubmittersRCV003452276

NM_024675.4(PALB2):c.2604T>A (p.Cys868Ter)

SNV
Unknown

Chr16:23626380

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395122230

rs_2142356386

1 SubmittersRCV003452279

NM_024675.4(PALB2):c.1111G>T (p.Glu371Ter)

SNV
Unknown

Chr16:23635435

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395133779

rs_1312378621

1 SubmittersRCV003452282

NM_024675.4(PALB2):c.2444C>A (p.Ser815Ter)

SNV
Unknown

Chr16:23629710

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395124202

rs_879254068

1 SubmittersRCV003452284

NM_024675.4(PALB2):c.3119T>G (p.Leu1040Ter)

SNV
Germline

Chr16:23614086

Pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395141471

rs_2142300225

2 SubmittersRCV003452298 RCV005455800

NM_024675.4(PALB2):c.2174C>G (p.Ser725Ter)

SNV
Unknown

Chr16:23629980

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395125643

rs_1567217931

1 SubmittersRCV003452315

NM_024675.4(PALB2):c.3403G>T (p.Gly1135Ter)

SNV
Unknown

Chr16:23603617

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395138242

rs_2142254584

1 SubmittersRCV003452326

NM_024675.4(PALB2):c.2647A>T (p.Lys883Ter)

SNV
Unknown

Chr16:23626337

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395122133

rs_1966842668

1 SubmittersRCV003452331

NM_024675.4(PALB2):c.1841T>A (p.Leu614Ter)

SNV
Unknown

Chr16:23630313

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395127846

rs_1555460628

1 SubmittersRCV003452370

NM_024675.4(PALB2):c.2580G>C (p.Glu860Asp)

SNV
Germline

Chr16:23629210

Conflicting classifications of pathogenicity

Condition: not provided
Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Conflicting Classifications

CA395123654

rs_1348398121

4 SubmittersRCV003477328 RCV003585417 RCV005356448

NM_024675.4(PALB2):c.62T>A (p.Leu21Ter)

SNV
Germline

Chr16:23638116

Pathogenic

Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Single Submitter

CA395139893

rs_769240800

1 SubmittersRCV003484442

NM_024675.4(PALB2):c.3327T>A (p.Cys1109Ter)

SNV
Germline

Chr16:23607887

Pathogenic

Hereditary breast ovarian cancer syndrome

Criteria Provided
Single Submitter

CA395139353

rs_2142271504

1 SubmittersRCV003484243

NM_024675.4(PALB2):c.2175A>T (p.Ser725=)

SNV
Germline

Chr16:23629979

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA494461128

rs_2142379081

2 SubmittersRCV003500951 RCV004366462

NM_024675.4(PALB2):c.3202-13T>C

SNV
Germline

Chr16:23608025

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Breast-ovarian cancer, familial, susceptibility to, 5
Pancreatic cancer, susceptibility to, 3
Fanconi anemia complementation group N
not specified
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA2697555733

rs_2142274636

5 SubmittersRCV003585421 RCV003596262 RCV005230518 RCV003500873

NM_024675.4(PALB2):c.442A>T (p.Lys148Ter)

SNV
Germline

Chr16:23636104

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395137253

rs_2142443334

1 SubmittersRCV003501301

NM_024675.4(PALB2):c.307G>C (p.Gly103Arg)

SNV
Germline

Chr16:23636239

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395138791

rs_2142446440

2 SubmittersRCV003501481 RCV004943084

NM_024675.4(PALB2):c.48+4C>A

SNV
Germline

Chr16:23641106

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA2697555740

rs_876659843

3 SubmittersRCV003500287 RCV005387207

NM_024675.4(PALB2):c.2786A>G (p.Tyr929Cys)

SNV
Germline

Chr16:23624057

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
PALB2-related disorder

Criteria Provided
Conflicting Classifications

CA395145070

rs_1249404804

3 SubmittersRCV003585684 RCV004723393

NM_024675.4(PALB2):c.1615G>A (p.Val539Ile)

SNV
Germline

Chr16:23634931

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395130420

rs_2142411065

2 SubmittersRCV003607625 RCV005468001

NM_024675.4(PALB2):c.927A>G (p.Ile309Met)

SNV
Germline

Chr16:23635619

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA395135283

rs_1326253995

2 SubmittersRCV003607879 RCV005387224

NM_024675.4(PALB2):c.2400T>A (p.Cys800Ter)

SNV
Germline

Chr16:23629754

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395124462

rs_2142373865

1 SubmittersRCV003607843

NM_024675.4(PALB2):c.50T>A (p.Leu17Ter)

SNV
Germline

Chr16:23638128

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395140025

rs_1567224232

1 SubmittersRCV003607890

NM_024675.4(PALB2):c.3252G>T (p.Ser1084=)

SNV
Germline

Chr16:23607962

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

CA494175748

rs_141570833

2 SubmittersRCV003608266 RCV005403344

NM_024675.4(PALB2):c.2582T>G (p.Leu861Ter)

SNV
Germline

Chr16:23629208

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395123639

rs_2142367705

1 SubmittersRCV003608365

NM_024675.4(PALB2):c.2992G>T (p.Gly998Ter)

SNV
Germline

Chr16:23622973

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

CA395143840

rs_1039184417

1 SubmittersRCV003608380

NM_024675.4(PALB2):c.1224T>G (p.Tyr408Ter)

SNV
Germline

Chr16:23635322

Pathogenic/Likely pathogenic

Breast-ovarian cancer, familial, susceptibility to, 5
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

CA395133110

rs_2142422250

2 SubmittersRCV004017206 RCV004943298

NM_024675.4(PALB2):c.1064T>A (p.Leu355Ter)

SNV
Germline

Chr16:23635482

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

CA395134053

rs_1597097263

1 SubmittersRCV004517722

NM_024675.4(PALB2):c.1838A>T (p.Gln613Leu)

SNV
Germline

Chr16:23630316

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA395127862

rs_1966865170

2 SubmittersRCV004517741 RCV005100631

NM_024675.4(PALB2):c.2653C>T (p.Pro885Ser)

SNV
Germline

Chr16:23626331

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Inherited breast cancer and ovarian cancer

Criteria Provided
Conflicting Classifications

CA395122114

rs_878855111

2 SubmittersRCV004517758 RCV004584242

NM_024675.4(PALB2):c.2817G>A (p.Leu939=)

SNV
Germline

Chr16:23624026

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

CA494181085

rs_1555459710

3 SubmittersRCV004517764 RCV005100633

NM_024675.4(PALB2):c.2997-1G>C

SNV
Germline

Chr16:23621479

Likely pathogenic

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Multiple Submitters
No Conflicts

rs_754465466

2 SubmittersRCV004589108 RCV005468117

NM_024675.4(PALB2):c.2793C>A (p.Leu931=)

SNV
Germline

Chr16:23624050

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome
Familial cancer of breast

Criteria Provided
Conflicting Classifications

3 SubmittersRCV004650735 RCV005102351

NM_024675.4(PALB2):c.1660G>T (p.Glu554Ter)

SNV
Germline

Chr16:23634886

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV004664045

NM_024675.4(PALB2):c.3350+1G>C

SNV
Germline

Chr16:23607863

Likely pathogenic

Condition: not provided
Familial cancer of breast

Criteria Provided
Multiple Submitters
No Conflicts

2 SubmittersRCV004697935 RCV005249713

NM_024675.4(PALB2):c.2053A>T (p.Lys685Ter)

SNV
Germline

Chr16:23630101

Likely pathogenic

PALB2-related disorder

No Assertion Criteria Provided

1 SubmittersRCV004728151

NM_024675.4(PALB2):c.2045C>A (p.Ser682Ter)

SNV
Germline

Chr16:23630109

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV004945566

NM_024675.4(PALB2):c.283A>T (p.Lys95Ter)

SNV
Germline

Chr16:23636263

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV004945583

NM_024675.4(PALB2):c.1873G>T (p.Glu625Ter)

SNV
Germline

Chr16:23630281

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV004945586

NM_024675.4(PALB2):c.237T>G (p.Tyr79Ter)

SNV
Germline

Chr16:23636309

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV004945589

NM_024675.4(PALB2):c.3114-2A>C

SNV
Germline

Chr16:23614093

Likely pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV004945614

NM_024675.4(PALB2):c.231T>A (p.Cys77Ter)

SNV
Germline

Chr16:23636315

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

1 SubmittersRCV005125127

NM_024675.4(PALB2):c.1951G>T (p.Gly651Ter)

SNV
Germline

Chr16:23630203

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

1 SubmittersRCV005138426

NM_024675.4(PALB2):c.733G>T (p.Ala245Ser)

SNV
Germline

Chr16:23635813

Conflicting classifications of pathogenicity

Familial cancer of breast
Hereditary cancer-predisposing syndrome

Criteria Provided
Conflicting Classifications

2 SubmittersRCV005187562 RCV005387383

NM_024675.4(PALB2):c.2515-2A>C

SNV
Germline

Chr16:23629277

Likely pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

1 SubmittersRCV005203142

NM_024675.4(PALB2):c.3173C>A (p.Ser1058Ter)

SNV
Germline

Chr16:23614032

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

1 SubmittersRCV005197201

NM_024675.4(PALB2):c.211+1G>C

SNV
Unknown

Chr16:23637849

Likely pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

1 SubmittersRCV005246180

NM_024675.4(PALB2):c.2959C>T (p.Gln987Ter)

SNV
Germline

Chr16:23623006

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV005251460

NM_024675.4(PALB2):c.2472T>A (p.Cys824Ter)

SNV
Germline

Chr16:23629682

Pathogenic

Breast-ovarian cancer, familial, susceptibility to, 5

Criteria Provided
Single Submitter

1 SubmittersRCV005365748

NM_024675.4(PALB2):c.2841G>A (p.Leu947=)

SNV
Germline

Chr16:23623124

Conflicting classifications of pathogenicity

Breast-ovarian cancer, familial, susceptibility to, 5
Familial cancer of breast

Criteria Provided
Conflicting Classifications

2 SubmittersRCV005362308 RCV005422603

NM_024675.4(PALB2):c.2518G>T (p.Glu840Ter)

SNV
Germline

Chr16:23629272

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV005427001

NM_024675.4(PALB2):c.271G>T (p.Glu91Ter)

SNV
Germline

Chr16:23636275

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV005451583

NM_024675.4(PALB2):c.160G>T (p.Glu54Ter)

SNV
Germline

Chr16:23637901

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV005451594

NM_024675.4(PALB2):c.1876A>T (p.Lys626Ter)

SNV
Germline

Chr16:23630278

Pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV005451598

NM_024675.4(PALB2):c.1A>T (p.Met1Leu)

SNV
Germline

Chr16:23641157

Likely pathogenic

Hereditary cancer-predisposing syndrome

Criteria Provided
Single Submitter

1 SubmittersRCV005451603

NM_024675.4(PALB2):c.3532G>T (p.Gly1178Ter)

SNV
Unknown

Chr16:23603488

Pathogenic

Familial cancer of breast

Criteria Provided
Single Submitter

1 SubmittersRCV005621820