A total 145 pathogenic variants reported in gene tet methylcytosine dioxygenase 2 (TET2)  
Variant Name Variant Type Variant Genomic Location Clinical Significance Phenotype Condition Review Status ClinGen Allele dbSNP ID Variation/condition record
NM_001127208.3(TET2):c.2429A>G (p.Gln810Arg) SNV
Germline		 Chr4:105236371 Conflicting classifications of pathogenicity not specified
Condition: not provided
TET2-related disorder		 Criteria Provided
Conflicting Classifications
 CA162280 rs_28555446

5 SubmittersRCV000122118RCV001753505RCV003945104
NM_001127208.3(TET2):c.521C>A (p.Pro174His) SNV
Germline		 Chr4:105234463 Conflicting classifications of pathogenicity not specified
Condition: not provided
TET2-related disorder		 Criteria Provided
Conflicting Classifications
 CA162340 rs_146031219

5 SubmittersRCV000122130RCV002262716RCV003952616
NM_001127208.3(TET2):c.3409+15T>A SNV
Germline		 Chr4:105237366 Conflicting classifications of pathogenicity not specified
Condition: not provided
TET2-related disorder		 Criteria Provided
Conflicting Classifications
 CA162404 rs_192879693

3 SubmittersRCV000122144RCV002514655RCV003422004
NM_001127208.3(TET2):c.1864C>T (p.Gln622Ter) SNV
Germline		 Chr4:105235806 Likely pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357796697 rs_1267284740

1 SubmittersRCV001531404
NM_001127208.3(TET2):c.3589A>G (p.Lys1197Glu) SNV
Germline		 Chr4:105242922 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357804703 rs_1231721810

1 SubmittersRCV001531405
NM_001127208.3(TET2):c.4354C>T (p.Arg1452Ter) SNV
Germline		 Chr4:105272735 Conflicting classifications of pathogenicity Condition: not provided Criteria Provided
Conflicting Classifications
 CA102778393 rs_1049545383

2 SubmittersRCV001768250
NM_001127208.3(TET2):c.3562A>T (p.Lys1188Ter) SNV
Germline		 Chr4:105242895 Pathogenic Third degree atrioventricular block No Assertion Criteria Provided
 CA357804632 rs_2476533556

1 SubmittersRCV002305645
NM_001127208.3(TET2):c.1588C>T (p.Gln530Ter) SNV
Germline		 Chr4:105235530 Likely pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA3031712 rs_377382567

1 SubmittersRCV002263353
NM_001127208.3(TET2):c.4210C>T (p.Arg1404Ter) SNV
Germline		 Chr4:105272591 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA102778345 rs_974106601

1 SubmittersRCV002616532
NM_001127208.3(TET2):c.3583A>G (p.Ile1195Val) SNV
Germline		 Chr4:105242916 Conflicting classifications of pathogenicity Condition: not provided Criteria Provided
Conflicting Classifications
 CA3032105 rs_568009712

2 SubmittersRCV002619595
NM_001127208.3(TET2):c.4393C>T (p.Arg1465Ter) SNV
Germline		 Chr4:105272774 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357811683 rs_1235228377

1 SubmittersRCV002575648
NM_001127208.3(TET2):c.1630C>T (p.Arg544Ter) SNV
Germline		 Chr4:105235572 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357795492 rs_1440692352

1 SubmittersRCV002727114
NM_001127208.3(TET2):c.2697T>G (p.Tyr899Ter) SNV
Germline		 Chr4:105236639 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357800024 rs_2110234873

1 SubmittersRCV002814878
NM_001127208.3(TET2):c.3765C>A (p.Tyr1255Ter) SNV
Germline		 Chr4:105243740 Pathogenic Condition: not provided
Angioimmunoblastic T-cell lymphoma		 Criteria Provided
Single Submitter
 CA357805331 rs_1352258641

2 SubmittersRCV002872600RCV003447637
NM_001127208.3(TET2):c.3061C>T (p.Gln1021Ter) SNV
Germline		 Chr4:105237003 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357801454 rs_1279700648

1 SubmittersRCV003048049
NM_001127208.3(TET2):c.1061C>G (p.Ser354Ter) SNV
Germline		 Chr4:105235003 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357793675 rs_1223795843

1 SubmittersRCV003040743
NM_001127208.3(TET2):c.3409+1G>A SNV
Germline		 Chr4:105237352 Likely pathogenic EBV-positive nodal T- and NK-cell lymphoma
Condition: not provided		 Criteria Provided
Single Submitter
 rs_772634266

2 SubmittersRCV004557990RCV005100269
NM_001127208.3(TET2):c.3954+5G>A SNV
Somatic		 Chr4:105259774 Pathogenic EBV-positive nodal T- and NK-cell lymphoma No Assertion Criteria Provided
 rs_575928986

1 SubmittersRCV004557991
NM_001127208.3(TET2):c.3955-2A>G SNV
Germline		 Chr4:105261757 Likely pathogenic Myelodysplastic syndrome
Immunodeficiency 75
EBV-positive nodal T- and NK-cell lymphoma		 Criteria Provided
Single Submitter
 rs_1242089483

2 SubmittersRCV005036827RCV004557992
NM_001127208.3(TET2):c.340C>T (p.Gln114Ter) SNV
Unknown		 Chr4:105234282 Pathogenic EBV-positive nodal T- and NK-cell lymphoma No Assertion Criteria Provided
 rs_1728692644

1 SubmittersRCV004557996
NM_001127208.3(TET2):c.3571C>T (p.Gln1191Ter) SNV
Unknown		 Chr4:105242904 Pathogenic EBV-positive nodal T- and NK-cell lymphoma No Assertion Criteria Provided
 rs_1729381211

1 SubmittersRCV004557997
NM_001127208.3(TET2):c.2224C>T (p.Gln742Ter) SNV
Germline		 Chr4:105236166 Pathogenic Condition: not provided
EBV-positive nodal T- and NK-cell lymphoma		 Criteria Provided
Single Submitter
 rs_2110232389

2 SubmittersRCV005100270RCV004557999
NM_001127208.3(TET2):c.2227C>T (p.Gln743Ter) SNV
Unknown		 Chr4:105236169 Pathogenic EBV-positive nodal T- and NK-cell lymphoma No Assertion Criteria Provided
 rs_1322900367

1 SubmittersRCV004558000
NM_001127208.3(TET2):c.2746C>T (p.Gln916Ter) SNV
Germline/somatic		 Chr4:105236688 Conflicting classifications of pathogenicity EBV-positive nodal T- and NK-cell lymphoma
Condition: not provided
Myelodysplastic syndrome
Immunodeficiency 75		 Criteria Provided
Conflicting Classifications
 CA3031947 rs_780710758

4 SubmittersRCV004558002RCV003720935RCV005399412
NM_001127208.3(TET2):c.1648C>T (p.Arg550Ter) SNV
Germline		 Chr4:105235590 Pathogenic Condition: not provided
EBV-positive nodal T- and NK-cell lymphoma		 Criteria Provided
Single Submitter
 CA3031727 rs_572712965

2 SubmittersRCV003779176RCV004558003
NM_001127208.3(TET2):c.5393C>G (p.Ser1798Ter) SNV
Somatic		 Chr4:105275903 Pathogenic EBV-positive nodal T- and NK-cell lymphoma No Assertion Criteria Provided
 rs_2110315013

1 SubmittersRCV004558005
NM_001127208.3(TET2):c.1526C>G (p.Ser509Ter) SNV
Somatic		 Chr4:105235468 Pathogenic EBV-positive nodal T- and NK-cell lymphoma No Assertion Criteria Provided
 rs_771408533

1 SubmittersRCV004558006
NM_001127208.3(TET2):c.576C>A (p.Tyr192Ter) SNV
Unknown		 Chr4:105234518 Pathogenic EBV-positive nodal T- and NK-cell lymphoma No Assertion Criteria Provided
 rs_1728711651

1 SubmittersRCV004558007
NM_001127208.3(TET2):c.3202C>T (p.Gln1068Ter) SNV
Germline		 Chr4:105237144 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357802496 rs_1728991935

1 SubmittersRCV003577309
NM_001127208.3(TET2):c.1860C>G (p.Tyr620Ter) SNV
Germline		 Chr4:105235802 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357796677 rs_745705515

1 SubmittersRCV003579257
NM_001127208.3(TET2):c.2428C>T (p.Gln810Ter) SNV
Germline		 Chr4:105236370 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357798982 rs_1386986367

1 SubmittersRCV003547837
NM_001127208.3(TET2):c.3496G>T (p.Glu1166Ter) SNV
Germline		 Chr4:105241425 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357804250 rs_2110249286

1 SubmittersRCV003554562
NM_001127208.3(TET2):c.2141C>G (p.Ser714Ter) SNV
Germline		 Chr4:105236083 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357797735 rs_1560544979

1 SubmittersRCV003563178
NM_001127208.3(TET2):c.4429G>T (p.Glu1477Ter) SNV
Germline		 Chr4:105272810 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357811761 rs_2476726335

1 SubmittersRCV003566642
NM_001127208.3(TET2):c.3594+1G>C SNV
Germline		 Chr4:105242928 Likely pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357804718 rs_1267484829

1 SubmittersRCV003574511
NM_001127208.3(TET2):c.1930C>T (p.Gln644Ter) SNV
Germline		 Chr4:105235872 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA3031783 rs_752071309

1 SubmittersRCV003677161
NM_001127208.3(TET2):c.1337T>G (p.Leu446Ter) SNV
Germline		 Chr4:105235279 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357794550 rs_1728783958

1 SubmittersRCV003669071
NM_001127208.3(TET2):c.2525C>G (p.Ser842Ter) SNV
Germline		 Chr4:105236467 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357799445 rs_2476501487

1 SubmittersRCV003708894
NM_001127208.3(TET2):c.553C>T (p.Gln185Ter) SNV
Germline		 Chr4:105234495 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357792207 rs_1224691808

1 SubmittersRCV003706296
NM_001127208.3(TET2):c.2020C>T (p.Gln674Ter) SNV
Germline		 Chr4:105235962 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357797315 rs_1352624446

1 SubmittersRCV003694802
NM_001127208.3(TET2):c.3250C>T (p.Gln1084Ter) SNV
Germline		 Chr4:105237192 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357802727 rs_2110237946

1 SubmittersRCV003696435
NM_001127208.3(TET2):c.346C>T (p.Gln116Ter) SNV
Germline		 Chr4:105234288 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357791261 rs_1728693166

1 SubmittersRCV003709697
NM_001127208.3(TET2):c.2185C>T (p.Gln729Ter) SNV
Germline		 Chr4:105236127 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357798271 rs_1323211736

1 SubmittersRCV003858639
NM_001127208.3(TET2):c.832C>T (p.Gln278Ter) SNV
Germline		 Chr4:105234774 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357793051 rs_2476483849

1 SubmittersRCV003857346
NM_001127208.3(TET2):c.3088C>T (p.Gln1030Ter) SNV
Germline		 Chr4:105237030 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA3032014 rs_780043982

1 SubmittersRCV003874293
NM_001127208.3(TET2):c.1264G>T (p.Gly422Ter) SNV
Germline		 Chr4:105235206 Pathogenic Condition: not provided Criteria Provided
Single Submitter
 CA357794388 rs_1165986811

1 SubmittersRCV003871365
NM_001127208.3(TET2):c.1954C>T (p.Gln652Ter) SNV
Germline		 Chr4:105235896 Pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005080157
NM_001127208.3(TET2):c.3149C>A (p.Ser1050Ter) SNV
Germline		 Chr4:105237091 Pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005133249
NM_001127208.3(TET2):c.2884C>T (p.Gln962Ter) SNV
Germline		 Chr4:105236826 Pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005134731
NM_001127208.3(TET2):c.4045-2A>C SNV
Germline		 Chr4:105269608 Likely pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005140441
NM_001127208.3(TET2):c.4183-1G>C SNV
Germline		 Chr4:105272563 Likely pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005140736
NM_001127208.3(TET2):c.2176C>T (p.Gln726Ter) SNV
Germline		 Chr4:105236118 Pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005147712
NM_001127208.3(TET2):c.1889A>G (p.Lys630Arg) SNV
Germline		 Chr4:105235831 Conflicting classifications of pathogenicity Condition: not provided
not specified		 Criteria Provided
Conflicting Classifications

2 SubmittersRCV005155250RCV005291190
NM_001127208.3(TET2):c.3151C>T (p.Gln1051Ter) SNV
Germline		 Chr4:105237093 Pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005162974
NM_001127208.3(TET2):c.1249C>T (p.Gln417Ter) SNV
Germline		 Chr4:105235191 Pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005172200
NM_001127208.3(TET2):c.3594+1G>T SNV
Germline		 Chr4:105242928 Likely pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005172926
NM_001127208.3(TET2):c.2596C>T (p.Gln866Ter) SNV
Germline		 Chr4:105236538 Pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005177379
NM_001127208.3(TET2):c.3594+1G>A SNV
Germline		 Chr4:105242928 Likely pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005164788
NM_001127208.3(TET2):c.2646C>A (p.Cys882Ter) SNV
Germline		 Chr4:105236588 Pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005203649
NM_001127208.3(TET2):c.2671C>T (p.Gln891Ter) SNV
Germline		 Chr4:105236613 Likely pathogenic Condition: not provided Criteria Provided
Single Submitter

1 SubmittersRCV005234312