GenTIGS

MICAL like 2 (MICALL2) Associated conditions: 1. Joubert syndrome

mRNA Information: Transcript Variants and Protein Isoforms

SNo.	Status	mRNA accession	Protein accession	Genomic DNA accession (Chromosome)	mRNA location on genomic DNA	Assembly	UniProtkb ID

Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.

PubMed Links for Transcript Variants (Isoforms)

Link 136 reference articles

Variant Information MICAL like 2 (MICALL2) Mutation Visualization Dashboard: Pathogenic variant distribution chart

ClinVar variants:Revealing mutagenic patterns

GO Term of MICAL like 2 (MICALL2)

SNo.	Reported in speceis	Evidence	Qualifier	GO term	Category	Pubmed Link
1	Homo sapiens	IEA	colocalizes_with	stress fiber	Component	-
2	Homo sapiens	ISS	colocalizes_with	stress fiber	Component	-
3	Homo sapiens	IPI	enables	protein binding	Function	25416956 31515488 32296183
4	Homo sapiens	IEA	located_in	cytoskeleton	Component	-
5	Homo sapiens	IBA	is_active_in	plasma membrane	Component	-
6	Homo sapiens	IEA	located_in	plasma membrane	Component	-
7	Homo sapiens	ISS	located_in	plasma membrane	Component	-
8	Homo sapiens	IEA	located_in	cell-cell junction	Component	-
9	Homo sapiens	ISS	located_in	cell-cell junction	Component	-
10	Homo sapiens	IEA	located_in	bicellular tight junction	Component	-
11	Homo sapiens	ISS	located_in	bicellular tight junction	Component	-
12	Homo sapiens	IBA	involved_in	actin cytoskeleton organization	Process	-
13	Homo sapiens	IEA	involved_in	actin cytoskeleton organization	Process	-
14	Homo sapiens	ISS	involved_in	actin cytoskeleton organization	Process	-
15	Homo sapiens	IEA	involved_in	actin filament polymerization	Process	-
16	Homo sapiens	ISS	involved_in	actin filament polymerization	Process	-
17	Homo sapiens	IDA	enables	filamin binding	Function	23890175
18	Homo sapiens	IEA	enables	filamin binding	Function	-
19	Homo sapiens	IEA	involved_in	neuron projection development	Process	-
20	Homo sapiens	ISS	involved_in	neuron projection development	Process	-
21	Homo sapiens	IBA	enables	small GTPase binding	Function	-
22	Homo sapiens	IEA	enables	small GTPase binding	Function	-
23	Homo sapiens	IEA	located_in	actin filament bundle	Component	-
24	Homo sapiens	ISS	colocalizes_with	actin filament bundle	Component	-
25	Homo sapiens	IBA	involved_in	endocytic recycling	Process	-
26	Homo sapiens	ISS	involved_in	endocytic recycling	Process	-
27	Homo sapiens	IEA	involved_in	Rab protein signal transduction	Process	-
28	Homo sapiens	IEA	involved_in	substrate adhesion-dependent cell spreading	Process	-
29	Homo sapiens	ISS	involved_in	substrate adhesion-dependent cell spreading	Process	-
30	Homo sapiens	IEA	enables	actinin binding	Function	-
31	Homo sapiens	IEA	located_in	cell projection	Component	-
32	Homo sapiens	ISS	located_in	neuron projection	Component	-
33	Homo sapiens	IEA	enables	metal ion binding	Function	-
34	Homo sapiens	IBA	enables	actin filament binding	Function	-
35	Homo sapiens	IEA	enables	actin filament binding	Function	-
36	Homo sapiens	ISS	enables	actin filament binding	Function	-
37	Homo sapiens	IEA	located_in	recycling endosome	Component	-
38	Homo sapiens	ISS	located_in	recycling endosome	Component	-
39	Homo sapiens	IEA	involved_in	bicellular tight junction assembly	Process	-
40	Homo sapiens	ISS	involved_in	bicellular tight junction assembly	Process	-
41	Homo sapiens	IEA	involved_in	endosome membrane tubulation	Process	-
42	Homo sapiens	HMP	involved_in	positive regulation of protein localization to mitochondrion	Process	24270810