Troponin T2, cardiac type (TNNT2) Associated conditions: 1. Restrictive cardiomyopathy 2. Dilated cardiomyopathy 1DD
| SNo. | Status | mRNA accession | Protein accession | Genomic DNA accession (Chromosome) | mRNA location on genomic DNA | Assembly | UniProtkb ID |
| 1 | REVIEWED | NM_000364.4 | NP_000355.2 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 2 | REVIEWED | NM_001001430.3 | NP_001001430.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 3 | REVIEWED | NM_001001431.3 | NP_001001431.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 4 | REVIEWED | NM_001001432.3 | NP_001001432.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 5 | REVIEWED | NM_001276345.2 | NP_001263274.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 6 | REVIEWED | NM_001276346.2 | NP_001263275.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 7 | REVIEWED | NM_001276347.2 | NP_001263276.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 8 | REVIEWED | NM_001406723.1 | NP_001393652.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 9 | REVIEWED | NM_001406724.1 | NP_001393653.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 10 | REVIEWED | NM_001406725.1 | NP_001393654.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 11 | REVIEWED | NM_001406726.1 | NP_001393655.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 12 | REVIEWED | NM_001406727.1 | NP_001393656.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
| 13 | REVIEWED | NM_001406728.1 | NP_001393657.1 | NC_000001.11 | (201359013..201377679, complement) | Reference GRCh38.p14 Primary Assembly | P45379 |
Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.
Variant Information Troponin T2, cardiac type (TNNT2) Mutation Visualization Dashboard: Pathogenic variant distribution chart
ClinVar variants:Revealing mutagenic patterns
| SNo. | Reported in speceis | Evidence | Qualifier | GO term | Category | Pubmed Link |
| 1 | Homo sapiens | IDA | contributes_to | microfilament motor activity | Function | 2530435 12093807 |
| 2 | Homo sapiens | IDA | enables | actin binding | Function | 8205619 |
| 3 | Homo sapiens | IPI | enables | protein binding | Function | 25416956 32296183 |
| 4 | Homo sapiens | IBA | enables | tropomyosin binding | Function | - |
| 5 | Homo sapiens | IDA | enables | tropomyosin binding | Function | 10850966 |
| 6 | Homo sapiens | IEA | enables | tropomyosin binding | Function | - |
| 7 | Homo sapiens | TAS | located_in | cytosol | Component | - |
| 8 | Homo sapiens | IBA | part_of | troponin complex | Component | - |
| 9 | Homo sapiens | IDA | part_of | troponin complex | Component | 2530435 12093807 12186860 |
| 10 | Homo sapiens | IEA | part_of | troponin complex | Component | - |
| 11 | Homo sapiens | IDA | located_in | striated muscle thin filament | Component | 12186860 |
| 12 | Homo sapiens | IEA | involved_in | regulation of muscle contraction | Process | - |
| 13 | Homo sapiens | IEA | involved_in | striated muscle contraction | Process | - |
| 14 | Homo sapiens | IMP | involved_in | regulation of heart contraction | Process | 15542288 |
| 15 | Homo sapiens | NAS | located_in | sarcomere | Component | 12840750 |
| 16 | Homo sapiens | TAS | located_in | sarcomere | Component | 16754800 |
| 17 | Homo sapiens | IDA | involved_in | muscle filament sliding | Process | 12186860 15923195 |
| 18 | Homo sapiens | NAS | involved_in | muscle filament sliding | Process | 12840750 |
| 19 | Homo sapiens | IBA | enables | troponin C binding | Function | - |
| 20 | Homo sapiens | IEA | enables | troponin C binding | Function | - |
| 21 | Homo sapiens | IPI | enables | troponin C binding | Function | 8205619 15542288 |
| 22 | Homo sapiens | IBA | enables | troponin I binding | Function | - |
| 23 | Homo sapiens | IEA | enables | troponin I binding | Function | - |
| 24 | Homo sapiens | IPI | enables | troponin I binding | Function | 15542288 |
| 25 | Homo sapiens | IDA | involved_in | negative regulation of ATP-dependent activity | Process | 10850966 12093807 |
| 26 | Homo sapiens | NAS | involved_in | negative regulation of ATP-dependent activity | Process | 12840750 |
| 27 | Homo sapiens | IDA | involved_in | positive regulation of ATP-dependent activity | Process | 10850966 12186860 |
| 28 | Homo sapiens | IPI | enables | identical protein binding | Function | 32296183 |
| 29 | Homo sapiens | IBA | involved_in | sarcomere organization | Process | - |
| 30 | Homo sapiens | IDA | involved_in | response to calcium ion | Process | 2530435 |
| 31 | Homo sapiens | IMP | involved_in | response to calcium ion | Process | 8205619 |
| 32 | Homo sapiens | IMP | involved_in | ventricular cardiac muscle tissue morphogenesis | Process | 16754800 |
| 33 | Homo sapiens | IBA | involved_in | cardiac muscle contraction | Process | - |
| 34 | Homo sapiens | IDA | involved_in | cardiac muscle contraction | Process | 25771144 |
| 35 | Homo sapiens | NAS | involved_in | cardiac muscle contraction | Process | 12840750 |
| 36 | Homo sapiens | IDA | located_in | cardiac myofibril | Component | 25771144 |
| 37 | Homo sapiens | IDA | part_of | cardiac Troponin complex | Component | 25771144 |