GenTIGSA Gene Database on Rare Genetic Disorders

AGBL carboxypeptidase 5 (AGBL5) Associated conditions:  1. Retinitis pigmentosa 
mRNA Information: Transcript Variants and Protein Isoforms
SNo. Status mRNA accession Protein accession Genomic DNA accession (Chromosome) mRNA location on genomic DNA Assembly UniProtkb ID
1 REVIEWED NM_001035507.3 NP_001030584.1 NC_000002.12 (27050363..27070617) Reference GRCh38.p14 Primary Assembly Q8NDL9
2 REVIEWED NM_021831.6 NP_068603.4 NC_000002.12 (27050363..27070617) Reference GRCh38.p14 Primary Assembly Q8NDL9
3 REVIEWED NR_104246.2 - NC_000002.12 (27050363..27070617) Reference GRCh38.p14 Primary Assembly Q8NDL9
4 REVIEWED NR_138023.2 - NC_000002.12 (27050363..27070617) Reference GRCh38.p14 Primary Assembly Q8NDL9

Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.

PubMed Links for Transcript Variants (Isoforms)
Link 133 reference articles

Variant Information AGBL carboxypeptidase 5 (AGBL5Mutation Visualization Dashboard: Pathogenic variant distribution chart
ClinVar variants:Revealing mutagenic patterns

GO Term of AGBL carboxypeptidase 5 (AGBL5)
SNo. Reported in speceis Evidence Qualifier GO term Category Pubmed Link
1Homo sapiensIEAenablescarboxypeptidase activityFunction
2Homo sapiensIBAenablesmetallocarboxypeptidase activityFunction
3Homo sapiensIEAenablesmetallocarboxypeptidase activityFunction
4Homo sapiensISSenablesmetallocarboxypeptidase activityFunction
5Homo sapiensIDAlocated_innucleusComponent23085998 
6Homo sapiensIEAlocated_innucleusComponent
7Homo sapiensISSlocated_innucleusComponent
8Homo sapiensIBAis_active_incytoplasmComponent
9Homo sapiensIDAlocated_incytoplasmComponent
10Homo sapiensIEAlocated_incytoplasmComponent
11Homo sapiensIEAlocated_inspindleComponent
12Homo sapiensIEAlocated_incytosolComponent
13Homo sapiensISSlocated_incytosolComponent
14Homo sapiensIEAinvolved_inproteolysisProcess
15Homo sapiensIEAenablespeptidase activityFunction
16Homo sapiensIEAenablesmetallopeptidase activityFunction
17Homo sapiensIEAenableszinc ion bindingFunction
18Homo sapiensIBAis_active_inmicrotubule cytoskeletonComponent
19Homo sapiensIBAenablestubulin bindingFunction
20Homo sapiensIEAenablestubulin bindingFunction
21Homo sapiensISSenablestubulin bindingFunction
22Homo sapiensIEAenableshydrolase activityFunction
23Homo sapiensIDAlocated_inmidbodyComponent23085998 
24Homo sapiensIEAlocated_inmidbodyComponent
25Homo sapiensIEAenablesmetal ion bindingFunction
26Homo sapiensIEAinvolved_indefense response to virusProcess
27Homo sapiensISSinvolved_indefense response to virusProcess
28Homo sapiensIDAlocated_inmitotic spindleComponent23085998