FA complementation group M (FANCM) Associated conditions: 1. Fanconi anemia 2. Hereditary breast ovarian cancer syndrome 3. Retinoblastoma
| SNo. | Status | mRNA accession | Protein accession | Genomic DNA accession (Chromosome) | mRNA location on genomic DNA | Assembly | UniProtkb ID |
| 1 | REVIEWED | NM_001308133.2 | NP_001295062.1 | NC_000014.9 | (45135929..45200889) | Reference GRCh38.p14 Primary Assembly | - |
| 2 | REVIEWED | NM_001308134.2 | NP_001295063.1 | NC_000014.9 | (45135929..45200889) | Reference GRCh38.p14 Primary Assembly | - |
| 3 | REVIEWED | NM_020937.4 | NP_065988.1 | NC_000014.9 | (45135929..45200889) | Reference GRCh38.p14 Primary Assembly | - |
Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.
Variant Information FA complementation group M (FANCM) Mutation Visualization Dashboard: Pathogenic variant distribution chart
IndiGenomes variants: Exploring and mapping pathogenic variants in gene FA complementation group M (FANCM)
ClinVar variants:Revealing mutagenic patterns
| SNo. | Reported in speceis | Evidence | Qualifier | GO term | Category | Pubmed Link |
| 1 | Homo sapiens | IEA | enables | nucleotide binding | Function | - |
| 2 | Homo sapiens | IBA | enables | four-way junction DNA binding | Function | - |
| 3 | Homo sapiens | IMP | involved_in | resolution of meiotic recombination intermediates | Process | 20347428 |
| 4 | Homo sapiens | IDA | located_in | chromatin | Component | 20347429 |
| 5 | Homo sapiens | IEA | enables | nucleic acid binding | Function | - |
| 6 | Homo sapiens | IEA | enables | DNA binding | Function | - |
| 7 | Homo sapiens | IDA | enables | chromatin binding | Function | 20347429 |
| 8 | Homo sapiens | IEA | enables | RNA helicase activity | Function | - |
| 9 | Homo sapiens | IEA | enables | helicase activity | Function | - |
| 10 | Homo sapiens | IPI | enables | protein binding | Function | 17289582 20347429 23932590 25416956 32296183 32769987 33961781 40205054 |
| 11 | Homo sapiens | IEA | enables | ATP binding | Function | - |
| 12 | Homo sapiens | IEA | located_in | nucleus | Component | - |
| 13 | Homo sapiens | IDA | located_in | nucleoplasm | Component | - |
| 14 | Homo sapiens | TAS | located_in | nucleoplasm | Component | - |
| 15 | Homo sapiens | TAS | located_in | cytosol | Component | - |
| 16 | Homo sapiens | IEA | involved_in | DNA repair | Process | - |
| 17 | Homo sapiens | IEA | involved_in | DNA damage response | Process | - |
| 18 | Homo sapiens | IBA | enables | four-way junction helicase activity | Function | - |
| 19 | Homo sapiens | IEA | enables | hydrolase activity | Function | - |
| 20 | Homo sapiens | IEA | enables | ATP hydrolysis activity | Function | - |
| 21 | Homo sapiens | IMP | involved_in | replication fork processing | Process | 20347428 |
| 22 | Homo sapiens | IEA | involved_in | homologous recombination | Process | - |
| 23 | Homo sapiens | IBA | involved_in | interstrand cross-link repair | Process | - |
| 24 | Homo sapiens | IDA | involved_in | interstrand cross-link repair | Process | 20347429 |
| 25 | Homo sapiens | IBA | enables | 3'-5' DNA helicase activity | Function | - |
| 26 | Homo sapiens | IEA | enables | 3'-5' DNA helicase activity | Function | - |
| 27 | Homo sapiens | IDA | part_of | Fanconi anaemia nuclear complex | Component | 20347428 20347429 |
| 28 | Homo sapiens | IBA | involved_in | double-strand break repair via synthesis-dependent strand annealing | Process | - |
| 29 | Homo sapiens | IDA | part_of | FANCM-MHF complex | Component | 20347428 |
| 30 | Homo sapiens | IMP | involved_in | positive regulation of protein monoubiquitination | Process | 29231814 |