Neural retina leucine zipper (NRL) Associated conditions: 1. Retinitis pigmentosa
| SNo. | Status | mRNA accession | Protein accession | Genomic DNA accession (Chromosome) | mRNA location on genomic DNA | Assembly | UniProtkb ID |
| 1 | REVIEWED | NM_001354768.3 | NP_001341697.1 | NC_000014.9 | (24078661..24114948, complement) | Reference GRCh38.p14 Primary Assembly | - |
| 2 | REVIEWED | NM_001354768.3 | NP_001341697.1 | NW_018654722.1 | (379639..415926, complement) | Reference GRCh38.p14 PATCHES | - |
| 3 | REVIEWED | NM_001354769.1 | NP_001341698.1 | NC_000014.9 | (24078661..24114948, complement) | Reference GRCh38.p14 Primary Assembly | - |
| 4 | REVIEWED | NM_001354769.1 | NP_001341698.1 | NW_018654722.1 | (379639..415926, complement) | Reference GRCh38.p14 PATCHES | - |
| 5 | REVIEWED | NM_001354770.2 | NP_001341699.1 | NC_000014.9 | (24078661..24114948, complement) | Reference GRCh38.p14 Primary Assembly | - |
| 6 | REVIEWED | NM_001354770.2 | NP_001341699.1 | NW_018654722.1 | (379639..415926, complement) | Reference GRCh38.p14 PATCHES | - |
| 7 | REVIEWED | NM_006177.5 | NP_006168.1 | NC_000014.9 | (24078661..24114948, complement) | Reference GRCh38.p14 Primary Assembly | - |
| 8 | REVIEWED | NM_006177.5 | NP_006168.1 | NW_018654722.1 | (379639..415926, complement) | Reference GRCh38.p14 PATCHES | - |
Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.
Variant Information Neural retina leucine zipper (NRL) Mutation Visualization Dashboard: Pathogenic variant distribution chart
ClinVar variants:Revealing mutagenic patterns
| SNo. | Reported in speceis | Evidence | Qualifier | GO term | Category | Pubmed Link |
| 1 | Homo sapiens | ISA | located_in | chromatin | Component | - |
| 2 | Homo sapiens | IBA | enables | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Function | - |
| 3 | Homo sapiens | IDA | enables | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Function | 8552602 17335001 |
| 4 | Homo sapiens | IBA | enables | DNA-binding transcription factor activity, RNA polymerase II-specific | Function | - |
| 5 | Homo sapiens | ISA | enables | DNA-binding transcription factor activity, RNA polymerase II-specific | Function | - |
| 6 | Homo sapiens | IDA | enables | DNA-binding transcription activator activity, RNA polymerase II-specific | Function | 8552602 |
| 7 | Homo sapiens | IMP | enables | DNA-binding transcription activator activity, RNA polymerase II-specific | Function | 17335001 |
| 8 | Homo sapiens | IEA | enables | DNA binding | Function | - |
| 9 | Homo sapiens | TAS | enables | DNA binding | Function | 1729696 |
| 10 | Homo sapiens | IEA | enables | DNA-binding transcription factor activity | Function | - |
| 11 | Homo sapiens | IPI | enables | protein binding | Function | 10887186 15028672 23956131 |
| 12 | Homo sapiens | IBA | is_active_in | nucleus | Component | - |
| 13 | Homo sapiens | IDA | located_in | nucleus | Component | 11477108 17335001 |
| 14 | Homo sapiens | IEA | located_in | nucleus | Component | - |
| 15 | Homo sapiens | TAS | located_in | nucleus | Component | 8939891 |
| 16 | Homo sapiens | IDA | located_in | nucleoplasm | Component | - |
| 17 | Homo sapiens | IDA | located_in | cytoplasm | Component | 11477108 |
| 18 | Homo sapiens | IEA | located_in | cytoplasm | Component | - |
| 19 | Homo sapiens | IEA | involved_in | regulation of DNA-templated transcription | Process | - |
| 20 | Homo sapiens | IBA | involved_in | regulation of transcription by RNA polymerase II | Process | - |
| 21 | Homo sapiens | IEA | involved_in | visual perception | Process | - |
| 22 | Homo sapiens | TAS | involved_in | visual perception | Process | 1729696 |
| 23 | Homo sapiens | IPI | enables | leucine zipper domain binding | Function | 10887186 |
| 24 | Homo sapiens | IDA | involved_in | positive regulation of transcription by RNA polymerase II | Process | 8552602 |
| 25 | Homo sapiens | IEA | involved_in | positive regulation of transcription by RNA polymerase II | Process | - |
| 26 | Homo sapiens | IMP | involved_in | positive regulation of transcription by RNA polymerase II | Process | 17335001 21981118 |
| 27 | Homo sapiens | TAS | involved_in | positive regulation of transcription by RNA polymerase II | Process | 8939891 |
| 28 | Homo sapiens | IBA | involved_in | retinal rod cell development | Process | - |
| 29 | Homo sapiens | IDA | enables | sequence-specific double-stranded DNA binding | Function | 28473536 |
| 30 | Homo sapiens | IEA | enables | promoter-specific chromatin binding | Function | - |