GenTIGS

ADP ribosylation factor like GTPase 3 (ARL3) Associated conditions: 1. Retinitis pigmentosa 2. Joubert syndrome

mRNA Information: Transcript Variants and Protein Isoforms

SNo.	Status	mRNA accession	Protein accession	Genomic DNA accession (Chromosome)	mRNA location on genomic DNA	Assembly	UniProtkb ID
1	REVIEWED	NM_004311.4	NP_004302.1	NC_000010.11	(102673730..102714396, complement)	Reference GRCh38.p14 Primary Assembly	-

Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.

PubMed Links for Transcript Variants (Isoforms)

Link 173 reference articles

Variant Information ADP ribosylation factor like GTPase 3 (ARL3) Mutation Visualization Dashboard: Pathogenic variant distribution chart

ClinVar variants:Revealing mutagenic patterns

GO Term of ADP ribosylation factor like GTPase 3 (ARL3)

SNo.	Reported in speceis	Evidence	Qualifier	GO term	Category	Pubmed Link
1	Homo sapiens	IEA	located_in	Golgi membrane	Component	-
2	Homo sapiens	IEA	enables	nucleotide binding	Function	-
3	Homo sapiens	IMP	involved_in	mitotic cytokinesis	Process	16525022
4	Homo sapiens	IEA	enables	magnesium ion binding	Function	-
5	Homo sapiens	IEA	involved_in	kidney development	Process	-
6	Homo sapiens	ISS	involved_in	kidney development	Process	-
7	Homo sapiens	IEA	enables	GTPase activity	Function	-
8	Homo sapiens	IPI	enables	protein binding	Function	11847227 16169070 18588884 22085962 26455799 27173435 28514442 30257685 32296183 33961781 35271311 40205054
9	Homo sapiens	IBA	enables	GTP binding	Function	-
10	Homo sapiens	IDA	enables	GTP binding	Function	18588884 22085962
11	Homo sapiens	IEA	enables	GTP binding	Function	-
12	Homo sapiens	TAS	enables	GTP binding	Function	8034651
13	Homo sapiens	IDA	located_in	nucleus	Component	16525022
14	Homo sapiens	IEA	located_in	nucleus	Component	-
15	Homo sapiens	IDA	located_in	nucleoplasm	Component	-
16	Homo sapiens	IBA	is_active_in	cytoplasm	Component	-
17	Homo sapiens	IEA	located_in	cytoplasm	Component	-
18	Homo sapiens	IDA	located_in	Golgi apparatus	Component	16525022
19	Homo sapiens	IDA	located_in	centrosome	Component	16525022
20	Homo sapiens	IEA	located_in	centrosome	Component	-
21	Homo sapiens	IEA	located_in	spindle	Component	-
22	Homo sapiens	IDA	located_in	spindle microtubule	Component	16525022
23	Homo sapiens	IDA	located_in	cytoplasmic microtubule	Component	12417528
24	Homo sapiens	IDA	NOT located_in	cilium	Component	17646400
25	Homo sapiens	IDA	located_in	cilium	Component	16525022
26	Homo sapiens	TAS	located_in	cilium	Component	-
27	Homo sapiens	IMP	acts_upstream_of_or_within	post-Golgi vesicle-mediated transport	Process	20106869
28	Homo sapiens	IEA	involved_in	Golgi to plasma membrane transport	Process	-
29	Homo sapiens	ISS	involved_in	Golgi to plasma membrane transport	Process	-
30	Homo sapiens	IDA	involved_in	small GTPase-mediated signal transduction	Process	22085962
31	Homo sapiens	IDA	enables	microtubule binding	Function	12417528
32	Homo sapiens	IEA	involved_in	protein transport	Process	-
33	Homo sapiens	IBA	is_active_in	microtubule cytoskeleton	Component	-
34	Homo sapiens	IDA	enables	GDP binding	Function	18588884
35	Homo sapiens	IEA	enables	GDP binding	Function	-
36	Homo sapiens	IDA	located_in	midbody	Component	16525022
37	Homo sapiens	IDA	located_in	photoreceptor connecting cilium	Component	12417528
38	Homo sapiens	IEA	involved_in	photoreceptor cell development	Process	-
39	Homo sapiens	ISS	involved_in	photoreceptor cell development	Process	-
40	Homo sapiens	IEA	enables	metal ion binding	Function	-
41	Homo sapiens	IEA	involved_in	cell division	Process	-
42	Homo sapiens	IBA	involved_in	cilium assembly	Process	-
43	Homo sapiens	IMP	involved_in	cilium assembly	Process	22085962
44	Homo sapiens	IMP	involved_in	protein localization to cilium	Process	30269812
45	Homo sapiens	HDA	located_in	extracellular exosome	Component	19056867
46	Homo sapiens	IEA	involved_in	protein localization to ciliary membrane	Process	-
47	Homo sapiens	ISS	involved_in	protein localization to ciliary membrane	Process	-