GenTIGS

Rho GTPase activating protein 35 (ARHGAP35) Associated conditions: 1. Irido-corneo-trabecular dysgenesis

mRNA Information: Transcript Variants and Protein Isoforms

SNo.	Status	mRNA accession	Protein accession	Genomic DNA accession (Chromosome)	mRNA location on genomic DNA	Assembly	UniProtkb ID
1	REVIEWED	NM_004491.5	NP_004482.4	NC_000019.10	(46860996..47005076)	Reference GRCh38.p14 Primary Assembly	-
2	REVIEWED	XR_002958305.2	-	NC_000019.10	(46860996..47005076)	Reference GRCh38.p14 Primary Assembly	-

Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.

PubMed Links for Transcript Variants (Isoforms)

Link 1115 reference articles

Variant Information Rho GTPase activating protein 35 (ARHGAP35) Mutation Visualization Dashboard: Pathogenic variant distribution chart

IndiGenomes variants: Exploring and mapping pathogenic variants in gene Rho GTPase activating protein 35 (ARHGAP35)

ClinVar variants:Revealing mutagenic patterns

GO Term of Rho GTPase activating protein 35 (ARHGAP35)

SNo.	Reported in speceis	Evidence	Qualifier	GO term	Category	Pubmed Link
1	Homo sapiens	IEA	enables	nucleotide binding	Function	-
2	Homo sapiens	IEA	enables	DNA binding	Function	-
3	Homo sapiens	IEA	enables	GTPase activity	Function	-
4	Homo sapiens	IBA	enables	GTPase activator activity	Function	-
5	Homo sapiens	IDA	enables	GTPase activator activity	Function	19673492
6	Homo sapiens	IEA	enables	GTPase activator activity	Function	-
7	Homo sapiens	TAS	enables	GTPase activator activity	Function	-
8	Homo sapiens	IEA	enables	GTP binding	Function	-
9	Homo sapiens	IDA	enables	phospholipid binding	Function	19673492
10	Homo sapiens	IEA	located_in	nucleus	Component	-
11	Homo sapiens	IEA	located_in	cytoplasm	Component	-
12	Homo sapiens	IBA	is_active_in	cytosol	Component	-
13	Homo sapiens	TAS	located_in	cytosol	Component	-
14	Homo sapiens	IEA	located_in	plasma membrane	Component	-
15	Homo sapiens	IEA	involved_in	signal transduction	Process	-
16	Homo sapiens	IBA	involved_in	Rho protein signal transduction	Process	-
17	Homo sapiens	IEA	involved_in	axon guidance	Process	-
18	Homo sapiens	ISS	involved_in	axon guidance	Process	-
19	Homo sapiens	IEA	involved_in	axonal fasciculation	Process	-
20	Homo sapiens	ISS	involved_in	axonal fasciculation	Process	-
21	Homo sapiens	IEA	involved_in	regulation of actin polymerization or depolymerization	Process	-
22	Homo sapiens	ISS	involved_in	regulation of actin polymerization or depolymerization	Process	-
23	Homo sapiens	IEA	enables	lipid binding	Function	-
24	Homo sapiens	IBA	involved_in	regulation of cell size	Process	-
25	Homo sapiens	IEA	involved_in	positive regulation of neuron projection development	Process	-
26	Homo sapiens	ISS	involved_in	positive regulation of neuron projection development	Process	-
27	Homo sapiens	IEA	located_in	actin cytoskeleton	Component	-
28	Homo sapiens	IEA	involved_in	cell migration	Process	-
29	Homo sapiens	ISS	involved_in	cell migration	Process	-
30	Homo sapiens	IEA	involved_in	central nervous system neuron axonogenesis	Process	-
31	Homo sapiens	ISS	involved_in	central nervous system neuron axonogenesis	Process	-
32	Homo sapiens	IEA	involved_in	mammary gland development	Process	-
33	Homo sapiens	ISS	involved_in	mammary gland development	Process	-
34	Homo sapiens	IEA	involved_in	establishment or maintenance of actin cytoskeleton polarity	Process	-
35	Homo sapiens	ISS	involved_in	establishment or maintenance of actin cytoskeleton polarity	Process	-
36	Homo sapiens	IEA	involved_in	regulation of actin cytoskeleton organization	Process	-
37	Homo sapiens	ISS	involved_in	regulation of actin cytoskeleton organization	Process	-
38	Homo sapiens	ISS	acts_upstream_of_or_within	negative regulation of Rho protein signal transduction	Process	-
39	Homo sapiens	IEA	located_in	ciliary basal body	Component	-
40	Homo sapiens	ISS	located_in	ciliary basal body	Component	-
41	Homo sapiens	IEA	involved_in	wound healing, spreading of cells	Process	-
42	Homo sapiens	ISS	involved_in	wound healing, spreading of cells	Process	-
43	Homo sapiens	IEA	involved_in	positive regulation of cilium assembly	Process	-
44	Homo sapiens	ISS	involved_in	positive regulation of cilium assembly	Process	-
45	Homo sapiens	IBA	involved_in	regulation of axonogenesis	Process	-
46	Homo sapiens	IEA	involved_in	regulation of axonogenesis	Process	-
47	Homo sapiens	ISS	involved_in	regulation of axonogenesis	Process	-
48	Homo sapiens	IEA	involved_in	regulation of small GTPase mediated signal transduction	Process	-
49	Homo sapiens	TAS	involved_in	regulation of small GTPase mediated signal transduction	Process	-
50	Homo sapiens	IEA	involved_in	neuron projection guidance	Process	-
51	Homo sapiens	ISS	involved_in	neuron projection guidance	Process	-