GenTIGSA Gene Database on Rare Genetic Disorders

Glutaryl-CoA dehydrogenase (GCDH) Associated conditions:  1. Glutaric aciduria, type 1 
mRNA Information: Transcript Variants and Protein Isoforms
SNo. Status mRNA accession Protein accession Genomic DNA accession (Chromosome) mRNA location on genomic DNA Assembly UniProtkb ID
1 REVIEWED NM_000159.4 NP_000150.1 NC_000019.10 (12891128..12899998) Reference GRCh38.p14 Primary Assembly Q92947
2 REVIEWED NM_013976.5 NP_039663.1 NC_000019.10 (12891128..12899998) Reference GRCh38.p14 Primary Assembly Q92947
3 REVIEWED NR_102316.1 - NC_000019.10 (12891128..12899998) Reference GRCh38.p14 Primary Assembly Q92947
4 REVIEWED NR_102317.1 - NC_000019.10 (12891128..12899998) Reference GRCh38.p14 Primary Assembly Q92947

Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.

PubMed Links for Transcript Variants (Isoforms)
Link 1105 reference articles

Variant Information Glutaryl-CoA dehydrogenase (GCDHMutation Visualization Dashboard: Pathogenic variant distribution chart

 

IndiGenomes variants: Exploring and mapping pathogenic variants in gene Glutaryl-CoA dehydrogenase (GCDH)
ClinVar variants:Revealing mutagenic patterns

GO Term of Glutaryl-CoA dehydrogenase (GCDH)
SNo. Reported in speceis Evidence Qualifier GO term Category Pubmed Link
1Homo sapiensIBAenablesfatty-acyl-CoA bindingFunction21873635 
2Homo sapiensIBAenablesglutaryl-CoA dehydrogenase activityFunction21873635 
3Homo sapiensIDAenablesglutaryl-CoA dehydrogenase activityFunction8541831 
4Homo sapiensIDAlocated_inmitochondrionComponent
5Homo sapiensTASlocated_inmitochondrial matrixComponent
6Homo sapiensIEAinvolved_intryptophan metabolic processProcess
7Homo sapiensIBAinvolved_infatty acid beta-oxidation using acyl-CoA dehydrogenaseProcess21873635 
8Homo sapiensIDAinvolved_infatty acid beta-oxidation using acyl-CoA dehydrogenaseProcess25416781 
9Homo sapiensIBAinvolved_infatty-acyl-CoA biosynthetic processProcess21873635 
10Homo sapiensIBAenablesflavin adenine dinucleotide bindingFunction21873635