Exosome component 2 (EXOSC2) Associated conditions: 1. Retinitis pigmentosa
| SNo. | Status | mRNA accession | Protein accession | Genomic DNA accession (Chromosome) | mRNA location on genomic DNA | Assembly | UniProtkb ID |
Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.
Variant Information Exosome component 2 (EXOSC2) Mutation Visualization Dashboard: Pathogenic variant distribution chart
ClinVar variants:Revealing mutagenic patterns
| SNo. | Reported in speceis | Evidence | Qualifier | GO term | Category | Pubmed Link |
| 1 | Homo sapiens | TAS | enables | 3'-5'-RNA exonuclease activity | Function | 8600032 |
| 2 | Homo sapiens | IBA | part_of | nuclear exosome (RNase complex) | Component | - |
| 3 | Homo sapiens | IDA | part_of | nuclear exosome (RNase complex) | Component | 26166824 |
| 4 | Homo sapiens | IBA | part_of | cytoplasmic exosome (RNase complex) | Component | - |
| 5 | Homo sapiens | IDA | part_of | exosome (RNase complex) | Component | 12419256 20531389 |
| 6 | Homo sapiens | IEA | part_of | exosome (RNase complex) | Component | - |
| 7 | Homo sapiens | IBA | involved_in | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Process | - |
| 8 | Homo sapiens | IBA | involved_in | nuclear-transcribed mRNA catabolic process | Process | - |
| 9 | Homo sapiens | IBA | enables | RNA binding | Function | - |
| 10 | Homo sapiens | IEA | enables | RNA binding | Function | - |
| 11 | Homo sapiens | IDA | NOT enables | RNA exonuclease activity | Function | 17174896 |
| 12 | Homo sapiens | IPI | enables | protein binding | Function | 11719186 12419256 12788944 15231747 15687258 16396833 17412707 17545563 18326031 20531386 20531389 21255825 24981860 26496610 28514442 32296183 33961781 40205054 |
| 13 | Homo sapiens | IDA | located_in | nucleus | Component | 17545563 20531386 |
| 14 | Homo sapiens | IEA | located_in | nucleus | Component | - |
| 15 | Homo sapiens | TAS | located_in | nucleus | Component | 8600032 |
| 16 | Homo sapiens | IDA | located_in | nucleoplasm | Component | - |
| 17 | Homo sapiens | TAS | located_in | nucleoplasm | Component | - |
| 18 | Homo sapiens | IDA | located_in | nucleolus | Component | 20531386 |
| 19 | Homo sapiens | IEA | located_in | nucleolus | Component | - |
| 20 | Homo sapiens | TAS | located_in | nucleolus | Component | - |
| 21 | Homo sapiens | IDA | located_in | cytoplasm | Component | 17545563 |
| 22 | Homo sapiens | IEA | located_in | cytoplasm | Component | - |
| 23 | Homo sapiens | TAS | located_in | cytoplasm | Component | 8600032 |
| 24 | Homo sapiens | IDA | located_in | cytosol | Component | 20531386 |
| 25 | Homo sapiens | TAS | located_in | cytosol | Component | - |
| 26 | Homo sapiens | IEA | involved_in | rRNA processing | Process | - |
| 27 | Homo sapiens | TAS | involved_in | rRNA processing | Process | 8600032 |
| 28 | Homo sapiens | IDA | involved_in | RNA processing | Process | 17174896 20531386 |
| 29 | Homo sapiens | IDA | involved_in | RNA catabolic process | Process | 17174896 20531386 |
| 30 | Homo sapiens | TAS | enables | 7S RNA binding | Function | 8600032 |
| 31 | Homo sapiens | IMP | involved_in | positive regulation of cell growth | Process | 17545563 |
| 32 | Homo sapiens | IBA | involved_in | U4 snRNA 3'-end processing | Process | - |
| 33 | Homo sapiens | IBA | involved_in | CUT catabolic process | Process | - |
| 34 | Homo sapiens | IBA | involved_in | nuclear polyadenylation-dependent rRNA catabolic process | Process | - |
| 35 | Homo sapiens | IBA | involved_in | TRAMP-dependent tRNA surveillance pathway | Process | - |
| 36 | Homo sapiens | IBA | involved_in | poly(A)-dependent snoRNA 3'-end processing | Process | - |