GenTIGS

Flavin containing dimethylaniline monoxygenase 3 (FMO3) Associated conditions: 1. Trimethylaminuria

mRNA Information: Transcript Variants and Protein Isoforms

SNo.	Status	mRNA accession	Protein accession	Genomic DNA accession (Chromosome)	mRNA location on genomic DNA	Assembly	UniProtkb ID
1	REVIEWED	NM_001002294.3	NP_001002294.1	NC_000001.11	(171090904..171117818)	Reference GRCh38.p14 Primary Assembly	Q53FW5
2	REVIEWED	NM_001319173.2	NP_001306102.1	NC_000001.11	(171090904..171117818)	Reference GRCh38.p14 Primary Assembly	Q53FW5
3	REVIEWED	NM_001319174.2	NP_001306103.1	NC_000001.11	(171090904..171117818)	Reference GRCh38.p14 Primary Assembly	Q53FW5
4	REVIEWED	NM_006894.6	NP_008825.4	NC_000001.11	(171090904..171117818)	Reference GRCh38.p14 Primary Assembly	Q53FW5

Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.

PubMed Links for Transcript Variants (Isoforms)

Link 1131 reference articles

Variant Information Flavin containing dimethylaniline monoxygenase 3 (FMO3) Mutation Visualization Dashboard: Pathogenic variant distribution chart

IndiGenomes variants: Exploring and mapping pathogenic variants in gene Flavin containing dimethylaniline monoxygenase 3 (FMO3)

ClinVar variants:Revealing mutagenic patterns

GO Term of Flavin containing dimethylaniline monoxygenase 3 (FMO3)

SNo.	Reported in speceis	Evidence	Qualifier	GO term	Category	Pubmed Link
1	Homo sapiens	IBA	enables	N,N-dimethylaniline monooxygenase activity	Function	21873635
2	Homo sapiens	IPI	enables	protein binding	Function	25910212 31515488 32296183
3	Homo sapiens	TAS	located_in	endoplasmic reticulum membrane	Component	-
4	Homo sapiens	IEA	enables	trimethylamine monooxygenase activity	Function	-
5	Homo sapiens	IDA	involved_in	taurine biosynthetic process	Process	32156684
6	Homo sapiens	TAS	located_in	intracellular membrane-bounded organelle	Component	9207220
7	Homo sapiens	IEA	enables	albendazole monooxygenase activity	Function	-
8	Homo sapiens	IDA	enables	hypotaurine dehydrogenase activity	Function	32156684
9	Homo sapiens	IEA	enables	flavin adenine dinucleotide binding	Function	-
10	Homo sapiens	IEA	enables	NADP binding	Function	-