GenTIGS

Aldolase, fructose-bisphosphate B (ALDOB) Associated conditions: 1. Hereditary fructosuria

mRNA Information: Transcript Variants and Protein Isoforms

SNo.	Status	mRNA accession	Protein accession	Genomic DNA accession (Chromosome)	mRNA location on genomic DNA	Assembly	UniProtkb ID
1	REVIEWED	NM_000035.4	NP_000026.2	NC_000009.12	(101420559..101435773, complement)	Reference GRCh38.p14 Primary Assembly	P05062

Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.

PubMed Links for Transcript Variants (Isoforms)

Link 173 reference articles

Variant Information Aldolase, fructose-bisphosphate B (ALDOB) Mutation Visualization Dashboard: Pathogenic variant distribution chart

IndiGenomes variants: Exploring and mapping pathogenic variants in gene Aldolase, fructose-bisphosphate B (ALDOB)

ClinVar variants:Revealing mutagenic patterns

GO Term of Aldolase, fructose-bisphosphate B (ALDOB)

SNo.	Reported in speceis	Evidence	Qualifier	GO term	Category	Pubmed Link
1	Homo sapiens	IBA	enables	fructose-bisphosphate aldolase activity	Function	21873635
2	Homo sapiens	IDA	enables	fructose-bisphosphate aldolase activity	Function	9244396 10625657 10970798 17576770 35122041
3	Homo sapiens	IPI	enables	protein binding	Function	18000879 35122041
4	Homo sapiens	IDA	located_in	microtubule organizing center	Component	18000879
5	Homo sapiens	IBA	is_active_in	cytosol	Component	21873635
6	Homo sapiens	IDA	located_in	cytosol	Component	35122041
7	Homo sapiens	TAS	located_in	cytosol	Component	-
8	Homo sapiens	IMP	involved_in	fructose metabolic process	Process	3383242
9	Homo sapiens	IEA	involved_in	gluconeogenesis	Process	-
10	Homo sapiens	IBA	involved_in	glycolytic process	Process	21873635
11	Homo sapiens	IDA	involved_in	glycolytic process	Process	10625657 10970798
12	Homo sapiens	IEA	involved_in	glycolytic process	Process	-
13	Homo sapiens	IDA	involved_in	NADH oxidation	Process	17576770
14	Homo sapiens	IDA	enables	cytoskeletal protein binding	Function	9244396
15	Homo sapiens	IBA	involved_in	fructose 1,6-bisphosphate metabolic process	Process	21873635
16	Homo sapiens	IDA	involved_in	fructose 1,6-bisphosphate metabolic process	Process	9244396 10625657
17	Homo sapiens	IGI	involved_in	positive regulation of ATP-dependent activity	Process	17576770
18	Homo sapiens	IDA	located_in	centriolar satellite	Component	18000879
19	Homo sapiens	IPI	enables	identical protein binding	Function	10625657
20	Homo sapiens	IDA	enables	ATPase binding	Function	17576770
21	Homo sapiens	IDA	enables	molecular adaptor activity	Function	35122041
22	Homo sapiens	IBA	enables	fructose-1-phosphate aldolase activity	Function	21873635
23	Homo sapiens	IDA	enables	fructose-1-phosphate aldolase activity	Function	2649152 10970798
24	Homo sapiens	IEA	involved_in	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	Process	-
25	Homo sapiens	IMP	enables	fructose binding	Function	10625657
26	Homo sapiens	HDA	located_in	extracellular exosome	Component	23533145
27	Homo sapiens	IGI	involved_in	vacuolar proton-transporting V-type ATPase complex assembly	Process	17576770
28	Homo sapiens	IMP	involved_in	negative regulation of pentose-phosphate shunt	Process	35122041