GenTIGSA Gene Database on Rare Genetic Disorders

Protein O-mannosyltransferase 1 (POMT1) Associated conditions:  1. Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1  2. Limb-girdle muscular dystrophy 
mRNA Information: Transcript Variants and Protein Isoforms
SNo. Status mRNA accession Protein accession Genomic DNA accession (Chromosome) mRNA location on genomic DNA Assembly UniProtkb ID
1 REVIEWED NR_148398.2 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
2 REVIEWED NM_007171.4 NP_009102.4 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
3 REVIEWED NR_148391.2 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
4 REVIEWED NR_148392.2 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
5 REVIEWED NR_148393.2 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
6 REVIEWED NR_148394.2 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
7 REVIEWED NR_148395.2 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
8 REVIEWED NR_148396.2 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
9 REVIEWED NR_148397.2 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
10 REVIEWED NM_001411024.1 NP_001397953.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
11 REVIEWED NR_148399.2 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
12 REVIEWED NR_148400.2 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
13 REVIEWED XR_001746160.3 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
14 REVIEWED XR_007061226.1 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
15 REVIEWED XR_007061227.1 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
16 REVIEWED XR_007061228.1 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
17 REVIEWED XR_007061229.1 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
18 REVIEWED XR_007061230.1 - NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
19 REVIEWED NM_001353198.2 NP_001340127.2 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
20 REVIEWED NM_001077366.2 NP_001070834.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
21 REVIEWED NM_001136113.2 NP_001129585.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
22 REVIEWED NM_001136114.2 NP_001129586.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
23 REVIEWED NM_001353193.2 NP_001340122.2 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
24 REVIEWED NM_001353194.2 NP_001340123.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
25 REVIEWED NM_001353195.2 NP_001340124.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
26 REVIEWED NM_001353196.2 NP_001340125.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
27 REVIEWED NM_001353197.2 NP_001340126.2 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
28 REVIEWED NM_001077365.2 NP_001070833.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
29 REVIEWED NM_001353199.2 NP_001340128.2 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
30 REVIEWED NM_001353200.2 NP_001340129.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
31 REVIEWED NM_001374689.1 NP_001361618.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
32 REVIEWED NM_001374690.1 NP_001361619.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
33 REVIEWED NM_001374691.1 NP_001361620.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
34 REVIEWED NM_001374692.1 NP_001361621.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
35 REVIEWED NM_001374693.1 NP_001361622.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1
36 REVIEWED NM_001374695.1 NP_001361624.1 NC_000009.12 (131502917..131523798) Reference GRCh38.p14 Primary Assembly Q9Y6A1

Transcript variants arise from alternative splicing during gene expression, producing multiple mRNA transcripts from a single gene, each encoding distinct protein isoforms.

PubMed Links for Transcript Variants (Isoforms)
Link 156 reference articles

Variant Information Protein O-mannosyltransferase 1 (POMT1Mutation Visualization Dashboard: Pathogenic variant distribution chart

 

IndiGenomes variants: Exploring and mapping pathogenic variants in gene Protein O-mannosyltransferase 1 (POMT1)
ClinVar variants:Revealing mutagenic patterns

GO Term of Protein O-mannosyltransferase 1 (POMT1)
SNo. Reported in speceis Evidence Qualifier GO term Category Pubmed Link
1Homo sapiensIMPenablesmannosyltransferase activityFunction28512129 
2Homo sapiensIEAlocated_inacrosomal vesicleComponent
3Homo sapiensIEAenablesdolichyl-phosphate-mannose-protein mannosyltransferase activityFunction
4Homo sapiensTASlocated_inendoplasmic reticulumComponent10366449 
5Homo sapiensIDAlocated_inendoplasmic reticulum membraneComponent14699049 
6Homo sapiensTASlocated_inendoplasmic reticulum membraneComponent
7Homo sapiensTASinvolved_inprotein O-linked glycosylationProcess10366449 
8Homo sapiensTASlocated_inmembraneComponent10366449 
9Homo sapiensIEAlocated_insarcoplasmic reticulumComponent
10Homo sapiensIEAinvolved_inextracellular matrix organizationProcess
11Homo sapiensIMPinvolved_inprotein O-linked mannosylationProcess28512129 
12Homo sapiensIEAenablesmetal ion bindingFunction
13Homo sapiensIEAinvolved_inpositive regulation of protein O-linked glycosylationProcess