Total 38 clinical symptoms reported for Wolfram syndrome  Very Frequent (4)Occasional (24)Frequent (10)

Diabetes insipidus	A state of excessive water intake and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus).	Very frequent
Optic atrophy	Atrophy of the optic nerve. Optic atrophy results from the death of the retinal ganglion cell axons that comprise the optic nerve and manifesting as a pale optic nerve on fundoscopy.   Synonyms:Optic nerve atrophy; Optic-nerve degeneration	Very frequent
Polydipsia	Excessive thirst manifested by excessive fluid intake.   Synonyms:Extreme thirst	Very frequent
Sensorineural hearing impairment	A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlear nerve.   Synonyms:Hearing loss, sensorineural; Sensorineural deafness; Sensorineural hearing loss	Very frequent