Total 32 clinical symptoms reported for Wilson disease
| Abnormality of the hand |
An abnormality affecting one or both hands.
Synonyms:Abnormal hands; Abnormality of the hand; Hand anomalies; Hand deformities |
Very frequent |
| Abnormality of the menstrual cycle |
An abnormality of the ovulation cycle.
Synonyms:Abnormality of the menstrual cycle |
Very frequent |
| Acute hepatic failure |
Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver.
Synonyms:Acute liver failure |
Very frequent |
| Acute hepatitis |
Acute hepatic injury resulting from inflammation typically accompanied by increased serum alanine transaminase activity. Etiologies include viral hepatitis, drugs, toxins, and autoimmune disorders.
Synonyms:Acute liver inflammation |
Very frequent |
| Aggressive behavior |
Aggressive behavior can denote verbal aggression, physical aggression against objects, physical aggression against people, and may also include aggression towards oneself.
Synonyms:Aggression; Aggressive behavior; Aggressive behaviour; Aggressiveness |
Very frequent |
| Anemia |
A reduction in erythrocytes volume or hemoglobin concentration.
Synonyms:Anaemia; Low number of red blood cells or hemoglobin |
Very frequent |
| Arthralgia |
Joint pain.
Synonyms:Arthralgias; Joint pain |
Very frequent |
| Arthritis |
Inflammation of a joint.
Synonyms:Arthritis; Joint inflammation |
Very frequent |
| Back pain |
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.
Synonyms:Back pain |
Very frequent |
| Bone pain |
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.
Synonyms:Bone pain |
Very frequent |
| Bruising susceptibility |
An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma.
Synonyms:Bruisability; Bruise easily; Bruising susceptibility; Easy bruisability; Easy bruising |
Very frequent |
| Cirrhosis |
A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function.
Synonyms:Hepatic cirrhosis; Scar tissue replaces healthy tissue in the liver |
Very frequent |
| Clumsiness |
Lack of physical coordination resulting in an abnormal tendency to drop items or bump into objects.
Synonyms:Clumsiness |
Very frequent |
| Depression |
Frequent feelings of being down, miserable, and/or hopeless; difficulty recovering from such moods; pessimism about the future; pervasive shame; feeling of inferior self-worth; thoughts of suicide and suicidal behavior.
Synonyms:Depression; Depressivity |
Very frequent |
| Difficulty walking |
Reduced ability to walk (ambulate).
Synonyms:Difficulty in walking; Difficulty walking; Walking disability |
Very frequent |
| Dysarthria |
Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed.
Synonyms:Difficulty articulating speech; Dysarthric speech |
Very frequent |
| Elevated hepatic transaminase |
Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage.
Synonyms:Abnormal liver enzymes; Abnormal liver function; Abnormal liver function tests; Elevated liver enzymes; Elevated serum transaminases; Elevated transaminases; High liver enzymes; Increased liver enzymes; Increased liver function tests; Increased transaminases; Raised liver enzymes; Subclinical abnormal liver function tests |
Very frequent |
| Failure to thrive |
Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.
Synonyms:Faltering weight; Postnatal failure to thrive; Weight faltering |
Very frequent |
| Hepatic steatosis |
Steatosis is a term used to denote lipid accumulation within hepatocytes.
Synonyms:Fatty infiltration of liver; Fatty liver; Liver steatosis; Steatosis |
Very frequent |
| Hepatitis |
Inflammation of the liver.
Synonyms:Liver inflammation |
Very frequent |
| Hepatomegaly |
Abnormally increased size of the liver.
Synonyms:Enlarged liver |
Very frequent |
| Hypersexuality |
Pathological persistent sexual disinhibiting behavior, directed at oneself or to others.
Synonyms:Sex addiction |
Very frequent |
| Increased body weight |
Abnormally increased body weight.
Synonyms:Increased body weight |
Very frequent |
| Intellectual disability |
Subnormal intellectual functioning which originates during the developmental period. Intellectual disability, previously referred to as mental retardation, has been defined as an IQ score below 70.
Synonyms:Intellectual disability; Mental deficiency; Mental retardation; Mental retardation, nonspecific; Mental-retardation; Nonprogressive intellectual disability; Nonprogressive mental retardation |
Very frequent |
| Jaundice |
Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.
Synonyms:Icterus; Jaundice; Yellow skin; Yellowing of the skin |
Very frequent |
| Kayser-Fleischer ring |
Grey-green or brownish-pigmented ring in the deep epithelial layers at the outer border of the cornea.
Synonyms:Fleischer's ring; Fleischer-Kayser ring; Fleischer-Struempell ring |
Very frequent |
| Pathologic fracture |
A pathologic fracture occurs when a bone breaks in an area that is weakened secondarily to another disease process such as tumor, infection, and certain inherited bone disorders. A pathologic fracture can occur without a degree of trauma required to cause fracture in healthy bone.
Synonyms:Spontaneous fracture |
Very frequent |
| Proximal muscle weakness in lower limbs |
A lack of strength of the proximal muscles of the legs.
Synonyms:Muscle weakness, proximal, lower limbs |
Very frequent |
| Pruritus |
Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus.
Synonyms:Itching; Itchy skin; Skin itching |
Very frequent |
| Splenomegaly |
Abnormal increased size of the spleen.
Synonyms:Increased spleen size |
Very frequent |
| Thrombocytopenia |
A reduction in the number of circulating thrombocytes.
Synonyms:Low platelet count |
Very frequent |
| Weight loss |
Reduction of total body weight.
Synonyms:Loss of weight |
Very frequent |