Total 57 clinical symptoms reported for Werner syndrome
Abnormal hair whorl |
An abnormal hair whorl (that is, a patch of hair growing in the opposite direction of the rest of the hair).
Synonyms:Abnormal hair whorl; Abnormal hair whorls; Abnormal whorl of hair |
Very frequent |
Abnormal thorax morphology |
Any abnormality of the thorax (the region of the body formed by the sternum, the thoracic vertebrae and the ribs).
Synonyms:Abnormality of the chest; Abnormality of the thorax; Structural abnormality of the chest wall |
Very frequent |
Abnormality of the voice |
Synonyms:Abnormality of the voice; Voice abnormality |
Very frequent |
Cataract |
A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule.
Synonyms:Cataracts; Clouding of the lens of the eye; Cloudy lens; Lens opacities; Lens opacity |
Very frequent |
Convex nasal ridge |
Nasal ridge curving anteriorly to an imaginary line that connects the nasal root and tip. The nose appears often also prominent, and the columella low.
Synonyms:Beaked nose; Beaklike protrusion; Convex dorsum of nose; Convex nasal dorsum; Hooked nose; Polly beak nasal deformity |
Very frequent |
Hypogonadism |
A decreased functionality of the gonad.
Synonyms:Decreased activity of gonads |
Very frequent |
Lipoatrophy |
Localized loss of fat tissue.
Synonyms:Atrophy of fat; Loss of fat tissue in localized area |
Very frequent |
Osteoporosis |
Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD).
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Very frequent |
Pili torti |
Pili (from Latin pilus, hair) torti (from Latin tortus, twisted) refers to short and brittle hairs that appear flattened and twisted when viewed through a microscope.
Synonyms:Flattened and twisted hair |
Very frequent |
Premature graying of hair |
Development of gray hair at a younger than normal age.
Synonyms:Early graying; Premature graying; Premature graying of hair; Premature greying; Premature hair graying |
Very frequent |
Prematurely aged appearance |
Synonyms:Precociously senile appearance; Prematurely aged appearance |
Very frequent |
Short stature |
A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to 'short stature' as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms).
Synonyms:Decreased body height; Height less than 3rd percentile; Short stature; Small stature; Stature below 3rd percentile |
Very frequent |
Slender build |
Asthenic habitus refers to a slender build with long limbs, an angular profile, and prominent muscles or bones.
Synonyms:Asthenic habitus; Slender build; Thin body habitus; Thin build |
Very frequent |
Sparse scalp hair |
Decreased number of hairs per unit area of skin of the scalp.
Synonyms:Decreased number of scalp follicles; Hypotrichosis on scalp; Reduced amount of scalp hair; Reduced/lack of hair on scalp; Reduction in the number of scalp follicles; Scalp hypotrichosis; Sparse scalp hair; Thinning scalp hair |
Very frequent |
White forelock |
A triangular depigmented region of white hairs located in the anterior midline of the scalp.
Synonyms:Poliosis of anterior hair; Poliosis of forelock hair; White part of hair above forehead |
Very frequent |