Total 5 clinical symptoms reported for Tyrosinemia type 1  Occasional (5)

Acute hepatic failure	Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver.   Synonyms:Acute liver failure	Occasional
Hepatocellular carcinoma	A kind of neoplasm of the liver that originates in hepatocytes and presents macroscopically as a soft and hemorrhagic tan mass in the liver.	Occasional
Hepatomegaly	Abnormally increased size of the liver.   Synonyms:Enlarged liver	Occasional
Rickets of the lower limbs	This information is currently in development.	Occasional
Splenomegaly	Abnormal increased size of the spleen.   Synonyms:Increased spleen size	Occasional