Total 63 clinical symptoms reported for Tay-Sachs disease  Very Frequent (3)Uncommon (4)Occasional (33)Not Applicable Or Unknown (1)Frequent (22)

Muscle weakness	Reduced strength of muscles.   Synonyms:Muscle weakness; Muscular weakness	Very frequent
Progressive spasticity	Spasticity that increases in degree with time.   Synonyms:Spasticity, progressive	Very frequent
Skeletal muscle atrophy	The presence of skeletal muscular atrophy (which is also known as amyotrophy).   Synonyms:Amyotrophy; Amyotrophy involving the extremities; Muscle atrophy; Muscle atrophy, neurogenic; Muscle degeneration; Muscle hypotrophy; Muscle wasting; Muscular atrophy; Neurogenic muscle atrophy; Neurogenic muscle atrophy, especially in the lower limbs; Neurogenic muscular atrophy	Very frequent