Total 18 clinical symptoms reported for Sandhoff disease  Very Frequent (11)Occasional (2)Frequent (5)

Abnormality of movement	An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements.   Synonyms:Abnormality of movement; Movement disorder; Unusual movement	Very frequent
Ataxia	Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of elementary neurological deficits including asynergy (lack of coordination between muscles, limbs and joints), dysmetria (lack of ability to judge distances that can lead to under- or overshoot in grasping movements), and dysdiadochokinesia (inability to perform rapid movements requiring antagonizing muscle groups to be switched on and off repeatedly).   Synonyms:Cerebellar ataxia	Very frequent
Blindness	Blindness is the condition of lacking visual perception defined as visual perception below 3/60 and/or a visual field of no greater than 10 degrees in radius around central fixation.   Synonyms:Blindness; Total vision loss	Very frequent
Cherry red spot of the macula	Pallor of the perifoveal macula of the retina with appearance of a small circular reddish choroid shape as seen through the fovea centralis due to relative transparancy of the macula.   Synonyms:Macular cherry red spot	Very frequent
Failure to thrive	Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.   Synonyms:Faltering weight; Postnatal failure to thrive; Weight faltering	Very frequent
Hearing impairment	A decreased magnitude of the sensory perception of sound.   Synonyms:Deafness; Hearing defect; Hearing impairment; Hypacusis	Very frequent
Kyphosis	Exaggerated anterior convexity of the thoracic vertebral column.   Synonyms:Gibbus deformity; Hunched back; Hyperkyphosis; Round back	Very frequent
Macrocephaly	Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium.   Synonyms:Increased size of cranium; Increased size of skull; Large head; Large head circumference; Macrocrania; Megacephaly	Very frequent
Motor deterioration	Loss of previously present motor (i.e., movement) abilities.   Synonyms:Progressive degeneration of movement	Very frequent
Progressive psychomotor deterioration	Synonyms:Progressive mental and motor deterioration	Very frequent
Seizure	A seizure is an intermittent abnormality of nervous system physiology characterised by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.   Synonyms:Epileptic seizure; Seizures	Very frequent