Total 46 clinical symptoms reported for Pyruvate dehydrogenase E1-alpha deficiency  Very Frequent (2)Occasional (31)Frequent (13)

Increased CSF lactate	Increased concentration of lactate in the cerebrospinal fluid.   Synonyms:Hyperlactatorachia; Increased cerebrospinal fluid lactate; Increased CSF lactic acid	Very frequent
Small for gestational age	Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age.   Synonyms:Birth weight less than 10th percentile; Low birth weight; Small for gestational age	Very frequent