Total 22 clinical symptoms reported for Progressive familial intrahepatic cholestasis type 2  Not Applicable Or Unknown (22)

Cirrhosis	A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function.   Synonyms:Hepatic cirrhosis; Scar tissue replaces healthy tissue in the liver	Not Applicable or Unknown
Diarrhea	Abnormally increased frequency (usually defined as three or more) loose or watery bowel movements a day.   Synonyms:Diarrhea; Watery stool	Not Applicable or Unknown
Failure to thrive	Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.   Synonyms:Faltering weight; FTT; Postnatal failure to thrive; Weight faltering	Not Applicable or Unknown
Fat malabsorption	Abnormality of the absorption of fat from the gastrointestinal tract.	Not Applicable or Unknown
Hepatocellular carcinoma	A kind of neoplasm of the liver that originates in hepatocytes and presents macroscopically as a soft and hemorrhagic tan mass in the liver.	Not Applicable or Unknown
Hepatomegaly	Abnormally increased size of the liver.   Synonyms:Enlarged liver	Not Applicable or Unknown
Intermittent jaundice	Jaundice that is sometimes present, sometimes not.   Synonyms:Intermittent icterus; Intermittent yellow skin; Intermittent yellowing of skin	Not Applicable or Unknown
Intrahepatic cholestasis	Impairment of bile flow due to obstruction in the small bile ducts within the liver.	Not Applicable or Unknown
Pruritus	Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus.   Synonyms:Itching; Itchy skin; Skin itching	Not Applicable or Unknown
Short stature	A height below that which is expected according to age and sex norms. Although there is no universally accepted definition of short stature, many refer to 'short stature' as height more than 2 standard deviations below the mean for age and sex (or below the 3rd percentile for age and sex dependent norms).   Synonyms:Decreased body height; Height less than 3rd percentile; Short stature; Small stature; Stature below 3rd percentile	Not Applicable or Unknown
Splenomegaly	Abnormal increased size of the spleen.   Synonyms:Increased spleen size; Large spleen	Not Applicable or Unknown
A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function.	Synonyms:Hepatic cirrhosis; Scar tissue replaces healthy tissue in the liver	Not Applicable or Unknown