Total 16 clinical symptoms reported for Obesity due to congenital leptin deficiency  Very Frequent (10)Uncommon (2)Frequent (4)

Absence of secondary sex characteristics	No secondary sexual characteristics are present at puberty.   Synonyms:No secondary sexual characteristics at puberty	Very frequent
Decreased proportion of CD4-positive helper T cells	A decreased proportion of circulating CD4-positive helper T cells relative to total T cell count.   Synonyms:Abnormality of CD4+ T cells; CD4 T cell lymphopenia; CD4+ T-cell lymphopenia	Very frequent
Decreased serum estradiol	A reduction below normal concentration of estradiol in the circulation.   Synonyms:Decreased serum estradiol	Very frequent
Decreased serum testosterone concentration	Synonyms:Decreased serum testosterone level; Decreased serum testosterone levels; Low serum testosterone level; Low serum testosterone levels	Very frequent
Decreased testicular size	Reduced volume of the testicle (the male gonad).   Synonyms:Decreased testicular size; Hypoplastic testes; Small testes; Small testis; Testicular hypoplasia	Very frequent
Gynecomastia	Abnormal development of large mammary glands in males resulting in breast enlargement.   Synonyms:Enlarged male breast; Gynaecomastia	Very frequent
Hypergonadotropic hypogonadism	Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay.   Synonyms:Hypergonadotrophic hypogonadism; Primary hypogonadism	Very frequent
Hypoplasia of the ovary	Developmental hypoplasia of the ovary.   Synonyms:Underdeveloped ovary	Very frequent
Polyphagia	A neurological anomaly with gross overeating associated with an abnormally strong desire or need to eat.   Synonyms:Hyperphagia; Voracious appetite	Very frequent
Primary amenorrhea	This information is currently in development.	Very frequent