Total 69 clinical symptoms reported for Neurofibromatosis type 1  Very Frequent (15)Occasional (35)Frequent (19)

Abnormality of the nervous system	An abnormality of the nervous system.   Synonyms:Abnormality of the nervous system; Neurologic abnormalities; Neurological abnormality	Very frequent
Astrocytoma	Astrocytoma is a neoplasm of the central nervous system derived from astrocytes. Astrocytes are a type of glial cell, and thus astrocytoma is a subtype of glioma.	Very frequent
Delayed puberty	Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty.   Synonyms:Delayed pubertal development; Delayed pubertal growth; Delayed puberty; Pubertal delay	Very frequent
Generalized hyperpigmentation	This information is currently in development.	Very frequent
Intellectual disability, mild	Mild intellectual disability is defined as an intelligence quotient (IQ) in the range of 50-69.   Synonyms:Intellectual disability, mild; Mental retardation, borderline-mild; Mild and nonprogressive mental retardation; Mild mental retardation	Very frequent
Lisch nodules	The presence of pigmented, oval and dome-shaped raised hamartomatous nevi of the iris..   Synonyms:Iris hamartomas	Very frequent
Macule	A flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin.   Synonyms:Flat, discolored area of skin	Very frequent
Melanocytic nevus	A oval and round, colored (usually medium-to dark brown, reddish brown, or flesh colored) lesion. Typically, a melanocytic nevus is less than 6 mm in diameter, but may be much smaller or larger.   Synonyms:Beauty mark; Melanocytic naevus; Melanocytic nevi; Nevocellular nevi; Pigmented naevi; Pigmented nevi	Very frequent
Meningioma	The presence of a meningioma, i.e., a benign tumor originating from the dura mater or arachnoid mater.	Very frequent
Multiple cafe-au-lait spots	The presence of six or more cafe-au-lait spots.	Very frequent
Multiple lipomas	The presence of multiple lipomas (a type of benign tissue made of fatty tissue).   Synonyms:Multiple fatty lumps	Very frequent
Neoplasm of the skin	A tumor (abnormal growth of tissue) of the skin.   Synonyms:Dermatological tumors; Skin tumors; Tumor of the skin	Very frequent
Plexiform neurofibroma	A neurofibroma in which Schwann cells proliferate inside the nerve sheath, producing an irregularly thickened, distorted, tortuous structure.	Very frequent
Specific learning disability	Impairment of certain skills such as reading or writing, coordination, self-control, or attention that interfere with the ability to learn. The impairment is not related to a global deficiency of intelligence.	Very frequent
Subcutaneous nodule	Slightly elevated lesions on or in the skin with a diameter of over 5 mm.   Synonyms:Firm lump under the skin; Growth of abnormal tissue under the skin	Very frequent