Total 27 clinical symptoms reported for Netherton syndrome  Very Frequent (13)Occasional (9)Frequent (5)

Abnormal hair morphology	An abnormality of the hair.   Synonyms:Abnormality of the hair; Hair abnormality	Very frequent
Acanthosis nigricans	A dermatosis characterized by thickened, hyperpigmented plaques, typically on the intertriginous surfaces and neck.   Synonyms:Darkened and thickened skin; Keratosis nigricans	Very frequent
Asthma	Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.   Synonyms:Asthma; Bronchial asthma	Very frequent
Congenital nonbullous ichthyosiform erythroderma	The term collodion baby applies to newborns who appear to have an extra layer of skin (known as a collodion membrane) that has a collodion-like quality. It is a descriptive term, not a specific diagnosis or disorder (as such, it is a syndrome). Affected babies are born in a collodion membrane, a shiny waxy outer layer to the skin. This is shed 10-14 days after birth, revealing the main symptom of the disease, extensive scaling of the skin caused by hyperkeratosis. With increasing age, the scaling tends to be concentrated around joints in areas such as the groin, the armpits, the inside of the elbow and the neck. The scales often tile the skin and may resemble fish scales.   Synonyms:Collodion baby; Congenital lamellar ichthyosis; Congenital non-bullous ichthyosis; Ichthyosis lammellaris; Ichthyosis, congenital, nonblistering; Nonbullous congenital ichthyosiform erythroderma; Nonbullous congenital ichthyosis	Very frequent
Eczema	Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding.   Synonyms:Eczema	Very frequent
Fine hair	Hair that is fine or thin to the touch.   Synonyms:Fine hair; Fine hair shaft; Fine hair texture; Thin hair; Thin hair shaft; Thin hair texture; Thinned hair	Very frequent
Ichthyosis	An abnormality of the skin characterized the presence of excessive amounts of dry surface scales on the skin resulting from an abnormality of keratinization.   Synonyms:Ichthyosiform abnormality of the skin; Ichthyotic skin	Very frequent
Immunologic hypersensitivity	Immunological states where the immune system produces harmful responses upon reexposure to sensitising antigens.	Very frequent
Irregular hyperpigmentation	This information is currently in development.	Very frequent
Malabsorption	Impaired ability to absorb one or more nutrients from the intestine.   Synonyms:Intestinal malabsorption; Malabsorption	Very frequent
Sparse scalp hair	Decreased number of hairs per unit area of skin of the scalp.   Synonyms:Decreased number of scalp follicles; Hypotrichosis on scalp; Reduced amount of scalp hair; Reduced/lack of hair on scalp; Reduction in the number of scalp follicles; Scalp hypotrichosis; Sparse scalp hair; Thinning scalp hair	Very frequent
Trichorrhexis nodosa	Trichorrhexis nodosa is the formation of nodes along the hair shaft through which breakage readily occurs. It is thus a focal defect in the hair fiber that is characterized by thickening or weak points (nodes) that cause the hair to break off easily. The result is defective, abnormally fragile hair.	Very frequent
Urticaria	Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure.   Synonyms:Hives	Very frequent