Total 28 clinical symptoms reported for Multiple sulfatase deficiency  Very Frequent (9)Occasional (1)Frequent (18)

Developmental regression	Loss of developmental skills, as manifested by loss of developmental milestones.   Synonyms:Loss of developmental milestones; Mental deterioration in childhood; Neurodevelopmental regression; Psychomotor regression; Psychomotor regression beginning in infancy; Psychomotor regression in infants; Psychomotor regression, progressive	Very frequent
Global developmental delay	A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age.   Synonyms:Delayed cognitive development; Delayed development; Delayed developmental milestones; Delayed intellectual development; Delayed milestones; Delayed psychomotor development; Developmental delay; Developmental delay in early childhood; Developmental delay, global; Developmental retardation; Lack of psychomotor development; Motor and developmental delay; Psychomotor delay; Psychomotor development deficiency; Psychomotor development failure; Psychomotor developmental delay; Retarded development; Retarded mental development; Retarded psychomotor development	Very frequent
Hepatomegaly	Abnormally increased size of the liver.   Synonyms:Enlarged liver	Very frequent
Ichthyosis	An abnormality of the skin characterized the presence of excessive amounts of dry surface scales on the skin resulting from an abnormality of keratinization.   Synonyms:Ichthyosiform abnormality of the skin; Ichthyotic skin	Very frequent
Intellectual disability	Subnormal intellectual functioning which originates during the developmental period. Intellectual disability, previously referred to as mental retardation, has been defined as an IQ score below 70.   Synonyms:Intellectual disability; Mental deficiency; Mental retardation; Mental retardation, nonspecific; Mental-retardation; Nonprogressive intellectual disability; Nonprogressive mental retardation	Very frequent
Neonatal hypotonia	Muscular hypotonia (abnormally low muscle tone) manifesting in the neonatal period.   Synonyms:Hypotonia, in neonatal onset; Hypotonia, neonatal; Low muscle tone, in neonatal onset	Very frequent
Rapid neurologic deterioration	This information is currently in development.	Very frequent
Splenomegaly	Abnormal increased size of the spleen.   Synonyms:Increased spleen size	Very frequent
Visual impairment	Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery.   Synonyms:Impaired vision; Loss of eyesight; Poor vision; Visual impairment	Very frequent