Total 56 clinical symptoms reported for Mucopolysaccharidosis type 1  Very Frequent (16)Occasional (12)Frequent (28)

Abnormal form of the vertebral bodies	Abnormal morphology of vertebral body.   Synonyms:Abnormally shaped vertebrae	Very frequent
Abnormality of epiphysis morphology	An anomaly of epiphysis, which is the expanded articular end of a long bone that developes from a secondary ossification center, and which during the period of growth is either entirely cartilaginous or is separated from the shaft by a cartilaginous disk.   Synonyms:Abnormal shape of end part of bone; Abnormality of the epiphyses; Anomaly of the epiphyses; Epiphyseal abnormality	Very frequent
Abnormality of the metaphysis	An abnormality of one or more metaphysis, i.e., of the somewhat wider portion of a long bone that is adjacent to the epiphyseal growth plate and grows during childhood.   Synonyms:Abnormality of the wide portion of a long bone	Very frequent
Abnormality of the voice	Synonyms:Abnormality of the voice; Voice abnormality	Very frequent
Chronic otitis media	Chronic otitis media refers to fluid, swelling, or infection of the middle ear that does not heal and may cause permanent damage to the ear.   Synonyms:Chronic infections of the middle ear; Otitis media, chronic	Very frequent
Coarse facial features	Absence of fine and sharp appearance of brows, nose, lips, mouth, and chin, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues.   Synonyms:Coarse face; Coarse facial appearance; Coarse facial features; Coarse facies	Very frequent
Corneal opacity	A reduction of corneal clarity.   Synonyms:Corneal clouding; Corneal opacities; Reduction of corneal clarity; Scarring or clouding of the cornea of the eye	Very frequent
Generalized hirsutism	Abnormally increased hair growth over much of the entire body.   Synonyms:Excessive hairiness over body	Very frequent
Hernia	This section is currently in development.	Very frequent
Inguinal hernia	Protrusion of the contents of the abdominal cavity through the inguinal canal.	Very frequent
Joint stiffness	Joint stiffness is a perceived sensation of tightness in a joint or joints when attempting to move them after a period of inactivity. Joint stiffness typically subsides over time.   Synonyms:Joint stiffness; Stiff joint; Stiff joints	Very frequent
Scoliosis	The presence of an abnormal lateral curvature of the spine.	Very frequent
Short stature	A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to 'short stature' as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms).   Synonyms:Decreased body height; Height less than 3rd percentile; Short stature; Small stature; Stature below 3rd percentile	Very frequent
Sinusitis	Inflammation of the paranasal sinuses owing to a viral, bacterial, or fungal infection, allergy, or an autoimmune reaction.   Synonyms:Sinus inflammation	Very frequent
Splenomegaly	Abnormal increased size of the spleen.   Synonyms:Increased spleen size	Very frequent
Split hand	A condition in which middle parts of the hand (fingers and metacarpals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic middle fingers over absent middel fingers as far as oligo- or monodactyl hands.   Synonyms:Claw hand; Claw hand deformities; Claw hands; Claw-hand deformities; Ectrodactyly of the hand; Hand ectrodactyly; Split hand; Split-hand	Very frequent