Total 12 clinical symptoms reported for L-2-hydroxyglutaric aciduria  Very Frequent (4)Occasional (1)Frequent (7)

Infectious encephalitis	A disorder of the brain caused by an infectious agent that presents with fever, headache, and an altered level of consciousness. There may also be focal or multifocal neurologic deficits, and focal or generalized seizure activity.   Synonyms:Brain inflammation	Very frequent
Intellectual disability, progressive	The term progressive intellectual disability should be used if intelligence decreases/deteriorates over time.   Synonyms:Intellectual disability, progressive; Mental retardation, progressive; Progressive mental retardation	Very frequent
Intellectual disability, severe	Severe mental retardation is defined as an intelligence quotient (IQ) in the range of 20-34.   Synonyms:Early and severe mental retardation; Intellectual disability, severe; Mental retardation, severe; Severe mental retardation	Very frequent
Seizure	A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.   Synonyms:Epileptic seizure; Seizures	Very frequent