Total 6 clinical symptoms reported for Ichthyosis bullosa of Siemens  Very Frequent (5)Occasional (1)

Abnormal blistering of the skin	The presence of one or more bullae on the skin, defined as fluid-filled blisters more than 5 mm in diameter with thin walls.   Synonyms:Abnormal blistering of the skin; Blister; Blistering, generalized; Blisters; Skin bullae	Very frequent
Acantholysis	The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes.	Very frequent
Ichthyosis	An abnormality of the skin characterized the presence of excessive amounts of dry surface scales on the skin resulting from an abnormality of keratinization.   Synonyms:Ichthyosiform abnormality of the skin; Ichthyotic skin	Very frequent
Palmoplantar keratoderma	Abnormal thickening of the skin of the palms of the hands and the soles of the feet.   Synonyms:Palmar and plantar keratoderma; Thickening of palms and soles	Very frequent
Thin skin	Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin.   Synonyms:Thin skin	Very frequent