Total 56 clinical symptoms reported for Hurler syndrome  Very Frequent (25)Occasional (6)Frequent (25)

Abnormal heart valve morphology	Any structural abnormality of a cardiac valve.   Synonyms:Abnormality of the heart valves; Valvular abnormality	Very frequent
Abnormal vertebral morphology	An abnormality of one or more of the vertebrae.   Synonyms:Abnormal vertebrae; Abnormality of the vertebrae; Vertebral anomalies	Very frequent
Abnormality of the skeletal system	An abnormality of the skeletal system.   Synonyms:Abnormality of the skeletal system; Skeletal abnormalities; Skeletal anomalies	Very frequent
Abnormality of the tonsils	An abnormality of the tonsils.	Very frequent
Anteverted nares	Anteriorly-facing nostrils viewed with the head in the Frankfurt horizontal and the eyes of the observer level with the eyes of the subject. This gives the appearance of an upturned nose (upturned nasal tip).   Synonyms:Anteverted nose; Anteverted nostrils; Nasal tip, upturned; Nostrils anteverted; Upturned nares; Upturned nasal tip; Upturned nose; Upturned nostrils	Very frequent
Cardiomyopathy	A myocardial disorder in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality.   Synonyms:Disease of the heart muscle	Very frequent
Cerebral palsy	Cerebral palsy describes a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to nonprogressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, and behaviour, by epilepsy, and by secondary musculoskeletal problems.   Synonyms:Cerebral paralysis; CP	Very frequent
Coarse facial features	Absence of fine and sharp appearance of brows, nose, lips, mouth, and chin, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues.   Synonyms:Coarse face; Coarse facial appearance; Coarse facial features; Coarse facies	Very frequent
Depressed nasal bridge	Posterior positioning of the nasal root in relation to the overall facial profile for age.   Synonyms:Depressed bridge of nose; Depressed nasal bridge; Depressed nasal root; Flat bridge of nose; Flat nasal bridge; Flat nasal root; Flat, nasal bridge; Flattened nasal bridge; Low nasal bridge; Low nasal root; Retruded bridge of nose; Retruded nasal bridge	Very frequent
Frontal bossing	Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline.   Synonyms:Frontal protruberance; Skull bossing	Very frequent
Full cheeks	Increased prominence or roundness of soft tissues between zygomata and mandible.   Synonyms:Apple cheeks; Big cheeks; Full cheeks; Increased size of cheeks; Large cheeks	Very frequent
Generalized hirsutism	Abnormally increased hair growth over much of the entire body.   Synonyms:Excessive hairiness over body	Very frequent
Global developmental delay	A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age.   Synonyms:Delayed cognitive development; Delayed development; Delayed developmental milestones; Delayed intellectual development; Delayed milestones; Delayed psychomotor development; Developmental delay; Developmental delay in early childhood; Developmental delay, global; Developmental retardation; Lack of psychomotor development; Motor and developmental delay; Psychomotor delay; Psychomotor development deficiency; Psychomotor development failure; Psychomotor developmental delay; Retarded development; Retarded mental development; Retarded psychomotor development	Very frequent
Hepatomegaly	Abnormally increased size of the liver.   Synonyms:Enlarged liver	Very frequent
Hernia	This information is currently in development.	Very frequent
Hypotonia	Hypotonia is an abnormally low muscle tone (the amount of tension or resistance to movement in a muscle). Even when relaxed, muscles have a continuous and passive partial contraction which provides some resistance to passive stretching. Hypotonia thus manifests as diminished resistance to passive stretching. Hypotonia is not the same as muscle weakness, although the two conditions can co-exist.   Synonyms:Low muscle tone; Low or weak muscle tone; Muscle hypotonia; Muscular hypotonia	Very frequent
Intellectual disability	Subnormal intellectual functioning which originates during the developmental period. Intellectual disability, previously referred to as mental retardation, has been defined as an IQ score below 70.   Synonyms:Intellectual disability; Mental deficiency; Mental retardation; Mental retardation, nonspecific; Mental-retardation; Nonprogressive intellectual disability; Nonprogressive mental retardation	Very frequent
Large face	Synonyms:Big face; Large face; Large facies	Very frequent
Limitation of joint mobility	A reduction in the freedom of movement of one or more joints.   Synonyms:Decreased joint mobility; Decreased mobility of joints; Limitation of joint mobility; Limited joint mobility; Limited joint motion	Very frequent
Rhinitis	Inflammation of the nasal mucosa with nasal congestion.   Synonyms:Nasal inflammation	Very frequent
Short neck	Diminished length of the neck.   Synonyms:Cervical shortening; Decreased cervical height; Decreased cervical length; Decreased length of neck; Short neck	Very frequent
Skeletal dysplasia	A general term describing features characterized by abnormal development of bones and connective tissues.	Very frequent
Splenomegaly	Abnormal increased size of the spleen.   Synonyms:Increased spleen size	Very frequent
Thick eyebrow	Increased density/number and/or increased diameter of eyebrow hairs.   Synonyms:Bushy eyebrows; Dense eyebrow; Heavy eyebrows; Hypertrichosis of the eyebrow; Prominent eyebrows; Thick eyebrow; Thick eyebrows	Very frequent
Wide nasal bridge	Increased breadth of the nasal bridge (and with it, the nasal root).   Synonyms:Broad nasal bridge; Broad nasal root; Broadened nasal bridge; Increased breadth of bridge of nose; Increased breadth of nasal bridge; Increased width of bridge of nose; Increased width of nasal bridge; Nasal bridge broad; Nasal bridge, wide; Wide bridge of nose; Wide nasal bridge; Widened nasal bridge	Very frequent