Total 45 clinical symptoms reported for Homocystinuria due to methylene tetrahydrofolate reductase deficiency  Very Frequent (6)Uncommon (10)Occasional (21)Frequent (8)

Behavioral abnormality	An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities.   Synonyms:Behavioral abnormality; Behavioral changes; Behavioral disorders; Behavioral disturbances; Behavioral problems; Behavioral/psychiatric abnormalities; Behavioural/Psychiatric abnormality; Psychiatric disorders; Psychiatric disturbances	Very frequent
Gait disturbance	The term gait disturbance can refer to any disruption of the ability to walk. In general, this can refer to neurological diseases but also fractures or other sources of pain that is triggered upon walking. However, in the current context gait disturbance refers to difficulty walking on the basis of a neurological or muscular disease.   Synonyms:Abnormal gait; Abnormal walk; Gait abnormalities; Gait difficulties; Gait disturbances; Impaired gait	Very frequent
Lower limb muscle weakness	Weakness of the muscles of the legs.   Synonyms:Lower extremity weakness; Lower limb muscle weakness; Lower limb weakness; Muscle weakness in lower limbs	Very frequent
Lower limb spasticity	Spasticity (velocity-dependent increase in tonic stretch reflexes with increased muscle tone and hyperexcitable tendon reflexes) in the muscles of the lower limbs, hips, and pelvis	Very frequent
Morphological central nervous system abnormality	A structural abnormality of the central nervous system.   Synonyms:Abnormality of the central nervous system; Morphological abnormality of the central nervous system; Morphological abnormality of the CNS	Very frequent
Upper motor neuron dysfunction	A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs.   Synonyms:Corticospinal tract dysfunction; Pyramidal tract dysfunction	Very frequent