Total 29 clinical symptoms reported for Holt-Oram syndrome  Very Frequent (4)Occasional (14)Frequent (11)

Abnormal cardiovascular system morphology	Any structural anomaly of the heart and blood vessels.   Synonyms:Abnormality of cardiovascular system morphology; Cardiovascular malformations	Very frequent
Abnormal clavicle morphology	Any abnormality of the clavicles (collar bones).   Synonyms:Abnormal clavicles; Abnormal collarbone; Abnormality of the clavicle	Very frequent
Joint stiffness	Joint stiffness is a perceived sensation of tightness in a joint or joints when attempting to move them after a period of inactivity. Joint stiffness typically subsides over time.   Synonyms:Joint stiffness; Stiff joint; Stiff joints	Very frequent
Split hand	A condition in which middle parts of the hand (fingers and metacarpals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic middle fingers over absent middle fingers as far as oligo- or monodactyl hands.   Synonyms:Ectrodactyly of the hand; Hand ectrodactyly; Split hand; Split-hand	Very frequent