Total 30 clinical symptoms reported for Hereditary diffuse leukoencephalopathy with spheroids  Very Frequent (9)Not Applicable Or Unknown (18)Frequent (3)

Corpus callosum atrophy	The presence of atrophy (wasting) of the corpus callosum.   Synonyms:Atrophic corpus callosum; Atrophy of the corpus callosum; Atrophy/Degeneration of the corpus callosum	Very frequent
Dysarthria	Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed.   Synonyms:Difficulty articulating speech; Dysarthric speech	Very frequent
Dysphagia	Difficulty in swallowing.   Synonyms:Difficulty swallowing; Poor swallowing; Swallowing difficulties; Swallowing difficulty	Very frequent
Gait disturbance	The term gait disturbance can refer to any disruption of the ability to walk.   Synonyms:Abnormal gait; Abnormal walk; Difficulty in walking; Gait abnormalities; Gait difficulties; Gait disturbances; Impaired gait; Walking disability	Very frequent
Global brain atrophy	Unlocalized atrophy of the brain with decreased total brain matter volume and increased ventricular size.   Synonyms:Diffuse brain atrophy; Generalized brain atrophy; Generalized brain degeneration; Generalized cerebral atrophy	Very frequent
Impaired executive functioning	A disturbance of executive functioning, which is broadly defined as the set of abilities that allow for the planning, executing, monitoring, and self-correcting of goal-directed behavior while inhibiting task-irrelevant behavior. At least some degree of executive skill is needed to complete most cognitive tasks, and deficits in executive abilities are central to many clinical conditions, including fronto-temporal dementia.	Very frequent
Memory impairment	An impairment of memory as manifested by a reduced ability to remember things such as dates and names, and increased forgetfulness.   Synonyms:Forgetfulness; Memory impairment; Memory loss; Memory problems; Poor memory	Very frequent
Parkinsonism	Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait.	Very frequent
Seizure	A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.   Synonyms:Epileptic seizure; Seizures	Very frequent