Total 22 clinical symptoms reported for Hb SS disease  Very Frequent (3)Uncommon (4)Occasional (5)Frequent (10)

Hemolytic anemia	A type of anemia caused by premature destruction of red blood cells (hemolysis).   Synonyms:Haemolytic anaemia; Increased hemolysis	Very frequent
Pain	An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.   Synonyms:Pain	Very frequent
Recurrent infections	Increased susceptibility to infections.   Synonyms:Frequent infections; Frequent, severe infections; Increased frequency of infection; infections, recurrent; Predisposition to infections; Recurrent infections; Susceptibility to infection	Very frequent