Total 24 clinical symptoms reported for GNE myopathy  Very Frequent (6)Uncommon (2)Occasional (7)Not Applicable Or Unknown (1)Frequent (8)

Fatty replacement of skeletal muscle	Muscle fibers degeneration resulting in fatty replacement of skeletal muscle fibers   Synonyms:Skeletal muscle fatty infiltration	Very frequent
Foot dorsiflexor weakness	Weakness of the muscles responsible for dorsiflexion of the foot, that is, of the movement of the toes towards the shin. The foot dorsiflexors include the tibialis anterior, the extensor hallucis longus, the extensor digitorum longus, and the peroneus tertius muscles.   Synonyms:Foot drop; Foot extensor weakness; Footdrop; Inability to heel walk; Inability to walk on heels	Very frequent
Lower limb muscle weakness	Weakness of the muscles of the legs.   Synonyms:Lower extremity weakness; Lower limb muscle weakness; Lower limb weakness; Muscle weakness in lower limbs	Very frequent
Muscle fiber inclusion bodies	This information is currently in development.	Very frequent
Rimmed vacuoles	Presence of abnormal vacuoles (membrane-bound organelles) in the sarcolemma. On histological staining with hematoxylin and eosin, rimmed vacuoles are popcorn-like clear vacuoles with a densely blue rim. The vacuoles are often associated with cytoplasmic and occasionally intranuclear eosinophilic inclusions.   Synonyms:'rimmed vacuoles' on biopsy; 'rimmed' vacuoles on biopsy	Very frequent
Tibialis muscle weakness	Muscle weakness affecting the tibialis anterior muscle.	Very frequent