Total 53 clinical symptoms reported for GAPO syndrome  Very Frequent (23)Occasional (17)Frequent (13)

Alopecia	A noncongenital process of hair loss, which may progress to partial or complete baldness.   Synonyms:Hair loss	Very frequent
Anteverted nares	Anteriorly-facing nostrils viewed with the head in the Frankfurt horizontal and the eyes of the observer level with the eyes of the subject. This gives the appearance of an upturned nose (upturned nasal tip).   Synonyms:Anteverted nose; Anteverted nostrils; Nasal tip, upturned; Nostrils anteverted; Upturned nares; Upturned nasal tip; Upturned nose; Upturned nostrils	Very frequent
Broad forehead	Width of the forehead or distance between the frontotemporales is more than two standard deviations above the mean (objective); or apparently increased distance between the two sides of the forehead.   Synonyms:Bitemporal widening; Broad forehead; Increased bitemporal dimension; Increased bitemporal width; Increased width of the forehead; Intertemporal widening; Wide forehead	Very frequent
Delayed eruption of teeth	Delayed tooth eruption, which can be defined as tooth eruption more than 2 SD beyond the mean eruption age.   Synonyms:Delayed dental development; Delayed dental eruption; Delayed eruption; Delayed eruption of teeth; Delayed teeth eruption; Delayed tooth eruption; Eruption, delayed; Late eruption of teeth; Late tooth eruption	Very frequent
Delayed skeletal maturation	A decreased rate of skeletal maturation. Delayed skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body.   Synonyms:Delayed bone age; Delayed bone age before puberty; Delayed bone maturation; Delayed skeletal development; Retarded bone age; Skeletal maturation retardation	Very frequent
Depressed nasal bridge	Posterior positioning of the nasal root in relation to the overall facial profile for age.   Synonyms:Depressed bridge of nose; Depressed nasal bridge; Depressed nasal root; Flat bridge of nose; Flat nasal bridge; Flat nasal root; Flat, nasal bridge; Flattened nasal bridge; Low nasal bridge; Low nasal root; Retruded bridge of nose; Retruded nasal bridge	Very frequent
Early balding	Loss of scalp hair at an earlier than normal age.   Synonyms:Early balding	Very frequent
Everted lower lip vermilion	An abnormal configuration of the lower lip such that it is turned outward i.e., everted, with the Inner aspect of the lower lip vermilion (normally opposing the teeth) being visible in a frontal view.   Synonyms:Drooping lower lip; Eclabium of lower lip; Everted lower lip; Everted prominent lower lip; Outward turned lower lip	Very frequent
Frontal bossing	Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline.   Synonyms:Frontal protruberance; Skull bossing	Very frequent
High forehead	An abnormally increased height of the forehead.   Synonyms:High forehead	Very frequent
Hyperextensible skin	A condition in which the skin can be stretched beyond normal, and then returns to its initial position.   Synonyms:Hyperelastic skin; Skin hyperelasticity; Skin hyperextensibility; Stretchable skin	Very frequent
Hypertelorism	Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes).   Synonyms:Excessive orbital separation; Increased distance between eye sockets; Increased distance between eyes; Increased interpupillary distance; Ocular hypertelorism; Wide-set eyes; Widely spaced eyes; Widened interpupillary distance	Very frequent
Joint hyperflexibility	Increased mobility and flexibility in the joint due to the tension in tissues such as ligaments and muscles.   Synonyms:Joints move beyond expected range of motion	Very frequent
Long philtrum	Distance between nasal base and midline upper lip vermilion border more than 2 SD above the mean. Alternatively, an apparently increased distance between nasal base and midline upper lip vermilion border.   Synonyms:Elongated philtrum; Increased height of philtrum; Increased length of philtrum; Increased vertical dimension of philtrum; Vertical hyperplasia of philtrum	Very frequent
Low-set ears	Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear.   Synonyms:Low set ears; Low-set ears; Low-set pinnae; Lowset ears; Melotia	Very frequent
Micrognathia	Developmental hypoplasia of the mandible.   Synonyms:Decreased size of lower jaw; Decreased size of mandible; Hypoplasia of lower jaw; Hypoplasia of mandible; Hypoplastic mandible; Hypoplastic mandible condyle; Hypotrophic lower jaw; Hypotrophic mandible; Little lower jaw; Little mandible; Lower jaw deficiency; Lower jaw hypoplasia; Lower jaw retrusion; Mandibular deficiency; Mandibular hypoplasia; Mandibular micrognathia; Mandibular retrognathia; Mandibular retrusion; Micrognathia of lower jaw; Micromandible; Robin mandible; Severe hypoplasia of mandible; Small jaw; Small lower jaw; Small mandible; Underdevelopment of lower jaw; Underdevelopment of mandible	Very frequent
Midface retrusion	Posterior positions and/or vertical shortening of the infraorbital and perialar regions, or increased concavity of the face and/or reduced nasolabial angle.   Synonyms:Decreased size of midface; Flat midface; Hypoplasia of midface; Midface deficiency; Midface hypoplasia; Midface retrusion; Midface, flat; Retrusive midface; Underdevelopment of midface	Very frequent
Prematurely aged appearance	Synonyms:Precociously senile appearance; Prematurely aged appearance	Very frequent
Short stature	A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to 'short stature' as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms).   Synonyms:Decreased body height; Height less than 3rd percentile; Short stature; Small stature; Stature below 3rd percentile	Very frequent
Sparse eyebrow	Decreased density/number of eyebrow hairs.   Synonyms:Hypotrichosis of eyebrow; Sparse eyebrow; Sparse eyebrows	Very frequent
Sparse eyelashes	Decreased density/number of eyelashes.   Synonyms:Hypotrichosis of eyelashes; Partial absence of eyelashes; Scant eyelashes; Scanty eyelashes; Sparse eyelashes; Thin eyelashes	Very frequent
Thick nasal alae	Increase in bulk of the ala nasi.   Synonyms:Ala nasi, thick; Thickening of the alae nasi	Very frequent
Underdeveloped supraorbital ridges	Flatness of the supraorbital portion of the frontal bones.   Synonyms:Depressed supraorbital margins; Depressed supraorbital ridge; Flat supraorbital margins; Flat supraorbital ridge; Flattened bony protrusion above eyes; Hypoplasia of supraorbital margins; Hypoplasia of the supraorbital ridges; Hypoplastic supraorbital ridges; Shallow orbital ridges; Shallow supraorbital ridge	Very frequent