Total 94 clinical symptoms reported for Ehlers-Danlos syndrome, type 4  Very Frequent (34)Occasional (48)Frequent (12)

Abnormal bleeding	An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.   Synonyms:Bleeding diathesis; Bleeding tendency; Hemorrhagic diathesis	Very frequent
Abnormal eyelash morphology	An abnormality of the eyelashes.   Synonyms:Abnormal eyelashes; Abnormality of the eyelashes; Eyelash abnormality	Very frequent
Abnormal heart valve morphology	Any structural abnormality of a cardiac valve.   Synonyms:Abnormality of the heart valves; Valvular abnormality	Very frequent
Abnormal oral frenulum morphology	An abnormality of the lingual frenulum, that is of the small fold of mucous membrane that attaches the tongue to the floor of the mouth, or the presence of accessory frenula in the oral cavity.   Synonyms:Abnormality of frenum of tongue; Abnormality of lingual frenum; Abnormality of oral frenula; Abnormality of oral frenum	Very frequent
Abnormality of the face	An abnormality of the face.   Synonyms:Abnormal face; Abnormality of the face; Facial abnormality	Very frequent
Abnormality of the skin	An abnormality of the skin.   Synonyms:Abnormality of the skin; Dermatopathy; Dermopathy	Very frequent
Aortic dissection	Aortic dissection refers to a tear in the intimal layer of the aorta causing a separation between the intima and the medial layers of the aorta.   Synonyms:Tear in inner wall of large artery that carries blood away from heart	Very frequent
Aplasia/Hypoplasia of the earlobes	Absence or underdevelopment of the ear lobes.   Synonyms:Absent/small ear lobes; Absent/underdeveloped ear lobes	Very frequent
Aplasia/Hypoplasia of the eyebrow	Absence or underdevelopment of the eyebrow.   Synonyms:Absence of eyebrow; Agenesis of eyebrow; Hypotrophic eyebrow; Lack of eyebrow; Missing eyebrow	Very frequent
Bladder diverticulum	Diverticulum (sac or pouch) in the wall of the urinary bladder.   Synonyms:Bladder diverticula	Very frequent
Bruising susceptibility	An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma.   Synonyms:Bruisability; Bruise easily; Bruising susceptibility; Easy bruisability; Easy bruising	Very frequent
Carious teeth	Caries is a multifactorial bacterial infection affecting the structure of the tooth. This term has been used to describe the presence of more than expected dental caries.   Synonyms:Caries; Cariosity of teeth; Dental caries; Dental cavities; Early dental caries; Frequent caries; Tooth cavities; Tooth decay	Very frequent
Cognitive impairment	Abnormal cognition is characterized by deficits in thinking, reasoning, or remembering.   Synonyms:Abnormality of cognition; Cognitive abnormality; Cognitive defects; Cognitive deficits; Cognitive impairment; Intellectual impairment	Very frequent
Cryptorchidism	Testis in inguinal canal. That is, absence of one or both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the scrotum.   Synonyms:Cryptorchism; Undescended testes; Undescended testis	Very frequent
Dermal translucency	An abnormally increased ability of the skin to permit light to pass through (translucency) such that subcutaneous structures such as veins display an increased degree of visibility.   Synonyms:Translucent skin	Very frequent
Epicanthus	A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus.   Synonyms:Epicanthal fold; Epicanthal folds; Epicanthic folds; Eye folds; Palpebronasal fold; Plica palpebronasalis; Prominent eye folds	Very frequent
Gastrointestinal infarctions	Synonyms:Death of digestive organ tissue due to poor blood supply; GI infarctions	Very frequent
Global developmental delay	A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age.   Synonyms:Delayed cognitive development; Delayed development; Delayed developmental milestones; Delayed intellectual development; Delayed milestones; Delayed psychomotor development; Developmental delay; Developmental delay in early childhood; Developmental delay, global; Developmental retardation; GDD; Lack of psychomotor development; Motor and developmental delay; Motormental retardation; Psychomotor delay; Psychomotor development deficiency; Psychomotor development failure; Psychomotor developmental delay; Retarded development; Retarded mental development; Retarded psychomotor development	Very frequent
Hypertelorism	Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes).   Synonyms:Excessive orbital separation; Increased distance between eye sockets; Increased distance between eyes; Increased interpupillary distance; Ocular hypertelorism; Wide-set eyes; Widely spaced eyes; Widened interpupillary distance	Very frequent
Hypertension	The presence of chronic increased pressure in the systemic arterial system.   Synonyms:Arterial hypertension; Systemic hypertension	Very frequent
Internal hemorrhage	The presence of hemorrhage within the body.   Synonyms:Internal bleeding	Very frequent
Macule	A flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin.   Synonyms:Flat, discolored area of skin	Very frequent
Melanocytic nevus	A oval and round, colored (usually medium-to dark brown, reddish brown, or flesh colored) lesion. Typically, a melanocytic nevus is less than 6 mm in diameter, but may be much smaller or larger.   Synonyms:Beauty mark; Melanocytic naevus; Melanocytic nevi; Nevocellular nevi; Pigmented naevi; Pigmented nevi	Very frequent
Mitral valve prolapse	One or both of the leaflets (cusps) of the mitral valve bulges back into the left atrium upon contraction of the left ventricle.	Very frequent
Pectus excavatum	A defect of the chest wall characterized by a depression of the sternum, giving the chest ('pectus') a caved-in ('excavatum') appearance.   Synonyms:Funnel chest	Very frequent
Peripheral arteriovenous fistula	This section is currently in development.	Very frequent
Pneumothorax	Accumulation of air in the pleural cavity leading to a partially or completely collapsed lung.   Synonyms:Collapsed lung	Very frequent
Prematurely aged appearance	Synonyms:Precociously senile appearance; Prematurely aged appearance	Very frequent
Protruding ear	Angle formed by the plane of the ear and the mastoid bone greater than the 97th centile for age (objective); or, outer edge of the helix more than 2 cm from the mastoid at the point of maximum distance (objective).   Synonyms:Prominent ear; Prominent ears	Very frequent
Short stature	A height below that which is expected according to age and sex norms. Although there is no universally accepted definition of short stature, many refer to 'short stature' as height more than 2 standard deviations below the mean for age and sex (or below the 3rd percentile for age and sex dependent norms).   Synonyms:Decreased body height; Height less than 3rd percentile; Short stature; Small stature; Stature below 3rd percentile	Very frequent
Sprengel anomaly	A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other).   Synonyms:Congenital, upward displacement of the scapula; High scapula; High shoulder blade; Sprengel deformity	Very frequent
Telecanthus	Distance between the inner canthi more than two standard deviations above the mean (objective); or, apparently increased distance between the inner canthi.   Synonyms:Corners of eye widely separated; Dystopia canthorum; Increased distance between medial canthi; Increased intercanthal distance	Very frequent
Thin skin	Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin.   Synonyms:Thin skin	Very frequent
Vascular dilatation	Abnormal outpouching or sac-like dilatation in the wall of an artery, vein or the heart.   Synonyms:Aneurysmal dilatation; Wider than typical opening or gap	Very frequent