Total 18 clinical symptoms reported for Desmin-related myofibrillar myopathy  Very Frequent (3)Uncommon (1)Occasional (6)Frequent (8)

Axial muscle weakness	Reduced strength of the axial musculature (i.e., of the muscles of the head and neck, spine, and ribs).	Very frequent
Distal lower limb muscle weakness	Reduced strength of the distal musculature of the legs.   Synonyms:Distal muscle weakness in lower limbs; Muscle weakness, lower limb, distal	Very frequent
Progressive muscle weakness	Synonyms:Muscle weakness, progressive; Progressive muscular weakness	Very frequent