Total 81 clinical symptoms reported for Coffin-Lowry syndrome  Very Frequent (31)Occasional (24)Frequent (26)

Abnormal dental morphology	An abnormality of the morphology of the tooth.   Synonyms:Abnormality of dental morphology; Abnormality of dental shape; Abnormality of shape of tooth; Abnormally shaped teeth; Deformity of teeth; Dental deformity; Dental malformations; Malformation of teeth; Malformed teeth; Misshapen teeth; Misshapened teeth	Very frequent
Abnormal diaphysis morphology	An abnormality of the structure or form of the diaphysis, i.e., of the main or mid-section (shaft) of a long bone.   Synonyms:Abnormal shape of shaft of long bone; Abnormality involving the diaphyses of the limbs; Abnormality of shaft of long bone of the limbs; Abnormality of the diaphyses; Anomaly of the limb diaphyses; Anomaly of the limb diaphyses morphology	Very frequent
Abnormal form of the vertebral bodies	Abnormal morphology of vertebral body.   Synonyms:Abnormal vertebral bodies; Abnormally shaped vertebrae	Very frequent
Abnormal speech pattern	An abnormality in the sound (volume) or cadence (rate) of speech.   Synonyms:Abnormal speech; Abnormal vocalization; Abnormality of speech or vocalization	Very frequent
Anteverted nares	Anteriorly-facing nostrils viewed with the head in the Frankfurt horizontal and the eyes of the observer level with the eyes of the subject. This gives the appearance of an upturned nose (upturned nasal tip).   Synonyms:Anteverted nose; Anteverted nostrils; Nasal tip, upturned; Nostrils anteverted; Upturned nares; Upturned nasal tip; Upturned nose; Upturned nostrils	Very frequent
Broad finger	Increased width of a non-thumb digit of the hand.   Synonyms:Broad finger; Broad fingers; Wide fingers	Very frequent
Coarse facial features	Absence of fine and sharp appearance of brows, nose, lips, mouth, and chin, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues.   Synonyms:Coarse face; Coarse facial appearance; Coarse facial features; Coarse facies	Very frequent
Craniofacial hyperostosis	Excessive growth of the craniofacial bones.   Synonyms:Excessive bone growth of the skull and face; Hyperostosis of craniofacial bones; Increased ossification of craniofacial bones	Very frequent
Delayed skeletal maturation	A decreased rate of skeletal maturation. Delayed skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body.   Synonyms:Delayed bone age; Delayed bone age before puberty; Delayed bone maturation; Delayed skeletal development; Retarded bone age; Skeletal maturation retardation	Very frequent
Depressed nasal bridge	Posterior positioning of the nasal root in relation to the overall facial profile for age.   Synonyms:Depressed bridge of nose; Depressed nasal bridge; Depressed nasal root; Flat bridge of nose; Flat nasal bridge; Flat nasal root; Flat, nasal bridge; Flattened nasal bridge; Low nasal bridge; Low nasal root; Retruded bridge of nose; Retruded nasal bridge	Very frequent
Downslanted palpebral fissures	The palpebral fissure inclination is more than two standard deviations below the mean.   Synonyms:Antimongoloid eye slant; Antimongoloid slant of palpebral fissures; Antimongoloid slanted palpebral fissures; Down slanting palpebral fissures; Down-slanted palpebral fissures; Down-slanting palpebral fissure; Down-slanting palpebral fissures; Downslanting palpebral fissure; Downslanting palpebral fissures; Downward slanted palpebral fissures; Downward slanting of the opening between the eyelids; Downward slanting palpebral fissures; Downward-slanting palpebral fissures; Palpebral fissures down-slanted	Very frequent
Epicanthus	A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus.   Synonyms:Epicanthal fold; Epicanthal folds; Epicanthic folds; Eye folds; Palpebronasal fold; Plica palpebronasalis; Prominent eye folds	Very frequent
Everted lower lip vermilion	An abnormal configuration of the lower lip such that it is turned outward i.e., everted, with the Inner aspect of the lower lip vermilion (normally opposing the teeth) being visible in a frontal view.   Synonyms:Drooping lower lip; Eclabium of lower lip; Everted lower lip; Everted prominent lower lip; Outward turned lower lip	Very frequent
Frontal bossing	Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline.   Synonyms:Frontal protuberance; Skull bossing	Very frequent
Hypertelorism	Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes).   Synonyms:Excessive orbital separation; Increased distance between eye sockets; Increased distance between eyes; Increased interpupillary distance; Ocular hypertelorism; Wide-set eyes; Widely spaced eyes; Widened interpupillary distance	Very frequent
Hypodontia	The absence of five or less teeth from the normal series by a failure to develop.   Synonyms:Failure of development of between one and six teeth	Very frequent
Hypotonia	Hypotonia is an abnormally low muscle tone (the amount of tension or resistance to movement in a muscle). Even when relaxed, muscles have a continuous and passive partial contraction which provides some resistance to passive stretching. Hypotonia thus manifests as diminished resistance to passive stretching. Hypotonia is not the same as muscle weakness, although the two conditions can co-exist.   Synonyms:Low muscle tone; Low or weak muscle tone; Muscle hypotonia; Muscular hypotonia	Very frequent
Intellectual disability	Intellectual disability, previously referred to as mental retardation, is characterized by subnormal intellectual functioning that occurs during the developmental period. It is defined by an IQ score below 70.   Synonyms:Intellectual disability; Mental deficiency; Mental retardation; Mental retardation, nonspecific; Mental-retardation; Nonprogressive intellectual disability; Nonprogressive mental retardation	Very frequent
Joint hypermobility	The capability that a joint (or a group of joints) has to move, passively and/or actively, beyond normal limits along physiological axes.   Synonyms:Double-Jointed; Extensible joints; Flexible joints; Hyperextensible joints; Increased joint mobility; Increased mobility of joints; Joint hyperextensibility; Joint hyperflexibility; Joint hyperlaxity; Joint laxity; Joints move beyond expected range of motion; Lax joints; Loose-jointedness	Very frequent
Kyphosis	Exaggerated anterior convexity of the thoracic vertebral column.   Synonyms:Gibbus deformity; Hunched back; Hyperkyphosis; Round back	Very frequent
Large hands	Synonyms:Disproportionately large hands; large hand; Large hands	Very frequent
Open mouth	A facial appearance characterized by a permanently or nearly permanently opened mouth.   Synonyms:Gaped jawed appearance; Gaped mouthed appearance; Open mouth; Slack jawed appearance	Very frequent
Pectus carinatum	A deformity of the chest caused by overgrowth of the ribs and characterized by protrusion of the sternum.   Synonyms:Pigeon chest	Very frequent
Pectus excavatum	A defect of the chest wall characterized by a depression of the sternum, giving the chest ('pectus') a caved-in ('excavatum') appearance.   Synonyms:Funnel chest	Very frequent
Scoliosis	The presence of an abnormal lateral curvature of the spine.	Very frequent
Severe global developmental delay	A severe delay in the achievement of motor or mental milestones in the domains of development of a child.   Synonyms:Global developmental delay, severe	Very frequent
Short stature	A height below that which is expected according to age and sex norms. Although there is no universally accepted definition of short stature, many refer to 'short stature' as height more than 2 standard deviations below the mean for age and sex (or below the 3rd percentile for age and sex dependent norms).   Synonyms:Decreased body height; Height less than 3rd percentile; Short stature; Small stature; Stature below 3rd percentile	Very frequent
Tapered finger	The gradual reduction in girth of the finger from proximal to distal.   Synonyms:Distally tapering fingers; Tapered finger; Tapered fingertips; Tapering fingers	Very frequent
Thick lower lip vermilion	Increased thickness of the lower lip, leading to a prominent appearance of the lower lip. The height of the vermilion of the lower lip in the midline is more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the lower lip in the frontal view (subjective).   Synonyms:Full lower lip vermilion; Increased height of lower lip vermilion; Increased volume of lower lip; Increased volume of lower lip vermilion; Plump lower lip; Prominent lower lip; Thick vermilion border of lower lip	Very frequent
Thick nasal alae	Increase in bulk of the ala nasi.   Synonyms:Ala nasi, thick; Thickening of the alae nasi	Very frequent
Widely spaced teeth	Increased spaces (diastemata) between most of the teeth in the same dental arch.   Synonyms:Generalized dental spacing; Generalized spacing of teeth; Multiple diastemata; Wide-spaced teeth; Widely spaced teeth; Widely-spaced teeth	Very frequent