Total 34 clinical symptoms reported for CK syndrome  Very Frequent (29)Frequent (5)

Abnormal cerebral cortex morphology	Any structural abnormality of the cerebral cortex.   Synonyms:Abnormality of the cerebral cortex	Very frequent
Almond-shaped palpebral fissure	A shape created by an acute downward arching of the upper eyelid and upward arching of the lower eyelid, toward the medial canthus, which gives the outline of the palpebral fissures the configuration of an almond. Thus, the maximum distance between the fissures is offset from, and medial to, the center point.   Synonyms:Almond shaped eyes; Almond-shaped opening between the eyelids	Very frequent
Aphasia	An acquired language impairment of some or all of the abilities to produce or comprehend speech and to read or write.   Synonyms:Difficulty finding words; Losing words; Loss of words	Very frequent
Asthenia	A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.   Synonyms:Lack of energy and strength; Weakness	Very frequent
Delayed speech and language development	A degree of language development that is significantly below the norm for a child of a specified age.   Synonyms:Deficiency of speech development; Delayed language development; Delayed speech; Delayed speech acquisition; Delayed speech and language development; Delayed speech development; Impaired speech and language development; Impaired speech development; Language delay; Language delayed; Language development deficit; Late-onset speech development; Poor language development; Speech and language delay; Speech and language difficulties; Speech delay	Very frequent
Dental crowding	Changes in alignment of teeth in the dental arch   Synonyms:Crowded teeth; Dental crowding; Dental overcrowding; Overcrowding of teeth	Very frequent
Epicanthus	A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus.   Synonyms:Epicanthal fold; Epicanthal folds; Epicanthic folds; Eye folds; Palpebronasal fold; Plica palpebronasalis; Prominent eye folds	Very frequent
Global developmental delay	A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age.   Synonyms:Delayed cognitive development; Delayed development; Delayed developmental milestones; Delayed intellectual development; Delayed milestones; Delayed psychomotor development; Developmental delay; Developmental delay in early childhood; Developmental delay, global; Developmental retardation; GDD; Lack of psychomotor development; Motor and developmental delay; Motormental retardation; Psychomotor delay; Psychomotor development deficiency; Psychomotor development failure; Psychomotor developmental delay; Retarded development; Retarded mental development; Retarded psychomotor development	Very frequent
High palate	Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective).   Synonyms:Elevated palate; High arched palate; High palate; High, arched palate; High-arched palate; Increased palatal height; Palate high-arched; Palate, high-arched	Very frequent
Intellectual disability	Intellectual disability, previously referred to as mental retardation, is characterized by subnormal intellectual functioning that occurs during the developmental period. It is defined by an IQ score below 70.   Synonyms:Intellectual disability; Mental deficiency; Mental retardation; Mental retardation, nonspecific; Mental-retardation; Nonprogressive intellectual disability; Nonprogressive mental retardation	Very frequent
Irritability	A proneness to anger, i.e., a tendency to become easily bothered or annoyed.   Synonyms:Irritability; Irritable; Irritable mood	Very frequent
Kyphoscoliosis	An abnormal curvature of the spine in both a coronal (lateral) and sagittal (back-to-front) plane.	Very frequent
Long face	Facial height (length) is more than 2 standard deviations above the mean (objective); or, an apparent increase in the height (length) of the face (subjective).   Synonyms:Elongation of face; Increased height of face; Increased length of face; Increased vertical dimension of face; Long face; Long facies; Vertical elongation of face; Vertical enlargement of face; Vertical excess of face; Vertical Facial Excess; Vertical hyperplasia of face; Vertical overgrowth of face	Very frequent
Long fingers	The middle finger is more than 2 SD above the mean for newborns 27 to 41 weeks EGA or above the 97th centile for children from birth to 16 years of age AND the five digits retain their normal length proportions relative to each other (i.e., it is not the case that the middle finger is the only lengthened digit), or, Fingers that appear disproportionately long compared to the palm of the hand.   Synonyms:Long fingers	Very frequent
Long toe	Toes that appear disproportionately long compared to the foot.   Synonyms:Increased length of toes; Long toe; Long toes	Very frequent
Lumbar hyperlordosis	An abnormal accentuation of the inward curvature of the spine in the lumbar region.   Synonyms:Exaggerated lumbar lordosis; Excessive inward curvature of lower spine; Increased lumbar lordosis; Lumbar lordosis; Prominent lumbar lordosis	Very frequent
Malar flattening	Underdevelopment of the malar prominence of the jugal bone (zygomatic bone in mammals), appreciated in profile, frontal view, and/or by palpation.   Synonyms:Decreased size of malar bone; Depressed malar region; Flat cheekbone; Malar hypoplasia; Underdevelopment of malar bone; Zygomatic flattening	Very frequent
Microcephaly	Head circumference below 2 standard deviations below the mean for age and sex.   Synonyms:Abnormally small cranium; Abnormally small skull; Decreased circumference of cranium; Decreased size of cranium; Decreased size of skull; Reduced head circumference; small cranium; Small head circumference	Very frequent
Microretrognathia	A form of developmental hypoplasia of the mandible in which the mandible is mislocalised posteriorly.   Synonyms:Retromicrognathia; Small retruded chin	Very frequent
Narrow face	Bizygomatic (upper face) and bigonial (lower face) width are both more than 2 standard deviations below the mean (objective); or, an apparent reduction in the width of the upper and lower face (subjective).   Synonyms:Decreased breadth of face; Decreased horizontal dimension of face; Decreased transverse dimension of face; Decreased width of face; Horizontal deficiency of face; Horizontal hypoplasia of face; Horizontal insufficiency of face; Narrow face; Narrow facies; Thin facies; Transverse deficiency of face; Transverse hypoplasia of face; Transverse insufficiency of face	Very frequent
Pachygyria	Pachygyria is a malformation of cortical development with abnormally wide gyri with sulci 1,5-3 cm apart and abnormally thick cortex measuring more than 5 mm (radiological definition). See also neuropathological definitions for 2-, 3-, and 4-layered lissencephaly.   Synonyms:Cerebral pachygyria; Fewer and broader ridges in brain; Macrogyria	Very frequent
Polymicrogyria	Polymicrogyria is a congenital malformation of the cerebral cortex characterized by abnormal cortical layering (lamination) and an excessive number of small gyri (folds).   Synonyms:More grooves in brain	Very frequent
Posteriorly rotated ears	A type of abnormal location of the ears in which the position of the ears is characterized by posterior rotation (the superior part of the ears is rotated towards the back of the head, and the inferior part of the ears towards the front).   Synonyms:Ear, posterior angulation, increased; Ears rotated toward back of head; Posteriorly angulated ears; Posteriorly rotated; Posteriorly rotated auricles; Posteriorly-angulated ears; Posteriorly-rotated ears	Very frequent
Prominent nasal bridge	Anterior positioning of the nasal root in comparison to the usual positioning for age.   Synonyms:Elevated nasal bridge; High nasal bridge; Prominent bridge of nose; Prominent nasal bridge; Prominent nasal root; Protruding bridge of nose; Protruding nasal bridge	Very frequent
Seizure	A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.   Synonyms:Epileptic seizure; Seizures	Very frequent
Sleep abnormality	An abnormal pattern in the quality, quantity, or characteristics of sleep.   Synonyms:Difficulty sleeping; Sleep disturbance; Sleep disturbances; Sleep dysfunction; Trouble sleeping	Very frequent
Slender build	Asthenic habitus refers to a slender build with long limbs, an angular profile, and prominent muscles or bones.   Synonyms:Asthenic habitus; Slender build; Thin body habitus; Thin build	Very frequent
Strabismus	A misalignment of the eyes so that the visual axes deviate from bifoveal fixation. The classification of strabismus may be based on a number of features including the relative position of the eyes, whether the deviation is latent or manifest, intermittent or constant, concomitant or otherwise and according to the age of onset and the relevance of any associated refractive error.   Synonyms:Cross-eyed; Squint; Squint eyes	Very frequent
Upslanted palpebral fissure	The palpebral fissure inclination is more than two standard deviations above the mean for age (objective); or, the inclination of the palpebral fissure is greater than typical for age.   Synonyms:Mongoloid slant; Upslanting palpebral fissures; Upward slanted palpebral fissures; Upward slanting of palpebral fissures; Upward slanting of the opening between the eyelids; Upward slanting palpebral fissures	Very frequent