Total 60 clinical symptoms reported for Alexander disease  Very Frequent (16)Occasional (21)Frequent (23)

Abnormal pyramidal sign	Functional neurological abnormalities related to dysfunction of the pyramidal tract.   Synonyms:Corticospinal signs; Pyramidal signs; Pyramidal tract signs	Very frequent
Abnormal speech pattern	An abnormality in the sound (volume) or cadence (rate) of speech.   Synonyms:Abnormal speech; Abnormal vocalization; Abnormality of speech or vocalization	Very frequent
Agenesis of corpus callosum	Absence of the corpus callosum as a result of the failure of the corpus callosum to develop, which can be the result of a failure in any one of the multiple steps of callosal development including cellular proliferation and migration, axonal growth or glial patterning at the midline.   Synonyms:Absence of corpus callosum; Absent corpus callosum; Agenesis of the corpus callosum; Callosal agenesis; Corpus callosum agenesis; Dysplastic or absent corpus callosum	Very frequent
Clonus	A series of rhythmic and involuntary muscle contractions (at a frequency of about 5 to 7 Hz) that occur in response to an abruptly applied and sustained stretch.   Synonyms:Involuntary rhythmic muscular contractions and relaxations	Very frequent
Failure to thrive	Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.   Synonyms:Faltering weight; FTT; Postnatal failure to thrive; Weight faltering	Very frequent
Frontal bossing	Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline.   Synonyms:Frontal protuberance; Skull bossing	Very frequent
Hyperreflexia	Hyperreflexia is the presence of hyperactive stretch reflexes of the muscles.   Synonyms:Increased deep tendon reflexes; Increased reflexes	Very frequent
Intellectual disability	Intellectual disability, previously referred to as mental retardation, is characterized by subnormal intellectual functioning that occurs during the developmental period. It is defined by an IQ score below 70.   Synonyms:Intellectual disability; Mental deficiency; Mental retardation; Mental retardation, nonspecific; Mental-retardation; Nonprogressive intellectual disability; Nonprogressive mental retardation	Very frequent
Large face	Synonyms:Big face; Large face; Large facies	Very frequent
Macrocephaly	Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium.   Synonyms:Increased size of cranium; Increased size of skull; Large head; Large head circumference; Macrocephalus; Macrocrania; Megacephaly	Very frequent
Megalencephaly	Diffuse enlargement of the entire cerebral hemispheres leading to macrocephaly (with or without overlying cortical dysplasia).   Synonyms:Macrencephaly	Very frequent
Nausea and vomiting	Nausea is a commonly encountered symptom that has been defined as an unpleasant painless subjective feeling that one will imminently vomit. Vomiting has been defined as the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity. While nausea and vomiting are often thought to exist on a temporal continuum, this is not always the case. There are situations when severe nausea may be present without emesis and less frequently, when emesis may be present without preceding nausea.   Synonyms:Nausea and vomiting	Very frequent
Scoliosis	The presence of an abnormal lateral curvature of the spine.	Very frequent
Seizure	A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.   Synonyms:Epileptic seizure; Seizures	Very frequent
Sleep abnormality	An abnormal pattern in the quality, quantity, or characteristics of sleep.   Synonyms:Difficulty sleeping; Sleep disturbance; Sleep disturbances; Sleep dysfunction; Trouble sleeping	Very frequent
Spasticity	A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes.   Synonyms:Involuntary muscle stiffness, contraction, or spasm; Muscle spasticity; Muscular spasticity	Very frequent