Total 69 clinical symptoms reported for Aicardi-Goutieres syndrome 4

Arrhinencephaly	This section is currently in development.	Very frequent
Global developmental delay	A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age. Synonyms:Delayed cognitive development; Delayed development; Delayed developmental milestones; Delayed intellectual development; Delayed milestones; Delayed psychomotor development; Developmental delay; Developmental delay in early childhood; Developmental delay, global; Developmental retardation; Lack of psychomotor development; Motor and developmental delay; Psychomotor delay; Psychomotor development deficiency; Psychomotor development failure; Psychomotor developmental delay; Retarded development; Retarded mental development; Retarded psychomotor development	Very frequent
Hypertonia	A condition in which there is increased muscle tone so that arms or legs, for example, are stiff and difficult to move. Synonyms:Hypertonicity; Increased muscle tone	Very frequent
Intellectual disability, profound	Profound mental retardation is defined as an intelligence quotient (IQ) below 20. Synonyms:IQ less than 20; Mental retardation, profound; Profound mental retardation	Very frequent
Multifocal cerebral white matter abnormalities	This section is currently in development.	Very frequent
Porencephalic cyst	A cavity within the cerebral hemisphere, filled with cerebrospinal fluid, that communicates directly with the ventricular system. Synonyms:Cavity within brain	Very frequent
Spasticity	A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes. Synonyms:Involuntary muscle stiffness, contraction, or spasm; Muscle spasticity; Muscular spasticity	Very frequent