Total 12 clinical symptoms reported for Acrokeratosis verruciformis of Hopf  Very Frequent (5)Occasional (1)Not Applicable Or Unknown (2)Frequent (4)

Epidermal acanthosis	Diffuse hypertrophy or thickening of the stratum spinosum of the epidermis (prickle cell layer of the skin).   Synonyms:Acanthosis; Acanthotic epidermis; Thickening of upper layer of skin	Very frequent
Hypergranulosis	Hypergranulosis is an increased thickness of the stratum granulosum.	Very frequent
Hyperkeratosis	Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum.	Very frequent
Nail dystrophy	Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate.   Synonyms:Dystrophic nails; Onychodystrophy; Poor nail formation	Very frequent
Skin-colored papule	A papule with the same color as the surrounding skin.   Synonyms:Flesh-colored papule	Very frequent